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Problems with measuring peripheral oxytocin: Can the data on oxytocin and human behavior be trusted?
Open accessAbstract
Research on the neurobiological and behavioral effects of oxytocin (OT), as well as on its possible therapeutic applications, has intensified in the past decade. Accurate determination of peripheral OT levels is essential to reach meaningful conclusions and to motivate, support and inform clinical interventions. Different, but concordant, methods for measuring plasma OT have been developed over the past four decades, but since 2004 several commercially available methods have been favored in research with humans. Evaluation of these methods reveals that they lack reliability when used on unextracted samples of human fluids, and that they tag molecules in addition to OT, yielding estimates that are wildly discrepant with an extensive body of earlier findings that were obtained using methods that are well validated, but more laborious. An accurate, specific, and readily available method for measuring OT that can be adopted as the standard in the field is urgently needed for advances in our understanding of OT's roles in cognition and behavior.
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In the citing paper
“These improvements have sought to address the main concern raised by McCullough et al. [7], namely that earlier ELISAs had a high rate of non-specific binding (when non-OT compounds bind to ‘OT-specific’ antibodies), leading to artificially elevated concentrations of OT.”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [7]
In the citing paper
“in recent evaluations the RIA method was shown to have low sensitivity in the majority of samples tested (McCullough et al., 2013)”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as McCullough et al., 2013
In the citing paper
“Both the commercially available immunoassays (RIA and EIA) have high heterogeneity and questionable validity (McCullough et al., 2013).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as McCullough et al., 2013
In the citing paper
“even in extracted samples the non-OT immunoreactive products of uncertain nature account for most of the measured immunoreactivity (McCullough et al., 2013).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as McCullough et al., 2013
In the citing paper
“With respect to other bodily fluids, such as saliva and urine, it has been demonstrated that the estimated levels are highly discrepant and weakly correlated to plasmatic levels (McCullough et al., 2013).”
From Peripheral oxytocin and vasopressin: Biomarkers of psychiatric disorders? A comprehensive systematic review and preliminary meta-analysis (2016) · cites this paper as McCullough et al., 2013
In the citing paper
“This advice has been largely ignored. Many studies have used this assay on unextracted human plasma, reporting mean concentrations of oxytocin and vasopressin of typically 100–500 pg/ml 3, 4, 5, 6, 114. Those that have diluted samples have done so by less than the manufacturer's recommendations, without confirming that their dilution is adequate.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [114]
In the citing paper
“Lyophilization has also been found to significantly increase the validity of measuring OT via ELISA [7, 21, 22]. Therefore, we used the lyophilisation process instead of the chemical process outlined in the manual.”
From Salivary oxytocin concentrations in males following intranasal administration of oxytocin: a double-blind, cross-over study (2015) · cites this paper as [7]
In the citing paper
“Furthermore, an increasing number of studies demonstrate the same effects of behavior, social context, and social relationships on both central and peripheral oxytocin measures (35–37).”
From Oxytocin reactivity during intergroup conflict in wild chimpanzees (2017) · cites this paper as [35]
In the citing paper
“The biological validity of peripheral oxytocin measurements with respect to central oxytocin patterns nonetheless is debated (33–35).”
From Oxytocin reactivity during intergroup conflict in wild chimpanzees (2017) · cites this paper as [35]
In the citing paper
“However, an increasing body of evidence shows that oxytocin pathways can involve coordinated central and peripheral oxytocin release, indicating that high peripheral measures reflect the release of central oxytocin.”
From Oxytocin reactivity during intergroup conflict in wild chimpanzees (2017) · cites this paper as [35]
In the citing paper
“Of note, the interpretation of peripheral OXT measurements is hampered by methodological issues (76) and the absence of a strong linear relationship between peripheral and central OXT concentrations (77).”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [76]
In the citing paper
“Studies that have examined CSF levels of oxytocin after intranasal administration have shown small CSF increases in animal models at around 40 minutes to 1 hour post-administration, 78,79”
From Beyond the hype and hope: critical considerations for intranasal oxytocin research in autism spectrum disorder (2017) · cites this paper as [79]
In the citing paper
“Non-extracted approaches may not have been appropriate as a methodology.48, 59”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [59]
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Citations
Cites
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Bioanalytical Method Validation—A Revisit with a Decade of Progress
Shah, V. P., Midha, K. K., Findlay, J. W. A., Hill, H. M., Hulse, J. D., McGilveray, I. J., McKay, G., Miller, K. J., Patnaik, R. N., Powell, M. L., et al. (2000) · Pharmaceutical Research · doi:10.1023/a:1007669411738 · Cited by 1,574
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
T he D iagnostic A pplications of S aliva — A R eview
Kaufman, E., & Lamster, I. B. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300209 · Cited by 887
Feldman, R., Weller, A., Zagoory-Sharon, O., & Levine, A. (2007) · Psychological Science · doi:10.1111/j.1467-9280.2007.02010.x · Cited by 787
Adult attachment predicts maternal brain and oxytocin response to infant cues.
Strathearn, L., Fonagy, P., Amico, J., & Montague, P. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.103 · Cited by 773
Plasma oxytocin levels in autistic children
Modahl, C., Green, L. A., Fein, D., Morris, M., Waterhouse, L., Feinstein, C., & Levin, H. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00439-3 · Cited by 728
Feldman, R., Gordon, I., Schneiderman, I., Weisman, O., & Zagoory-Sharon, O. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.01.013 · Cited by 638
Oxytocin is associated with human trustworthiness
ZAK, P., KURZBAN, R., & MATZNER, W. (2005) · Hormones and Behavior · doi:10.1016/j.yhbeh.2005.07.009 · Cited by 595
Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504767102 · Cited by 570
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521
Lower CSF oxytocin concentrations in women with a history of childhood abuse
Heim, C., Young, L. J., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.112 · Cited by 518
Grewen, K. M., Girdler, S. S., Amico, J., & Light, K. C. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000170341.88395.47 · Cited by 513
Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice
Neumann, I. D., Maloumby, R., Beiderbeck, D. I., Lukas, M., & Landgraf, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.003 · Cited by 511
Oxytocin Receptors and Human Parturition: A Dual Role for Oxytocin in the Initiation of Labor
Fuchs, A., Fuchs, F., Husslein, P. W., Soloff, M. S., & Fernström, M. J. (1982) · Science · doi:10.1126/science.6278592 · Cited by 494
Empathy toward strangers triggers oxytocin release and subsequent generosity
Barraza, J. A., & Zak, P. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04504.x · Cited by 489
Feldman, R., Gordon, I., & Zagoory‐Sharon, O. (2011) · Developmental Science · doi:10.1111/j.1467-7687.2010.01021.x · Cited by 486
Holt-Lunstad, J., Birmingham, W. A., & Light, K. C. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318187aef7 · Cited by 473
Modulating social behavior with oxytocin: How does it work? What does it mean?
Churchland, P. S., & Winkielman, P. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.003 · Cited by 464
Bos, P. A., Panksepp, J., Bluthé, R.-M., & Honk, J. V. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2011.01.002 · Cited by 429
Preanalytical variability: the dark side of the moon in laboratory testing
Lippi, G., Guidi, G. C., Mattiuzzi, C., & Plebani, M. (2006) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2006.073 · Cited by 416
Sensitive Parenting Is Associated with Plasma Oxytocin and Polymorphisms in the OXTR and CD38 Genes
Feldman, R., Zagoory-Sharon, O., Weisman, O., Schneiderman, I., Gordon, I., Maoz, R., Shalev, I., & Ebstein, R. P. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.025 · Cited by 393
Graustella, A. J., & MacLeod, C. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.002 · Cited by 379
Van IJzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.008 · Cited by 365
A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research
MacDonald, E., Dadds, M. R., Brennan, J. L., Williams, K., Levy, F., & Cauchi, A. J. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.02.015 · Cited by 359
Schneiderman, I., Zagoory-Sharon, O., Leckman, J. F., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.021 · Cited by 333
Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin
Szeto, A., McCabe, P. M., Nation, D. A., Tabak, B. A., Rossetti, M. A., McCullough, M. E., Schneiderman, N., & Mendez, A. J. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31821df0c2 · Cited by 330
Oxytocin: Behavioral Associations and Potential as a Salivary Biomarker
SUE CARTER, C., POURNAJAFI‐NAZARLOO, H., KRAMER, K. M., ZIEGLER, T. E., WHITE‐TRAUT, R., BELLO, D., & SCHWERTZ, D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1384.006 · Cited by 323
Oxytocin during pregnancy and early postpartum: Individual patterns and maternal-fetal attachment
Levine, A., Zagoory-Sharon, O., Feldman, R., & Weller, A. (2007) · Peptides · doi:10.1016/j.peptides.2007.04.016 · Cited by 315
Oxytocin, vasopressin and pair bonding: implications for autism
Hammock, E. A. D., & Young, L. J. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1939 · Cited by 296
The role of oxytocin in parturition
BLANKS, A. (2003) · BJOG: An International Journal of Obstetrics and Gynaecology · doi:10.1016/s1470-0328(03)00024-7 · Cited by 296
The contributions of oxytocin and vasopressin pathway genes to human behavior
Ebstein, R. P., Knafo, A., Mankuta, D., Chew, S. H., & Lai, P. S. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.014 · Cited by 283
ZAK, P. J., KURZBAN, R., & MATZNER, W. T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.025 · Cited by 282
Taylor, S. E., Saphire-Bernstein, S., & Seeman, T. E. (2010) · Psychological Science · doi:10.1177/0956797609356507 · Cited by 256
Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats
Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A.-L., Petrosino, S., Piscitelli, F., Legros, J.-J., Geenen, V., Foti, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025565 · Cited by 254
Gordon, I., Zagoory‐Sharon, O., Schneiderman, I., Leckman, J. F., Weller, A., & Feldman, R. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00649.x · Cited by 232
Salonia, A., Nappi, R. E., Pontillo, M., Daverio, R., Smeraldi, A., Briganti, A., Fabbri, F., Zanni, G. E., Rigatti, P., & Montorsi, F. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.10.002 · Cited by 229
Evidence of dysregulated peripheral oxytocin release among depressed women
Cyranowski, J. M., Hofkens, T. L., Frank, E., Seltman, H., Cai, H.-M., & Amico, J. A. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318188ade4 · Cited by 220
Nandi, P., & Lunte, S. M. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2009.07.064 · Cited by 220
Nissen, E., Uvnäs‐Moberg, K., Svensson, K., Stock, S., Widström, A., & Winberg, J. (1996) · Early Human Development · doi:10.1016/0378-3782(96)01725-2 · Cited by 216
Kagerbauer, S. M., Martin, J., Schuster, T., Blobner, M., Kochs, E. F., & Landgraf, R. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12038 · Cited by 212
Oxytocin in Human Plasma: Correlation with Neurophysin and Stimulation with Estrogen*
Amico, J. A., SEIF, S. M., & ROBINSON, A. G. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-5-988 · Cited by 177
Human neuroimaging of oxytocin and vasopressin in social cognition
Zink, C. F., & Meyer-Lindenberg, A. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.01.016 · Cited by 176
Weisman, O., Zagoory‐Sharon, O., Schneiderman, I., Gordon, I., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.011 · Cited by 175
Sharing secrets: oxytocin and trust in schizophrenia
Kéri, S., Kiss, I., & Kelemen, O. (2009) · Social Neuroscience · doi:10.1080/17470910802319710 · Cited by 167
Key elements of bioanalytical method validation for macromolecules
Kelley, M. M., & Desilva, B. S. (2007) · The AAPS Journal · doi:10.1208/aapsj0902017 · Cited by 153
Jonas, W., Johansson, L. M., Nissen, E., Ejdebäck, M., Ransjö-Arvidson, A. B., & Uvnäs-Moberg, K. (2009) · Breastfeeding Medicine · doi:10.1089/bfm.2008.0002 · Cited by 150
Grewen, K. M., Davenport, R. E., & Light, K. C. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00968.x · Cited by 146
Low CSF oxytocin reflects high intent in suicide attempters
Jokinen, J., Chatzittofis, A., Hellström, C., Nordström, P., Uvnäs-Moberg, K., & Åsberg, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.016 · Cited by 143
Detection of salivary oxytocin levels in lactating women
White‐Traut, R., Watanabe, K., Pournajafi‐Nazarloo, H., Schwertz, D., Bell, A., & Carter, C. S. (2009) · Developmental Psychobiology · doi:10.1002/dev.20376 · Cited by 142
CHARD, T., BOYD, N. R. H., FORSLING, M. L., McNEILLY, A. S., & LANDON, J. (1970) · Journal of Endocrinology · doi:10.1677/joe.0.0480223 · Cited by 140
Vasopressin-oxytocin in cerebrospinal fluid of schizophrenic patients and normal controls
Beckmann, H., Lang, R. E., & Gattaz, W. F. (1985) · Psychoneuroendocrinology · doi:10.1016/0306-4530(85)90056-3 · Cited by 138
Elevated salivary levels of oxytocin persist more than 7 h after intranasal administration
van IJzendoorn, M. H., Bhandari, R., van der Veen, R., Grewen, K. M., & Bakermans-Kranenburg, M. J. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00174 · Cited by 137
Savoie, N., Garofolo, F., van Amsterdam, P., Bansal, S. K., Beaver, C., Bedford, P., Booth, B. P., Evans, C. A., Jemal, M., Lefebvre, M., et al. (2010) · Bioanalysis · doi:10.4155/bio.10.164 · Cited by 124
The physiological role of hormones in saliva
Gröschl, M. (2009) · Bioessays · doi:10.1002/bies.200900013 · Cited by 122
Intranasal oxytocin administration is reflected in human saliva
Weisman, O., Zagoory-Sharon, O., & Feldman, R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.014 · Cited by 120
Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism
Arregger, A. L., Contreras, L. N., Tumilasci, O. R., Aquilano, D. R., & Cardoso, E. M. L. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02937.x · Cited by 118
Oxytocin indexes relational distress following interpersonal harms in women
Tabak, B. A., McCullough, M. E., Szeto, A., Mendez, A. J., & McCabe, P. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.004 · Cited by 116
Oxytocin is not a valid biomarker when measured in saliva by immunoassay
Horvat-Gordon, M., Granger, D. A., Schwartz, E. B., Nelson, V. J., & Kivlighan, K. T. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.01.007 · Cited by 111
Plasma oxytocin levels in women during labor with or without epidural analgesia: a prospective study
Rahm, V.-A., Hallgren, A., Högberg, H., Hurtig, I., & Odlind, V. (2002) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1034/j.1600-0412.2002.811107.x · Cited by 109
Isolation, assay, and secretion of individual human neurophysins.
ROBINSON, A. G. (1975) · Journal of Clinical Investigation · doi:10.1172/jci107939 · Cited by 107
AMICO, J. A., ULBRECHT, J. S., & ROBINSON, A. G. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-64-2-340 · Cited by 105
Sex and species differences in plasma oxytocin using an enzyme immunoassay
Kramer, K. M., Cushing, B. S., Carter, C. S., Wu, J., & Ottinger, M. A. (2004) · Canadian Journal of Zoology · doi:10.1139/z04-098 · Cited by 99
Oxytocin in human pregnancy and parturition.
Dawood, M., Raghavan, K. S., POCIASK, C., & Fuchs, F. D. (1978) · PubMed · Cited by 93
U-shaped relation between plasma oxytocin levels and behavior in the trust game
Zhong, S., Monakhov, M., Mok, H. P., Tong, T., Lai, P. S., Chew, S. H., & Ebstein, R. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051095 · Cited by 90
Robinson, I. C. A. F. (1980) · Journal of Immunoassay · doi:10.1080/01971528008058475 · Cited by 82
Zhang, G., Zhang, Y., Fast, D. M., Lin, Z., & Steenwyk, R. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.04.041 · Cited by 79
Fetal and Maternal Oxytocin in Human Parturition
Chard, T. (1989) · American Journal of Perinatology · doi:10.1055/s-2007-999566 · Cited by 77
Stimulation of 5-HT1A and 5-HT2/5-HT1C receptors induce oxytocin release in the male rat
Bagdy, G., & Kalogeras, K. T. (1993) · Brain Research · doi:10.1016/0006-8993(93)90521-n · Cited by 76
A Novel Oxytocin-Like and Vasotocin-Like Peptide in Human Plasma after Administration of Estrogen*
Amico, J. A., ERVIN, M. G., Leake, R. D., Fisher, D. A., Finn, F. M., & ROBINSON, A. G. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-1-5 · Cited by 74
Oxytocin response in a trust game and habituation of arousal
Kéri, S., & Kiss, I. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.11.011 · Cited by 72
Oxytocin levels in maternal and fetal plasma, amniotic fluid, and neonatal plasma and urine
Kuwabara, Y., Takeda, S., Mizuno, M., & Sakamoto, S. (1987) · Archives of Gynecology and Obstetrics · doi:10.1007/bf00931436 · Cited by 70
Uvnäs‐Moberg, K., Alster, P., & Svensson, T. H. (1992) · Psychopharmacology · doi:10.1007/bf02247726 · Cited by 68
Huffmeijer, R., Alink, L. R. A., Mattie Tops, A., Grewen, K., Light, K. C., Bakermans‐Kranenburg, M. J., & van IJzendoorn, M. H. (2012) · PubMed · Cited by 62
Breast-feeding and plasma oxytocin concentrations.
Lucas, A., Drewett, R., & Mitchell, M. D. (1980) · BMJ · doi:10.1136/bmj.281.6244.834 · Cited by 59
Listening to neuropeptides by microdialysis: Echoes and new sounds?
Wotjak, C. T., Landgraf, R., & Engelmann, M. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.03.017 · Cited by 58
Plasma Oxytocin Concentrations in Man after Different Routes of Administration of Synthetic Oxytocin
Landgraf, R. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1210444 · Cited by 51
IS OXYTOCIN INVOLVED IN PARTURITION?
Sellers, S. M., Hodgson, H. T., Mountford, L. A., Mitchell, M. D., Anderson, A. B. M., & Turnbull, A. C. (1981) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1981.tb01273.x · Cited by 51
Plasma oxytocin during third stage of labour: comparison of natural and active management.
Thornton, S., Davison, J. M., & Baylis, P. H. (1988) · BMJ · doi:10.1136/bmj.297.6642.167 · Cited by 50
Effect of apomorphine on oxytocin concentrations in different brain areas and plasma of male rats
Melis, M., Argiolas, A., Stancampiano, R., & Gessa, G. L. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90497-t · Cited by 50
Kiss, I., Levy‐Gigi, E., & Kéri, S. (2011) · Biological Psychology · doi:10.1016/j.biopsycho.2011.08.005 · Cited by 45
Uvnäs-Moberg, K., Hillegaart, V., Alster, P., & Ahlénius, S. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00078-0 · Cited by 44
Microdialysis applications in neuroscience
Lee, G. J., Park, J. H., & Park, H. K. (2008) · Neurological Research · doi:10.1179/174313208x289570 · Cited by 44
Péqueux, C., Breton, C., Jc, H., Hagelstein, M.-T., Martens, H., Winkler, R., Geenen, V. G., & Legros, J. (2002) · PubMed · Cited by 44
Releases of oxytocin and prolactin during breast massage and suckling in puerperal women
Yokoyama, Y., Ueda, T., Irahara, M., & Aono, T. (1994) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(94)90131-7 · Cited by 44
An Exploratory Study of Neurohormonal Responses of Healthy Men to Massage
Bello, D., White-Traut, R., Schwertz, D., Pournajafi-Nazarloo, H., & Carter, C. S. (2008) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.0660 · Cited by 38
Plasma oxytocin in response to pharmaco-challenge to d-fenfluramine and placebo in healthy men
Lee, R., García, F., de Kar, L. D. V., Hauger, R., & Coccaro, E. F. (2003) · Psychiatry Research · doi:10.1016/s0165-1781(03)00070-2 · Cited by 34
Determination of oxytocin in milk of cows administered oxytocin
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Metadata
- Authors
- McCullough, M. E., Churchland, P. S., & Mendez, A. J.
- Affiliations
- University of Miami (US)
- University of California San Diego (US)
- Corresponding author
- Mendez, Armando J.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 37
- Issue
- 8
- Pages
- 1485-1492
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2124961114
- Cited by
- 416
- References
- 108
- Citations by year
- 2026: 17 · 2025: 14 · 2024: 24 · 2023: 17 · 2022: 21 · 2021: 42 · 2020: 32 · 2019: 36 · 2018: 40 · 2017: 46 · 2016: 50 · 2015: 42 · 2014: 26 · 2013: 9
- FWCI
- 5.61
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, assay validation, method reliability, cross-reactivity
- MeSH terms
- Humans, Immunoenzyme Techniques, Oxytocin, Radioimmunoassay, Reproducibility of Results
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