Cited by 268Neuroendocrine regulation and behaviorAttachment and Relationship DynamicsChild Abuse and Trauma

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Maternal Neglect: Oxytocin, Dopamine and the Neurobiology of Attachment

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Strathearn, L.·2011·Journal of Neuroendocrinology

DOI 10.1111/j.1365-2826.2011.02228.xPMC PMC3319675

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Abstract

Maternal neglect, including physical and emotional neglect, is a pervasive public health challenge with serious long‐term effects on child health and development. I provide an overview of the neurobiological basis of maternal caregiving, aiming to better understand how to prevent and respond to maternal neglect. Drawing from both animal and human studies, key biological systems are identified that contribute to maternal caregiving behaviour, focusing on the oxytocinergic and dopaminergic systems. Mesocorticolimbic and nigrostriatal dopamine pathways contribute to the processing of infant‐related sensory cues leading to a behavioural response. Oxytocin may activate the dopaminergic reward pathways in response to social cues. Human neuroimaging studies are summarised that demonstrate parallels between animal and human maternal caregiving responses in the brain. By comparing different patterns of human adult attachment, we gain a clearer understanding of how differences in maternal brain and endocrine responses may contribute to maternal neglect. For example, in insecure/dismissing attachment, which may be associated with emotional neglect, we see reduced activation of the mesocorticolimbic dopamine reward system in response to infant face cues, as well as decreased peripheral oxytocin response to mother–infant contact. We are currently testing whether the administration of intranasal oxytocin, as part of a randomised placebo controlled trial, may reverse some of these neurological differences, and potentially augment psychosocial and behavioural interventions for maternal neglect.

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Untitled work
(1969) · Cited by 18,340
Epigenetic programming by maternal behavior
Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690
Adult attachment representations, parental responsiveness, and infant attachment: a meta-analysis on the predictive validity of the adult attachment interview
van IJzendoorn, M. H. (1995) · Psychological Bulletin · doi:10.1037/0033-2909.117.3.387 · Cited by 2,243
Nongenomic Transmission Across Generations of Maternal Behavior and Stress Responses in the Rat
Francis, D., Diorio, J., Liu, D., & Meaney, M. J. (1999) · Science · doi:10.1126/science.286.5442.1155 · Cited by 1,965
Attachment, exploration, and separation: illustrated by the behavior of one-year-olds in a strange situation
Ainsworth, M. D. S., & Bell, S. M. (1970) · Child Development · doi:10.2307/1127388 · Cited by 1,764
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610
The neural correlates of maternal and romantic love
Bartels, A., & Zeki, S. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.003 · Cited by 1,497
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Oxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258
Maternal Representations of Attachment during Pregnancy Predict the Organization of Infant-Mother Attachment at One Year of Age
Fonagy, P., Steele, H., & Steele, M. (1991) · Child Development · doi:10.1111/j.1467-8624.1991.tb01578.x · Cited by 1,173
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
The Development of the person: the Minnesota study of risk and adaptation from birth to adulthood
(2005) · Choice Reviews Online · doi:10.5860/choice.43-2509 · Cited by 1,080
Oxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
Computational roles for dopamine in behavioural control
Montague, P. R., Hyman, S. E., & Cohen, J. D. (2004) · Nature · doi:10.1038/nature03015 · Cited by 966
Temporal Prediction Errors in a Passive Learning Task Activate Human Striatum
McClure, S. M., Berns, G. S., & Montague, P. R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00154-5 · Cited by 917
Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin
Pedersen, C. A., & Prange, A. J. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.12.6661 · Cited by 841
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798
Adult attachment predicts maternal brain and oxytocin response to infant cues.
Strathearn, L., Fonagy, P., Amico, J., & Montague, P. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.103 · Cited by 773
Self-citation
The first 10,000 Adult Attachment Interviews: distributions of adult attachment representations in clinical and non-clinical groups
Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2009) · Attachment & Human Development · doi:10.1080/14616730902814762 · Cited by 742
Predictability modulates human brain response to reward
Berns, G. S., McClure, S. M., Pagnoni, G., & Montague, P. R. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02793.2001 · Cited by 711
Dopamine Release in Response to a Psychological Stress in Humans and Its Relationship to Early Life Maternal Care: A Positron Emission Tomography Study Using [ 11 C]Raclopride
Pruessner, J. C., Champagne, F., Meaney, M. J., & Dagher, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3422-03.2004 · Cited by 709
Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors
Champagne, F., Diorio, J., Sharma, S., & Meaney, M. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221224598 · Cited by 707
Assessing adult attachment.
Feeney, J. A., Noller, P., & Hanrahan, M. U. (1994) · Cited by 687
Maternal Care Associated with Methylation of the Estrogen Receptor-α1b Promoter and Estrogen Receptor-α Expression in the Medial Preoptic Area of Female Offspring
Champagne, F. A., Weaver, I. C. G., Diorio, J., Dymov, S., Szyf, M., & Meaney, M. J. (2006) · Endocrinology · doi:10.1210/en.2005-1119 · Cited by 675
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
Francis, D. D., Diorio, J., Plotsky, P. M., & Meaney, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07840.2002 · Cited by 663
The Development of the Person: The Minnesota Study of Risk and Adaptation from Birth to Adulthood
Freud, S. (2006) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.2006.60.4.407 · Cited by 648
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624
School performance and disciplinary problems among abused and neglected children
Eckenrode, J., Laird, M., & Doris, J. (1993) · Developmental Psychology · doi:10.1037/0012-1649.29.1.53 · Cited by 609
Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518
Stress During Gestation Alters Postpartum Maternal Care and the Development of the Offspring in a Rodent Model
Champagne, F. A., & Meaney, M. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.016 · Cited by 510
The developmental consequence of different patterns of maltreatment
Egeland, B. R., Sroufe, L. A., & Erickson, M. F. (1983) · Child Abuse & Neglect · doi:10.1016/0145-2134(83)90053-4 · Cited by 499
Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat
Francis, D. D., Champagne, F. C., & Meaney, M. J. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00599.x · Cited by 496
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas.
Pedersen, C. A., Caldwell, J. D., Walker, C., Ayers, G., & Mason, G. A. (1994) · Behavioral Neuroscience · doi:10.1037/0735-7044.108.6.1163 · Cited by 475
What’s in a smile? Maternal brain responses to infant facial cues
Strathearn, L., Li, J., Fonagy, P., & Montague, P. R. (2008) · Pediatrics · doi:10.1542/peds.2007-1566 · Cited by 460
Self-citation
Chapter 21 Like mother, like daughter: evidence for non-genomic transmission of parental behavior and stress responsivity
Champagne, F., & Meaney, M. J. (2001) · Progress in Brain Research · doi:10.1016/s0079-6123(01)33022-4 · Cited by 455
Is social attachment an addictive disorder?
Insel, T. R. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00148-3 · Cited by 430
Mothers' Internal Models of Relationships and Children's Behavioral and Developmental Status: A Study of Mother-Child Interaction
Crowell, J. A., & Feldman, S. S. (1988) · Child Development · doi:10.2307/1130490 · Cited by 418
A computational substrate for incentive salience
McClure, S. M., Daw, N. D., & Montague, P. R. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00177-2 · Cited by 416
Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat
Champagne, F. A., Chretien, P., Stevenson, C. W., Zhang, T. Y., Gratton, A., & Meaney, M. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5322-03.2004 · Cited by 398
Breastfeeding, brain activation to own infant cry, and maternal sensitivity
Kim, P., Feldman, R., Mayes, L. C., Eicher, V., Thompson, N., Leckman, J. F., & Swain, J. E. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2011.02406.x · Cited by 386
Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty
Champagne, F. A., & Meaney, M. J. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.6.1353 · Cited by 381
Dopamine and Oxytocin Interactions Underlying Behaviors: Potential Contributions to Behavioral Disorders
Baskerville, T. A., & Douglas, A. J. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00154.x · Cited by 377
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
Tomizawa, K., Iga, N., Lü, Y.-F., Moriwaki, A., Matsushita, M., Li, S., Miyamoto, O., Itano, T., & Matsui, H. (2003) · Nature Neuroscience · doi:10.1038/nn1023 · Cited by 372
Oxytocin–dopamine interactions mediate variations in maternal behavior in the rat
Shahrokh, D. K., Zhang, T.-Y., Diorio, J., Gratton, A., & Meaney, M. J. (2010) · Endocrinology · doi:10.1210/en.2009-1271 · Cited by 366
Baby schema modulates the brain reward system in nulliparous women
Glocker, M. L., Langleben, D. D., Ruparel, K., Loughead, J. W., Valdez, J. N., Griffin, M. D., Sachser, N., & Gur, R. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811620106 · Cited by 365
Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats
Numan, M., & Stolzenberg, D. S. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.10.002 · Cited by 361
A potential role for thalamocingulate circuitry in human maternal behavior
Lorberbaum, J. P., Newman, J. D., Horwitz, A. R., Dubno, J. R., Lydiard, R. B., Hamner, M. B., Bohning, D. E., & George, M. S. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01284-7 · Cited by 359
Oxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352
Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys
Winslow, J. T., Noble, P. L., Lyons, C. K., Sterk, S. M., & Insel, T. R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300128 · Cited by 345
The Functional Neuroanatomy of Maternal Love: Mother’s Response to Infant’s Attachment Behaviors
Noriuchi, M., Kikuchi, Y., & Senoo, A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.018 · Cited by 334
Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse?
Meaney, M. J., Brake, W., & Gratton, A. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00040-3 · Cited by 325
Characterization of the oxytocin system regulating affiliative behavior in female prairie voles
Ross, H. E., Cole, C. D., Smith, Y., Neumann, I. D., Landgraf, R., Murphy, A. Z., & Young, L. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.055 · Cited by 309
Impact of Hostility and Withdrawal in Interparental Conflict on Parental Emotional Unavailability and Children's Adjustment Difficulties
Sturge‐Apple, M. L., Davies, P. T., & Cummings, E. M. (2006) · Child Development · doi:10.1111/j.1467-8624.2006.00963.x · Cited by 299
Motherhood improves learning and memory
Kinsley, C. H., Madonia, L., Gifford, G. W., Tureski, K., Griffin, G. R., Lowry, C., Williams, J., Collins, J., McLearie, H., & Lambert, K. G. (1999) · Nature · doi:10.1038/45957 · Cited by 297
Oxytocin receptors in the nucleus accumbens facilitate “spontaneous” maternal behavior in adult female prairie voles
Olazábal, D. E., & Young, L. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.017 · Cited by 289
Adult Attachment, Parent Emotion, and Observed Parenting Behavior: Mediator and Moderator Models
Adam, E. K., Gunnar, M. R., & Tanaka, A. (2004) · Child Development · doi:10.1111/j.1467-8624.2004.00657.x · Cited by 271
Post-learning intranasal oxytocin modulates human memory for facial identity
Savaskan, E., Ehrhardt, R., Schulz, A., Walter, M., & Schächinger, H. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.12.004 · Cited by 262
Isolation rearing in rats: pre- and postsynaptic changes in striatal dopaminergic systems
Hall, F. S., Wilkinson, L. S., Humby, T., Inglis, W., Kendall, D. A., Marsden, C. A., & Robbins, T. W. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00510-8 · Cited by 261
Hypothalamic Neural Circuits Regulating Maternal Responsiveness Toward Infants
Numan, M. (2006) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582306288790 · Cited by 258
The cross-generation transmission of oxytocin in humans
Feldman, R., Gordon, I., & Zagoory-Sharon, O. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.005 · Cited by 256
Dopamine Receptor Blockade in the Nucleus Accumbens Inhibits Maternal Retrieval and Licking, but Enhances Nursing Behavior in Lactating Rats
Keer, S. E., & Stern, J. M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00116-x · Cited by 250
The human parental brain: In vivo neuroimaging
Swain, J. E. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.10.017 · Cited by 234
Motherhood and the hormones of pregnancy modify concentrations of hippocampal neuronal dendritic spines
Kinsley, C. H., Trainer, R., Stafisso-Sandoz, G., Quadros, P. S., Keyser‐Marcus, L., Hearon, C., Meyer, E. A. A., Hester, N. W., Morgan, M. D., & Kozub, F. J. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.05.017 · Cited by 233
Behavioural disturbances associated with hyperdopaminergia in dopamine-transporter knockout mice
Spielewoy, C., Roubert, C., Hamon, M., Nosten‐Bertrand, M., Betancur, C., & Bruno Giros, A. (2000) · Behavioural Pharmacology · doi:10.1097/00008877-200006000-00011 · Cited by 228
Maternal brain response to own baby‐cry is affected by cesarean section delivery
Swain, J. E., Tasgin, E., Mayes, L. C., Feldman, R., Todd Constable, R., & Leckman, J. F. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01963.x · Cited by 206
Does Breastfeeding Protect Against Substantiated Child Abuse and Neglect? A 15-Year Cohort Study
Strathearn, L., Mamun, A. A., Najman, J. M., & O'Callaghan, M. J. (2009) · PEDIATRICS · doi:10.1542/peds.2007-3546 · Cited by 203
Self-citation
Neglected Children: Research, Practice, and Policy
Dubowitz, H. (1999) · Sage eBooks · doi:10.4135/9781452225586 · Cited by 199
Functional Magnetic Resonance Imaging Shows Oxytocin Activates Brain Regions Associated with Mother–Pup Bonding during Suckling
Febo, M., Numan, M., & Ferris, C. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3604-05.2005 · Cited by 197
The effects of D1 or D2 dopamine receptor antagonism in the medial preoptic area, ventral pallidum, or nucleus accumbens on the maternal retrieval response and other aspects of maternal behavior in rats.
Numan, M., Numan, M. J., Pliakou, N., Stolzenberg, D. S., Mullins, O. J., Murphy, J. M., & Smith, C. D. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.6.1588 · Cited by 186
Oxytocin Facilitation of Maternal Behavior in Sheepa
Keverne, E. B., & Kendrick, K. M. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb34348.x · Cited by 183
Importance of Early Neglect for Childhood Aggression
Kotch, J. B., Lewis, T., Hussey, J. M., English, D., Thompson, R., Litrownik, A. J., Runyan, D. K., Bangdiwala, S. I., Margolis, B., & Dubowitz, H. (2008) · Pediatrics · doi:10.1542/peds.2006-3622 · Cited by 183
Child Abuse and Neglect and Cognitive Function at 14 Years of Age: Findings From a Birth Cohort
Mills, R. J., Alati, R., O'Callaghan, M. J., Najman, J. M., Williams, G. M., Bor, W., & Strathearn, L. (2010) · PEDIATRICS · doi:10.1542/peds.2009-3479 · Cited by 181
Self-citation
Intracranial dialysis measurement of oxytoxin, monoamine and uric acid release from the olfactory bulb and substantia nigra of sheep during parturition, suckling, separation from lambs and eating
Kendrick, K. M., Keverne, E. B., Chapman, C., & Baldwin, B. A. (1988) · Brain Research · doi:10.1016/0006-8993(88)91455-2 · Cited by 175
Oxytocin Control of Maternal Behavior Regulation by Sex Steroids and Offspring Stimulia
PEDERSEN, C. A. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb51916.x · Cited by 172
From ultrasocial to antisocial: A role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?
McGregor, I. S., Callaghan, P. D., & Hunt, G. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.132 · Cited by 171
Raising Parents
Crittenden, P. M. (2013) · Routledge eBooks · doi:10.4324/9780203069776 · Cited by 159
Child neglect: outcomes in high-risk urban preschoolers
Dubowitz, H., Papas, M. A., Black, M. M., & Starr, R. H. (2002) · Pediatrics · doi:10.1542/peds.109.6.1100 · Cited by 159
Raising parents: attachment, parenting and child safety
(2009) · Choice Reviews Online · doi:10.5860/choice.46-5326 · Cited by 159
Maternally separated rats show deficits in maternal care in adulthood
Lovic, V., González, A., & Fleming, A. S. (2001) · Developmental Psychobiology · doi:10.1002/dev.1024 · Cited by 149
The effects of child maltreatment on language development
Allen, R. E., & Oliver, J. M. (1982) · Child Abuse & Neglect · doi:10.1016/0145-2134(82)90033-3 · Cited by 148
Oxytocin, prolactin, milk production and their relationship with personality traits in women after vaginal delivery or Cesarean section
Nissen, E., Gustavsson, P. J., Widström, A., & Uvnäs‐Moberg, K. (1998) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674829809044221 · Cited by 148
Childhood Neglect and Cognitive Development in Extremely Low Birth Weight Infants: A Prospective Study
Strathearn, L., Gray, P. H., O'Callaghan, F., & Wood, D. O. (2001) · PEDIATRICS · doi:10.1542/peds.108.1.142 · Cited by 143
Self-citation
Disruption of maternal parenting circuitry by addictive process: rewiring of reward and stress systems
Rutherford, H. J. V., Williams, S. K., Moy, S., Mayes, L. C., & Johns, J. M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00037 · Cited by 140
Emotional sensitivity for motherhood: Late pregnancy is associated with enhanced accuracy to encode emotional faces
Pearson, R. M., Lightman, S. L., & Evans, J. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.09.013 · Cited by 136
Exposure to Chronic Pregnancy Stress Reverses Peripartum-Associated Adaptations: Implications for Postpartum Anxiety and Mood Disorders
Hillerer, K. M., Reber, S. O., Neumann, I. D., & Slattery, D. A. (2011) · Endocrinology · doi:10.1210/en.2011-1091 · Cited by 122
An Information-Processing Perspective on the Behavior of Neglectful Parents
Crittenden, P. M. (1993) · Criminal Justice and Behavior · doi:10.1177/0093854893020001004 · Cited by 114
Is Attachment Transmitted Across Generations? The Plot Thickens
Shah, P. E., Fonagy, P., & Strathearn, L. (2010) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104510365449 · Cited by 102
Self-citation
Previous maternal experience potentiates the effect of parturition on oxytocin receptor mRNA expression in the paraventricular nucleus
Broad, K. D., Lévy, F., Evans, G., Kimura, T., Keverne, E. B., & Kendrick, K. M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00782.x · Cited by 100
Child Neglect: Causes and Contributors
Crittenden, P. M. (1999) · Sage eBooks · doi:10.4135/9781452225586.n3 · Cited by 96
Developmental science and psychoanalysis. Integration and innovation
(2008) · Psychoanalytic Psychotherapy · doi:10.1080/02668730802102708 · Cited by 93
Changes in Oxytocin Immunoreactivity and mRNA Expression in the Sheep Brain during Pregnancy, Parturition and Lactation and in Response to Oestrogen and Progesterone
Broad, K. D., Kendrick, K. M., SIRINATHSINGHJI, D. J. S., & Keverne, E. B. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00505.x · Cited by 90
Patterns of Language Comprehension Deficit in Abused and Neglected Children
Fox, L., Long, S. H., & Langlois, A. (1988) · Journal of Speech and Hearing Disorders · doi:10.1044/jshd.5303.239 · Cited by 86
Child Neglect: A Review of Definitions and Measurement Research
Zuravin, S. J. (1999) · Sage eBooks · doi:10.4135/9781452225586.n2 · Cited by 80
Cocaine addiction in mothers: Potential effects on maternal care and infant development
Strathearn, L., & Mayes, L. C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05142.x · Cited by 80
Self-citation
Motherhood Induces and Maintains Behavioral and Neural Plasticity across the Lifespan in the Rat
Kinsley, C. H., Bardi, M., Karelina, K., Rima, B., Christon, L., Friedenberg, J. M., & Griffin, G. R. (2007) · Archives of Sexual Behavior · doi:10.1007/s10508-007-9277-x · Cited by 79
Maternal imprints and the origins of variation
Champagne, F. A. (2011) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.02.016 · Cited by 74
Child Neglect: The Family with a Hole in the Middle
Garbarino, J., & Collins, C. C. (1999) · Sage eBooks · doi:10.4135/9781452225586.n1 · Cited by 72
Effects of cocaine on the contents of neurohypophyseal hormones in the plasma and in different brain structures in rats
Sarnyai, Z., Vecsernyés, M., Laczi, F., Bíró, É., Szabó, G., & Kovács, G. L. (1992) · Neuropeptides · doi:10.1016/0143-4179(92)90006-i · Cited by 66
Child Neglect: Short-Term and Long-Term Outcomes
Gaudin, J. M. (1999) · Sage eBooks · doi:10.4135/9781452225586.n5 · Cited by 65
Oxytocin modulates unconditioned fear response in lactating dams: An fMRI study
Febo, M., Shields, J., Ferris, C. F., & King, J. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.09.043 · Cited by 47
Introduction to Addiction Reviews 2
Uhl, G. R., & for the Editorial Advisory Board (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05418.x · Cited by 8

Research works printed but not linked: 3

US Department of Health and Human Services, 2010, Child Maltreatment 2009
Sedlak AJ, 1996, The Third National Incidence Study On Child Abuse And Neglect
Strathearn L, 2008, Does Chronic Cocaine Use Affect a Mother’s Brain Response to Baby Face Cues? A pilot fMRI study

Sorted by citations

Early skin-to-skin contact for mothers and their healthy newborn infants
Moore, E. R., Bergman, N., Anderson, G. C., & Medley, N. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003519.pub4 · Cited by 1,930
The Neurobiology of Human Attachments
Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839
“Yet, while DA neurons function as general-purpose stimulators to reward-related targets, it is their close links with OT receptors in striatum, where OT receptors abound [18,19], that imbue attachment bonds with incentive value and direct action toward affiliative goals, such as maternal care [9,20,21].”
Future Directions in Childhood Adversity and Youth Psychopathology
McLaughlin, K. A. (2016) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2015.1110823 · Cited by 576
“Alternatively, given the central role of the mesolimbic dopamine system in attachment-related behavior (Strathearn, 2011), the absence or unpredictability of an attachment figure in early development may reduce opportunities for learning about the rewarding nature of affiliative interactions and social bonds; the abse…”
Background
Long-term Cognitive, Psychological, and Health Outcomes Associated With Child Abuse and Neglect
Strathearn, L., Giannotti, M., Mills, R., Kisely, S., Najman, J., & Abajobir, A. (2020) · Pediatrics · doi:10.1542/peds.2020-0438 · Cited by 401
Self-citation
Substance use during pregnancy
Forray, A. (2016) · F1000Research · doi:10.12688/f1000research.7645.1 · Cited by 322

See all 268

Authors: Strathearn, L.
Affiliations: Baylor College of Medicine (US)
Corresponding author: Strathearn, L.
ORCID: Strathearn, L.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2011-10-18
Volume: 23
Issue: 11
Pages: 1054-1065
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1111/j.1365-2826.2011.02228.x
PMC: PMC3319675
OpenAlex: W1586996126
Cited by: 268
References: 105
Citations by year: 2026: 6 · 2025: 10 · 2024: 15 · 2023: 18 · 2022: 18 · 2021: 16 · 2020: 24 · 2019: 20 · 2018: 23 · 2017: 18 · 2016: 29 · 2015: 21 · 2014: 20 · 2013: 19 · 2012: 10
FWCI: 2.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Drug Abuse (R01DA026437, P01DA022446, P0 DA022446)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065819)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: maternal neglect, maternal care, oxytocin, dopamine, attachment, nigrostriatal dopamine pathway, emotional neglect, infant face processing, mother-infant contact, intranasal oxytocin
MeSH terms: Child, Child Abuse, Dopamine, Humans, Mothers, Oxytocin

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Maternal Neglect: Oxytocin, Dopamine and the Neurobiology of Attachment

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