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Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates

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Monosov, Ilya E., Haber, Suzanne N., Leuthardt, Eric C., Jezzini, Ahmad·2020·Current Biology

DOI 10.1016/j.cub.2020.10.009PMC PMC8197026

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Abstract

The brain mechanism for controlling continuous behavior in dynamic contexts must mediate action selection and learning across many timescales, responding differentially to the level of environmental uncertainty and volatility. In this review, we argue that a part of the frontal cortex known as the anterior cingulate cortex (ACC) is particularly well suited for this function. First, the ACC is interconnected with prefrontal, parietal, and subcortical regions involved in valuation and action selection. Second, the ACC integrates diverse, behaviorally relevant information across multiple timescales, producing output signals that temporally encapsulate decision and learning processes and encode high-dimensional information about the value and uncertainty of future outcomes and subsequent behaviors. Third, the ACC signals behaviorally relevant information flexibly, displaying the capacity to represent information about current and future states in a valence-, context-, task- and action-specific manner. Fourth, the ACC dynamically controls instrumental- and non-instrumental information seeking behaviors to resolve uncertainty about future outcomes. We review electrophysiological and circuit disruption studies in primates to develop this point, discuss its relationship to novel therapeutics for neuropsychiatric disorders in humans, and conclude by relating ongoing research in primates to studies of medial frontal cortical regions in rodents.

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Authors: Monosov, I. E., Haber, S. N., Leuthardt, E. C., & Jezzini, A.
Affiliations: Washington University in St. Louis (US)
Harvard University (US)
Corresponding author: Monosov, Ilya E.
ORCID: Monosov, Ilya E.
Haber, Suzanne N.
Leuthardt, Eric C.
Jezzini, Ahmad
Venue: Current Biology
Publisher: Elsevier BV
Published: 2020-12
Volume: 30
Issue: 23
Pages: R1442-R1454
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/j.cub.2020.10.009
PMC: PMC8197026
OpenAlex: W3110978274
Cited by: 118
References: 143
Citations by year: 2026: 22 · 2025: 26 · 2024: 28 · 2023: 16 · 2022: 17 · 2021: 8 · 2020: 1
FWCI: 1.42
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 371 d)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: McKnight Foundation (R01CA203861, MH045573)
National Institute of Mental Health (R01CA203861, R01MH110594, R01MH116937, MH106435)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: anterior cingulate cortex, action selection, uncertainty, outcome valuation, information seeking, operant conditioning, decision-making, frontal cortex, neuropsychiatric disorders, medial frontal cortex, rodents
MeSH terms: Cortical Excitability, Animals, Behavior, Animal, Central Nervous System Diseases, Choice Behavior, Disease Models, Animal, Drug Evaluation, Preclinical, Frontal Lobe, Gyrus Cinguli, Humans, Learning, Macaca mulatta, Neurons, Reward, Uncertainty, Information Seeking Behavior

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Anterior Cingulate Cortex and the Control of Dynamic Behavior in Primates

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