Cited by 254Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on Behavior

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Neural Substrates of Decision Making in Adults With Attention Deficit Hyperactivity Disorder

Ernst, Monique, Kimes, Alane S., London, Edythe D., Matochik, John A., Eldreth, Dana, Tata, Satya, Contoreggi, Carlo, Leff, Michelle, Bolla, Karen·2003·American Journal of Psychiatry

DOI 10.1176/appi.ajp.160.6.1061

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Abstract

OBJECTIVE: The characteristics of attention deficit hyperactivity disorder (ADHD) include abnormalities in reward responsivity that may interfere with decision making. The study examined reward responsivity in ADHD by comparing the neural correlates of decision making in adults with childhood-onset ADHD and in healthy adults. METHOD: The neural correlates of performance on a decision-making task and a control task were compared in 10 adults with ADHD and 12 age-matched healthy volunteers by using [(15)O]H(2)O positron emission tomography. The decision-making task tested the ability to weigh short-term rewards against long-term losses. The control task matched all components of the decision-making task except for the decision-making process and related contingency. RESULTS: The ventral and dorsolateral prefrontal cortex and the insula were activated during performance of the decision-making task in both the ADHD and healthy groups; however, activation in the ADHD group was less extended and did not involve other regions, such as anterior cingulate and hippocampus, that subserve emotion/memory processes. Direct comparison of data from the ADHD subjects and the healthy volunteers suggested that the healthy subjects engaged the hippocampal and insular regions more than did the ADHD subjects and that the ADHD subjects recruited the caudal part of the right anterior cingulate more than did the healthy subjects. CONCLUSIONS: The findings suggest that the neural circuits engaged during decision making differ in subjects with ADHD and healthy comparison subjects. This difference may explain observed deficits in motivated behaviors in ADHD. A better understanding of the nature of these deficits could ultimately be applied to refine treatment strategies for ADHD.

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Authors: Ernst, M., Kimes, A. S., London, E. D., Matochik, J. A., Eldreth, D., Tata, S., Contoreggi, C., Leff, M., & Bolla, K.
ORCID: Kimes, Alane S.
London, Edythe D.
Eldreth, Dana
Leff, Michelle
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2003-06-01
Volume: 160
Issue: 6
Pages: 1061-1070
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.160.6.1061
OpenAlex: W2151854266
Cited by: 254
References: 46
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 8 · 2017: 5 · 2016: 11 · 2015: 12 · 2014: 21 · 2013: 12 · 2012: 21
FWCI: 10.42
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA11426, R01DA011426)
National Center for Research Resources (RR0 2719, M01RR002719)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: attention deficit hyperactivity disorder, decision-making, reward sensitivity, neural correlates, ventral prefrontal cortex, dorsolateral prefrontal cortex, insula, anterior cingulate cortex, hippocampus, motivated behavior, adult ADHD
MeSH terms: Adult, Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Cerebral Cortex, Decision Making, Female, Frontal Lobe, Humans, Male, Middle Aged, Motivation, Regional Blood Flow, Reward, Task Performance and Analysis, Tomography, Emission-Computed, Prefrontal Cortex

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Neural Substrates of Decision Making in Adults With Attention Deficit Hyperactivity Disorder

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