Cited by 55Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

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Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders

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Arnsten, Amy F.T., Wang, Min·2016·Annual Review of Pharmacology and Toxicology

DOI 10.1146/annurev-pharmtox-010715-103617PMC PMC4734124

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Abstract

Medications to treat cognitive disorders are increasingly needed, yet researchers have had few successes in this challenging arena. Cognitive abilities in primates arise from highly evolved N-methyl-d-aspartate (NMDA) receptor circuits in layer III of the dorsolateral prefrontal cortex. These circuits have unique modulatory needs that can differ from the layer V neurons that predominate in rodents, but they offer multiple therapeutic targets. Cognitive improvement often requires low doses that enhance the pattern of information held in working memory, whereas higher doses can produce nonspecific changes that obscure information. Identifying appropriate doses for clinical trials may be helped by assessments in monkeys and by flexible, individualized dose designs. The use of guanfacine (Intuniv) for prefrontal cortical disorders was based on research in monkeys, supporting this approach. Coupling our knowledge of higher primate circuits with the powerful methods now available in drug design will help create effective treatments for cognitive disorders.

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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · cited 1×
“The rostral and dorsomedial aspects of the PFC also play important roles in social cognition, including so-called theory of mind, the ability to think about what another person must be thinking (19, 20).”
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
The Organization of Networks within the Orbital and Medial Prefrontal Cortex of Rats, Monkeys and Humans
Ongur, D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.206 · Cited by 2,627
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357
Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
Braak, H., Thal, D. R., Ghebremedhin, E., & Del Tredici, K. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318232a379 · Cited by 2,194
The prefrontal cortex
Fuster, J. M. (1997) · Cited by 2,095
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960
Principles of Frontal Lobe Function
Stuss, D. T. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195134971.001.0001 · Cited by 1,731
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
Regulation of NMDA receptor trafficking by amyloid-β
Snyder, E. M., Nong, Y., Almeida, C. G., Paul, S., Moran, T., Choi, E. Y., Nairn, A. C., Salter, M. W., Lombroso, P. J., Gouras, G. K., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1503 · Cited by 1,561 · cited 1×
“However, it is important to note that nic-α7R agonists may not be appropriate for cognitive disorders in the aged, as evidence from mouse models of AD suggests that nic-α7R stimulation can cause NMDAR internalization in the presence of beta amyloid (Aβ) oligomers (113).”
From Reactive to Proactive and Selective Control: Developing a Richer Model for Stopping Inappropriate Responses
Aron, A. R. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.024 · Cited by 1,236
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
Abel, T., Nguyen, P. V., Barad, M., Deuel, T. A. S., Kandel, E. R., & Bourtchouladze, R. (1997) · Cell · doi:10.1016/s0092-8674(00)81904-2 · Cited by 1,217
Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory
Vijayraghavan, S., Wang, M., Birnbaum, S. G., Williams, G. V., & Arnsten, A. F. T. (2007) · Nature Neuroscience · doi:10.1038/nn1846 · Cited by 1,013
Self-citation
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.
Pearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., & Powell, T. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4531 · Cited by 987
Neurobiology of Executive Functions: Catecholamine Influences on Prefrontal Cortical Functions
Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.019 · Cited by 948
Self-citation
The reduced neuropil hypothesis: a circuit based model of schizophrenia
Selemon, L. D., & Goldman-Rakic, P. S. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00281-9 · Cited by 909
Abnormally High Neuronal Density in the Schizophrenic Cortex
Selemon, L. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950220015005 · Cited by 876
Neuronal KCNQ potassium channels:physislogy and role in disease
Jentsch, T. J. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036198 · Cited by 850
Do thin spines learn to be mushroom spines that remember?
Bourne, J., & Harris, K. M. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.009 · Cited by 843
α2A-Adrenoceptors Strengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex
Wang, M., Ramos, B. P., Paspalas, C. D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Brennan, A., Dudley, A., Nou, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.015 · Cited by 672
Self-citation
Do Rats Have Prefrontal Cortex? The Rose-Woolsey-Akert Program Reconsidered
Preuss, T. M. (1995) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1995.7.1.1 · Cited by 666
Functional magnetic resonance imaging evidence for a hierarchical organization of the prefrontal cortex
Badre, D., & D'Esposito, M. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.12.2082 · Cited by 615
Reduction of Nightmares and Other PTSD Symptoms in Combat Veterans by Prazosin: A Placebo-Controlled Study
Raskind, M. A., Peskind, E. R., Kanter, E. D., Petrie, E. C., Radant, A. D., Thompson, C. E., Dobie, D. J., Hoff, D., Rein, R. J., Straits-Tröster, K. A., et al. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.371 · Cited by 607
Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
Gabernet, L., Jadhav, S. P., Feldman, D. E., Carandini, M., & Scanziani, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.022 · Cited by 599
Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk
Cannon, T. D., Chung, Y., He, G., Sun, D., Jacobson, A., van Erp, T. G. M., McEwen, S., Addington, J., Bearden, C. E., Cadenhead, K., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.023 · Cited by 599
A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder
Scahill, L., Chappell, P. B., Kim, Y. S., Schultz, R. T., Katsovich, L., Shepherd, E., Arnsten, A. F. T., Cohen, D. J., & Leckman, J. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1067 · Cited by 588
Self-citation
Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer’s disease: a quantitative study of visual and auditory cortices
Lewis, D., Campbell, M., Terry, R., & Morrison, J. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-06-01799.1987 · Cited by 578
Dissociating executive functions of the prefrontal cortex.
Robbins, T. W. (1996) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1996.0131 · Cited by 574
Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses
Arnsten, A. F. T., Wang, M. J., & Paspalas, C. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.038 · Cited by 538
Self-citation
The Evolution of the Brain, the Human Nature of Cortical Circuits, and Intellectual Creativity
DeFelipe, J. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00029 · Cited by 527
NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Wang, M., Yang, Y., Wang, C.-J., Gamo, N. J., Jin, L. E., Mazer, J. A., Morrison, J. H., Wang, X.-J., & Arnsten, A. F. T. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.032 · Cited by 489
Self-citation
The Contribution of α2-Noradrenergic Mechanisms to Prefrontal Cortical Cognitive Function: Potential Significance for Attention-Deficit Hyperactivity Disorder
Arnsten, A. F. T. (1996) · Archives of General Psychiatry · doi:10.1001/archpsyc.1996.01830050084013 · Cited by 458
Self-citation
Cortex, Cognition and the Cell: New Insights into the Pyramidal Neuron and Prefrontal Function
Elston, G. N. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg093 · Cited by 440
Properties of Hyperpolarization-Activated Pacemaker Current Defined by Coassembly of Hcn1 and Hcn2 Subunits and Basal Modulation by Cyclic Nucleotide
Chen, S., Wang, J., & Siegelbaum, S. A. (2001) · The Journal of General Physiology · doi:10.1085/jgp.117.5.491 · Cited by 416
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1
Hayashi-Takagi, A., Takaki, M., Graziane, N., Seshadri, S., Murdoch, H., Dunlop, A. J., Makino, Y., Seshadri, A. J., Ishizuka, K., Srivastava, D. P., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2487 · Cited by 399
Prefrontal Contributions to Metacognition in Perceptual Decision Making
Fleming, S. M., Huijgen, J., & Dolan, R. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6489-11.2012 · Cited by 391
The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes
Arnsten, A., Cai, J., & Goldman-Rakic, P. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-11-04287.1988 · Cited by 391
Self-citation
Multiple apparent alpha-noradrenergic receptor binding sites in rat brain: effect of 6-hydroxydopamine
U’PRICHARD, D. C., BECHTEL, W. D., ROUOT, B. M., & SNYDER, S. H. (1979) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11406-5 · Cited by 384
The effects of stress exposure on prefrontal cortex: Translating basic research into successful treatments for post-traumatic stress disorder
Arnsten, A. F. T., Raskind, M. A., Taylor, F. B., & Connor, D. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.002 · Cited by 381
Self-citation
Anatomy of the Prefrontal Cortex
Fuster, J. M. (2008) · The Prefrontal Cortex · doi:10.1016/b978-0-12-373644-4.00002-5 · Cited by 364
Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman‐Rakic, P. S. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.65.6.1464 · Cited by 358
Cognitive Inflexibility after Prefrontal Serotonin Depletion Is Behaviorally and Neurochemically Specific
Clarke, H., Walker, S., Dalley, J., Robbins, T., & Roberts, A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj120 · Cited by 351
Reduced communication between frontal and temporal lobes during talking in schizophrenia
Ford, J. M., Mathalon, D. H., Whitfield‐Gabrieli, S., Faustman, W. O., & Roth, W. T. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01335-x · Cited by 332
Control of visual cortical signals by prefrontal dopamine
Noudoost, B., & Moore, T. (2011) · Nature · doi:10.1038/nature09995 · Cited by 324
Pathophysiologically based treatment interventions in schizophrenia
Lewis, D. A., & González‐Burgos, G. (2006) · Nature Medicine · doi:10.1038/nm1478 · Cited by 324
Selective D2 receptor actions on the functional circuitry of working memory
Wang, M., Vijayraghavan, S., & Goldman-Rakic, P. S. (2004) · Science · doi:10.1126/science.1091162 · Cited by 319
Self-citation
Protein kinase C overactivity impairs prefrontal cortical regulation of working memory
Birnbaum, S. G., Yuan, P. X., Wang, M., Vijayraghavan, S., Bloom, A. K., Davis, D. J., Gobeske, K. T., Sweatt, J. D., Manji, H. K., & Arnsten, A. F. T. (2004) · Science · doi:10.1126/science.1100021 · Cited by 318
Self-citation
A Randomized, Double-Blind, Placebo-Controlled Study of Guanfacine Extended Release in Children and Adolescents With Attention-Deficit/Hyperactivity Disorder
Biederman, J., Melmed, R. D., Patel, A., McBurnett, K., Konow, J., Lyne, A., Scherer, N., & for the SPD503 Study Group (2008) · Pediatrics · doi:10.1542/peds.2006-3695 · Cited by 317
Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia
Cannon, T. D., Thompson, P. M., van Erp, T. G. M., Toga, A. W., Poutanen, V.-P., HUTTUNEN, M. O., Lönnqvist, J. K., Standerskjold-Nordenstam, C.-G., Narr, K. L., Khaledy, M., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052023499 · Cited by 315
Switching of NMDA Receptor 2A and 2B Subunits at Thalamic and Cortical Synapses during Early Postnatal Development
Liu, X.-B., Murray, K. D., & Jones, E. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2476-04.2004 · Cited by 313
An Open Trial of Guanfacine in the Treatment of Attention-Deficit Hyperactivity Disorder
Hunt, R. D., Arnsten, A. F. T., & Asbell, M. D. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199501000-00013 · Cited by 308
Self-citation
Intrinsic circuit organization of the major layers and sublayers of the dorsolateral prefrontal cortex in the rhesus monkey
Kritzer, M. F., & Goldman‐Rakic, P. S. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590109 · Cited by 300
Effects of frontal lobe damage on interference effects in working memory
Thompson‐Schill, S. L., Jonides, J. J., Marshuetz, C. S., SMITH, E. E., D’Esposito, M., Kan, I. P., Knight, R. T., & Diane Swick, A. (2002) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.2.2.109 · Cited by 291
Pyramidal Cells of the Frontal Lobe: All the More Spinous to Think With
Elston, G. N. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-j0002.2000 · Cited by 289
Autism Spectrum Disorders and Schizophrenia: Meta-Analysis of the Neural Correlates of Social Cognition
Sugranyes, G., Kyriakopoulos, M., Corrigall, R. J., Taylor, E., & Frangou, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025322 · Cited by 289
Rostral and Orbital Prefrontal Cortex Dysfunction in the Manic State of Bipolar Disorder
Blumberg, H. P., Stern, E. R., Ricketts, S., Martínez, D., de Asis, J. M., White, T. G., Epstein, J., Isenberg, N., McBride, P., Kemperman, I., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.12.1986 · Cited by 288
A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex
Birnbaum, S., Gobeske, K. T., Auerbach, J., Taylor, J. R., & Arnsten, A. F. T. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00138-9 · Cited by 281
Self-citation
REDD1 is essential for stress-induced synaptic loss and depressive behavior
Ota, K. T., Liu, R.-J., Voleti, B., Maldonado-Aviles, J. G., Duric, V., Iwata, M., Dutheil, S., Duman, C., Boikess, S., Lewis, D. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3513 · Cited by 267
Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission.
Mrzljak, L., Levey, A. I., & Goldman-Rakic, P. S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.11.5194 · Cited by 256
Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations
Williams, D. K., Wang, J., & Papke, R. L. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.05.001 · Cited by 252
Guanfacine treatment of comorbid attention-deficit hyperactivity disorder and Tourette's syndrome: preliminary clinical experience
CHAPPELL, P. B., RIDDLE, M. A., SCAHILL, L., LYNCH, K. A., SCHULTZ, R., ARNSTEN, A., LECKMAN, J. F., & COHEN, D. J. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199509000-00010 · Cited by 250
Self-citation
Pathology of Layer V Pyramidal Neurons in the Prefrontal Cortex of Patients With Schizophrenia
Black, J. E., Kodish, I. M., Grossman, A. W., Klintsova, A. Y., Orlovskaya, D., Vostrikov, V., Uranova, N., & Greenough, W. T. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.742 · Cited by 250
Development of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder
Shaw, P., Lalonde, F., Lepage, C., Rabin, C., Eckstrand, K., Sharp, W., Greenstein, D., Evans, A., Giedd, J. N., & Rapoport, J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.103 · Cited by 249 · cited 7×
“There is existing interest in nic-α7R agonists for the treatment of schizophrenia (103) and ADHD (104, 105), and the data from monkeys encourage this approach.”
Influential
Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia
Weickert, C. S., Fung, S. J., Catts, V. S., Schofield, P. R., Allen, K. M., Moore, L., Newell, K. A., Pellen, D., Huang, X.-F., Catts, S. V., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.137 · Cited by 247
Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness
Manji, H. K., & Lenox, R. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00235-8 · Cited by 241
Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25
Nagy, G., Reim, K., Matti, U., Brose, N., Binz, T., Rettig, J., Neher, E., & Sørensen, J. B. (2004) · Neuron · doi:10.1016/s0896-6273(04)00038-8 · Cited by 239
Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress
Hains, A. B., Vu, M. A. T., Maciejewski, P. K., van Dyck, C. H., Gottron, M., & Arnsten, A. F. T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908563106 · Cited by 234
Self-citation
Schizophrenia and the α7 Nicotinic Acetylcholine Receptor
Martin, L. F., & Freedman, R. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78008-4 · Cited by 213
Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study
Zarate, C. A., Singh, J. B., Carlson, P. J., Quiroz, J., Jolkovsky, L., Luckenbaugh, D. A., & Manji, H. K. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00530.x · Cited by 208
Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors
Gyoneva, S., & Traynelis, S. F. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.458901 · Cited by 204
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
Yang, Y., Paspalas, C. D., Jin, L. E., Picciotto, M. R., Arnsten, A. F. T., & Wang, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307849110 · Cited by 188
Self-citation
Essential Role for the PKC Target MARCKS in Maintaining Dendritic Spine Morphology
Calabrese, B., & Halpain, S. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.027 · Cited by 187
Delayed-response deficit induced by local injection of the α2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys
Li, B.-M., & Mei, Z.-T. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80034-2 · Cited by 186
Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine
Franowicz, J. S., Kessler, L. E., Borja, C. M. D., Kobilka, B. K., Limbird, L. E., & Arnsten, A. F. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08771.2002 · Cited by 185
Self-citation
Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: Stereologic analysis of prefrontal cortex area 9
Bussière, T., Giannakopoulos, P., Bouras, C., Perl, D. P., Morrison, J. H., & Hof, P. R. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10760 · Cited by 185 · cited 3×
“Thus, dysfunction of the lateral PFC results in cognitive disorders such as schizophrenia (4) and AD (2), whereas dysfunction of the ventral and/or medial PFC is associated with mood disorders such as depression (23, 24) or obsessive-compulsive disorder (OCD) (25).”
Distinctive transcriptome alterations of prefrontal pyramidal neurons in schizophrenia and schizoaffective disorder
Arion, D., Corradi, J. P., Tang, S., Datta, D., Boothe, F., He, A., Cacace, A. M., Zaczek, R., Albright, C. F., Tseng, G., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.171 · Cited by 177
Specializations of the granular prefrontal cortex of primates: Implications for cognitive processing
Elston, G. N., Benavides‐Piccione, R., Elston, A., Zietsch, B., Defelipe, J., Manger, P., Casagrande, V., & Kaas, J. H. (2006) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20278 · Cited by 167
Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: Focus on cognition
Wilens, T. E., & Decker, M. W. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.002 · Cited by 164
Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys
Li, B. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00070-6 · Cited by 162
Dynamic network connectivity: a new form of neuroplasticity
Arnsten, A. F. T., Paspalas, C. D., Gamo, N. J., Yang, Y., & Wang, M. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.003 · Cited by 160
Self-citation
A Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 2 Blocks a Hallucinogenic Drug Model of Psychosis
Benneyworth, M. A., Xiang, Z., Smith, R. L., Garcia, E. E., Conn, P. J., & Sanders‐Bush, E. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.035170 · Cited by 159
Local infusion of an α-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys
Mao, Z.-M., Arnsten, A. F. T., & Li, B.-M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00139-0 · Cited by 156
Self-citation
The Role of Prefrontal Dopamine D1 Receptors in the Neural Mechanisms of Associative Learning
Puig, M. V., & Miller, E. K. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.018 · Cited by 155
A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC
Hongpaisan, J., & Alkon, D. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709311104 · Cited by 149
Dopamine’s Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders
Arnsten, A. F. T., Wang, M., & Paspalas, C. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010512 · Cited by 149
Self-citation
cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Carlyle, B. C., Nairn, A. C., Wang, M., Yang, Y., Jin, L. E., Simen, A. A., Ramos, B. P., Bordner, K. A., Craft, G. E., Davies, P., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322360111 · Cited by 139
Self-citation
Daytime Prazosin Reduces Psychological Distress to Trauma Specific Cues in Civilian Trauma Posttraumatic Stress Disorder
Taylor, F. B., Lowe, K., Thompson, C. E., McFall, M., Peskind, E. R., Kanter, E. D., Allison, N., Williams, J., Martin, P., & Raskind, M. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.023 · Cited by 138
Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia
Paspalas, C. D., Wang, M., & Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs152 · Cited by 136
Self-citation
Behavioral and Neural Changes after Gains and Losses of Conditioned Reinforcers
Seo, H., & Lee, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4726-08.2009 · Cited by 131
The α -2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys
Franowicz, J. S., & Arnsten, A. F. T. (1998) · Psychopharmacology · doi:10.1007/s002130050533 · Cited by 119
Self-citation
Influence of Highly Distinctive Structural Properties on the Excitability of Pyramidal Neurons in Monkey Visual and Prefrontal Cortices
Amatrudo, J. M., Weaver, C. M., Crimins, J. L., Hof, P. R., Rosene, D. L., & Luebke, J. I. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2581-12.2012 · Cited by 115
Neurobiology of Obsessive Compulsive Disorder
Insel, T. R., & Winslow, J. (1992) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30211-9 · Cited by 113
Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
Fox, H. C., Seo, D., Tuit, K., Hansen, J., Kimmerling, A., Morgan, P. T., & Sinha, R. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111430746 · Cited by 112
Norepinephrine Drives Persistent Activity in Prefrontal Cortex via Synergistic α1 and α2 Adrenoceptors
Zhang, Z., Matos, S. C., Jego, S., Adamantidis, A., & Séguéla, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066122 · Cited by 110
Distribution of mGluR1α and mGluR5 immunolabeling in primate prefrontal cortex
Muly, E. C., Maddox, M., & Smith, Y. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10937 · Cited by 110
Neural correlates of strategic reasoning during competitive games
Seo, H., Cai, X., Donahue, C. H., & Lee, D. (2014) · Science · doi:10.1126/science.1256254 · Cited by 108
An open-label study of guanfacine extended release for traumatic stress related symptoms in children and adolescents
Connor, D. F., Grasso, D. J., Slivinsky, M. D., Pearson, G. S., & Banga, A. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2012.0119 · Cited by 102
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence
Hayashi-Takagi, A., Araki, Y., Nakamura, M., Vollrath, B., Duron, S. G., Yan, Z., Kasai, H., Huganir, R. L., Campbell, D. A., & Sawa, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321109111 · Cited by 101
Differential Regulation of α7 Nicotinic Receptor Gene (CHRNA7) Expression in Schizophrenic Smokers
Mexal, S., Berger, R., Logel, J., Ross, R. G., Freedman, R., & Leonard, S. S. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9233-4 · Cited by 101
Differential Contributions of Dopamine and Serotonin to Orbitofrontal Cortex Function in the Marmoset
Walker, S. C., Robbins, T. W., & Roberts, A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn136 · Cited by 99
Stress Impairs Prefrontal Cortical Function via D1 Dopamine Receptor Interactions With Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Gamo, N. J., Lur, G., Higley, M. J., Wang, M., Paspalas, C. D., Vijayraghavan, S., Yang, Y., Ramos, B. P., Peng, K., Kata, A., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.01.009 · Cited by 97
Self-citation
Locomotor hyperactivity induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys
Ma, C.-L., Arnsten, A. F. T., & Li, B.-M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.004 · Cited by 96 · cited 1×
“Conversely, infusion of yohimbine into the dlPFC impairs working memory (78) and impulse control (79) and induces locomotor hyperactivity (80).”
Self-citation
The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003
Arnsten, A. F. T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht195 · Cited by 94
Self-citation
Neural Substrates of Dopamine D2 Receptor Modulated Executive Functions in the Monkey Prefrontal Cortex
Puig, M. V., & Miller, E. K. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu096 · Cited by 94
Expression of the NR2B‐NMDA receptor subunit and its Tbr‐1/CINAP regulatory proteins in postmortem brain suggest altered receptor processing in schizophrenia
Kristiansen, L. V., Patel, S. A., Haroutunian, V. H., & Meador‐Woodruff, J. H. (2010) · Synapse · doi:10.1002/syn.20754 · Cited by 87
The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder
Arnsten, A. F. T. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.133 · Cited by 83
Self-citation
?7-Nicotinic Receptors and Cognition
Levin, E. D. (2012) · Current Drug Targets · doi:10.2174/138945012800398937 · Cited by 82
A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation
McKee, S. A., Potenza, M. N., Kober, H., Sofuoglu, M., Arnsten, A. F., Picciotto, M. R., Weinberger, A. H., Ashare, R., & Sinha, R. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114562091 · Cited by 75
Self-citation
Presynaptic inhibition by clonidine of neurotransmitter amino acid release in various brain regions
Kamisaki, Y., Hamahashi, T., Hamada, T., Maeda, K., & Itoh, T. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90511-2 · Cited by 75
Targeting α7 Nicotinic Acetylcholine Receptors in the Treatment of Schizophrenia
Hajós, M., & Rogers, B. N. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361434 · Cited by 73
Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: Altered working memory and BOLD response
McAllister, T. W., McDonald, B. C., Flashman, L. A., Ferrell, R. B., Tosteson, T. D., Yanofsky, N. N., Grove, M. R., & Saykin, A. J. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.06.022 · Cited by 70
Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey
Young, M. E., Ohm, D. T., Dumitriu, D., Rapp, P. R., & Morrison, J. H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.008 · Cited by 70
Chronic stimulation of alpha-2A-adrenoceptors with guanfacine protects rodent prefrontal cortex dendritic spines and cognition from the effects of chronic stress
Hains, A. B., Yabe, Y., & Arnsten, A. F. T. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.01.001 · Cited by 70 · cited 4×
“Repeated guanfacine administration may actually increase the number of spines on layer II/III neurons under basal conditions (86) and enhance PFC spine maturation in vitro (87).”
InfluentialSelf-citation
Selective deficit in no-go performance induced by blockade of prefrontal cortical α2-adrenoceptors in monkeys
Ma, C.-L., Qi, X.-L., Peng, J.-Y., & Li, B.-M. (2003) · NeuroReport · doi:10.1097/01.wnr.0000070831.57864.7b · Cited by 69
Effects of ?2-adrenoceptor agonists on locus coeruleus firing rate and brain noradrenaline turnover in N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)-treated rats
Engberg, G., & Eriksson, E. (1991) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/bf00169548 · Cited by 68
Presynaptic Mechanism Underlying cAMP-Induced Synaptic Potentiation in Medial Prefrontal Cortex Pyramidal Neurons
Huang, C., & Hsu, K. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.018093 · Cited by 68
Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation
MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J. P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S., & Houslay, M. D. (2011) · Biochemical Journal · doi:10.1042/bj20101184 · Cited by 65
Development of M 1 mAChR Allosteric and Bitopic Ligands: Prospective Therapeutics for the Treatment of Cognitive Deficits
Davie, B. J., Christopoulos, A., & Scammells, P. J. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400086m · Cited by 64
You’d Better Think Twice: Post-Decision Perceptual Confidence
Hirtz, R., Weiß, T., & Witte, O. W. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.05.049 · Cited by 59
Expression of the NR2B-NMDA receptor trafficking complex in prefrontal cortex from a group of elderly patients with schizophrenia
Kristiansen, L. V., Bakir, B., Haroutunian, V. H., & Meador‐Woodruff, J. H. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.02.1069 · Cited by 57
Sleep and dreaming: induction and mediation of REM sleep by cholinergic mechanisms
Hobson, J. A. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90130-d · Cited by 55
Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: Implications for schizophrenia
Curley, A. A., Eggan, S. M., Lazarus, M. S., Huang, Z. J., Volk, D. W., & Lewis, D. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.10.018 · Cited by 51
Reciprocal regulation of PKA and Rac signaling
Bachmann, V. A., Riml, A., Huber, R. G., Baillie, G. S., Liedl, K. R., Valovka, T., & Stefan, E. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215902110 · Cited by 51
Effects of α-2A adrenergic receptor agonist on time and risk preference in primates
Kim, S., Bobeica, I., Gamo, N. J., Arnsten, A. F. T., & Lee, D. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2520-0 · Cited by 47
Self-citation
Signaling mechanism underlying α2A‐adrenergic suppression of excitatory synaptic transmission in the medial prefrontal cortex of rats
Yi, F., Liu, S., Luo, F., Zhang, X., & Li, B. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12257 · Cited by 37
Guanfacine is an effective countermeasure for hypobaric hypoxia-induced cognitive decline
Kauser, H., Sahu, S., Kumar, S., & Panjwani, U. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.09.023 · Cited by 33
Smoking improves divided attention in schizophrenia
Ahlers, E., Hahn, E. W., Ta, T. M. T., Goudarzi, E., Dettling, M., & Neuhaus, A. H. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3525-2 · Cited by 31
Lost in Transition: Aging-Related Changes in Executive Control by the Medial Prefrontal Cortex
Caetano, M. S., Horst, N. K., Harenberg, L., Liu, B., Arnsten, A. F. T., & Laubach, M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6011-11.2012 · Cited by 30
Self-citation
Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish
Opler, L. A., Opler, M. G. A., & Arnsten, A. F. T. (2016) · CNS Spectrums · doi:10.1017/s1092852914000686 · Cited by 28
Self-citation
Possible Influence of Variant of the P-Glycoprotein Gene ( MDR1/ABCB1 ) on Clinical Response to Guanfacine in Children with Pervasive Developmental Disorders and Hyperactivity
McCracken, J. T., Aman, M. G., McDougle, C. J., Tierney, E., Shiraga, S., Whelan, F., Arnold, L. E., Posey, D. J., Ritz, L., Vitiello, B., et al. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0059 · Cited by 28
Stimulation of α2A-adrenoceptors promotes the maturation of dendritic spines in cultured neurons of the medial prefrontal cortex
Ren, W.-W., Liu, Y., & Li, B.-M. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.10.001 · Cited by 23
Rapid induction of REDD1 gene expression in macrophages in response to stress-related catecholamines
Yanagawa, Y., Hiraide, S., Matsumoto, M., & Togashi, H. (2014) · Immunology Letters · doi:10.1016/j.imlet.2013.12.015 · Cited by 16
Cerebral localization of emotion based on clinical-neuropathological correlations: methodological issues.
Robinson, R. G., & Lipsey, J. R. (1985) · PubMed · Cited by 14
Selective deficit in no-go performance induced by blockade of prefrontal cortical α2-adrenoceptorsin monkeys
Ma, C., Qi, X.-L., Peng, J., & Li, B. (2003) · Neuroreport · doi:10.1097/00001756-200305230-00021 · Cited by 9

Research works printed but not linked: 3

Goldman-Rakic PS, 1987, Handbook of Physiology, The Nervous System, Higher Functions of the Brain, 373
Robinson RG, 1985, Psychiatr. Dev., 3, 335
10.3389/fnana.2011.00029 · DOI · Paper page

Sorted by citations

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“Guanfacine, a speci ﬁ c α 2-AR antagonist, has been used to treat cognitive disorders linked to PFC dysfunction [251].”
Method
Role of Prefrontal Persistent Activity in Working Memory
Riley, M. R., & Constantinidis, C. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00181 · Cited by 251
Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex
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Self-citation
Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective
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See all 55

Authors: Arnsten, A. F. T., & Wang, M.
Affiliations: Yale University (US)
ORCID: Arnsten, Amy F.T.
Wang, Min
Venue: Annual Review of Pharmacology and Toxicology
Publisher: Annual Reviews
Published: 2016-01-06
Volume: 56
Issue: 1
Pages: 339-360
ISSN: 0362-1642 (ISSN-L)
1545-4304
DOI: 10.1146/annurev-pharmtox-010715-103617
PMC: PMC4734124
OpenAlex: W2134555567
Cited by: 50
References: 138
Citations by year: 2024: 5 · 2023: 1 · 2021: 4 · 2020: 10 · 2019: 6 · 2018: 15 · 2017: 7 · 2016: 2
FWCI: 1.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Annual Review of Pharmacology and Toxicology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (DP1AG047744, R01AG043430)
National Institute of Mental Health (R01MH093354, R01MH100064)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: cognitive disorders, prefrontal cortex, NMDA receptor, dorsolateral prefrontal cortex, working memory, guanfacine, dose-response relationship, nonhuman primate model, drug development, cognitive enhancement
MeSH terms: Animals, Cognition, Cognition Disorders, Humans, Neurons, Prefrontal Cortex

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Targeting Prefrontal Cortical Systems for Drug Development: Potential Therapies for Cognitive Disorders

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