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Cited by 375Functional Brain Connectivity StudiesAdvanced MRI Techniques and ApplicationsSleep and Wakefulness Research

Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages

Fukunaga, Masaki, Horovitz, Silvina G., van Gelderen, Peter, de Zwart, Jacco A., Jansma, J. Martijn, Ikonomidou, Vasiliki N., Chu, Renxin, Deckers, Roel H.R., Leopold, David A., Duyn, Jeff H.·2006·Magnetic Resonance Imaging
DOI 10.1016/j.mri.2006.04.018
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Abstract

A number of recent studies of human brain activity using blood-oxygen-level-dependent (BOLD) fMRI and EEG have reported the presence of spatiotemporal patterns of correlated activity in the absence of external stimuli. Although these patterns have been hypothesized to contain important information about brain architecture, little is known about their origin or about their relationship to active cognitive processes such as conscious awareness and monitoring of the environment. In this study, we have investigated the amplitude and spatiotemporal characteristics of resting-state activity patterns and their dependence on the subjects' alertness. For this purpose, BOLD fMRI was performed at 3.0 T on 12 normal subjects using a visual stimulation protocol, followed by a 27 min rest period, during which subjects were allowed to fall asleep. In subjects who were asleep at the end of the scan, we found (a) a higher amplitude of BOLD signal fluctuation during rest compared with subjects who were awake at the end of the scan; (b) spatially independent patterns of correlated activity that involve all of gray matter, including deep brain nuclei; (c) many patterns that were consistent across subjects; (d) that average percentage levels of fluctuation in visual cortex (VC) and whole brain were higher in subjects who were asleep (up to 1.71% and 1.16%, respectively) than in those who were awake (up to 1.15% and 0.96%) at the end of the scan and were comparable with those levels evoked by inte…

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  • fMRI studies measuring BOLD signals have demonstrated widespread hemodynamic alterations during NREM sleep.

    “In addition, functional magnetic resonance imaging (fMRI) studies measuring blood-oxygenation-level-dependent (BOLD) signals have demonstrated widespread hemodynamic alterations during NREM sleep (9-15).”

    From Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep (2019) · cites this paper as [9]

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Cited by

Sorted by citations

Authors
Fukunaga, M., Horovitz, S. G., van Gelderen, P., de Zwart, J. A., Jansma, J. M., Ikonomidou, V. N., Chu, R., Deckers, R. H. R., Leopold, D. A., & Duyn, J. H.
Affiliations
National Institutes of Health (US)
Corresponding author
Fukunaga, Masaki
ORCID
Venue
Magnetic Resonance Imaging
Publisher
Elsevier BV
Published
2006-10
Volume
24
Issue
8
Pages
979-992
ISSN
0730-725X (ISSN-L)
DOI
10.1016/j.mri.2006.04.018
OpenAlex
W2002738263
Cited by
375
References
10
Citations by year
2026: 13 · 2025: 23 · 2024: 18 · 2023: 13 · 2022: 16 · 2021: 18 · 2020: 15 · 2019: 16 · 2018: 17 · 2017: 18 · 2016: 24 · 2015: 31 · 2014: 20 · 2013: 28 · 2012: 17
FWCI
7.55
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Magnetic Resonance Imaging (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Oxford
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords
resting-state brain activity, BOLD signal fluctuations, sleep, alertness, visual cortex, thalamus, deep brain nuclei, visual stimulation, brain architecture, conscious awareness
MeSH terms
Adult, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Photic Stimulation, Rest, Sleep Stages, Reproducibility of Results

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