Cited by 110Schizophrenia research and treatmentNeuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

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A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia

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Feifel, David, Shilling, Paul D., MacDonald, Kai·2016·Biological Psychiatry

DOI 10.1016/j.biopsych.2015.07.025PMC PMC5673255

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Abstract

Schizophrenia is a disabling, heterogeneous disorder with clinical features that can be parsed into three domains: positive symptoms, negative symptoms, and cognitive deficits. Current antipsychotic drugs produce fairly robust clinical benefit against positive symptoms but typically have minimal therapeutic effects on negative symptoms and cognitive deficits. Oxytocin (OT) is a nonapeptide that, in addition to its role as a hormone regulating peripheral reproductive-relevant functions, acts as a neurotransmitter in the brain. Several lines of preclinical and clinical research suggest that the OT system may play a role in regulating the expression of schizophrenia spectrum disorders and that targeting the central OT system may yield novel treatments to address these symptoms. In this review, we summarize the extant preclinical and clinical evidence relevant to the role of OT in schizophrenia with particular emphasis on its putative therapeutic effects on each of the three above-mentioned clinical domains.

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Authors: Feifel, D., Shilling, P. D., & MacDonald, K.
Affiliations: University of California San Diego (US)
Corresponding author: Feifel, David
ORCID: Feifel, David
Shilling, Paul D.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2016-02
Volume: 79
Issue: 3
Pages: 222-233
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2015.07.025
PMC: PMC5673255
OpenAlex: W1441608289
Cited by: 110
References: 132
Citations by year: 2026: 2 · 2025: 8 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 12 · 2020: 11 · 2019: 11 · 2018: 10 · 2017: 17 · 2016: 18
FWCI: 2.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Goodenough Neuroscience Research Fund
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin, schizophrenia, positive symptoms, negative symptoms, cognitive impairment, oxytocinergic system, antipsychotic drugs, new drugs, schizophrenia spectrum disorders
MeSH terms: Animals, Brain, Cognition, Cognition Disorders, Disease Models, Animal, Humans, Oxytocin, Schizophrenia, Schizophrenic Psychology

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A Review of Oxytocin’s Effects on the Positive, Negative, and Cognitive Domains of Schizophrenia

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