Cited by 4,396Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesNeurological Disease Mechanisms and Treatments

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Microglia: a sensor for pathological events in the CNS

Kreutzberg, Georg W·1996·Trends in Neurosciences

DOI 10.1016/0166-2236(96)10049-7

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Abstract

The most characteristic feature of microglial cells is their rapid activation in response to even minor pathological changes in the CNS. Microglia activation is a key factor in the defence of the neural parenchyma against infectious diseases, inflammation, trauma, ischaemia, brain tumours and neurodegeneration. Microglia activation occurs as a graded response in vivo. The transformation of microglia into potentially cytotoxic cells is under strict control and occurs mainly in response to neuronal or terminal degeneration, or both. Activated microglia are mainly scavenger cells but also perform various other functions in tissue repair and neural regeneration. They form a network of immune alert resident macrophages with a capacity for immune surveillance and control. Activated microglia can destroy invading micro-organisms, remove potentially deleterious debris, promote tissue repair by secreting growth factors and thus facilitate the return to tissue homeostasis. An understanding of intercellular signalling pathways for microglia proliferation and activation could form a rational basis for targeted intervention on glial reactions to injuries in the CNS.

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Authors: Kreutzberg, G. W.
Affiliations: Max Planck Institute of Psychiatry (DE)
Corresponding author: Kreutzberg, Georg W
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1996-08
Volume: 19
Issue: 8
Pages: 312-318
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/0166-2236(96)10049-7
OpenAlex: W2109759840
Cited by: 4,396
References: 67
Citations by year: 2026: 37 · 2025: 63 · 2024: 71 · 2023: 82 · 2022: 104 · 2021: 144 · 2020: 159 · 2019: 126 · 2018: 158 · 2017: 167 · 2016: 161 · 2015: 169 · 2014: 217 · 2013: 216 · 2012: 227
FWCI: 11.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: microglia, microglial activation, CNS pathology, neuroinflammation, neurodegeneration, brain injury, immune surveillance, tissue repair, nerve regeneration, intercellular communication, glial reaction, neuroprotection
MeSH terms: Animals, Central Nervous System, Central Nervous System Diseases, Humans, Microglia

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Microglia: a sensor for pathological events in the CNS

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