CoChat
Sign Up
Cited by 61

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Autophagy and ageing: Insights from invertebrate model organisms

Lionaki, Eirini, Markaki, Maria, Tavernarakis, Nektarios·2013·Ageing Research Reviews
DOI 10.1016/j.arr.2012.05.001
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.arr.2012.05.001

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 181

  1. Alavez, 2011, Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan, Nature, 472, 226, 10.1038/nature09873 · DOI · Paper page
  2. Alvers, 2009, Autophagy is required for extension of yeast chronological life span by rapamycin, Autophagy, 5, 847, 10.4161/auto.8824 · DOI · Paper page
  3. Apfeld, 1998, Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span, Cell, 95, 199, 10.1016/S0092-8674(00)81751-1 · DOI
  4. Arum, 2007, Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity, Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62, 951, 10.1093/gerona/62.9.951 · DOI
  5. Barth, 2011, Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis, Cell Death and Differentiation, 18, 915, 10.1038/cdd.2010.157 · DOI · Paper page
  6. Bass, 2007, Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans, Mechanisms of Ageing and Development, 128, 546, 10.1016/j.mad.2007.07.007 · DOI
  7. Bauer, 2006, New tricks of an old molecule: lifespan regulation by p53, Aging Cell, 5, 437, 10.1111/j.1474-9726.2006.00228.x · DOI
  8. Bauer, 2007, Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling, Proceedings of the National Academy of Sciences of the United States of America, 104, 13355, 10.1073/pnas.0706121104 · DOI
  9. Bauer, 2009, dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster, Aging (Albany, NY), 1, 38, 10.18632/aging.100001 · DOI
  10. Berdichevsky, 2006, C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span, Cell, 125, 1165, 10.1016/j.cell.2006.04.036 · DOI
  11. Bishop, 2007, Genetic links between diet and lifespan: shared mechanisms from yeast to humans, Nature Reviews Genetics, 8, 835, 10.1038/nrg2188 · DOI
  12. Bjedov, 2010, Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster, Cell Metabolism, 11, 35, 10.1016/j.cmet.2009.11.010 · DOI · Paper page
  13. Boveris, 1972, The cellular production of hydrogen peroxide, Biochemical Journal, 128, 617, 10.1042/bj1280617 · DOI
  14. Boya, 2009, Beclin 1: a BH3-only protein that fails to induce apoptosis, Oncogene, 28, 2125, 10.1038/onc.2009.83 · DOI
  15. Calabrese, 2011, Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity, Molecular Aspects of Medicine, 32, 279, 10.1016/j.mam.2011.10.007 · DOI · Paper page
  16. Carra, 2008, HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy, Journal of Biological Chemistry, 283, 1437, 10.1074/jbc.M706304200 · DOI
  17. Carra, 2009, HspB8 participates in protein quality control by a non-chaperone-like mechanism that requires eIF2{alpha} phosphorylation, Journal of Biological Chemistry, 284, 5523, 10.1074/jbc.M807440200 · DOI
  18. Carra, 2010, Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases, Journal of Biological Chemistry, 285, 37811, 10.1074/jbc.M110.127498 · DOI
  19. Cassada, 1975, The dauerlarva, a post-embryonic developmental variant of the nematode Caenorhabditis elegans, Developmental Biology, 46, 326, 10.1016/0012-1606(75)90109-8 · DOI
  20. Chen, 2011, The regulation of autophagy – unanswered questions, Journal of Cell Science, 124, 161, 10.1242/jcs.064576 · DOI
  21. Ciechomska, 2009, Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function, Oncogene, 28, 2128, 10.1038/onc.2009.60 · DOI
  22. Clancy, 2001, Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein, Science, 292, 104, 10.1126/science.1057991 · DOI
  23. Copeland, 2009, Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain, Current Biology, 19, 1591, 10.1016/j.cub.2009.08.016 · DOI · Paper page
  24. Curran, 2009, A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants, Nature, 459, 1079, 10.1038/nature08106 · DOI
  25. Demontis, 2010, FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging, Cell, 143, 813, 10.1016/j.cell.2010.10.007 · DOI · Paper page
  26. Derry, 2001, Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance, Science, 294, 591, 10.1126/science.1065486 · DOI
  27. Doonan, 2008, Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans, Genes and Development, 22, 3236, 10.1101/gad.504808 · DOI · Paper page
  28. Dwivedi, 2009, Autophagy genes mediate the effect of calcineurin on life span in C. elegans, Autophagy, 5, 604, 10.4161/auto.5.5.8157 · DOI
  29. Feng, 2001, Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans, Developmental Cell, 1, 633, 10.1016/S1534-5807(01)00071-5 · DOI
  30. Florez-McClure, 2007, Decreased insulin-receptor signaling promotes the autophagic degradation of beta-amyloid peptide in C. elegans, Autophagy, 3, 569, 10.4161/auto.4776 · DOI
  31. Garigan, 2002, Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation, Genetics, 161, 1101, 10.1093/genetics/161.3.1101 · DOI · Paper page
  32. Giannakou, 2004, Long-lived Drosophila with overexpressed dFOXO in adult fat body, Science, 305, 361, 10.1126/science.1098219 · DOI
  33. Giannakou, 2007, Role of insulin-like signalling in Drosophila lifespan, Trends in Biochemical Sciences, 32, 180, 10.1016/j.tibs.2007.02.007 · DOI
  34. Gomez, 2007, The l-isoaspartyl-O-methyltransferase in Caenorhabditis elegans larval longevity and autophagy, Developmental Biology, 303, 493, 10.1016/j.ydbio.2006.11.023 · DOI
  35. Guarente, 2000, Genetic pathways that regulate ageing in model organisms, Nature, 408, 255, 10.1038/35041700 · DOI
  36. Hansen, 2007, Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans, Aging Cell, 6, 95, 10.1111/j.1474-9726.2006.00267.x · DOI · Paper page
  37. Hara, 2006, Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice, Nature, 441, 885, 10.1038/nature04724 · DOI · Paper page
  38. Hardie, 2004, The AMP-activated protein kinase pathway—new players upstream and downstream, Journal of Cell Science, 117, 5479, 10.1242/jcs.01540 · DOI
  39. Harman, 1956, Aging: a theory based on free radical and radiation chemistry, Journal of Gerontology, 11, 298, 10.1093/geronj/11.3.298 · DOI · Paper page
  40. Harman, 1972, The biologic clock: the mitochondria, Journal of the American Geriatrics Society, 20, 145, 10.1111/j.1532-5415.1972.tb00787.x · DOI
  41. Hars, 2007, Autophagy regulates ageing in C. elegans, Autophagy, 3, 93, 10.4161/auto.3636 · DOI · Paper page
  42. Hashimoto, 2009, Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans, Genes to Cells, 14, 717, 10.1111/j.1365-2443.2009.01306.x · DOI
  43. Hay, 2004, Upstream and downstream of mTOR, Genes and Development, 18, 1926, 10.1101/gad.1212704 · DOI · Paper page
  44. Heidler, 2010, Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1, Biogerontology, 11, 183, 10.1007/s10522-009-9239-x · DOI
  45. Heydari, 2000, Age-related alterations in the activation of heat shock transcription factor 1 in rat hepatocytes, Experimental Cell Research, 256, 83, 10.1006/excr.2000.4808 · DOI · Paper page
  46. Honda, 1999, The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans, FASEB Journal, 13, 1385, 10.1096/fasebj.13.11.1385 · DOI
  47. Honjoh, 2009, Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans, Nature, 457, 726, 10.1038/nature07583 · DOI
  48. Huang, 2002, Autophagy in yeast: a review of the molecular machinery, Cell Structure and Function, 27, 409, 10.1247/csf.27.409 · DOI
  49. Hwang, 2011, Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection, Aging (Albany, NY), 3, 304, 10.18632/aging.100292 · DOI
  50. Hwangbo, 2004, Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body, Nature, 429, 562, 10.1038/nature02549 · DOI
  51. Ibanez, 2006, Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa, Brain: A Journal of Neurology, 129, 686, 10.1093/brain/awl005 · DOI
  52. Irobi, 2004, Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy, Nature Genetics, 36, 597, 10.1038/ng1328 · DOI
  53. Jang, 1997, Cancer chemopreventive activity of resveratrol, a natural product derived from grapes, Science, 275, 218, 10.1126/science.275.5297.218 · DOI · Paper page
  54. Jia, 2004, The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span, Development, 131, 3897, 10.1242/dev.01255 · DOI · Paper page
  55. Jia, 2007, Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans, Autophagy, 3, 21, 10.4161/auto.3528 · DOI
  56. Jin, 2012, PINK1- and Parkin-mediated mitophagy at a glance, Journal of Cell Science, 125, 795, 10.1242/jcs.093849 · DOI
  57. Johnson, 2002, Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease, Journal of Inherited Metabolic Disease, 25, 197, 10.1023/A:1015677828407 · DOI
  58. Junger, 2003, The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling, Journal of Biology, 2, 20, 10.1186/1475-4924-2-20 · DOI
  59. Kaeberlein, 2005, Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients, Science, 310, 1193, 10.1126/science.1115535 · DOI · Paper page
  60. Kaeberlein, 2008, Protein translation, 2008, Aging Cell, 7, 777, 10.1111/j.1474-9726.2008.00439.x · DOI
  61. Kaeberlein, 2006, Lifespan extension in Caenorhabditis elegans by complete removal of food, Aging Cell, 5, 487, 10.1111/j.1474-9726.2006.00238.x · DOI
  62. Kang, 2008, To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation, Autophagy, 4, 82, 10.4161/auto.5154 · DOI
  63. Kang, 2010, Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis, FEBS Journal, 277, 66, 10.1111/j.1742-4658.2009.07413.x · DOI
  64. Kapahi, 2004, Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway, Current Biology, 14, 885, 10.1016/j.cub.2004.03.059 · DOI · Paper page
  65. Kayser, 2004, The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans, Mechanisms of Ageing and Development, 125, 455, 10.1016/j.mad.2004.04.002 · DOI
  66. Kenyon, 1993, A C. elegans mutant that lives twice as long as wild type, Nature, 366, 461, 10.1038/366461a0 · DOI · Paper page
  67. Kenyon, 2010, The genetics of ageing, Nature, 464, 504, 10.1038/nature08980 · DOI · Paper page
  68. Kimura, 1997, daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans, Science, 277, 942, 10.1126/science.277.5328.942 · DOI
  69. Kirkwood, 2005, Understanding the odd science of aging, Cell, 120, 437, 10.1016/j.cell.2005.01.027 · DOI · Paper page
  70. Kirkwood, 2008, A systematic look at an old problem, Nature, 451, 644, 10.1038/451644a · DOI
  71. Klee, 1980, Concerted role of calmodulin and calcineurin in calcium regulation, Annals of the New York Academy of Sciences, 356, 43, 10.1111/j.1749-6632.1980.tb29598.x · DOI
  72. Klionsky, 2003, A unified nomenclature for yeast autophagy-related genes, Developmental Cell, 5, 539, 10.1016/S1534-5807(03)00296-X · DOI
  73. Klionsky, 2005, The molecular machinery of autophagy: unanswered questions, Journal of Cell Science, 118, 7, 10.1242/jcs.01620 · DOI
  74. Kourtis, 2009, Autophagy and cell death in model organisms, Cell Death and Differentiation, 16, 21, 10.1038/cdd.2008.120 · DOI
  75. Kourtis, 2011, Cellular stress response pathways and ageing: intricate molecular relationships, EMBO Journal, 30, 2520, 10.1038/emboj.2011.162 · DOI
  76. Kwon, 2010, A new DAF-16 isoform regulates longevity, Nature, 466, 498, 10.1038/nature09184 · DOI
  77. Lane, 1992, Cancer. p53, guardian of the genome, Nature, 358, 15, 10.1038/358015a0 · DOI · Paper page
  78. Lee, 2008, A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy, Proceedings of the National Academy of Sciences of the United States of America, 105, 3374, 10.1073/pnas.0712145105 · DOI
  79. Lee, 2007, ATG1, an autophagy regulator, inhibits cell growth by negatively regulating S6 kinase, EMBO Reports, 8, 360, 10.1038/sj.embor.7400917 · DOI
  80. Lee, 2010, Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity, Current Biology, 20, 2131, 10.1016/j.cub.2010.10.057 · DOI
  81. Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 88, 323, 10.1016/S0092-8674(00)81871-1 · DOI · Paper page
  82. Levine, 2004, Development by self-digestion: molecular mechanisms and biological functions of autophagy, Developmental Cell, 6, 463, 10.1016/S1534-5807(04)00099-1 · DOI
  83. Levine, 2008, Autophagy in the pathogenesis of disease, Cell, 132, 27, 10.1016/j.cell.2007.12.018 · DOI · Paper page
  84. Liang, 2007, The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis, Nature Cell Biology, 9, 218, 10.1038/ncb1537 · DOI
  85. Lin, 1997, daf-16: an HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans, Science, 278, 1319, 10.1126/science.278.5341.1319 · DOI
  86. Lin, 1998, Extended life-span and stress resistance in the Drosophila mutant methuselah, Science, 282, 943, 10.1126/science.282.5390.943 · DOI
  87. Ling, 2011, Brain aging and Abeta1-42 neurotoxicity converge via deterioration in autophagy-lysosomal system: a conditional Drosophila model linking Alzheimer's neurodegeneration with aging, Acta Neuropathologica, 121, 183, 10.1007/s00401-010-0772-0 · DOI
  88. Liu, 2004, A Fenton reaction at the endoplasmic reticulum is involved in the redox control of hypoxia-inducible gene expression, Proceedings of the National Academy of Sciences of the United States of America, 101, 4302, 10.1073/pnas.0400265101 · DOI · Paper page
  89. Longo, 2006, Sirtuins in aging and age-related disease, Cell, 126, 257, 10.1016/j.cell.2006.07.002 · DOI · Paper page
  90. Luo, 2007, Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation, EMBO Journal, 26, 380, 10.1038/sj.emboj.7601484 · DOI
  91. Luong, 2006, Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity, Cell Metabolism, 4, 133, 10.1016/j.cmet.2006.05.013 · DOI
  92. Madeo, 2010, Spermidine: a novel autophagy inducer and longevity elixir, Autophagy, 6, 160, 10.4161/auto.6.1.10600 · DOI
  93. Markaki, 2010, Modeling human diseases in Caenorhabditis elegans, Biotechnology Journal, 5, 1261, 10.1002/biot.201000183 · DOI
  94. Martin, 2005, The expanding TOR signaling network, Current Opinion in Cell Biology, 17, 158, 10.1016/j.ceb.2005.02.008 · DOI
  95. Martins, 2011, Hormesis, cell death and aging, Aging (Albany, NY), 3, 821, 10.18632/aging.100380 · DOI
  96. Mathew, 2009, Autophagy suppresses tumorigenesis through elimination of p62, Cell, 137, 1062, 10.1016/j.cell.2009.03.048 · DOI
  97. McPhee, 2009, Autophagy in Drosophila melanogaster, Biochimica et Biophysica Acta, 1793, 1452, 10.1016/j.bbamcr.2009.02.009 · DOI
  98. Melendez, 2003, Autophagy genes are essential for dauer development and life-span extension in C. elegans, Science, 301, 1387, 10.1126/science.1087782 · DOI · Paper page
  99. Melendez, 2009, Autophagy in C. elegans, WormBook, 24, 1, 10.1895/wormbook.1.147.1 · DOI
  100. Menzies, 2010, Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy, Human Molecular Genetics, 19, 4573, 10.1093/hmg/ddq385 · DOI
  101. Milton, 2012, Oxidative stress in synapse development and function, Developmental Neurobiology, 72, 100, 10.1002/dneu.20957 · DOI
  102. Morselli, 2011, Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome, Journal of Cell Biology, 192, 615, 10.1083/jcb.201008167 · DOI
  103. Neufeld, 2010, TOR-dependent control of autophagy: biting the hand that feeds, Current Opinion in Cell Biology, 22, 157, 10.1016/j.ceb.2009.11.005 · DOI
  104. Nezis, 2012, Selective autophagy in Drosophila, International Journal of Cell Biology, 10.1155/2012/146767 · DOI
  105. Nojima, 2003, The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif, Journal of Biological Chemistry, 278, 15461, 10.1074/jbc.C200665200 · DOI
  106. Ogg, 1997, The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans, Nature, 389, 994, 10.1038/40194 · DOI
  107. Oh, 2005, JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16, Proceedings of the National Academy of Sciences of the United States of America, 102, 4494, 10.1073/pnas.0500749102 · DOI
  108. Pallanck, 2006, Neurodegenerative disease: pink, parkin and the brain, Nature, 441, 1058, 10.1038/4411058a · DOI
  109. Pan, 2007, Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans, Aging Cell, 6, 111, 10.1111/j.1474-9726.2006.00266.x · DOI
  110. Panowski, 2007, PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans, Nature, 447, 550, 10.1038/nature05837 · DOI
  111. Parsons, 1995, Inherited stress resistance and longevity: a stress theory of ageing, Heredity, 75, 216, 10.1038/hdy.1995.126 · DOI
  112. Pattingre, 2005, Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy, Cell, 122, 927, 10.1016/j.cell.2005.07.002 · DOI · Paper page
  113. Poole, 2008, The PINK1/Parkin pathway regulates mitochondrial morphology, Proceedings of the National Academy of Sciences of the United States of America, 105, 1638, 10.1073/pnas.0709336105 · DOI · Paper page
  114. Py, 2009, A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses, Autophagy, 5, 393, 10.4161/auto.5.3.7762 · DOI
  115. Ravikumar, 2005, Dynein mutations impair autophagic clearance of aggregate-prone proteins, Nature Genetics, 37, 771, 10.1038/ng1591 · DOI · Paper page
  116. Rea, 2005, Metabolism in the Caenorhabditis elegans Mit mutants, Experimental Gerontology, 40, 841, 10.1016/j.exger.2005.06.015 · DOI
  117. Reinke, 2010, Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size, Molecular Genetics and Metabolism, 100, 274, 10.1016/j.ymgme.2010.03.013 · DOI
  118. Ren, 2009, Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity, Experimental Gerontology, 44, 228, 10.1016/j.exger.2008.10.002 · DOI
  119. Riezman, 2004, Why do cells require heat shock proteins to survive heat stress?, Cell Cycle, 3, 61, 10.4161/cc.3.1.625 · DOI
  120. Rogina, 2002, Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction, Science, 298, 1745, 10.1126/science.1078986 · DOI
  121. Rogina, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction, Proceedings of the National Academy of Sciences of the United States of America, 101, 15998, 10.1073/pnas.0404184101 · DOI · Paper page
  122. Rubinsztein, 2005, Dyneins, autophagy, aggregation and neurodegeneration, Autophagy, 1, 177, 10.4161/auto.1.3.2050 · DOI
  123. Rubinsztein, 2011, Autophagy and aging, Cell, 146, 682, 10.1016/j.cell.2011.07.030 · DOI · Paper page
  124. Rutkowski, 2011, Phylogeny and function of the invertebrate p53 superfamily, Cold Spring Harbor Perspectives in Biology, 2, a001131
  125. Salih, 2008, FoxO transcription factors in the maintenance of cellular homeostasis during aging, Current Opinion in Cell Biology, 20, 126, 10.1016/j.ceb.2008.02.005 · DOI · Paper page
  126. Samara, 2008, Autophagy is required for necrotic cell death in Caenorhabditis elegans, Cell Death and Differentiation, 15, 105, 10.1038/sj.cdd.4402231 · DOI
  127. Samara, 2008, Autophagy and cell death in Caenorhabditis elegans, Current Pharmaceutical Design, 14, 97, 10.2174/138161208783378770 · DOI
  128. Samokhvalov, 2008, Autophagy protects against hypoxic injury in C. elegans, Autophagy, 4, 1034, 10.4161/auto.6994 · DOI
  129. Sarbassov, 2005, Growing roles for the mTOR pathway, Current Opinion in Cell Biology, 17, 596, 10.1016/j.ceb.2005.09.009 · DOI
  130. Sarkar, 2007, Small molecules enhance autophagy and reduce toxicity in Huntington's disease models, Nature Chemical Biology, 3, 331, 10.1038/nchembio883 · DOI
  131. Scott, 2004, Role and regulation of starvation-induced autophagy in the Drosophila fat body, Developmental Cell, 7, 167, 10.1016/j.devcel.2004.07.009 · DOI
  132. Senoo-Matsuda, 2003, A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging, Journal of Biological Chemistry, 278, 22031, 10.1074/jbc.M211377200 · DOI
  133. Shaw, 2007, The C. elegans TGF-beta dauer pathway regulates longevity via insulin signaling, Current Biology, 17, 1635, 10.1016/j.cub.2007.08.058 · DOI
  134. Sheaffer, 2008, The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging, Current Biology, 18, 1355, 10.1016/j.cub.2008.07.097 · DOI
  135. Shen, 2009, Autophagy promotes synapse development in Drosophila, Journal of Cell Biology, 187, 71, 10.1083/jcb.200907109 · DOI · Paper page
  136. Simonsen, 2008, Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila, Autophagy, 4, 176, 10.4161/auto.5269 · DOI · Paper page
  137. Soukas, 2009, Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans, Genes and Development, 23, 496, 10.1101/gad.1775409 · DOI · Paper page
  138. Stetler, 2010, Heat shock proteins: cellular and molecular mechanisms in the central nervous system, Progress in Neurobiology, 92, 184, 10.1016/j.pneurobio.2010.05.002 · DOI
  139. Sun, 1999, FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies, Molecular and Cellular Biology, 19, 216, 10.1128/MCB.19.1.216 · DOI
  140. Sun, 2002, Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster, Genetics, 161, 661, 10.1093/genetics/161.2.661 · DOI
  141. Syntichaki, 2007, eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans, Nature, 445, 922, 10.1038/nature05603 · DOI · Paper page
  142. Talloczy, 2002, Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway, Proceedings of the National Academy of Sciences of the United States of America, 99, 190, 10.1073/pnas.012485299 · DOI
  143. Tanaka, 2010, Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network, FEBS Letters, 584, 1386, 10.1016/j.febslet.2010.02.060 · DOI
  144. Tang, 2005, Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L, Human Genetics, 116, 222, 10.1007/s00439-004-1218-3 · DOI
  145. Tatar, 2001, A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function, Science, 292, 107, 10.1126/science.1057987 · DOI
  146. Tavernarakis, 2008, The effects of p53 on whole organism longevity are mediated by autophagy, Autophagy, 4, 870, 10.4161/auto.6730 · DOI · Paper page
  147. Tee, 2005, mTOR, translational control and human disease, Seminars in Cell and Developmental Biology, 16, 29, 10.1016/j.semcdb.2004.11.005 · DOI
  148. Tian, 2009, epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans, Autophagy, 5, 608, 10.4161/auto.5.5.8624 · DOI
  149. Tian, 2010, C. elegans screen identifies autophagy genes specific to multicellular organisms, Cell, 141, 1042, 10.1016/j.cell.2010.04.034 · DOI · Paper page
  150. Tissenbaum, 2001, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, Nature, 410, 227, 10.1038/35065638 · DOI · Paper page
  151. Toivonen, 2007, No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects, PLoS Genetics, 3, e95, 10.1371/journal.pgen.0030095 · DOI
  152. Toth, 2007, Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans, Journal of Cell Science, 120, 1134, 10.1242/jcs.03401 · DOI
  153. Toth, 2008, Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans, Autophagy, 4, 330, 10.4161/auto.5618 · DOI
  154. Tower, 2011, Heat shock proteins and Drosophila aging, Experimental Gerontology, 46, 355, 10.1016/j.exger.2010.09.002 · DOI
  155. Tullet, 2008, Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans, Cell, 132, 1025, 10.1016/j.cell.2008.01.030 · DOI · Paper page
  156. Twig, 2008, Fission and selective fusion govern mitochondrial segregation and elimination by autophagy, EMBO Journal, 27, 433, 10.1038/sj.emboj.7601963 · DOI · Paper page
  157. Valente, 2004, Hereditary early-onset Parkinson's disease caused by mutations in PINK1, Science, 304, 1158, 10.1126/science.1096284 · DOI · Paper page
  158. Vellai, 2009, The regulation of aging: does autophagy underlie longevity?, Trends in Cell Biology, 19, 487, 10.1016/j.tcb.2009.07.007 · DOI
  159. Ventura, 2006, Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases, Experimental Gerontology, 41, 974, 10.1016/j.exger.2006.06.060 · DOI
  160. Ventura, 2009, p53/CEP-1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress, Aging Cell, 8, 380, 10.1111/j.1474-9726.2009.00482.x · DOI
  161. Viswanathan, 2005, A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span, Developmental Cell, 9, 605, 10.1016/j.devcel.2005.09.017 · DOI
  162. Vos, 2010, HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones, Human Molecular Genetics, 19, 4677, 10.1093/hmg/ddq398 · DOI
  163. Vos, 2011, Small heat shock proteins, protein degradation and protein aggregation diseases, Autophagy, 7, 101, 10.4161/auto.7.1.13935 · DOI
  164. Vousden, 2007, p53 in health and disease, Nature Reviews Molecular Cell Biology, 8, 275, 10.1038/nrm2147 · DOI
  165. Wang, 2003, JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila, Developmental Cell, 5, 811, 10.1016/S1534-5807(03)00323-X · DOI
  166. Wang, 2005, JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling, Cell, 121, 115, 10.1016/j.cell.2005.02.030 · DOI
  167. Wang, 2008, Fat metabolism links germline stem cells and longevity in C. elegans, Science, 322, 957, 10.1126/science.1162011 · DOI
  168. Wang, 2006, Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO, Mechanisms of Ageing and Development, 127, 48, 10.1016/j.mad.2005.09.005 · DOI
  169. Wu, 2009, JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy, Mechanisms of Development, 126, 624, 10.1016/j.mod.2009.06.1082 · DOI
  170. Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016 · DOI · Paper page
  171. Xie, 2007, Autophagosome formation: core machinery and adaptations, Nature Cell Biology, 9, 1102, 10.1038/ncb1007-1102 · DOI
  172. Yamada, 2008, Programmed cell death of primordial germ cells in Drosophila is regulated by p53 and the outsiders monocarboxylate transporter, Development, 135, 207, 10.1242/dev.010389 · DOI
  173. Yamamoto, 2011, Insulin receptor substrate chico acts with the transcription factor FOXO to extend Drosophila lifespan, Aging Cell, 10, 729, 10.1111/j.1474-9726.2011.00716.x · DOI
  174. Yang, 2010, Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans, Aging Cell, 9, 433, 10.1111/j.1474-9726.2010.00571.x · DOI
  175. Yang, 2010, A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans, PLoS Biology, 8, e1000556, 10.1371/journal.pbio.1000556 · DOI
  176. Yang, 2008, Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery, Proceedings of the National Academy of Sciences of the United States of America, 105, 7070, 10.1073/pnas.0711845105 · DOI
  177. Yang, 2010, Eaten alive: a history of macroautophagy, Nature Cell Biology, 12, 814, 10.1038/ncb0910-814 · DOI
  178. Ye, 2010, Resveratrol attenuates radiation damage in Caenorhabditis elegans by preventing oxidative stress, Journal of Radiation Research, 51, 473, 10.1269/jrr.10009 · DOI
  179. Yiu, 2010, Inhibitory effects of resveratrol on the Epstein–Barr virus lytic cycle, Molecules, 15, 7115, 10.3390/molecules15107115 · DOI
  180. Zhang, 2010, Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation, European Journal of Pharmacology, 636, 1, 10.1016/j.ejphar.2010.03.043 · DOI
  181. Ziviani, 2010, Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin, Proceedings of the National Academy of Sciences of the United States of America, 107, 5018, 10.1073/pnas.0913485107 · DOI · Paper page

Cited by

Sorted by citations

See all 61

Metadata

Authors
Lionaki, E., Markaki, M., & Tavernarakis, N.
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2013-01
Volume
12
Issue
1
Pages
413-428
ISSN
1568-1637
DOI
10.1016/j.arr.2012.05.001
Cited by
61
References
44
Language
en
Licence
Funders
  • Ministry of National Education and Religious Affairs
  • Seventh Framework Programme
  • European Research Council

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review