Cited by 924Child Abuse and TraumaPosttraumatic Stress Disorder ResearchPsychoanalysis and Psychopathology Research

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Hippocampal volume in women victimized by childhood sexual abuse

STEIN, M. B., KOVEROLA, C., HANNA, C., TORCHIA, M. G., McCLARTY, B.·1997·Psychological Medicine

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Abstract

BACKGROUND: Several prior studies have found reduced hippocampal volume in victims of psychological trauma with post-traumatic stress disorder (PTSD). We were interested to determine if this finding was evident in women who were victimized by severe sexual abuse in childhood. METHODS: In this study, hippocampal volume was measured using quantitative magnetic resonance imaging (MRI) in 21 women who reported being severely sexually abused in childhood and 21 socio-demographically similar women without abuse histories. RESULTS: Women who reported sexual victimization in childhood had significantly reduced (5% smaller) left-sided hippocampal volume compared to the non-victimized women. Hippocampal volume was also smaller on the right side, but this failed to reach statistical significance. Left-sided hippocampal volume correlated highly (rs = -0.73) with dissociative symptom severity, but not with indices of explicit memory functioning. CONCLUSIONS: These findings, which are generally consistent with prior reports of reduced hippocampal volume in combat veterans with PTSD, suggest that diminished hippocampal size may be either a consequence of trauma exposure or a risk factor for the development of psychiatric complications following trauma exposure. The observed relationship between symptom severity and hippocampal volume suggests that mesial temporal lobe dysfunction may directly mediate certain aspects of PTSD and dissociative disorder symptomatology.

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Authors: STEIN, M. B., KOVEROLA, C., HANNA, C., TORCHIA, M. G., & McCLARTY, B.
Affiliations: University of California San Diego (US)
ORCID: TORCHIA, M. G.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 1997-07
Volume: 27
Issue: 4
Pages: 951-959
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291797005242
OpenAlex: W2045217506
Cited by: 924
References: 73
Citations by year: 2026: 7 · 2025: 6 · 2024: 35 · 2023: 12 · 2022: 17 · 2021: 18 · 2020: 18 · 2019: 17 · 2018: 29 · 2017: 23 · 2016: 31 · 2015: 50 · 2014: 35 · 2013: 34 · 2012: 38
FWCI: 27.99
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: hippocampal volume, child sexual abuse, post-traumatic stress disorder, dissociation, dissociative symptoms, brain structure, women, declarative memory, trauma exposure
MeSH terms: Adult, Alcohol Drinking, Analysis of Variance, Child, Child Abuse, Sexual, Cross-Sectional Studies, Dissociative Disorders, Female, Hippocampus, Humans, Neurotic Disorders, Severity of Illness Index, Stress Disorders, Post-Traumatic, Case-Control Studies

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Hippocampal volume in women victimized by childhood sexual abuse

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