Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

Principles of neural science

(1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90076-5 · Cited by 9,089

Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide

Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029

Bilirubin Is an Antioxidant of Possible Physiological Importance

Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 2,948

The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667 · cited 1×

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

Maines, M. D. (1997) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,505

Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway

Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153

Two's company, three's a crowd: can H 2 S be the third endogenous gaseous transmitter?

Wang, R. (2002) · The FASEB Journal · doi:10.1096/fj.02-0211hyp · Cited by 1,807

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

Tenhunen, R., Marver, H. S., & Schmid, R. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.61.2.748 · Cited by 1,803

Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications

Maines, M. D. (1988) · The FASEB Journal · doi:10.1096/fasebj.2.10.3290025 · Cited by 1,707

Carbon Monoxide: a Putative Neural Messenger

Verma, A., Hirsch, D. J., Glatt, C. E., Ronnett, G. V., & Snyder, S. H. (1993) · Science · doi:10.1126/science.7678352 · Cited by 1,563

Microsomal Heme Oxygenase

Tenhunen, R., Marver, H. S., & Schmid, R. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63477-5 · Cited by 1,357

P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function

Roman, R. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00021.2001 · Cited by 1,309

Reduced stress defense in heme oxygenase 1-deficient cells

Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10925 · Cited by 1,291

Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.

Keyse, S. M., & Tyrrell, R. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.1.99 · Cited by 1,264

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

Yachie, A., Niida, Y., Wada, T., Igarashi, N., Kaneda, H., Toma, T., Ohta, K., Kasahara, Y., & Koizumi, S. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4165 · Cited by 1,255

Ferritin: a cytoprotective antioxidant strategem of endothelium.

Balla, G., Jacob, H. S., Balla, J., Rosenberg, M., Nath, K., Apple, F., Eaton, J. W., & Vercellotti, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37165-0 · Cited by 1,097

Biliverdin reductase: A major physiologic cytoprotectant

Barañano, D. E., Rao, M., Ferris, C. D., & Snyder, S. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252626999 · Cited by 1,088

Oxygen Activation by Cytochrome P-4501

White, R. E., & Coon, M. J. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.001531 · Cited by 1,023 · cited 1×

A vertebrate globin expressed in the brain

Burmester, T., Weich, B., Reinhardt, S., & Hankeln, T. (2000) · Nature · doi:10.1038/35035093 · Cited by 1,023

Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice

Lee, T.-S., & Chau, L.-Y. (2002) · Nature Medicine · doi:10.1038/nm0302-240 · Cited by 1,019

Heme oxygenase 1 is required for mammalian iron reutilization

Poss, K. D., & Tonegawa, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10919 · Cited by 1,016

Carbon Monoxide-Releasing Molecules: Characterization of Biochemical and Vascular Activities

Motterlini, R., Clark, J. E., Foresti, R., Sarathchandra, P., Mann, B. E., & Green, C. J. (2002) · Circulation Research · doi:10.1161/hh0202.104530 · Cited by 998

Carbon Monoxide Generated by Heme Oxygenase 1 Suppresses Endothelial Cell Apoptosis

Brouard, S., Otterbein, L. E., Anrather, J., Tobiasch, E., Bach, F. H., Choi, A. M. K., & Soares, M. P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1015 · Cited by 984

Heme oxygenase: colors of defense against cellular stress

Otterbein, L. E., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.6.l1029 · Cited by 870

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress

Motterlini, R., Foresti, R., Bassi, R., & Green, C. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00294-x · Cited by 846

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

Mccoubrey, W. K., Huang, T. J., & Maines, M. D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00725.x · Cited by 823

The heme synthesis and degradation pathways: role in oxidant sensitivity

Ryter, S. W., & Tyrrell, R. M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00223-3 · Cited by 820

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Lee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5375 · Cited by 782

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

Maines, M. D., Trakshel, G. M., & Kutty, R. K. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42488-4 · Cited by 759

Principles of Neural Science, 4th ed.

SCHULTZ, S. K. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.662 · Cited by 753

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

Doré, S., Takahashi, M., Ferris, C. D., Hester, L. D., Guastella, D., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2445 · Cited by 699

Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat.

Nath, K. A., Balla, G., Vercellotti, G. M., Balla, J., Jacob, H. S., Levitt, M. D., & Rosenberg, M. E. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115847 · Cited by 686

Cardioprotective Actions by a Water-Soluble Carbon Monoxide–Releasing Molecule

Clark, J. E., Naughton, P., Shurey, S., Green, C. J., Johnson, T. R., Mann, B. E., Foresti, R., & Motterlini, R. (2003) · Circulation Research · doi:10.1161/01.res.0000084381.86567.08 · Cited by 673

Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

Stone, J. R., & Marletta, M. A. (1994) · Biochemistry · doi:10.1021/bi00184a036 · Cited by 647

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf516 · Cited by 637

Pro-oxidant and cytotoxic effects of circulating heme

Jeney, V., Balla, J., Yachie, A., Varga, Z., Vercellotti, G. M., Eaton, J. W., & Balla, G. (2002) · Blood · doi:10.1182/blood.v100.3.879 · Cited by 633

Induction of heme oxygenase: a general response to oxidant stress in cultured mammalian cells.

Applegate, L. A., Lüscher, P., & Tyrrell, R. M. (1991) · PubMed · Cited by 629

Expression of heme oxygenase-1 can determine cardiac xenograft survival

Soares, M. P., Lin, Y., Anrather, J., Csizmadia, E., Takigami, K., Sato, K., Grey, S. T., Colvin, R. B., Choi, A. M., Poss, K. D., et al. (1998) · Nature Medicine · doi:10.1038/2063 · Cited by 612

Prostaglandin endoperoxide synthase: structure and catalysis

Smith, W. L., & Marnett, L. J. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90119-3 · Cited by 601

Neonatal Hyperbilirubinemia

Dennery, P. A., Seidman, D. S., & Stevenson, D. K. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102223440807 · Cited by 598

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

Balla, J., Jacob, H. S., Balla, G., Nath, K., Eaton, J. W., & Vercellotti, G. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9285 · Cited by 591

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

Goldberg, M. A., & Schneider, T. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41787-x · Cited by 572

Microsatellite Polymorphism in the Heme Oxygenase-1 Gene Promoter Is Associated with Susceptibility to Emphysema

Yamada, N., Yamaya, M., Okinaga, S., Nakayama, K., Sekizawa, K., Shibahara, S., & Sasaki, H. (2000) · The American Journal of Human Genetics · doi:10.1086/302729 · Cited by 568

Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin

Tan, D., Manchester, L. C., Hardeland, R., Lopez‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541

Different Faces of the Heme-Heme Oxygenase System in Inflammation

Wagener, F. A. D. T. G., Volk, H.-D., Willis, D., Abraham, N. G., Soares, M. P., Adema, G. J., & Figdor, C. G. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.5 · Cited by 537

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1

Ogawa, K. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2835 · Cited by 528

Heme oxygenase-1 protects against vascular constriction and proliferation

Duckers, H. J., Boehm, M., True, A. L., Yet, S.-F., San, H., Park, J. L., Clinton Webb, R., Lee, M.-E., Nabel, G. J., & Nabel, E. G. (2001) · Nature Medicine · doi:10.1038/89068 · Cited by 525

Haem oxygenase-1 prevents cell death by regulating cellular iron

Ferris, C. D., Jaffrey, S. R., Sawa, A., Takahashi, M., Brady, S. D., Barrow, R. K., Tysoe, S. A., Wolosker, H., Barañano, D. E., Doré, S., et al. (1999) · Nature Cell Biology · doi:10.1038/11072 · Cited by 509

Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

Otterbein, L. E., Kolls, J. K., Mantell, L. L., Cook, J. L., Alam, J., & Choi, A. M. K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5342 · Cited by 492

Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury

Amersi, F., Buelow, R., Kato, H., Ke, B., Coito, A. J., Shen, X.-D., Zhao, D., Zaky, J., Melinek, J., Lassman, C. R., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7903 · Cited by 474

Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.

Brüne, B., & Ullrich, V (1987) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13029-0 · Cited by 471

Endothelium-Dependent and -Independent Vasodilation Involving Cyclic GMP: Relaxation Induced by Nitric Oxide, Carbon Monoxide and Light

Furchgott, R. F., & Jothianandan, D. (1991) · Journal of Vascular Research · doi:10.1159/000158843 · Cited by 469

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

Zhuo, M., Small, S. A., Kandel, E. R., & Hawkins, R. D. (1993) · Science · doi:10.1126/science.8100368 · Cited by 467

Carbon Monoxide Generated by Heme Oxygenase-1 Suppresses the Rejection of Mouse-to-Rat Cardiac Transplants

Sato, K., Balla, J., Otterbein, L., Smith, R. N., Brouard, S., Lin, Y., Csizmadia, E., Sevigny, J., Robson, S. C., Vercellotti, G., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.4185 · Cited by 461

Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel

Williams, S. E. J., Wootton, P., Mason, H. S., Bould, J., Iles, D. E., Riccardi, D., Peers, C., & Kemp, P. J. (2004) · Science · doi:10.1126/science.1105010 · Cited by 458

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

Hancock, W. W., Buelow, R., Sayegh, M. H., & Turka, L. A. (1998) · Nature Medicine · doi:10.1038/3982 · Cited by 453

NPAS2: A Gas-Responsive Transcription Factor

Dioum, E. M., Rutter, J., Tuckerman, J. R., Gonzalez, G., Gilles-Gonzalez, M.-A., & McKnight, S. L. (2002) · Science · doi:10.1126/science.1078456 · Cited by 432

Does carbon monoxide have a physiological function?

Marks, G. S., Brien, J. F., Nakatsu, K., & McLaughlin, B. E. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90544-3 · Cited by 425

Combined Serum Paraoxonase Knockout/Apolipoprotein E Knockout Mice Exhibit Increased Lipoprotein Oxidation and Atherosclerosis

Shih, D. M., Xia, Y.-R., Wang, X.-P., Miller, E., Castellani, L. W., Subbanagounder, G., Cheroutre, H., Faull, K. F., Berliner, J. A., Witztum, J. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910376199 · Cited by 425

Reversal of HO‐1 related cytoprotection with increased expression is due to reactive iron

Suttner, D. M., & Dennery, P. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.13.1800 · Cited by 424

Nitrosation and oxidation in the regulation of gene expression

Marshall, H. E., Merchant, K., & Stamler, J. S. (2000) · The FASEB Journal · doi:10.1096/fj.00.011rev · Cited by 424

Cardiac-Specific Expression of Heme Oxygenase-1 Protects Against Ischemia and Reperfusion Injury in Transgenic Mice

Yet, S.-F., Tian, R., Layne, M. D., Wang, Z. Y., Maemura, K., Solovyeva, M., Ith, B., Melo, L. G., Zhang, L., Ingwall, J. S., et al. (2001) · Circulation Research · doi:10.1161/hh1401.093314 · Cited by 420

Overexpression of Heme Oxygenase‐1 Is Neuroprotective in a Model of Permanent Middle Cerebral Artery Occlusion in Transgenic Mice

Panahian, N., Yoshiura, M., & Maines, M. D. (1999) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1999.721187.x · Cited by 416

Transcriptional control of rat heme oxygenase by heat shock.

Shibahara, S., Müller, R. M., & Taguchi, H. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45138-1 · Cited by 412

Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice

Yet, S.-F., Perrella, M. A., Layne, M. D., Hsieh, C.-M., Maemura, K., Kobzik, L., Wiesel, P., Christou, H., Kourembanas, S., & Lee, M.-E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6163 · Cited by 410

Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells

Alam, J., Wicks, C., Stewart, D., Gong, P., Touchard, C., Otterbein, S., Choi, A. M. K., Burow, M. E., & Tou, J.-S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004729200 · Cited by 407

Identification of binding sites for transcription factors NF-kappa B and AP-2 in the promoter region of the human heme oxygenase 1 gene.

Lavrovsky, Y., Schwartzman, M. L., Levere, R. D., Kappas, A., & Abraham, N. G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.5987 · Cited by 403

Metabolism and the Control of Circadian Rhythms

Rutter, J., Reick, M., & McKnight, S. L. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.142857 · Cited by 402

Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation.

Zakhary, R., Gaine, S. P., Dinerman, J. L., Ruat, M., Flavahan, N. A., & Snyder, S. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.795 · Cited by 401

Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis

Fujita, T., Toda, K., Karimova, A., Yan, S.-F., Naka, Y., Yet, S.-F., & Pinsky, D. J. (2001) · Nature Medicine · doi:10.1038/87929 · Cited by 398

Life with Carbon Monoxide

Ragsdale, S. W. (2004) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230490496577 · Cited by 397

The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.

Tenhunen, R., Marver, H. S., & Schmid, R. (1970) · PubMed · Cited by 392

Heme oxygenase-1-derived bilirubin ameliorates postischemic myocardial dysfunction

Clark, J. E., Foresti, R., Sarathchandra, P., Kaur, H., Green, C. J., & Motterlini, R. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.2.h643 · Cited by 392

Annual Review of Pharmacology,

Williams, J. F. (1975) · Archives of Internal Medicine · doi:10.1001/archinte.1975.00330100136032 · Cited by 386

Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.

Suematsu, M., Goda, N., Sano, T., Kashiwagi, S., Egawa, T., Shinoda, Y., & Ishimura, Y. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118300 · Cited by 385

Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme.

Friebe, A., Schultz, G., & Koesling, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01078.x · Cited by 352

Mapping the Pathways for O2 Entry Into and Exit from Myoglobin

Scott, E. E., Gibson, Q. H., & Olson, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008282200 · Cited by 350

Induction of Heme Oxygenase-1 Suppresses Venular Leukocyte Adhesion Elicited by Oxidative Stress: Role of Bilirubin Generated by the Enzyme

Hayashi, S., Takamiya, R., Yamaguchi, T., Matsumoto, K., Tojo, S. J., Tamatani, T., Kitajima, M., Makino, N., Ishimura, Y., & Suematsu, M. (1999) · Circulation Research · doi:10.1161/01.res.85.8.663 · Cited by 350

Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide.

Morita, T., & Kourembanas, S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118334 · Cited by 350

Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

Lee, P. J., Alam, J., Wiegand, G. W., & Choi, A. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10393 · Cited by 345

Activation and Entrainment Mapping Defines the Tricuspid Annulus as the Anterior Barrier in Typical Atrial Flutter

Kalman, J. M., Olgin, J. E., Saxon, L. A., Fisher, W. G., Lee, R. J., & Lesh, M. D. (1996) · Circulation · doi:10.1161/01.cir.94.3.398 · Cited by 344

Structural and functional analysis of hypoxia-inducible factor 1

Semenza, G. L., Agani, F., Booth, G., Forsythe, J., Iyer, N., Jiang, B.-H., Leung, S., Roe, R., Wiener, C., & Yu, A. (1997) · Kidney International · doi:10.1038/ki.1997.77 · Cited by 343

Carbon Monoxide Controls the Proliferation of Hypoxic Vascular Smooth Muscle Cells

Morita, T., Mitsialis, S. A., Koike, H., Liu, Y., & Kourembanas, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32804 · Cited by 332

Carbon monoxide‐induced vasorelaxation and the underlying mechanisms

Wang, R., Wang, Z., & Wu, L. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701222 · Cited by 331

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

Palmer, L. A., Semenza, G. L., Stoler, M. H., & Johns, R. A. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.2.l212 · Cited by 331

Adenovirus-Mediated Heme Oxygenase-1 Gene Transfer Inhibits the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

Juan, S.-H., Lee, T.-S., Tseng, K.-W., Liou, J.-Y., Shyue, S.-K., Wu, K. K., & Chau, L.-Y. (2001) · Circulation · doi:10.1161/hc3801.095663 · Cited by 331

Nitric Oxide Induces Heme Oxygenase-1 Gene Expression and Carbon Monoxide Production in Vascular Smooth Muscle Cells

Durante, W., Kroll, M. H., Christodoulides, N., Peyton, K. J., & Schafer, A. I. (1997) · Circulation Research · doi:10.1161/01.res.80.4.557 · Cited by 329

Increased Blood Flow Through the Portal System in Cirrhotic Rats

Vorobioff, J., Bredfeldt, J. E., & Groszmann, R. J. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80072-4 · Cited by 327

Soluble guanylate cyclase purified from bovine lung contains heme and copper

Gerzer, R., Böhme, E., Hofmann, F., & Schultz, G. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80429-2 · Cited by 326

Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers

Scapagnini, G., Foresti, R., Calabrese, V., Stella, A. M. G., Green, C. J., & Motterlini, R. (2002) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12118-9 · Cited by 323

Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain.

Zhang, J., & Piantadosi, C. A. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115980 · Cited by 320

Nitric oxide: a mediator in rat tubularhypoxia/reoxygenation injury.

Yu, L., Gengaro, P. E., Niederberger, M., Burke, T. J., & Schrier, R. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.5.1691 · Cited by 318

NO-mediated activation of heme oxygenase: endogenous cytoprotection against oxidative stress to endothelium

Motterlini, R., Foresti, R., Intaglietta, M., & Winslow, R. M. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.270.1.h107 · Cited by 317

Human heme oxygenase cDNA and induction of its mRNA by hemin

YOSHIDA, T., BIRO, P., COHEN, T., MÜLLER, R. M., & SHIBAHARA, S. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb13811.x · Cited by 317

Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis

Shiraishi, F., Curtis, L. M., Truong, L., Poss, K., Visner, G. A., Madsen, K., Nick, H. S., & Agarwal, A. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.5.f726 · Cited by 315

The pulmonary circulation of homozygous or heterozygous eNOS-null mice is hyperresponsive to mild hypoxia

Fagan, K. A., Fouty, B. W., Tyler, R. C., Morris, K. G., Hepler, L. K., Sato, K., LeCras, T. D., Abman, S. H., Weinberger, H. D., Huang, P. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3862 · Cited by 309

Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron.

Eisenstein, R. S., Garcia-Mayol, D., Pettingell, W., & Munro, H. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.688 · Cited by 308

Heme Oxygenase-1-derived Carbon Monoxide Requires the Activation of Transcription Factor NF-κB to Protect Endothelial Cells from Tumor Necrosis Factor-α-mediated Apoptosis

Brouard, S., Berberat, P. O., Tobiasch, E., Seldon, M. P., Bach, F. H., & Soares, M. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108317200 · Cited by 306

Vasoactive properties of CORM‐3, a novel water‐soluble carbon monoxide‐releasing molecule

Foresti, R., Hammad, J., Clark, J. E., Johnson, T. R., Mann, B. E., Friebe, A., Green, C. J., & Motterlini, R. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705825 · Cited by 303

Gene Therapy Strategy for Long-Term Myocardial Protection Using Adeno-Associated Virus-Mediated Delivery of Heme Oxygenase Gene

Melo, L. G., Agrawal, R., Zhang, L., Rezvani, M., Mangi, A. A., Ehsan, A., Griese, D. P., Dell’Acqua, G., Mann, M. J., Oyama, J., et al. (2002) · Circulation · doi:10.1161/hc0502.103363 · Cited by 303

Neural Heme Oxygenase-1 Expression in Idiopathic Parkinson's Disease

Schipper, H. M., Liberman, A., & Stopa, E. G. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6752 · Cited by 300

Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species.

Balla, G., Vercellotti, G. M., Müller‐Eberhard, U., Eaton, J. W., & Jacob, H. S. (1991) · PubMed · Cited by 298

Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage

Llesuy, S. F., & Tomaro, M. L. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(94)90067-1 · Cited by 297

Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice

Ishikawa, K., Sugawara, D., Wang, X.-P., Suzuki, K., Itabe, H., Maruyama, Y., & Lusis, A. J. (2001) · Circulation Research · doi:10.1161/01.res.88.5.506 · Cited by 295

Cooperativity in the dissociation of nitric oxide from hemoglobin.

Moore, E. G., & Gibson, Q. H. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33557-3 · Cited by 293

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

Petrache, I., Otterbein, L. E., Alam, J., Wiegand, G. W., & Choi, A. M. K. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.2.l312 · Cited by 293

Inhibition of Hypoxia-inducible Factor 1 Activation by Carbon Monoxide and Nitric Oxide

Huang, L. E., Willmore, W. G., Gu, J., Goldberg, M. A., & Bunn, H. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.9038 · Cited by 291

The History of Cell Respiration and Cytochrome

Keilin, D. (1966) · Medical Entomology and Zoology · Cited by 287

Treatment with Tin Prevents the Development of Hypertension in Spontaneously Hypertensive Rats

Sacerdoti, D., Escalante, B., Abraham, N. G., McGiff, J. C., Levere, R. D., & Schwartzman, M. L. (1989) · Science · doi:10.1126/science.2492116 · Cited by 278

Carbon Monoxide Produced by Heme Oxygenase-1 Suppresses T Cell Proliferation via Inhibition of IL-2 Production

Pae, H.-O., Oh, G.-S., Choi, B.-M., Chae, S.-C., Kim, Y.-M., Chung, K.-R., & Chung, H.-T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4744 · Cited by 274

The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis

Foresti, R., & Motterlini, R. (1999) · Free Radical Research · doi:10.1080/10715769900301031 · Cited by 274

Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels

Tang, X. D., Xu, R., Reynolds, M. F., Garcia, M. L., Heinemann, S. H., & Hoshi, T. (2003) · Nature · doi:10.1038/nature02003 · Cited by 270

Heme Oxygenase-1: Redox Regulation and Role in the Hepatic Response to Oxidative Stress

Bauer, M., & Bauer, I. (2002) · Antioxidants & Redox Signaling · doi:10.1089/152308602760598891 · Cited by 264

Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide-mediated microvascular relaxation.

Goda, N., Suzuki, K., Naito, M., Takeoka, S., Tsuchida, E., Ishimura, Y., Tamatani, T., & Suematsu, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1324 · Cited by 264

Reversal of long-term potentiation by inhibitors of haem oxygenase

Stevens, C. F., & Wang, Y. (1993) · Nature · doi:10.1038/364147a0 · Cited by 262

The Indispensability of Heme Oxygenase-1 in Protecting against Acute Heme Protein-Induced Toxicity in Vivo

Nath, K. A., Haggard, J. J., Croatt, A. J., Grande, J. P., Poss, K. D., & Alam, J. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65024-9 · Cited by 262

Bach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells

Kitamuro, T., Takahashi, K., Ogawa, K., Udono-Fujimori, R., Takeda, K., Furuyama, K., Nakayama, M., Sun, J., Fujita, H., Hida, W., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209939200 · Cited by 262

Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P -450 Is Not Essential for This Enzyme Activity

Maines, M. D., & Kappas, A. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.11.4293 · Cited by 261

Induction of heme oxygenase in toxic renal injury: A protective role in cisplatin nephrotoxicity in the rat

Agarwal, A., Balla, J., Alam, J., Croatt, A. J., & Nath, K. A. (1995) · Kidney International · doi:10.1038/ki.1995.414 · Cited by 260

Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform.

Trakshel, G. M., Kutty, R. K., & Maines, M. D. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67358-2 · Cited by 259

Carbon monoxide-mediated brain lipid peroxidation in the rat

Thom, S. R. (1990) · Journal of Applied Physiology · doi:10.1152/jappl.1990.68.3.997 · Cited by 258

Mechanism of Sodium Arsenite-mediated Induction of Heme Oxygenase-1 in Hepatoma Cells

Elbirt, K. K., Whitmarsh, A. J., Davis, R. J., & Bonkovsky, H. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8922 · Cited by 254

Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS

Thorup, C., Jones, C. L., Gross, S. S., Moore, L. C., & Goligorsky, M. S. (1999) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1999.277.6.f882 · Cited by 251

THE EFFECT OF CARBON MONOXIDE ON THE OXYHEMOGLOBIN DISSOCIATION CURVE

Roughton, F. J. W., & Darling, R. C. (1944) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1944.141.1.17 · Cited by 250

The Biological Significance and Physiological Role of Heme Oxygenase

Abraham, N. G., Drummond, G. S., Lutton, J. D., & Kappas, A. (1996) · Cellular Physiology and Biochemistry · doi:10.1159/000154819 · Cited by 248

Vascular Smooth Muscle Cell Heme Oxygenases Generate Guanylyl Cyclase–Stimulatory Carbon Monoxide

Christodoulides, N., Durante, W., Kroll, M. H., & Schafer, A. I. (1995) · Circulation · doi:10.1161/01.cir.91.9.2306 · Cited by 245

Carbon Monoxide: An Endogenous Modulator of the Nitric Oxide–Cyclic GMP Signaling System

Ingi, T., Cheng, J., & Ronnett, G. V. (1996) · Neuron · doi:10.1016/s0896-6273(00)80103-8 · Cited by 244

The Chemical Modification of KCa Channels by Carbon Monoxide in Vascular Smooth Muscle Cells

Wang, R., & Wu, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8222 · Cited by 244

Heme oxygenase–1 deficiency: The first autopsy case

Kawashima, A., Oda, Y., Yachie, A., Koizumi, S., & Nakanishi, I. (2002) · Human Pathology · doi:10.1053/hupa.2002.30217 · Cited by 244

Dealing with iron: Common structural principles in proteins that transport iron and heme

Baker, H. M., Anderson, B. F., & Baker, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0637295100 · Cited by 243

The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury

Sikorski, E. M., Hock, T., Hill-Kapturczak, N., & Agarwal, A. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00297.2003 · Cited by 238

Nitric oxide and carbon monoxide: parallel roles as neural messengers

Snyder, S. H., Jaffrey, S. R., & Zakhary, R. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00032-5 · Cited by 237

Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide

Zakhary, R., Poss, K. D., Jaffrey, S. R., Ferris, C. D., Tonegawa, S., & Snyder, S. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14848 · Cited by 236

Heme oxygenase: Protective gene or Trojan horse

Platt, J. L., & Nath, K. A. (1998) · Nature Medicine · doi:10.1038/3947 · Cited by 235

The physiological significance of heme oxygenase

Abraham, N. G., Lin, J. H.-C., Schwartzman, M. L., Levere, R. D., & Shibahara, S. (1988) · International Journal of Biochemistry · doi:10.1016/0020-711x(88)90093-6 · Cited by 234

The direct effect of carbon monoxide on K Ca channels in vascular smooth muscle cells

Wang, R., Wu, L., & Wang, Z. (1997) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s004240050398 · Cited by 228

Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene

Hayashi, S., Omata, Y., Sakamoto, H., Higashimoto, Y., Hara, T., Sagara, Y., & Noguchi, M. (2004) · Gene · doi:10.1016/j.gene.2004.04.002 · Cited by 227

Heme Oxygenase Mechanism: Evidence for an Electrophilic, Ferric Peroxide Species

Ortiz de Montellano, P. R. (1998) · Accounts of Chemical Research · doi:10.1021/ar960207q · Cited by 224

In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.

Fang, J. Q., Sawa, T., Akaike, T., Akuta, T., Sahoo, S. K., Greish, K. F., Hamada, A., & Maeda, H. (2003) · PubMed · Cited by 223

Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo

Guo, Y., Stein, A. B., Wu, W.-J., Tan, W., Zhu, X., Li, Q.-H., Dawn, B., Motterlini, R., & Bolli, R. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00971.2003 · Cited by 221

Carbon Monoxide and Nitric Oxide Suppress the Hypoxic Induction of Vascular Endothelial Growth Factor Gene via the 5′ Enhancer

Liu, Y., Christou, H., Morita, T., Laughner, E., Semenza, G. L., & Kourembanas, S. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.24.15257 · Cited by 220

Anti-Inflammatory Actions of the Heme Oxygenase-1 Pathway

Alcaraz, M., Fernandez, P., & Guillen, M. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033453749 · Cited by 220

Carbon Monoxide Protects against Liver Failure through Nitric Oxide–induced Heme Oxygenase 1

Zuckerbraun, B. S., Billiar, T. R., Otterbein, S. L., Kim, P. K. M., Liu, F., Choi, A. M. K., Bach, F. H., & Otterbein, L. E. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031003 · Cited by 219

Gene transfer of human heme oxygenase into coronary endothelial cells potentially promotes angiogenesis

Deramaudt, B. M. J. M., Braunstein, S., Remy, P., & Abraham, N. G. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980101)68:1<121::aid-jcb12>3.0.co;2-k · Cited by 214

Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene

Lautier, D., Luscher, P., & Tyrrell, R. M. (1992) · Carcinogenesis · doi:10.1093/carcin/13.2.227 · Cited by 213

Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.

Dennery, P. A., Spitz, D. R., Yang, G., Tatarov, A., Lee, C. S., Shegog, M. L., & Poss, K. D. (1998) · Journal of Clinical Investigation · doi:10.1172/jci448 · Cited by 212

Induction of Heme Oxygenase‐1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease

Premkumar, D. R. D., Smith, M. A., Richey, P. L., Petersen, R. B., Castellani, R., Kutty, R. K., Wiggert, B., Perry, G., & Kalaria, R. N. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031399.x · Cited by 211

Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosis

Foresti, R., Sarathchandra, P., Clark, J., Green, C. J., & Motterlini, R. (1999) · Biochemical Journal · doi:10.1042/0264-6021:3390729 · Cited by 209

Basis of guanylate cyclase activation by carbon monoxide.

Kharitonov, V. G., Sharma, V. S., Pilz, R. B., Magde, D., & Koesling, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.7.2568 · Cited by 207

Nucleotide sequence and organization of the rat heme oxygenase gene.

Müller, R. M., Taguchi, H., & Shibahara, S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48315-9 · Cited by 204

Prevention of Hypoxia-Induced Pulmonary Hypertension by Enhancement of Endogenous Heme Oxygenase-1 in the Rat

Christou, H., Morita, T., Hsieh, C.-M., Koike, H., Arkonac, B., Perrella, M. A., & Kourembanas, S. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1224 · Cited by 204

Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells.

Wagner, C. T., Durante, W., Christodoulides, N., Hellums, J. D., & Schafer, A. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119569 · Cited by 203

Increased Expression of Antioxidant and Antiapoptotic Genes in Islets That May Contribute to β-Cell Survival During Chronic Hyperglycemia

Laybutt, D. R., Kaneto, H., Hasenkamp, W., Grey, S., Jonas, J.-C., Sgroi, D. C., Groff, A., Ferran, C., Bonner-Weir, S., Sharma, A., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.2.413 · Cited by 202

Resurgence of carbon monoxide: an endogenous gaseous vasorelaxing factor

Wang, R. (1998) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-76-1-1 · Cited by 201

Biological Chemistry of Carbon Monoxide

Piantadosi, C. A. (2002) · Antioxidants & Redox Signaling · doi:10.1089/152308602753666316 · Cited by 201

Mechanism of YC-1-Induced Activation of Soluble Guanylyl Cyclase

Friebe, A., & Koesling, D. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.123 · Cited by 201

Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes

Xue, L., Farrugia, G., Miller, S. M., Ferris, C. D., Snyder, S. H., & Szurszewski, J. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1851 · Cited by 200

Normal and Heat‐Induced Patterns of Expression of Heme Oxygenase‐1 (HSP32) in Rat Brain: Hyperthermia Causes Rapid Induction of mRNA and Protein

Ewing, J. F., Haber, S. N., & Maines, M. D. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09373.x · Cited by 195

Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide

Thom, S. R., Fisher, D., Xu, Y. A., Notarfrancesco, K., & Ischiropoulos, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.3.1305 · Cited by 192

A Heme Oxygenase Product, Presumably Carbon Monoxide, Mediates a Vasodepressor Function in Rats

Johnson, R. A., Lavesa, M., Askari, B., Abraham, N. G., & Nasjletti, A. (1995) · Hypertension · doi:10.1161/01.hyp.25.2.166 · Cited by 192

Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment

Fang, J., Akaike, T., & Maeda, H. (2004) · Apoptosis · doi:10.1023/b:appt.0000012119.83734.4e · Cited by 191

In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2

Ewing, J. F., & Maines, M. D. (1992) · Molecular and Cellular Neuroscience · doi:10.1016/1044-7431(92)90068-d · Cited by 187

Catabolism of heme in vivo: comparison of the simultaneous production of bilirubin and carbon monoxide

Landaw, S. A., Callahan, E. W., & Schmid, R. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106311 · Cited by 186

Oxidative Stress and Induction of Heme Oxygenase-1 in the Kidney in Sickle Cell Disease

Nath, K. A., Grande, J. P., Haggard, J. J., Croatt, A. J., Katusic, Z. S., Solovey, A., & Hebbel, R. P. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64037-0 · Cited by 185

Carbon monoxide of vascular origin attenuates the sensitivity of renal arterial vessels to vasoconstrictors

Kaide, J.-I., Zhang, F., Wei, Y., Jiang, H., Yu, C., Wang, W., Balazy, M., Abraham, N. G., & Nasjletti, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11218 · Cited by 184

Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis

McCoubrey, W. K., Huang, T. J., & Maines, M. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12568 · Cited by 183

Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer's Disease

Takahashi, M., Doré, S., Ferris, C. D., Tomita, T., Sawa, A., Wolosker, H., Borchelt, D. R., Iwatsubo, T., Kim, S.-H., Thinakaran, G., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00125-2 · Cited by 183

Protective effect of heme oxygenase induction in ischemic acute renal failure

Shimizu, H., Takahashi, T., Suzuki, T., Yamasaki, A., Fujiwara, T., Odaka, Y., Hirakawa, M., Fujita, H., & Akagi, R. (2000) · Critical Care Medicine · doi:10.1097/00003246-200003000-00033 · Cited by 183

Haptoglobin, an inflammation-inducible plasma protein

Wang, Y., Kinzie, E., Berger, F. G., Lim, S.-K., & Baumann, H. (2001) · Redox Report · doi:10.1179/135100001101536580 · Cited by 183

Overexpression of Heme Oxygenase in Neuronal Cells, the Possible Interaction with Tau

Takeda, A., Perry, G., Abraham, N. G., Dwyer, B. E., Kutty, R. K., Laitinen, J. T., Petersen, R. B., & Smith, M. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.8.5395 · Cited by 183

Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32.

Maines, M. D., Mayer, R. D., Ewing, J. F., & McCoubrey, W. K. (1993) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10290-5 · Cited by 182

Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth

Doi, K., Akaike, T., Fujii, S., Tanaka, S., Ikebe, N., Beppu, T., Shibahara, S., Ogawa, M., & Maeda, H. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690624 · Cited by 182

Carbon monoxide inhibits apoptosis in vascular smooth muscle cells

Liu, X. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00410-8 · Cited by 182

The cellular Na+ pump as a site of action for carbon monoxide and glutamate: A mechanism for long-term modulation of cellular activity

Nathanson, J. A., Scavone, C., Scanlon, C., & McKee, M. (1995) · Neuron · doi:10.1016/0896-6273(95)90222-8 · Cited by 182

Cell Biology of Heme

PONKA, P. (1999) · The American Journal of the Medical Sciences · doi:10.1097/00000441-199910000-00004 · Cited by 182

Activation of soluble guanylate cyclase by carbon monoxide and inhibition by superoxide anion

BRÜNE, B., SCHMIDT, K., & ULLRICH, V. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb19276.x · Cited by 181

Induction of Heme Oxygenase-1 Inhibits NAD(P)H Oxidase Activity by Down-regulating Cytochrome b558 Expression via the Reduction of Heme Availability

Taillé, C., El-Benna, J., Lanone, S., Dang, M.-C., Ogier-Denis, E., Aubier, M., & Boczkowski, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310661200 · Cited by 181

Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells

Tacchini, L. (2001) · Carcinogenesis · doi:10.1093/carcin/22.9.1363 · Cited by 180

Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide

Hartsfield, C. L., Alam, J., Cook, J. L., & Choi, A. M. K. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.273.5.l980 · Cited by 177

Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1

Tullius, S. G., Nieminen-Kelh??, M., Buelow, R., Reutzel-Selke, A., Martins, P. N., Pratschke, J., Bachmann, U., Lehmann, M., Southard, D., Iyer, S., et al. (2002) · Transplantation · doi:10.1097/00007890-200209150-00001 · Cited by 176

VISIBLE LIGHT PHOTOCHEMICAL RELEASE OF NITRIC OXIDE FROM S‐NITROSOGLUTATHIONE: POTENTIAL PHOTOCHEMOTHERAPEUTIC APPLICATIONS

Sexton, D. J., Muruganandam, A., McKenney, D. J., & Mutus, B. (1994) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1994.tb05065.x · Cited by 174

Vascular Endothelial Cells Generate Peroxynitrite in Response to Carbon Monoxide Exposure

Thom, S. R., Xu, Y. A., & Ischiropoulos, H. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970041h · Cited by 173

Leçons sur les effets des substances toxiques et medicamenteuses / par M. Claude Bernard.

Bernard, C. (1857) · doi:10.5962/bhl.title.1834 · Cited by 171

Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice

Poss, K. D., Thomas, M. J., Ebralidze, A. K., O'Dell, T. J., & Tonegawa, S. (1995) · Neuron · doi:10.1016/0896-6273(95)90177-9 · Cited by 168

Effect of heme arginate administration on blood pressure in spontaneously hypertensive rats.

Levere, R. D., Martasek, P., Escalante, B., Schwartzman, M. L., & Abraham, N. G. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114686 · Cited by 166

Metalloporphyrins inhibit nitric oxide-dependent cGMP formation in vivo

Luo, D., & Vincent, S. R. (1994) · European Journal of Pharmacology: Molecular Pharmacology · doi:10.1016/0922-4106(94)90149-x · Cited by 165

Nitric Oxide-20–Hydroxyeicosatetraenoic Acid Interaction in the Regulation of K+Channel Activity and Vascular Tone in Renal Arterioles

Sun, C.-W., Alonso-Galicia, M., Taheri, M. R., Falck, J. R., Harder, D. R., & Roman, R. J. (1998) · Circulation Research · doi:10.1161/01.res.83.11.1069 · Cited by 165

NO and CO as second messengers in oxygen sensing in the carotid body

Prabhakar, N. R. (1999) · Respiration Physiology · doi:10.1016/s0034-5687(99)00019-5 · Cited by 164

Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress

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