Cited by 288Regulation of Appetite and ObesityNerve injury and regenerationHypothalamic control of reproductive hormones

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The lighter side of BDNF

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Noble, Emily E., Billington, Charles J., Kotz, Catherine M., Wang, ChuanFeng·2011·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI 10.1152/ajpregu.00776.2010PMC PMC3293512

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Abstract

Brain-derived neurotrophic factor (BDNF) mediates energy metabolism and feeding behavior. As a neurotrophin, BDNF promotes neuronal differentiation, survival during early development, adult neurogenesis, and neural plasticity; thus, there is the potential that BDNF could modify circuits important to eating behavior and energy expenditure. The possibility that “faulty” circuits could be remodeled by BDNF is an exciting concept for new therapies for obesity and eating disorders. In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (TrkB), are extensively expressed in areas associated with feeding and metabolism. Hypothalamic BDNF and TrkB appear to inhibit food intake and increase energy expenditure, leading to negative energy balance. In the hippocampus, the involvement of BDNF in neural plasticity and neurogenesis is important to learning and memory, but less is known about how BDNF participates in energy homeostasis. We review current research about BDNF in specific brain locations related to energy balance, environmental, and behavioral influences on BDNF expression and the possibility that BDNF may influence energy homeostasis via its role in neurogenesis and neural plasticity.

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See all 288

Authors: Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C.
Affiliations: University of Minnesota (US)
Corresponding author: Wang, ChuanFeng
ORCID: Noble, Emily E.
Billington, Charles J.
Kotz, Catherine M.
Wang, ChuanFeng
Venue: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher: American Physiological Society
Published: 2011-05
Volume: 300
Issue: 5
Pages: R1053-R1069
ISSN: 0363-6119 (ISSN-L)
1522-1490
DOI: 10.1152/ajpregu.00776.2010
PMC: PMC3293512
OpenAlex: W2096180958
Cited by: 284
References: 292
Citations by year: 2026: 8 · 2025: 11 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 13 · 2020: 23 · 2019: 15 · 2018: 15 · 2017: 15 · 2016: 25 · 2015: 25 · 2014: 23 · 2013: 28 · 2012: 28
FWCI: 2.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (P30DK050456, R01DK080782)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: brain-derived neurotrophic factor, TrkB receptor, hypothalamus, hippocampus, energy homeostasis, feeding behavior, energy expenditure, neurogenesis, neuroplasticity, obesity, eating disorders, neurotrophins
MeSH terms: Animals, Feeding and Eating Disorders, Brain, Eating, Energy Metabolism, Feeding Behavior, Homeostasis, Humans, Neuronal Plasticity, Obesity, Signal Transduction, Brain-Derived Neurotrophic Factor, Receptor, trkB, Neurogenesis

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