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Stem cells and the impact of ROS signaling

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Bigarella, Carolina L., Liang, Raymond, Ghaffari, Saghi·2014·Development

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Abstract

An appropriate balance between self-renewal and differentiation is crucial for stem cell function during both early development and tissue homeostasis throughout life. Recent evidence from both pluripotent embryonic and adult stem cell studies suggests that this balance is partly regulated by reactive oxygen species (ROS), which, in synchrony with metabolism, mediate the cellular redox state. In this Primer, we summarize what ROS are and how they are generated in the cell, as well as their downstream molecular targets. We then review recent findings that provide molecular insights into how ROS signaling can influence stem cell homeostasis and lineage commitment, and discuss the implications of this for reprogramming and stem cell ageing. We conclude that ROS signaling is an emerging key regulator of multiple stem cell populations.

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Low production of reactive oxygen species and high DNA repair: mechanism of radioresistance of prostate cancer stem cells.
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Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation
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“F or p er so na l u se o nl y. (Bigarella et al. 2014); therefore, it will be important to identify and target the specific antioxidant pathways selectively used by cancer cells to maintain redox balance.”
Background
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See all 632

Authors: Bigarella, C. L., Liang, R., & Ghaffari, S.
Venue: Development
Publisher: The Company of Biologists
Published: 2014-11-15
Volume: 141
Issue: 22
Pages: 4206-4218
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.107086
OpenAlex: W2011074645
Cited by: 632
References: 173
FWCI: 12.78
Type: journal article
Language: en
Open access: green

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Stem cells and the impact of ROS signaling

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