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Cited by 1,095

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells

Open access
Stappenbeck, Thaddeus S., Hooper, Lora V., Gordon, Jeffrey I.·2002·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.202604299
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Abstract

The adult mouse intestine contains an intricate vascular network. The factors that control development of this network are poorly understood. Quantitative three-dimensional imaging studies revealed that a plexus of branched interconnected vessels developed in small intestinal villi during the period of postnatal development that coincides with assembly of a complex society of indigenous gut microorganisms (microbiota). To investigate the impact of this environmental transition on vascular development, we compared the capillary networks of germ-free mice with those of ex-germ-free animals colonized during or after completion of postnatal gut development. Adult germ-free mice had arrested capillary network formation. The developmental program can be restarted and completed within 10 days after colonization with a complete microbiota harvested from conventionally raised mice, or with Bacteroides thetaiotaomicron , a prominent inhabitant of the normal mouse/human gut. Paneth cells in the intestinal epithelium secrete antibacterial peptides that affect luminal microbial ecology. Comparisons of germ-free and B. thetaiotaomicron -colonized transgenic mice lacking Paneth cells established that microbial regulation of angiogenesis depends on this lineage. These findings reveal a previously unappreciated mechanism of postnatal animal development, where microbes colonizing a mucosal surface are assigned responsibility for regulating elaboration of the underlying microvasculature by signaling through a bacteria-sensing epithelial cell.

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Metadata

Authors
Stappenbeck, T. S., Hooper, L. V., & Gordon, J. I.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2002-11-13
Volume
99
Issue
24
Pages
15451-15455
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.202604299
OpenAlex
W2169619812
Cited by
1,095
References
1
FWCI
6.59
Type
journal article
Language
en
Open access
green

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