Cited by 574Infant Nutrition and HealthGut microbiota and healthMicrobial Metabolites in Food Biotechnology

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Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways

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Marcobal, Angela, Barboza, Mariana, Sonnenburg, Erica D., Pudlo, Nicholas, Martens, Eric C., Desai, Prerak, Lebrilla, Carlito B., Weimer, Bart C., Mills, David A., German, J. Bruce, Sonnenburg, Justin L.·2011·Cell Host & Microbe

DOI 10.1016/j.chom.2011.10.007PMC PMC3227561

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Abstract

Newborns are colonized with an intestinal microbiota shortly after birth, but the factors governing the retention and abundance of specific microbial lineages are unknown. Nursing infants consume human milk oligosaccharides (HMOs) that pass undigested to the distal gut, where they may be digested by microbes. We determined that the prominent neonate gut residents, Bacteroides thetaiotaomicron and Bacteroides fragilis, induce the same genes during HMO consumption that are used to harvest host mucus glycans, which are structurally similar to HMOs. Lacto-N-neotetraose, a specific HMO component, selects for HMO-adapted species such as Bifidobacterium infantis, which cannot use mucus, and provides a selective advantage to B. infantis in vivo when biassociated with B. thetaiotaomicron in the gnotobiotic mouse gut. This indicates that the complex oligosaccharide mixture within HMOs attracts both mutualistic mucus-adapted species and HMO-adapted bifidobacteria to the infant intestine that likely facilitate both milk and future solid food digestion.

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Impact of human milk bacteria and oligosaccharides on neonatal gut microbiota establishment and gut health
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Xu, X., Xu, P., Ma, C., Tang, J., & Zhang, X. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.12.009 · Cited by 249
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Lewis, W. G., Robinson, L. S., Gilbert, N. M., Perry, J. C., & Lewis, A. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.453654 · Cited by 183
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Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp.
Schwalm, N. D., & Groisman, E. A. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.06.009 · Cited by 167
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Dedrick, S., Sundaresh, B., Huang, Q., Brady, C., Yoo, T., Cronin, C. T., Rudnicki, C., Flood, M., Momeni, B., Ludvigsson, J., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00078 · Cited by 170
Sialidases from gut bacteria: a mini-review
Juge, N., Tailford, L. E., & Owen, C. D. (2016) · Biochemical Society Transactions · doi:10.1042/bst20150226 · Cited by 172
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2′-fucosyllactose: an abundant, genetically determined soluble glycan present in human milk
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Lu, J. N., & Claud, E. C. (2018) · Developmental Psychobiology · doi:10.1002/dev.21806 · Cited by 152
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Bode, L., Kuhn, L., Kim, H., Hsiao, L., Nissan, C., Sinkala, M., Kankasa, C., Mwiya, M., Thea, D. M., & Aldrovandi, G. M. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.039503 · Cited by 126
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Huang, W., Yin, H., Yang, Y., Jin, L., Lu, G., & Dang, Z. (2021) · Science of The Total Environment · doi:10.1016/j.scitotenv.2021.146264 · Cited by 125
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Cheng, C., Wei, H., Xu, C., Xie, X., Jiang, S., & Peng, J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.01047-18 · Cited by 123
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Fostering of advanced mutualism with gut microbiota by Immunoglobulin A
Sutherland, D. B., Suzuki, K., & Fagarasan, S. (2016) · Immunological Reviews · doi:10.1111/imr.12384 · Cited by 115
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Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides
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Authors: Marcobal, A., Barboza, M., Sonnenburg, E. D., Pudlo, N., Martens, E. C., Desai, P., Lebrilla, C. B., Weimer, B. C., Mills, D. A., German, J. B., & Sonnenburg, J. L.
Affiliations: Stanford Medicine (US)
University of California, Davis (US)
University of Michigan (US)
Corresponding author: Sonnenburg, Justin L.
ORCID: Barboza, Mariana
Sonnenburg, Erica D.
Pudlo, Nicholas
Martens, Eric C.
Desai, Prerak
Lebrilla, Carlito B.
Weimer, Bart C.
Mills, David A.
German, J. Bruce
Sonnenburg, Justin L.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2011-11
Volume: 10
Issue: 5
Pages: 507-514
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2011.10.007
PMC: PMC3227561
OpenAlex: W2060872094
Cited by: 574
References: 31
Citations by year: 2026: 25 · 2025: 50 · 2024: 51 · 2023: 48 · 2022: 53 · 2021: 63 · 2020: 54 · 2019: 38 · 2018: 37 · 2017: 36 · 2016: 27 · 2015: 26 · 2014: 27 · 2013: 19 · 2012: 18
FWCI: 19.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 655 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (1dp2od006515-01)
University of California, San Diego
National Institute of Diabetes and Digestive and Kidney Diseases (DK084214, K01DK084214, R01DK085025)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (IR01HD061923, R01HD061923)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: human milk oligosaccharides, Bacteroides thetaiotaomicron, Bacteroides fragilis, Bifidobacterium infantis, lacto-N-neotetraose, neonatal gut microbiota, mutualism
MeSH terms: Animals, Animals, Newborn, Bacteroides, Breast Feeding, Humans, Milk, Milk, Human, Mucus, Oligosaccharides, Polysaccharides, Gastrointestinal Tract, Mice

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Bacteroides in the Infant Gut Consume Milk Oligosaccharides via Mucus-Utilization Pathways

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