Cell Death: The Significance of Apoptosis

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

Gavrieli, Y., Sherman, Y., & Ben-Sasson, S. A. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.493 · Cited by 9,444

Apoptosis in the Pathogenesis and Treatment of Disease

Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

Oltval, Z. N., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)90509-o · Cited by 6,003

The biochemistry of apoptosis

Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 5,779

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166

Ischemic Cell Death in Brain Neurons

Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043

Cell death during development of the nervous system

Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824

Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain

Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055

Functional significance of cell volume regulatory mechanisms

LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884

Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis

Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.8.1481 · Cited by 1,871

Lethal effect of the anti-Fas antibody in mice

Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536

Autophagic cell death: the story of a misnomer

Kroemer, G., & Levine, B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2529 · Cited by 1,453

Apoptosis in Myocytes in End-Stage Heart Failure

Narula, J., Haider, N., Virmani, R., DiSalvo, T. G., Kolodgie, F. D., Hajjar, R. J., Schmidt, U., Semigran, M. J., Dec, G. W., & Khaw, B.-A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351603 · Cited by 1,430

Crosstalk between apoptosis.; necrosis and autophagy

Nikoletopoulou, V., Markaki, M., Palikaras, K., & Tavernarakis, N. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.001 · Cited by 1,366

Cell death and control of cell survival in the oligodendrocyte lineage

Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345

Triggering and modulation of apoptosis by oxidative stress

Chandra, J., Samali, A., & Orrenius, S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00302-6 · Cited by 1,335

A matter of life and death

Green, D. R., & Evan, G. I. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00024-7 · Cited by 1,254

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization

Bossy‐Wetzel, E., Newmeyer, D. D., & Green, D. R. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.37 · Cited by 1,225

The changing landscape of ischaemic brain injury mechanisms

Lee, J.-M., Zipfel, G. J., & Choi, D. W. (1999) · Nature · doi:10.1038/399a007 · Cited by 1,102

Caspases in apoptosis and beyond

Li, J., & Yuan, J. (2008) · Oncogene · doi:10.1038/onc.2008.297 · Cited by 1,090

Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.

Strasser, A., Harris, A. W., Huang, D. C., Krammer, P. H., & Cory, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00304.x · Cited by 784

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

Liu, X. Z., Xu, X. M., Hu, R., Du, C., Zhang, S. X., McDonald, J. W., Dong, H. X., Wu, Y. J., Fan, G. S., Jacquin, M. F., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-14-05395.1997 · Cited by 770

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

Busciglio, J., & Yankner, B. A. (1995) · Nature · doi:10.1038/378776a0 · Cited by 741

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

Lee, A., Whyte, M. K. B., & Haslett, C. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.4.283 · Cited by 714

Role of mitochondria in oxidative stress and ageing

Lenaz, G. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00120-0 · Cited by 650

The Glutamatergic Dysfunction Hypothesis for Schizophrenia

Coyle, J. T. (1996) · Harvard Review of Psychiatry · doi:10.3109/10673229609017192 · Cited by 568

Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

Vercammen, D., Brouckaert, G., Denecker, G., Van de Craen, M., Declercq, W., Fiers, W., & Vandenabeele, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.5.919 · Cited by 556

Horizontal transfer of oncogenes by uptake of apoptotic bodies

Bergsmedh, A., Szeles, A., Henriksson, M., Bratt, A., Folkman, M. J., Spetz, A.-L., & Holmgren, L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.101129998 · Cited by 550

A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death

D'Adamio, F., Zollo, O., Moraca, R., Ayroldi, E., Bruscoli, S., Bartoli, A., Cannarile, L., Migliorati, G., & Riccardi, C. (1997) · Immunity · doi:10.1016/s1074-7613(00)80398-2 · Cited by 444

Apoptosis induced by environmental stresses and amphotericin B in Candida albicans

Phillips, A. J., Sudbery, I., & Ramsdale, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2332326100 · Cited by 398

Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

Paumen, M. B., Ishida, Y., Muramatsu, M., Yamamoto, M., & Honjo, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3324 · Cited by 349

Modification of ion homeostasis by lipid peroxidation: roles in neuronal degeneration and adaptive plasticity

Mattson, M. P. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01188-0 · Cited by 344

Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue

Cardoso, L., Herman, B. C., Verborgt, O., Laudier, D., Majeska, R. J., & Schaffler, M. B. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081210 · Cited by 340

Yeast and apoptosis

Jin, C., & Reed, J. C. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm832 · Cited by 340

Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.

Weiss, M. J., & Orkin, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9623 · Cited by 296

The lighter side of BDNF

Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00776.2010 · Cited by 284

The immune response to secondary necrotic cells

Sachet, M., Liang, Y. Y., & Oehler, R. (2017) · Apoptosis · doi:10.1007/s10495-017-1413-z · Cited by 282

Elevation of Mitochondrial Transmembrane Potential and Reactive Oxygen Intermediate Levels Are Early Events and Occur Independently from Activation of Caspases in Fas Signaling

Banki, K., Hutter, E., Gonchoroff, N. J., & Perl, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1466 · Cited by 276

A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells

Belloc, F., Dumain, P., Boisseau, M. R., Jalloustre, C., Reiffers, J., Bernard, P., & Lacombe, F. (1994) · Cytometry · doi:10.1002/cyto.990170108 · Cited by 250

Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells

Fu, W., Begley, J. G., Killen, M. W., & Mattson, M. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7264 · Cited by 248

Identification of apoptotic changes in osteocytes in normal and pathological human bone

Noble, B. S., Stevens, H., Loveridge, N., & Reeve, J. (1997) · Bone · doi:10.1016/s8756-3282(96)00365-1 · Cited by 230

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3211 · Cited by 220

Singlet Oxygen, Photodynamic Therapy, and Mechanisms of Cancer Cell Death

Maharjan, P. S., & Bhattarai, H. K. (2022) · Journal of Oncology · doi:10.1155/2022/7211485 · Cited by 222

PrP Deposition, Microglial Activation, and Neuronal Apoptosis in Murine Scrapie

Williams, A., Lucassen, P. J., Ritchie, D., & Bruce, M. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6424 · Cited by 204

Macrophage Clearance of Apoptotic Cells: A Critical Assessment

Gordon, S., & Plüddemann, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00127 · Cited by 201

Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain

Chopp, M., Li, Y., Jiang, N., Zhang, R. L., & Prostak, J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199607000-00007 · Cited by 185

Mammary gland involution is delayed by activated Akt in transgenic mice

Schwertfeger, K. L., Richert, M. M., & Anderson, S. M. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.6.0663 · Cited by 169

Programmed cell death and the control of cell survival

Raff, M. C., Barres, B. A., Burne, J. F., Coles, H. S. R., Ishizaki, Y., & Jacobson, M. D. (1994) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.1994.0104 · Cited by 166

Lithium Protects against Anesthesia-induced Developmental Neuroapoptosis

Straiko, M. M. W., Young, C., Cattano, D., Creeley, C. E., Wang, H., Smith, D. J., Johnson, S. A., Li, E. S., & Olney, J. W. (2009) · Anesthesiology · doi:10.1097/aln.0b013e31819b5eab · Cited by 142

Cytochrome c release and caspase activation after traumatic brain injury

Sullivan, P. G., Keller, J. N., Bussen, W. L., & Scheff, S. W. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02968-2 · Cited by 129

Elevated Hepatic Fatty Acid Oxidation, High Plasma Fibroblast Growth Factor 21, and Fasting Bile Acids in Nonalcoholic Steatohepatitis

Dasarathy, S., Yang, Y., McCullough, A. J., Marczewski, S., Bennett, C., & Kalhan, S. C. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e328345c8c7 · Cited by 124

Alternative Germ Cell Death Pathway in Drosophila Involves HtrA2/Omi, Lysosomes, and a Caspase-9 Counterpart

Yacobi-Sharon, K., Namdar, Y., & Arama, E. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.02.002 · Cited by 119

Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages

Shiratsuchi, A., Watanabe, I., Takeuchi, O., Akira, S., & Nakanishi, Y. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2039 · Cited by 112

Caspase-9 is activated in a cytochrome c-independent manner early during TNFα-induced apoptosis in murine cells

McDonnell, M. A., Wang, D., Khan, S. M., Vander Heiden, M. G., & Kelekar, A. (2003) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401271 · Cited by 109

Differential apoptotic pathways in human keratinocyte HaCaT cells exposed to UVB and UVC

Takasawa, R., Nakamura, H., Mori, T., & Tanuma, S. (2005) · Apoptosis · doi:10.1007/s10495-005-0901-8 · Cited by 109

Macrophage phagocytosis of wound neutrophils

Meszaros, A. J., Reichner, J. S., & Albina, J. E. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.1.35 · Cited by 103

Nucleocytoplasmic transport of plasmid DNA: a perilous journey from the cytoplasm to the nucleus

Lechardeur, D., & Lukacs, G. L. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.882 · Cited by 99

Reactive Oxygen Species as Mediators of Photoreceptor Apoptosisin Vitro

Carmody, R. J., McGowan, A. J., & Cotter, T. G. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4421 · Cited by 98

Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis

Plemel, J. R., Caprariello, A. V., Keough, M. B., Henry, T. J., Tsutsui, S., Chu, T. H., Schenk, G. J., Klaver, R., Yong, V. W., & Stys, P. K. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201602028 · Cited by 97

Essential role of phosphatidylserine externalization in apoptosing cell phagocytosis by macrophages

Shiratsuchi, A., Osada, S., Kanazawa, S., & Nakanishi, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8663 · Cited by 86

Development of the human adrenal zona reticularis: morphometric and immunohistochemical studies from birth to adolescence

Hui, X.-G., Akahira, J.-I., Suzuki, T., Nio, M., Nakamura, Y., Suzuki, H., Rainey, W. E., & Sasano, H. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0127 · Cited by 83

A BH3 Mimetic for Killing Cancer Cells

Green, D. R. (2016) · Cell · doi:10.1016/j.cell.2016.05.080 · Cited by 79

Quaternary ammonium silane-functionalized, methacrylate resin composition with antimicrobial activities and self-repair potential

Gong, S.-Q., Niu, L.-N., Kemp, L. K., Yiu, C. K. Y., Ryou, H., Qi, Y.-P., Blizzard, J. D., Nikonov, S., Brackett, M. G., Messer, R. L. W., et al. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.05.031 · Cited by 75

Ras biochemistry and farnesyl transferase inhibitors. A literature survey

Crul, M., de Klerk, G. J., Beijnen, J. H., & Schellens, J. H. (2001) · Anti-Cancer Drugs · doi:10.1097/00001813-200103000-00001 · Cited by 75

Maternal behavior regulates long‐term hippocampal expression of BAX and apoptosis in the offspring

Weaver, I. C. G., Grant, R. J., & Meaney, M. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01054.x · Cited by 73

Transforming growth factor-beta potently inhibits the viability- promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells

Jacobsen, F., Stokke, T., & Jacobsen, S. (1995) · Blood · doi:10.1182/blood.v86.8.2957.2957 · Cited by 71

Ultrastructural Aspects of Autoschizis: A New Cancer Cell Death Induced by the Synergistic Action of Ascorbate/Menadione on Human Bladder Carcinoma Cells

Gilloteaux, J., Jamison, J. M., Arnold, D., Taper, H. S., & Summers, J. L. (2001) · Ultrastructural Pathology · doi:10.1080/019131201300343810 · Cited by 61

Overexpression of Neuronal Pentraxin 1 Is Involved in Neuronal Death Evoked by Low K+ in Cerebellar Granule Cells

DeGregorio-Rocasolano, N., Gasull, T., & Trullas, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007967200 · Cited by 56

Senescence and epigenetic dysregulation in cancer

Neumeister, P., Albanese, C., Balent, B., Greally, J., & Pestell, R. G. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00079-1 · Cited by 56

Apoptotic bone cells may be engulfed by osteoclasts during alveolar bone resorption in young rats

Boabaid, F., Cerri, P. S., & Katchburian, E. (2001) · Tissue and Cell · doi:10.1054/tice.2001.0179 · Cited by 53

Hdm2 is a ubiquitin ligase of Ku70-Akt promotes cell survival by inhibiting Hdm2-dependent Ku70 destabilization

Gama, V, Gomez, J. A., Mayo, L. D., Jackson, M. W., Danielpour, D., Song, K., Haas, A. L., Laughlin, M. J., & Matsuyama, S. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.6 · Cited by 46

Osteoblasts engulf apoptotic bodies during alveolar bone formation in the rat maxilla

Cerri, P. S. (2005) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20220 · Cited by 45

Decrease in the number and apoptosis of alveolar bone osteoclasts in estrogen‐treated rats

Faloni, A. P. S., Sasso‐Cerri, E., Katchburian, E., & Cerri, P. S. (2007) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00932.x · Cited by 40

Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

Al-Okbi, S. Y., Mohamed, D. A., Kandil, E., Abo-Zeid, M. A., Mohammed, S. E., & Ahmed, E. K. (2017) · Grasas y Aceites · doi:10.3989/gya.0796161 · Cited by 31

Mitochondrial Transmembrane Potential and Reactive Oxygen Species Generation Regulate the Enhanced Effect of CCCP on TRAIL-Induced SNU-638 Cell Apoptosis

CHAUDHARI, A. A., SEOL, J.-W., KANG, S.-J., & PARK, S.-Y. (2008) · Journal of Veterinary Medical Science · doi:10.1292/jvms.70.537 · Cited by 22

Safety Assemment of Centella asiatica in albino rats

Oruganti, M., Roy, B. K., Singh, K. K., Prasad, R., & Kumar, S. (2010) · Pharmacognosy Journal · doi:10.1016/s0975-3575(10)80043-4 · Cited by 18

Autophagy Regulates the Post-Translational Cleavage of BCL-2 and Promotes Neuronal Survival

Lossi, L., Gambino, G., Salio, C., & Merighi, A. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.82 · Cited by 16

Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells

Waghmare, I., & Kango-Singh, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0158081 · Cited by 14

Conserved nucleolar stress at the onset of cell death

Golstein, P. (2017) · The FEBS Journal · doi:10.1111/febs.14095 · Cited by 7

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