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Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

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Xiong, Yumei, Miyamoto, Norimasa, Shibata, Kenji, Valasek, Mark A., Motoike, Toshiyuki, Kedzierski, Rafal M., Yanagisawa, Masashi·2004·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.2637002100

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Abstract

Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo . Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2–C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of propionate increases circulating leptin levels in mice. The concentrations of short-chain fatty acids required to stimulate leptin production are within physiological ranges, suggesting the relevance of this pathway in vivo .

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Authors: Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M., & Yanagisawa, M.
Venue: Proceedings of the National Academy of Sciences
Publisher: Proceedings of the National Academy of Sciences
Published: 2004-01-13
Volume: 101
Issue: 4
Pages: 1045-1050
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.2637002100
OpenAlex: W2032767323
Cited by: 731
References: 6
FWCI: 3.70
Type: journal article
Language: en
Open access: green

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Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

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