Cited by 106Telomeres, Telomerase, and SenescenceResilience and Mental HealthAging and Gerontology Research

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An Intricate Dance: Life Experience, Multisystem Resiliency, and Rate of Telomere Decline Throughout the Lifespan

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Puterman, Eli, Epel, Elissa·2012·Social and Personality Psychology Compass

DOI 10.1111/j.1751-9004.2012.00465.xPMC PMC3496269

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Abstract

Accumulation of life stressors predicts accelerated development and progression of diseases of aging. Telomere length, the DNA‐based biomarker indicating cellular aging, is a mechanism of disease development, and is shortened in a dose response fashion by duration and severity of life stressor exposures. Telomere length captures the interplay between genetics, life experiences and psychosocial and behavioral factors. Over the past several years, psychological stress resilience, healthy lifestyle factors, and social connections have been associated with longer telomere length and it appears that these factors can protect individuals from stress‐induced telomere shortening. In the current review, we highlight these findings, and illustrate that combining these ‘multisystem resiliency’ factors may strengthen our understanding of aging, as these powerful factors are often neglected in studies of aging. In naturalistic studies, the effects of chronic stress exposure on biological pathways are rarely main effects, but rather a complex interplay between adversity and resiliency factors. We suggest that chronic stress effects can be best understood by directly testing if the deleterious effects of stress on biological aging processes, in this case the cell allostasis measure of telomere shortening, are mitigated in individuals with high levels of multisystem resiliency. Without attending to such interactions, stress effects are often masked and missed. Taking account of the cluster of positive buffering factors that operate across the lifespan will take us a step further in understanding healthy aging. While these ideas are applied to the telomere length literature for illustration, the concept of multisystem resiliency might apply to aging broadly, from cellular to systemic health.

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Short Telomeres Are Associated With Increased Carotid Atherosclerosis in Hypertensive Subjects
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A priori–defined dietary patterns and markers of cardiovascular disease risk in the Multi-Ethnic Study of Atherosclerosis (MESA)
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Relationship between Physical Activity Level, Telomere Length, and Telomerase Activity
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Telomeres and Telomerase: The Means to the End (Nobel Lecture)
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Diet, nutrition and telomere length
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Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspects
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Race/ethnicity and telomere length in the Multi‐Ethnic Study of Atherosclerosis
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Immunology: Understanding The Immune System
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Telomere Length Trajectory and Its Determinants in Persons with Coronary Artery Disease: Longitudinal Findings from the Heart and Soul Study
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Poor maternal nutrition followed by accelerated postnatal growth leads to telomere shortening and increased markers of cell senescence in rat islets
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Preface to The Biology of Disadvantage: Socioeconomic Status and Health
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Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA)
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Short Telomeres in Depression and the General Population Are Associated with a Hypocortisolemic State
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Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity
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Telomere Length, Current Perceived Stress, and Urinary Stress Hormones in Women
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Promoting Functional Health in Midlife and Old Age: Long-Term Protective Effects of Control Beliefs, Social Support, and Physical Exercise
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Shortened telomeres in individuals with abuse in alcohol consumption
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Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women
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The end of the (DNA) line.
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Telomere attrition as ageing biomarker.
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Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease
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Stress appraisals and cellular aging: A key role for anticipatory threat in the relationship between psychological stress and telomere length
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Social relationships and health: Is feeling positive, negative, or both (ambivalent) about your social ties related to telomeres?
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Low birth weight is associated with altered immune function in rural Bangladeshi children: a birth cohort study
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Leukocyte Telomere Length and Carotid Artery Intimal Medial Thickness
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Neurodevelopmental Biology Associated with Childhood Sexual Abuse
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Maternal diet influences DNA damage, aortic telomere length, oxidative stress, and antioxidant defense capacity in rats
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Accelerated Telomere Attrition Is Associated with Relative Household Income, Diet and Inflammation in the pSoBid Cohort
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Modeling multisystem biological risk in young adults: The Coronary Artery Risk Development in Young Adults Study
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The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder
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Healthy Lifestyle and Leukocyte Telomere Length in U.S. Women
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Educational attainment but not measures of current socioeconomic circumstances are associated with leukocyte telomere length in healthy older men and women
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PARENTING PRACTICES, SOCIAL SKILLS AND PEER RELATIONSHIPS IN ADOLESCENCE
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Life Stress, Emotional Health, and Mean Telomere Length in the European Prospective Investigation into Cancer (EPIC)-Norfolk Population Study
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Shorter telomeres are associated with obesity and weight gain in the elderly
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Mice Deficient in Telomerase Activity Develop Hypertension Because of an Excess of Endothelin Production
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Depression and Leukocyte Telomere Length in Patients With Coronary Heart Disease: Data From The Heart and Soul Study
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Physical activity moderates effects of stressor-induced rumination on cortisol reactivity
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Associations between Rotating Night Shifts, Sleep Duration, and Telomere Length in Women
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Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis
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Shorter Leukocyte Telomere Length in Midlife Women with Poor Sleep Quality
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See What You Think
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Telomere shortening in formerly abused and never abused women.
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“For example, past duration of stressor exposure (whether it be caregiving, depression, or violence) is directly related to telomere length (Epel et al., 2004; Humphreys et al., 2011; Wolkowitz et al., 2011).”
BackgroundSelf-citation
Telomeres in a Life-Span Perspective
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Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primates
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The Role of Stressors and Psychosocial Variables in the Stress Process: A Study of Chronic Caregiver Stress
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Telomere biology in cardiovascular disease: the TERC-/- mouse as a model for heart failure and ageing
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No association between socio‐economic status and white blood cell telomere length
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Relationships and Inflammation across the Lifespan: Social Developmental Pathways to Disease
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Emotional and Physiological Responses to Social-Evaluative Threat
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“Individuals respond to acute and chronic stressors with large differences in emotional and cognitive regulatory processes (Dickerson, 2008; Dickerson, Gruenewald, & Kemeny, 2004; Kirschbaum, Pirke, & Hellhammer, 1993; Lazarus & Folkman, 1984; McRae, Jacobs, Ray, John, & Gross, 2012).”
Background
Telomerase and Cancer
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Telomeres are shorter in placental trophoblasts of pregnancies complicated with intrauterine growth restriction (IUGR)
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Physical Fitness and Telomere Length in Patients with Coronary Heart Disease: Findings from the Heart and Soul Study
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Hostility and Cellular Aging in Men from the Whitehall II Cohort
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Telomere length and adiposity in a racially diverse sample
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Socioeconomic status and telomere length: the West of Scotland Coronary Prevention Study: Table 1
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Psychosocial Predictors of Coronary Artery Calcification Progression in Postmenopausal Women
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Leukocyte telomere length and marital status among middle-aged adults
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Telomere length may be associated with hypertension
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Erratum: Telomere dysfunction induces metabolic and mitochondrial compromise
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Indirect effect of financial strain on daily cortisol output through daily negative to positive affect index in the Coronary Artery Risk Development in Young Adults Study
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The Future of Aging
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See all 106

Authors: Puterman, E., & Epel, E.
Affiliations: University of California, San Francisco (US)
ORCID: Puterman, Eli
Epel, Elissa
Venue: Social and Personality Psychology Compass
Publisher: Wiley
Published: 2012-11
Volume: 6
Issue: 11
Pages: 807-825
ISSN: 1751-9004 (ISSN-L)
DOI: 10.1111/j.1751-9004.2012.00465.x
PMC: PMC3496269
OpenAlex: W2109862117
Cited by: 106
References: 187
Citations by year: 2026: 2 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 12 · 2018: 14 · 2017: 6 · 2016: 15 · 2015: 9 · 2014: 11 · 2013: 3 · 2012: 1
FWCI: 5.14
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4 d)
Locations: Social and Personality Psychology Compass (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
University of California, San Francisco
National Institute on Aging (R01AG030424)
National Heart, Lung, and Blood Institute (K99HL109247, R01HL108821)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords: telomere length, telomere shortening, chronic stress, psychological resilience, healthy aging, cellular aging, allostasis, social connectedness, healthy lifestyle factors, life events, lifespan development

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An Intricate Dance: Life Experience, Multisystem Resiliency, and Rate of Telomere Decline Throughout the Lifespan

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