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Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny

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Guilliams, Martin, Ginhoux, Florent, Jakubzick, Claudia, Naik, Shalin H., Onai, Nobuyuki, Schraml, Barbara U., Segura, Elodie, Tussiwand, Roxane, Yona, Simon·2014·Nature Reviews Immunology
DOI 10.1038/nri3712
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Abstract

The mononuclear phagocyte system (MPS) has historically been categorized into monocytes, dendritic cells and macrophages on the basis of functional and phenotypical characteristics. However, considering that these characteristics are often overlapping, the distinction between and classification of these cell types has been challenging. In this Opinion article, we propose a unified nomenclature for the MPS. We suggest that these cells can be classified primarily by their ontogeny and secondarily by their location, function and phenotype. We believe that this system permits a more robust classification during both steady-state and inflammatory conditions, with the benefit of spanning different tissues and across species.

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Metadata

Authors
Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, E., Tussiwand, R., & Yona, S.
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2014-07-18
Volume
14
Issue
8
Pages
571-578
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
DOI
10.1038/nri3712
OpenAlex
W2036564362
Cited by
1,819
References
18
FWCI
9.50
Type
journal article
Language
en
Open access
bronze
Licence
www.springer.com/tdm (tdm)

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Guilliams, M., Ginhoux, F., Jakubzick, C., Naik, S. H., Onai, N., Schraml, B. U., Segura, E., Tussiwand, R., & Yona, S. (2014). Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nature Reviews Immunology. https://doi.org/10.1038/nri3712

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