A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Cited by (162)

Items 101–162 of 162

  1. Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health
    Strausz, Satu, Ruotsalainen, Sanni, Ollila, Hanna M., Karjalainen, Juha, Kiiskinen, Tuomo, Reeve, Mary, Kurki, Mitja, Mars, Nina, Havulinna, Aki S., Luonsi, Elina et al. · 2021 · European Respiratory Journal
  2. Correlated genotypes in friendship networks
    Fowler, James H., Settle, Jaime E., Christakis, Nicholas A. · 2011 · Proceedings of the National Academy of Sciences
  3. A Lifetime of Aldosterone Excess: Long-Term Consequences of Altered Regulation of Aldosterone Production for Cardiovascular Function
    Connell, John M. C., MacKenzie, Scott M., Freel, E. Marie, Fraser, Robert, Davies, Eleanor · 2008 · Endocrine Reviews
  4. Genetics of Type 2 Diabetes
    Ahlqvist, Emma, Ahluwalia, Tarunveer Singh, Groop, Leif · 2011 · Clinical Chemistry
  5. Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates
    Taylor, Amy E., Davies, Neil M., Ware, Jennifer J., VanderWeele, Tyler, Smith, George Davey, Munafò, Marcus R. · 2014 · Economics & Human Biology
  6. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals
    Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen et al. · 2014 · Human Molecular Genetics
  7. DNA Repair by Reversal of DNA Damage
    Yi, C., He, C. · 2013 · Cold Spring Harbor Perspectives in Biology
  8. Gene-Environment Interactions Controlling Energy and Glucose Homeostasis and the Developmental Origins of Obesity
    Bouret, Sebastien, Levin, Barry E., Ozanne, Susan E. · 2015 · Physiological Reviews
  9. N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
    Zou, Shui, Toh, Joel D. W., Wong, Kendra H. Q., Gao, Yong-Gui, Hong, Wanjin, Woon, Esther C. Y. · 2016 · Scientific Reports
  10. m6A RNA Methylation Controls Neural Development and Is Involved in Human Diseases
    Du, Kunzhao, Zhang, Longbin, Lee, Trevor, Sun, Tao · 2019 · Molecular Neurobiology
  11. Unraveling the directional link between adiposity and inflammation: A bidirectional Mendelian randomization approach
    Welsh, Paul, Polisecki, Eliana, Robertson, Michele, Jahn, Sabine, Buckley, Brendan M., de Craen, Anton J. M., Ford, Ian, Jukema, J. Wouter, Macfarlane, Peter W., Packard, Chris J. et al. · 2010 · The Journal of Clinical Endocrinology & Metabolism
  12. Beyond BMI: Conceptual Issues Related to Overweight and Obese Patients
    Müller, Manfred James, Braun, Wiebke, Enderle, Janna, Bosy-Westphal, Anja · 2016 · Obesity Facts
  13. Learning one’s genetic risk changes physiology independent of actual genetic risk
    Turnwald, Bradley P., Goyer, J. Parker, Boles, Danielle Z., Silder, Amy, Delp, Scott L., Crum, Alia J. · 2018 · Nature Human Behaviour
  14. Latest approaches for the treatment of obesity
    Jackson, V Margaret, Breen, Danna M, Fortin, Jean-Philippe, Liou, Alice, Kuzmiski, J Brent, Loomis, A Katrina, Rives, Marie-Laure, Shah, Bhavik, Carpino, Philip A · 2015 · Expert Opinion on Drug Discovery
  15. The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression
    Samaan, Z, Anand, S, Zhang, X, Desai, D, Rivera, M, Pare, G, Thabane, L, Xie, C, Gerstein, H, Engert, J C et al. · 2013 · Molecular Psychiatry
  16. New targets to treat obesity and the metabolic syndrome
    Martin, Kathleen A., Mani, Mitra V., Mani, Arya · 2015 · European Journal of Pharmacology
  17. Genetic determinants of pubertal timing in the general population
    Gajdos, Zofia K.Z., Henderson, Katherine D., Hirschhorn, Joel N., Palmert, Mark R. · 2010 · Molecular and Cellular Endocrinology
  18. An association study of the m6A genes with major depressive disorder in Chinese Han population
    Du, Tingfu, Rao, Shuquan, Wu, Lin, Ye, Ning, Liu, Zeyue, Hu, Huiling, Xiu, Jianbo, Shen, Yan, Xu, Qi · 2015 · Journal of Affective Disorders
  19. A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes
    Razquin, C, Martinez, J A, Martinez-Gonzalez, M A, Bes-Rastrollo, M, Fernández-Crehuet, J, Marti, A · 2010 · International Journal of Obesity
  20. The promise of new anti-obesity therapies arising from knowledge of genetic obesity traits
    Hinney, Anke, Körner, Antje, Fischer-Posovszky, Pamela · 2022 · Nature Reviews Endocrinology
  21. Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
    Southam, L., Soranzo, N., Montgomery, S. B., Frayling, T. M., McCarthy, M. I., Barroso, I., Zeggini, E. · 2009 · Diabetologia
  22. Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis
    Eriksson, Joel, Haring, Robin, Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik, Hansen, Torben, Mellström, Dan, Pedersen, Oluf, Nauck, Matthias et al. · 2017 · PLOS ONE
  23. Genetic Link Between Obesity and MMP14-Dependent Adipogenic Collagen Turnover
    Chun, Tae-Hwa, Inoue, Mayumi, Morisaki, Hiroko, Yamanaka, Itaru, Miyamoto, Yoshihiro, Okamura, Tomonori, Sato-Kusubata, Kaori, Weiss, Stephen J. · 2010 · Diabetes
  24. Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues
    Rapuano, Kristina M., Zieselman, Amanda L., Kelley, William M., Sargent, James D., Heatherton, Todd F., Gilbert-Diamond, Diane · 2017 · Proceedings of the National Academy of Sciences
  25. The connection between microbiome and schizophrenia
    Golofast, Bogdana, Vales, Karel · 2020 · Neuroscience & Biobehavioral Reviews
  26. Genome-wide association study of height-adjusted BMI in childhood identifies functional variant in ADCY3: GWAS of Height-Adjusted BMI
    Stergiakouli, Evangelia, Gaillard, Romy, Tavaré, Jeremy M., Balthasar, Nina, Loos, Ruth J., Taal, Hendrik R., Evans, David M., Rivadeneira, Fernando, St Pourcain, Beate, Uitterlinden, André G. et al. · 2014 · Obesity
  27. Excess mortality in hyperthyroidism: the influence of preexisting comorbidity and genetic confounding: a Danish nationwide register-based cohort study of twins and singletons
    Brandt, Frans, Almind, Dorthe, Christensen, Kaare, Green, Anders, Brix, Thomas Heiberg, Hegedüs, Laszlo · 2012 · The Journal of Clinical Endocrinology & Metabolism
  28. Molecular Nutrition Research—The Modern Way Of Performing Nutritional Science
    Norheim, Frode, Gjelstad, Ingrid, Hjorth, Marit, Vinknes, Kathrine, Langleite, Torgrim, Holen, Torgeir, Jensen, Jørgen, Dalen, Knut, Karlsen, Anette, Kielland, Anders et al. · 2012 · Nutrients
  29. Epigenetics in diabetic nephropathy, immunity and metabolism
    Keating, Samuel T., van Diepen, Janna A., Riksen, Niels P., El-Osta, Assam · 2018 · Diabetologia
  30. The Genetics of Major Depression
    Flint, Jonathan, Kendler, Kenneth S. · 2014 · Neuron
  31. Insulin Resistance in Type 1 Diabetes: Pathophysiological, Clinical, and Therapeutic Relevance
    Apostolopoulou, Maria, Lambadiari, Vaia, Roden, Michael, Dimitriadis, George D · 2025 · Endocrine Reviews
  32. Obesity and eating behavior from the perspective of twin and genetic research
    Silventoinen, Karri, Konttinen, Hanna · 2020 · Neuroscience & Biobehavioral Reviews
  33. Challenges in the study of causation of obesity: Conference on ‘Multidisciplinary approaches to nutritional problems’ Symposium on ‘Diabetes and health’
    Sørensen, Thorkild I. A. · 2009 · Proceedings of the Nutrition Society
  34. Toward Objective Monitoring of Ingestive Behavior in Free‐living Population
    Sazonov, Edward S., Schuckers, Stephanie A.C., Lopez‐Meyer, Paulo, Makeyev, Oleksandr, Melanson, Edward L., Neuman, Michael R., Hill, James O. · 2009 · Obesity
  35. Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively
    The GIANT consortium, Wood, Andrew R., Tyrrell, Jessica, Beaumont, Robin, Jones, Samuel E., Tuke, Marcus A., Ruth, Katherine S., Yaghootkar, Hanieh, Freathy, Rachel M., Murray, Anna et al. · 2016 · Diabetologia
  36. Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women
    Huerta-Chagoya, Alicia, Vázquez-Cárdenas, Paola, Moreno-Macías, Hortensia, Tapia-Maruri, Leonardo, Rodríguez-Guillén, Rosario, López-Vite, Erika, García-Escalante, Guadalupe, Escobedo-Aguirre, Fernando, Parra-Covarrubias, Adalberto, Cordero-Brieño, Roberto et al. · 2015 · PLOS ONE
  37. The financial costs, behaviour and psychology of obesity: A one health analysis
    Bomberg, E., Birch, L., Endenburg, N., German, A.J., Neilson, J., Seligman, H., Takashima, G., Day, M.J. · 2017 · Journal of Comparative Pathology
  38. Gene × environment interaction of vigorous exercise and body mass index among male Vietnam-era twins
    McCaffery, Jeanne M, Papandonatos, George D, Bond, Dale S, Lyons, Michael J, Wing, Rena R · 2009 · The American Journal of Clinical Nutrition
  39. Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis
    Liu, Qianwen, Zhu, Zhaozhong, Kraft, Peter, Deng, Qiaolin, Stener-Victorin, Elisabet, Jiang, Xia · 2022 · BMC Medicine
  40. IRX3 and IRX5 Inhibit Adipogenic Differentiation of Hypertrophic Chondrocytes and Promote Osteogenesis
    Tan, Zhijia, Kong, Mingpeng, Wen, Songjia, Tsang, Kwok Yeung, Niu, Ben, Hartmann, Christine, Chan, Danny, Hui, Chi-chung, Cheah, Kathryn S.E. · 2020 · Journal of Bone and Mineral Research
  41. Genetic Variation at the FTO Locus Influences RBL2 Gene Expression
    Jowett, Jeremy B.M., Curran, Joanne E., Johnson, Matthew P., Carless, Melanie A., Göring, Harald H.H., Dyer, Thomas D., Cole, Shelley A., Comuzzie, Anthony G., MacCluer, Jean W., Moses, Eric K. et al. · 2010 · Diabetes
  42. The future of genetics in psychology and psychiatry: microarrays, genome‐wide association, and non‐coding RNA
    Plomin, Robert, Davis, Oliver S.P. · 2009 · Journal of Child Psychology and Psychiatry
  43. Crossed wires: 3D genome misfolding in human disease
    Norton, Heidi K., Phillips-Cremins, Jennifer E. · 2017 · Journal of Cell Biology
  44. Insights into the constellating drivers of satiety impacting dietary patterns and lifestyle
    Rakha, Allah, Mehak, Fakiha, Shabbir, Muhammad Asim, Arslan, Muhammad, Ranjha, Muhammad Modassar Ali Nawaz, Ahmed, Waqar, Socol, Claudia Terezia, Rusu, Alexandru Vasile, Hassoun, Abdo, Aadil, Rana Muhammad · 2022 · Frontiers in Nutrition
  45. Mangiferin facilitates islet regeneration and β-cell proliferation through upregulation of cell cycle and β-cell regeneration regulators
    Wang, Hai-Lian, Li, Chun-Yang, Zhang, Bin, Liu, Yuan-De, Lu, Bang-Min, Shi, Zheng, An, Na, Zhao, Liang-Kai, Zhang, Jing-Jing, Bao, Jin-Ku et al. · 2014 · International Journal of Molecular Sciences
  46. Phenotype Refinement Strengthens the Association of AHR and CYP1A1 Genotype with Caffeine Consumption
    McMahon, George, Taylor, Amy E., Davey Smith, George, Munafò, Marcus R. · 2014 · PLoS ONE
  47. Meta-Analysis of Genome-Wide Association Studies
    de Bakker, Paul I.W., Neale, Benjamin M., Daly, Mark J. · 2010 · Cold Spring Harbor Protocols
  48. FTO Gene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean Women
    Song, Do Kyeong, Lee, Hyejin, Oh, Jee-Young, Hong, Young Sun, Sung, Yeon-Ah · 2014 · Diabetes & Metabolism Journal
  49. Genetic variants in MTNR1B affecting insulin secretion
    Müssig, Karsten, Staiger, Harald, Machicao, Fausto, Häring, Hans-Ulrich, Fritsche, Andreas · 2010 · Annals of Medicine
  50. Obesity: Clinical Impact, Pathophysiology, Complications, and Modern Innovations in Therapeutic Strategies
    Ullah, Mohammad Iftekhar, Tamanna, Sadeka · 2025 · Medicines
  51. Streptozotocin-induced astrocyte mitochondrial dysfunction is ameliorated by FTO inhibitor MO-I-500
    Cockova, Zuzana, Honc, Ondrej, Telensky, Petr, Olsen, Mark J., Novotny, Jiri · 2021 · ACS Chemical Neuroscience
  52. Erasing m6A-dependent transcription signature of stress-sensitive genes triggers antidepressant actions
    Wu, Peng-Fei, Han, Qian-Qian, Chen, Fu-Feng, Shen, Tian-Tian, Li, Yi-Heng, Cao, Yu, Chen, Jian-Guo, Wang, Fang · 2021 · Neurobiology of Stress
  53. Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
    Vogel, Carla IG, Scherag, André, Brönner, Günter, Nguyen, Thuy T, Wang, Hai-Jun, Grallert, Harald, Bornhorst, Alexa, Rosskopf, Dieter, Völzke, Henry, Reinehr, Thomas et al. · 2009 · BMC Medical Genetics
  54. TFAP2B-Dietary Protein and Glycemic Index Interactions and Weight Maintenance after Weight Loss in the DiOGenes Trial
    Stocks, Tanja, Ängquist, Lars, Hager, Jörg, Charon, Celine, Holst, Claus, Martinez, J. Alfredo, Saris, Wim H.M., Astrup, Arne, Sørensen, Thorkild I.A., Larsen, Lesli H. · 2013 · Human Heredity
  55. Replication of FTO gene associated with lean mass in a meta-analysis of genome-wide association studies
    Ran, Shu, Jiang, Zi-Xuan, He, Xiao, Liu, Yu, Zhang, Yu-Xue, Zhang, Lei, Pei, Yu-Fang, Zhang, Meng, Hai, Rong, Gu, Gui-Shan et al. · 2020 · Scientific Reports
  56. Obesity and Exercise: New Insights and Perspectives
    James, Natasha Maria, Stanford, Kristin I · 2025 · Endocrine Reviews
  57. Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring
    Kaspi, Antony, Khurana, Ishant, Ziemann, Mark, Connor, Timothy, Spolding, Briana, Zimmet, Paul, Walder, Ken, El‐Osta, Assam · 2018 · Molecular Nutrition & Food Research
  58. GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates
    Dashti, Hassan S, Jones, Samuel E, Wood, Andrew R, Lane, Jacqueline M, van Hees, Vincent T., Wang, Heming, Rhodes, Jessica A, Song, Yanwei, Patel, Krunal, Anderson, Simon G et al. · 2018
  59. Food Addiction and Cues in Prader-Willi Syndrome
    von Deneen, Karen M., Gold, Mark S., Liu, Yijun · 2009 · Journal of Addiction Medicine
  60. Pharmacogenetics: potential role in the treatment of diabetes and obesity
    Vella, Adrian, Camilleri, Michael · 2008 · Expert Opinion on Pharmacotherapy
  61. Association of mtDNA M/N haplogroups with systemic lupus erythematosus: a case-control study of Han Chinese women
    Tang, Youzhou, Wang, Li, Zhu, Min, Yang, Ming, Zhong, Kuangbiao, Du, Qing, Zhang, Hao, Gui, Ming · 2015 · Scientific Reports
  62. Use of Genome-Wide Expression Data to Mine the “Gray Zone” of GWA Studies Leads to Novel Candidate Obesity Genes
    Naukkarinen, Jussi, Surakka, Ida, Pietiläinen, Kirsi H., Rissanen, Aila, Salomaa, Veikko, Ripatti, Samuli, Yki-Järvinen, Hannele, van Duijn, Cornelia M., Wichmann, H.-Erich, Kaprio, Jaakko et al. · 2010 · PLoS Genetics