Cited by 3,837Genetics, Aging, and Longevity in Model OrganismsParathyroid Disorders and TreatmentsTelomeres, Telomerase, and Senescence

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, Makoto, Matsumura, Yutaka, Aizawa, Hiroki, Kawaguchi, Hiroshi, Suga, Tatsuo, Utsugi, Toshihiro, Ohyama, Yoshio, Kurabayashi, Masahiko, Kaname, Tadashi, Kume, Eisuke, Iwasaki, Hitoshi, Iida, Akihiro, Shiraki-Iida, Takako, Nishikawa, Satoshi, Nagai, Ryozo, Nabeshima, Yo-ichi·1997·Nature

DOI 10.1038/36285

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Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

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A new method for predicting signal sequence cleavage sites
von HEIJNE, G. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.11.4683 · Cited by 4,473
Positional Cloning of the Werner's Syndrome Gene
Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705
Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
Barlow, C., Hirotsune, S., Paylor, R. E., Liyanage, M., Eckhaus, M., Collins, F. S., Shiloh, Y., Crawley, J. N., Ried, T., Tagle, D. A., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)80086-0 · Cited by 1,465
The Bloom's syndrome gene product is homologous to RecQ helicases
Ellis, N. A., Groden, J. L., Ye, T.-Z., Straughen, J. E., Lennon, D. J., Ciocci, S., Proytcheva, M. A., & GERMAN, J. L. (1995) · Cell · doi:10.1016/0092-8674(95)90105-1 · Cited by 1,385
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. E. L. (1990) · Elsevier eBooks · doi:10.1016/c2013-0-11470-5 · Cited by 1,219
Handbook of the Biology of Aging
Finch, C. E., & Schneider, E. L. (1990) · DigitalGeorgetown (Georgetown University Library) · Cited by 1,210
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
Human growth hormone and human aging
CORPAS, E., HARMAN, S. M., & BLACKMAN, M. R. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-1-20 · Cited by 911
Locating protein-coding regions in human DNA sequences by a multiple sensor-neural network approach.
Uberbacher, E. C., & Mural, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11261 · Cited by 652
Osteoporosis: Etiology, diagnosis, and management
(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80791-1 · Cited by 605

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Robbins, S. L., Angell, M. A. & Kumar, V. in Basic Pathology 3–27 (Igaku-shoin/Saunders, Tokyo, 1981).
Chuttani, A. & Gilchrest, B. A. in Handbook of Physiology, 11: Aging (ed. Masoro, E. J.) 309–324 (Oxford Univ. Press, New York, 1995).
Sparrow, D. & Weiss, S. T. in Handbook of Physiology, 11: Aging (ed. Masoro, E. J.) 475–483 (Oxford Univ. Press, New York, 1995).
Sambrook, J., Fritsch, E. F. & Maniatis, T. Molecular Cloning (Cold Spring Harbor Laboratory Press, New York, 1989).

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Fang, Y., Ding, X., Zhang, Y., Cai, L., Ge, Y., Ma, K., Xu, R., Li, S., Song, M., Zhu, H., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02389-y · Cited by 96
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Zota, A. R., Mitro, S. D., Robinson, J. F., Hamilton, E. G., Park, J.-S., Parry, E., Zoeller, R. T., & Woodruff, T. J. (2018) · Environment International · doi:10.1016/j.envint.2017.12.030 · Cited by 95
Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB
Zhao, X., Chen, Y., Tan, X., Zhang, L., Zhang, H., Li, Z., Liu, S., Li, R., Lin, T., Liao, R., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5077 · Cited by 93
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Tang, M., Frank, D., Hendricks, A., Ir, D., Esamai, F., Liechty, E., Hambidge, K., & Krebs, N. (2017) · Nutrients · doi:10.3390/nu9070776 · Cited by 94
Muscle and adipose tissue morphology, insulin sensitivity and beta-cell function in diabetic and nondiabetic obese patients: effects of bariatric surgery.
Camastra, S., Vitali, A., Anselmino, M., Gastaldelli, A., Bellini, R., Berta, R., Severi, I., Baldi, S., Astiarraga, B., Barbatelli, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08444-6 · Cited by 93
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Turner, A. G., Ong, C.-L. Y., Gillen, C. M., Davies, M. R., West, N. P., McEwan, A. G., & Walker, M. J. (2015) · mBio · doi:10.1128/mbio.00278-15 · Cited by 93
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Franzin, R., Stasi, A., Fiorentino, M., Stallone, G., Cantaluppi, V., Gesualdo, L., & Castellano, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00734 · Cited by 93
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Gronier, B., Savignac, H. M., Di Miceli, M., Idriss, S. M., Tzortzis, G., Anthony, D., & Burnet, P. W. J. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.11.001 · Cited by 91
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Social interactions elicit rapid shifts in functional connectivity in the social decision-making network of zebrafish
Teles, M. C., Almeida, O., Lopes, J. S., & Oliveira, R. F. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.1099 · Cited by 87
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Authors: Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., & Nabeshima, Y.-I.
Affiliations: Gunma University (JP)
The University of Tokyo (JP)
Institute of Molecular Embryology and Genetics, Kumamoto University (JP)
National Center of Neurology and Psychiatry (JP)
Corresponding author: Nabeshima, Yo-ichi
ORCID: Matsumura, Yutaka
Aizawa, Hiroki
Kawaguchi, Hiroshi
Kurabayashi, Masahiko
Kaname, Tadashi
Iwasaki, Hitoshi
Nishikawa, Satoshi
Nagai, Ryozo
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1997-11-06
Volume: 390
Issue: 6655
Pages: 45-51
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/36285
OpenAlex: W2114360920
Cited by: 3,837
References: 26
Citations by year: 2026: 117 · 2025: 194 · 2024: 234 · 2023: 195 · 2022: 213 · 2021: 220 · 2020: 239 · 2019: 212 · 2018: 225 · 2017: 178 · 2016: 208 · 2015: 194 · 2014: 167 · 2013: 170 · 2012: 154
FWCI: 9.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Keywords: Klotho gene, aging, lifespan, mouse mutations, infertility, arteriosclerosis, osteoporosis, emphysema, skin atrophy, β-glucosidase, membrane proteins, age-related diseases

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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