The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
de Lecea, L., Kilduff, T. S., Peyron, C., Gao, X.-B., Foye, P. E., Danielson, P. E., Fukuhara, C., Battenberg, E. L. F., Gautvik, V. T., Bartlett, F. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.322 · Cited by 3,878 · cited 1×
“Hypocretin (Hcrt or orexin) was discovered in 1998 (de Lecea et al., 1998; Sakurai et al., 1998).”
Neurons containing hypocretin (orexin) project to multiple neuronal systems
Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., & Kilduff, T. S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-23-09996.1998 · Cited by 3,466
Narcolepsy in orexin Knockout Mice
Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81973-x · Cited by 3,095
Fos Expression in Orexin Neurons Varies with Behavioral State
Estabrooke, I. V., McCarthy, M. T., Ko, E., Chou, T. C., Chemelli, R. M., Yanagisawa, M., Saper, C. B., & Scammell, T. E. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01656.2001 · Cited by 654
Locus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task
Aston-Jones, G., Rajkowski, J., Kubiak, P., & Alexinsky, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04467.1994 · Cited by 637
A neural circuit for circadian regulation of arousal
Aston-Jones, G., Chen, S., Zhu, Y., & Oshinsky, M. L. (2001) · Nature Neuroscience · doi:10.1038/89522 · Cited by 632
Acuna-Goycolea, C., Li, Y., & van den Pol, A. N. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5416-03.2004 · Cited by 69
de Waal, F. B. M., Aureli, F., & Judge, P. G. (2000) · Scientific American · doi:10.1038/scientificamerican0500-76 · Cited by 66
Cited by
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Saper, C. B., Fuller, P. M., Pedersen, N. P., Lu, J., & Scammell, T. E. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.032 · Cited by 1,404
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Adamantidis, A. R., Zhang, F., Aravanis, A. M., Deisseroth, K., & de Lecea, L. (2007) · Nature · doi:10.1038/nature06310 · Cited by 1,341
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Sakurai, T. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2092 · Cited by 1,276
Clues to the functions of mammalian sleep
Siegel, J. M. (2005) · Nature · doi:10.1038/nature04285 · Cited by 1,040
Self-citationMeerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948
Hypocretin (orexin) cell loss in Parkinson's disease
Thannickal, T. C., Lai, Y.-Y., & Siegel, J. M. (2007) · Brain · doi:10.1093/brain/awm097 · Cited by 566
Self-citationRole for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., & de Lecea, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507480102 · Cited by 520
Hypocretin (orexin) loss in Parkinson's disease
Fronczek, R., Overeem, S., Lee, S. Y. Y., Hegeman, I. M., van Pelt, J., van Duinen, S. G., Lammers, G. J., & Swaab, D. F. (2007) · Brain · doi:10.1093/brain/awm090 · Cited by 463
Hassani, O. K., Lee, M. G., & Jones, B. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811400106 · Cited by 451
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403
The orexin system regulates alcohol-seeking in rats
Lawrence, A. J., Cowen, M. S., Yang, H., Chen, F., & Oldfield, B. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706789 · Cited by 392
Hypothalamic Regulation of Sleep and Arousal
Szymusiak, R., & McGinty, D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.027 · Cited by 294
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282
Neurophysiology of sleep and wakefulness: basic science and clinical implications
Schwartz, J., & Roth, T. (2008) · Current Neuropharmacology · doi:10.2174/157015908787386050 · Cited by 289
The neurobiological basis of narcolepsy
Mahoney, C. E., Cogswell, A., Koralnik, I. J., & Scammell, T. E. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0097-x · Cited by 289
Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour
Bonnavion, P., Mickelsen, L. E., Fujita, A., de Lecea, L., & Jackson, A. C. (2016) · The Journal of Physiology · doi:10.1113/jp271946 · Cited by 271
The roles of the reward system in sleep and dreaming
Perogamvros, L., & Schwartz, S. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.010 · Cited by 239
The Neurobiology of Sleep and Wakefulness
Schwartz, M. D., & Kilduff, T. S. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.002 · Cited by 207
Clasadonte, J., Scemes, E., Wang, Z., Boison, D., & Haydon, P. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.022 · Cited by 200
REM sleep characteristics in narcolepsy and REM sleep behavior disorder
Dauvilliers, Y., Rompré, S., Gagnon, J.-F., Vendette, M., Petit, D., & Montplaisir, J. (2007) · Sleep · doi:10.1093/sleep/30.7.844 · Cited by 197
Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
Saper, C. B. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53014-6 · Cited by 178
Balcita‐Pedicino, J. J., & Sesack, S. R. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21420 · Cited by 150
Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus
Honjoh, S., Sasai, S., Schiereck, S. S., Nagai, H., Tononi, G., & Cirelli, C. (2018) · Nature Communications · doi:10.1038/s41467-018-04497-x · Cited by 118
Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression
Li, S.-B., Borniger, J. C., Yamaguchi, H., Hédou, J., Gaudilliere, B., & de Lecea, L. (2020) · Science Advances · doi:10.1126/sciadv.abc2590 · Cited by 121
Amygdala lesions reduce cataplexy in orexin knock-out mice
Burgess, C. R., Oishi, Y., Mochizuki, T., Peever, J. H., & Scammell, T. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5632-12.2013 · Cited by 108
Shining light on wakefulness and arousal
de Lecea, L., Carter, M. E., & Adamantidis, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.032 · Cited by 103
de Lecea, L., & Sutcliffe, J. G. (2005) · The FEBS Journal · doi:10.1111/j.1742-4658.2005.04981.x · Cited by 105
REM sleep: A biological and psychological paradox
Siegel, J. M. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.01.001 · Cited by 102
Self-citationPhysiological arousal: a role for hypothalamic systems
Adamantidis, A., & de Lecea, L. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7521-8 · Cited by 95
Koban, M., Le, W. W., & Hoffman, G. E. (2006) · Endocrinology · doi:10.1210/en.2005-0695 · Cited by 85
Hypocretin as a Hub for Arousal and Motivation
Tyree, S. M., Borniger, J. C., & de Lecea, L. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00413 · Cited by 83
Sleep and dreaming are for important matters
Perogamvros, L., Dang-Vu, T. T., Desseilles, M., & Schwartz, S. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00474 · Cited by 77
“REVIEW ARTICLE published: 25 July 2013 doi: 10.3389/fpsyg.2013.00474 Sleep and dreaming are for important matters”
BackgroundInfluentialSexually Dimorphic Changes of Hypocretin (Orexin) in Depression
Lu, J., Zhao, J., Balesar, R., Fronczek, R., Zhu, Q.-B., Wu, X.-Y., Hu, S.-H., Bao, A.-M., & Swaab, D. F. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.043 · Cited by 77
Orexin-A Hyperphagia: Hindbrain Participation in Consummatory Feeding Responses
Baird, J.-P., Choe, A., Loveland, J. L., Beck, J., Mahoney, C. E., Lord, J. S., & Grigg, L. A. (2009) · Endocrinology · doi:10.1210/en.2008-0293 · Cited by 65
Overview of orexin/hypocretin system
Mieda, M., & Sakurai, T. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59489-1.00002-1 · Cited by 64
Thomasy, H. E., Febinger, H. Y., Ringgold, K. M., Gemma, C., & Opp, M. R. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.03.001 · Cited by 37
Siclari, F., & Tononi, G. (2016) · The Neurology of Conciousness · doi:10.1016/b978-0-12-800948-2.00007-8 · Cited by 27
Tononi, G. (2009) · The Neurology of Consciousness · doi:10.1016/b978-0-12-374168-4.00008-3 · Cited by 16
The Many Unknowns of Partial Sensory Disconnection during Sleep: A Review of the Literature
Cirelli, C., & Tononi, G. (2024) · Clinical and Translational Neuroscience · doi:10.3390/ctn8010009 · Cited by 15
Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice
Somach, R. T., Jean, I. D., Farrugia, A. M., & Cohen, A. S. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2023.0125 · Cited by 13
Metadata
- Authors
- Mileykovskiy, B. Y., Kiyashchenko, L. I., & Siegel, J. M.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 46
- Issue
- 5
- Pages
- 787-798
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2085712847
- Cited by
- 848
- References
- 9
- FWCI
- 21.79
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.