Dendritic Spines: The Locus of Structural and Functional Plasticity

Dendritic Spine Dynamics Are Regulated by Monocular Deprivation and Extracellular Matrix Degradation

Oray, S., Majewska, A., & Sur, M. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.001 · Cited by 296

Dendritic Spine Loss and Synaptic Alterations in Alzheimer’s Disease

Knobloch, M., & Mansuy, I. M. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8018-z · Cited by 296

Molecular Identity of Dendritic Voltage-Gated Sodium Channels

Lorincz, A., & Nusser, Z. (2010) · Science · doi:10.1126/science.1187958 · Cited by 296

The X-linked mental retardation protein oligophrenin-1 is required for dendritic spine morphogenesis

Govek, E.-E., Newey, S. E., Akerman, C. J., Cross, J. R., Van der Veken, L., & Van Aelst, L. (2004) · Nature Neuroscience · doi:10.1038/nn1210 · Cited by 293

Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons

Roussignol, G., Ango, F., Romorini, S., Tu, J. C., Sala, C., Worley, P. F., Bockaert, J., & Fagni, L. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4354-04.2005 · Cited by 293

Spine Formation and Correlated Assembly of Presynaptic and Postsynaptic Molecules

Okabe, S., Miwa, A., & Okado, H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06105.2001 · Cited by 291

Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia

Sweet, R. A., Henteleff, R. A., Zhang, W., Sampson, A. R., & Lewis, D. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.67 · Cited by 290

Synaptic amplification by dendritic spines enhances input cooperativity

Harnett, M. T., Makara, J. K., Spruston, N., Kath, W. L., & Magee, J. C. (2012) · Nature · doi:10.1038/nature11554 · Cited by 288

Inhibition of Dendritic Spine Morphogenesis and Synaptic Transmission by Activity-Inducible Protein Homer1a

Sala, C., Futai, K., Yamamoto, K., Worley, P. F., Hayashi, Y., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06327.2003 · Cited by 288

EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP

Irie, F., & Yamaguchi, Y. (2002) · Nature Neuroscience · doi:10.1038/nn964 · Cited by 286

The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neurons

Zagrebelsky, M., Holz, A., Dechant, G., Barde, Y.-A., Bonhoeffer, T., & Korte, M. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2492-05.2005 · Cited by 286

Homeostatic signaling: the positive side of negative feedback

Turrigiano, G. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.04.004 · Cited by 285

Altered Cortical Synaptic Morphology and Impaired Memory Consolidation in Forebrain- Specific Dominant-Negative PAK Transgenic Mice

Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280

Two-photon optogenetics of dendritic spines and neural circuits

Packer, A. M., Peterka, D. S., Hirtz, J. J., Prakash, R., Deisseroth, K., & Yuste, R. (2012) · Nature Methods · doi:10.1038/nmeth.2249 · Cited by 279

22q13 deletion syndrome

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Activity-induced targeting of profilin and stabilization of dendritic spine morphology

Ackermann, M., & Matus, A. (2003) · Nature Neuroscience · doi:10.1038/nn1135 · Cited by 276

Nonlinear Regulation of Unitary Synaptic Signals by CaV2.3 Voltage-Sensitive Calcium Channels Located in Dendritic Spines

Bloodgood, B. L., & Sabatini, B. L. (2007) · Neuron · doi:10.1016/j.neuron.2006.12.017 · Cited by 273

Rapid functional maturation of nascent dendritic spines

Zito, K., Scheuss, V., Knott, G., Hill, T., & Svoboda, K. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.054 · Cited by 272

NGL family PSD-95–interacting adhesion molecules regulate excitatory synapse formation

Kim, S., Burette, A., Chung, H. S., Kwon, S.-K., Woo, J., Lee, H. W., Kim, K., Kim, H., Weinberg, R. J., & Kim, E. (2006) · Nature Neuroscience · doi:10.1038/nn1763 · Cited by 272

Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile‐X knockout mice

Irwin, S. A., Idupulapati, M., Gilbert, M. E., Harris, J. B., Chakravarti, A. B., Rogers, E. J., Crisostomo, R. A., Larsen, B. P., Mehta, A., Alcantara, C. J., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10500 · Cited by 270

An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling

Impey, S., Davare, M., Lasiek, A., Fortin, D., Ando, H., Varlamova, O., Obrietan, K., Soderling, T. R., Goodman, R. H., & Wayman, G. A. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.10.005 · Cited by 270

Activity-regulated dynamic behavior of early dendritic protrusions: evidence for different types of dendritic filopodia

Portera-Cailliau, C., Pan, D. T., & Yuste, R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07129.2003 · Cited by 269

Activity-Dependent Redistribution and Essential Role of Cortactin in Dendritic Spine Morphogenesis

Hering, H., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-37-11759.2003 · Cited by 269

NMDA Receptor-Mediated Subthreshold Ca2+Signals in Spines of Hippocampal Neurons

Kovalchuk, Y., Eilers, J., Lisman, J., & Konnerth, A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-05-01791.2000 · Cited by 269

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

Kvajo, M., McKellar, H., Arguello, P. A., Drew, L. J., Moore, H., MacDermott, A. B., Karayiorgou, M., & Gogos, J. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802615105 · Cited by 268

Miniature synaptic transmission and BDNF modulate dendritic spine growth and form in rat CA1 neurones

Tyler, W. J., & Pozzo‐Miller, L. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.052639 · Cited by 267

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1–PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons

Ricciardi, S., Ungaro, F., Hambrock, M., Rademacher, N., Stefanelli, G., Brambilla, D., Sessa, A., Magagnotti, C., Bachi, A., Giarda, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2566 · Cited by 266

The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons

Niu, S., Yabut, O., & D'Arcangelo, G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1917-08.2008 · Cited by 266

Dysfunctional and Compensatory Prefrontal Cortical Systems, Genes and the Pathogenesis of Schizophrenia

Tan, H.-Y., Callicott, J. H., & Weinberger, D. R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm069 · Cited by 266

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

Mabb, A. M., Judson, M. C., Zylka, M. J., & Philpot, B. D. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.04.001 · Cited by 263

Independent regulation of calcium revealed by imaging dendritic spines

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Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion

Mukai, J., Dhilla, A., Drew, L. J., Stark, K. L., Cao, L., MacDermott, A. B., Karayiorgou, M., & Gogos, J. A. (2008) · Nature Neuroscience · doi:10.1038/nn.2204 · Cited by 260

Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

Steiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259

The spine neck filters membrane potentials

Araya, R., Jiang, J., Eisenthal, K. B., & Yuste, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608755103 · Cited by 258

Local functions for FMRP in axon growth cone motility and activity-dependent regulation of filopodia and spine synapses

Antar, L. N., Li, C., Zhang, H., Carroll, R. C., & Bassell, G. J. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.02.001 · Cited by 258

Silent synapses speak up

Malenka, R. C., & Nicoll, R. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80362-1 · Cited by 257

Stability of dendritic spines and synaptic contacts is controlled by αN-catenin

Abe, K., Chisaka, O., van Roy, F., & Takeichi, M. (2004) · Nature Neuroscience · doi:10.1038/nn1212 · Cited by 255

Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations

Chapleau, C. A., Calfa, G. D., Lane, M. C., Albertson, A. J., Larimore, J. L., Kudo, S., Armstrong, D. L., Percy, A. K., & Pozzo-Miller, L. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.001 · Cited by 252

Regulation of dendritic spine motility and stability by Rac1 and Rho kinase: evidence for two forms of spine motility

Tashiro, A., & Yuste, R. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.04.001 · Cited by 249

Activity-Dependent Clustering of Functional Synaptic Inputs on Developing Hippocampal Dendrites

Kleindienst, T., Winnubst, J., Roth-Alpermann, C., Bonhoeffer, T., & Lohmann, C. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.015 · Cited by 249

LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses

Dunah, A. W., Hueske, E., Wyszynski, M., Hoogenraad, C. C., Jaworski, J., Pak, D. T., Simonetta, A., Liu, G., & Sheng, M. (2005) · Nature Neuroscience · doi:10.1038/nn1416 · Cited by 247

TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines

Fujii, R., & Takumi, T. (2005) · Journal of Cell Science · doi:10.1242/jcs.02692 · Cited by 247

Endoplasmic Reticulum Ca2+ Handling in Excitable Cells in Health and Disease

Stutzmann, G. E., & Mattson, M. P. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003814 · Cited by 247

Disorder-associated mutations lead to functional inactivation of neuroligins

Chih, B., Afridi, S. K., Clark, L., & Scheiffele, P. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh158 · Cited by 242

Lamina-Specific Reductions in Dendritic Spine Density in the Prefrontal Cortex of Subjects With Schizophrenia

Kolluri, N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1200 · Cited by 241

The Arg451Cys-Neuroligin-3 Mutation Associated with Autism Reveals a Defect in Protein Processing

Comoletti, D., De Jaco, A., Jennings, L. L., Flynn, R. E., Gaietta, G., Tsigelny, I., Ellisman, M. H., & Taylor, P. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0468-04.2004 · Cited by 240

A new gene involved in X-linked mental retardation identified by analysis of an X;2 balanced translocation

Zemni, R., Bienvenu, T., Vinet, M. C., Sefiani, A., Carrié, A., Billuart, P., McDonell, N., Couvert, P., Francis, F., Chafey, P., et al. (2000) · Nature Genetics · doi:10.1038/72829 · Cited by 239

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS

Tran, T. S., Rubio, M. E., Clem, R. L., Johnson, D., Case, L., Tessier-Lavigne, M., Huganir, R. L., Ginty, D. D., & Kolodkin, A. L. (2009) · Nature · doi:10.1038/nature08628 · Cited by 238

N-WASP and the Arp2/3 Complex Are Critical Regulators of Actin in the Development of Dendritic Spines and Synapses

Wegner, A. M., Nebhan, C. A., Hu, L., Majumdar, D., Meier, K. M., Weaver, A. M., & Webb, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801555200 · Cited by 233

Drebrin-Dependent Actin Clustering in Dendritic Filopodia Governs Synaptic Targeting of Postsynaptic Density-95 and Dendritic Spine Morphogenesis

Takahashi, H., Sekino, Y., Tanaka, S., Mizui, T., Kishi, S., & Shirao, T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06586.2003 · Cited by 232

CaM-kinases: modulators of synaptic plasticity

Soderling, T. R. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00090-8 · Cited by 231

Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia

Hill, J. J., Hashimoto, T., & Lewis, D. A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001792 · Cited by 228

A role for myosin VI in postsynaptic structure and glutamate receptor endocytosis

Osterweil, E., Wells, D. G., & Mooseker, M. S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410091 · Cited by 228

Activity-Dependent Synaptogenesis: Regulation by a CaM-Kinase Kinase/CaM-Kinase I/βPIX Signaling Complex

Saneyoshi, T., Wayman, G., Fortin, D., Davare, M., Hoshi, N., Nozaki, N., Natsume, T., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.016 · Cited by 228

Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype

Lanz, T. A., Carter, D. B., & Merchant, K. M. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00079-2 · Cited by 227

Rapid modulation of spine morphology by the 5-HT 2A serotonin receptor through kalirin-7 signaling

Jones, K. A., Srivastava, D. P., Allen, J. A., Strachan, R. T., Roth, B. L., & Penzes, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905884106 · Cited by 226

Transgenic miR132 Alters Neuronal Spine Density and Impairs Novel Object Recognition Memory

Hansen, K. F., Sakamoto, K., Wayman, G. A., Impey, S., & Obrietan, K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015497 · Cited by 225

Differential distribution of endoplasmic reticulum controls metabotropic signaling and plasticity at hippocampal synapses

Holbro, N., Grunditz, Å., & Oertner, T. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905110106 · Cited by 223

Spine Expansion and Stabilization Associated with Long-Term Potentiation

Yang, Y., Wang, X.-B., Frerking, M., & Zhou, Q. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3998-07.2008 · Cited by 222

Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

Makino, H., & Malinow, R. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.036 · Cited by 222

Regulation of Dendritic Spine Morphogenesis by Insulin Receptor Substrate 53, a Downstream Effector of Rac1 and Cdc42 Small GTPases

Choi, J., Ko, J., Racz, B., Burette, A., Lee, J.-R., Kim, S., Na, M., Lee, H. W., Kim, K., Weinberg, R. J., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3212-04.2005 · Cited by 221

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

Dumanis, S. B., Tesoriero, J. A., Babus, L. W., Nguyen, M. T., Trotter, J. H., Ladu, M. J., Weeber, E. J., Turner, R. S., Xu, B., Rebeck, G. W., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4026-09.2009 · Cited by 220

Signal enhancement in distal cortical dendrites by means of interactions between active dendritic spines

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GluR1 Links Structural and Functional Plasticity at Excitatory Synapses

Kopec, C. D., Real, E., Kessels, H. W., & Malinow, R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3503-07.2007 · Cited by 220

Microtubules in Dendritic Spine Development

Gu, J., Firestein, B. L., & Zheng, J. Q. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2509-08.2008 · Cited by 219

A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory

Soderling, S. H., Guire, E. S., Kaech, S., White, J., Zhang, F., Schutz, K., Langeberg, L. K., Banker, G., Raber, J., & Scott, J. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3209-06.2006 · Cited by 217

Critical role of TRPC6 channels in the formation of excitatory synapses

Zhou, J., Du, W., Zhou, K., Tai, Y., Yao, H., Jia, Y., Ding, Y., & Wang, Y. (2008) · Nature Neuroscience · doi:10.1038/nn.2127 · Cited by 216

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca 2+ /Calmodulin-dependent protein kinase II

Ciani, L., Boyle, K. A., Dickins, E., Sahores, M., Anane, D., Lopes, D. M., Gibb, A. J., & Salinas, P. C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018132108 · Cited by 215

TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation

Amaral, M. D., & Pozzo-Miller, L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5499-06.2007 · Cited by 214

A Preformed Complex of Postsynaptic Proteins Is Involved in Excitatory Synapse Development

Gerrow, K., Romorini, S., Nabi, S. M., Colicos, M. A., Sala, C., & El-Husseini, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.015 · Cited by 214

Estrogen synthesis in the brain—Role in synaptic plasticity and memory

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Rapid modulation of long‐term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons

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The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis

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The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

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Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons.

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Glial ephrin-A3 regulates hippocampal dendritic spine morphology and glutamate transport

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The novel Rho-GTPase activating gene MEGAP / srGAP3 has a putative role in severe mental retardation

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Chapter 2 PKMζ, LTP maintenance, and the dynamic molecular biology of memory storage

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Dendritic spines lost during glutamate receptor activation reemerge at original sites of synaptic contact

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Changes in the postsynaptic density with long‐term potentiation in the dentate gyrus

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Synaptic amplification by active membrane in dendritic spines

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EphB Receptors Couple Dendritic Filopodia Motility to Synapse Formation

Kayser, M. S., Nolt, M. J., & Dalva, M. B. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.007 · Cited by 206

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

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Rap2-JNK Removes Synaptic AMPA Receptors during Depotentiation

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Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons

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SynGAP regulates spine formation

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Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities

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Caveolin Proteins Are Essential for Distinct Effects of Membrane Estrogen Receptors in Neurons

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Change in the Shape of Dendritic Spines Caused by Overexpression of Drebrin in Cultured Cortical Neurons

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The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development

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Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

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Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system

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Mechanism of the distance-dependent scaling of Schaffer collateral synapses in rat CA1 pyramidal neurons

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Abnormal Long-Lasting Synaptic Plasticity and Cognition in Mice Lacking the Mental Retardation Gene Pak3

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Synaptopodin Regulates Plasticity of Dendritic Spines in Hippocampal Neurons

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The Mental Retardation Protein PAK3 Contributes to Synapse Formation and Plasticity in Hippocampus

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Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Activity-Dependent Filopodia Growth and Spine Formation

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A Critical Role for Myosin IIB in Dendritic Spine Morphology and Synaptic Function

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The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the βPIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42

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Dendritic Growth and Spine Formation in Response to Estrogen in the Developing Purkinje Cell

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Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

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Kalirin-7 Is Required for Synaptic Structure and Function

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TrkB Has a Cell-Autonomous Role in the Establishment of Hippocampal Schaffer Collateral Synapses

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Ras Signaling Mechanisms Underlying Impaired GluR1-Dependent Plasticity Associated with Fragile X Syndrome

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Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity

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N-cadherin mediates plasticity-induced long-term spine stabilization

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The PAR-6 Polarity Protein Regulates Dendritic Spine Morphogenesis through p190 RhoGAP and the Rho GTPase

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