Cited by 354Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityParkinson's Disease Mechanisms and Treatments

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Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice

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Szczypka, Mark S, Kwok, Keith, Brot, Michelle D, Marck, Brett T, Matsumoto, Alvin M, Donahue, Brian A, Palmiter, Richard D·2001·Neuron

DOI 10.1016/s0896-6273(01)00319-1

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Abstract

Dopamine-deficient (DD) mice cannot synthesize dopamine (DA) in dopaminergic neurons due to selective inactivation of the tyrosine hydroxylase gene in those neurons. These mice become hypoactive and hypophagic and die of starvation by 4 weeks of age. We used gene therapy to ascertain where DA replacement in the brain restores feeding and other behaviors in DD mice. Restoration of DA production within the caudate putamen restores feeding on regular chow and nest-building behavior, whereas restoration of DA production in the nucleus accumbens restores exploratory behavior. Replacement of DA to either region restores preference for sucrose or a palatable diet without fully rescuing coordination or initiation of movement. These data suggest that a fundamental difference exists between feeding for sustenance and the ability to prefer rewarding substances.

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Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070
Chemical Neuroanatomy
Emson, P. C., Heffher, R. R., & Pearson, J. (1984) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198409000-00010 · Cited by 1,651
Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610
Neuronal Coding of Prediction Errors
Schultz, W., & Dickinson, A. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.473 · Cited by 1,427
The organization of the projection from the cerebral cortex to the striatum in the rat
McGeorge, A. J., & Faull, R. L. M. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90128-0 · Cited by 1,360
Adipsia and Aphagia after 6‐Hydroxydopamine Induced Degeneration of the Nigro‐striatal Dopamine System
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb11001.x · Cited by 1,294
Signals That Regulate Food Intake and Energy Homeostasis
Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W. (1998) · Science · doi:10.1126/science.280.5368.1378 · Cited by 1,177
From Lesions to Leptin
Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160

Show all 57 references

Research works printed but not linked: 2

Cote, 1999, Depression, Neurology, 52, 7
Smith, 1995, Dopamine and food reward, Prog. Psychobiol. Physiol. Psychol., 16, 83

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Self-citation
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Authors: Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D.
Affiliations: Howard Hughes Medical Institute (US)
United States Department of Veterans Affairs (US)
Corresponding author: Palmiter, Richard D
ORCID: Matsumoto, Alvin M
Palmiter, Richard D
Venue: Neuron
Publisher: Elsevier BV
Published: 2001-05
Volume: 30
Issue: 3
Pages: 819-828
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(01)00319-1
OpenAlex: W2102590502
Cited by: 354
References: 57
Citations by year: 2026: 6 · 2025: 10 · 2024: 6 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 15 · 2019: 13 · 2018: 17 · 2017: 15 · 2016: 23 · 2015: 17 · 2014: 12 · 2013: 14 · 2012: 26
FWCI: 5.27
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4460 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (5 P30 DK35816-14, P30DK035816)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD008121, HD-08121)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords: dopamine deficiency, caudate-putamen, nucleus accumbens, tyrosine hydroxylase, gene therapy, feeding behavior, hypophagia, nest building behavior, exploratory behavior, sucrose preference, reward, dopamine replacement therapy
MeSH terms: Adenoviridae, Animals, Dopamine, Feeding Behavior, Female, Food Preferences, Immunohistochemistry, Levodopa, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Movement, Nesting Behavior, Nucleus Accumbens, Recombinant Proteins, Transduction, Genetic, Tyrosine 3-Monooxygenase, Dopamine Agents, Neostriatum, Dietary Sucrose, Mice

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Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice

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