The 2007 WHO Classification of Tumours of the Central Nervous System

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Louis, David N., Ohgaki, Hiroko, Wiestler, Otmar D., Cavenee, Webster K., Burger, Peter C., Jouvet, Anne, Scheithauer, Bernd W., Kleihues, Paul·2007·Acta Neuropathologica

DOI 10.1007/s00401-007-0243-4

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Abstract

The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneuronal tumour of the fourth ventricle, papillary tumour of the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis. Histological variants were added if there was evidence of a different age distribution, location, genetic profile or clinical behaviour; these included pilomyxoid astrocytoma, anaplastic medulloblastoma and medulloblastoma with extensive nodularity. The WHO grading scheme and the sections on genetic profiles were updated and the rhabdoid tumour predisposition syndrome was added to the list of familial tumour syndromes typically involving the nervous system. As in the previous, 2000 edition of the WHO 'Blue Book', the classification is accompanied by a concise commentary on clinico-pathological characteristics of each tumour type. The 2007 WHO classification is based on the consensus of an international Working Group of 25 pathologists and geneticists, as well as contributions from more than 70 international experts overall, and is presented as the standard for the definition of brain tumours to the clinical oncology and cancer research communities world-wide.

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Untitled work
(2015) · Europe PMC (PubMed Central)

Authors: Louis, D. N., Ohgaki, H., Wiestler, O. D., Cavenee, W. K., Burger, P. C., Jouvet, A., Scheithauer, B. W., & Kleihues, P.
Venue: Acta Neuropathologica
Publisher: Springer Science and Business Media LLC
Published: 2007-07-06
Volume: 114
Issue: 2
Pages: 97-109
ISSN: 0001-6322 (ISSN-L)
1432-0533
DOI: 10.1007/s00401-007-0243-4
OpenAlex: W1560814177
Cited by: 15,397
References: 0
FWCI: 214.26
Type: journal article
Language: en
Open access: hybrid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

The 2007 WHO Classification of Tumours of the Central Nervous System

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cited by

Metadata

Record

About these checks

Data sources