Cited by 462Eating Disorders and BehaviorsRegulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

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Obesity and the brain: how convincing is the addiction model?

Ziauddeen, Hisham, Farooqi, I. Sadaf, Fletcher, Paul C.·2012·Nature Reviews Neuroscience

DOI 10.1038/nrn3212

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Abstract

An increasingly influential perspective conceptualizes both obesity and overeating as a food addiction accompanied by corresponding brain changes. Because there are far-reaching implications for clinical practice and social policy if it becomes widely accepted, a critical evaluation of this model is important. We examine the current evidence for the link between addiction and obesity, identifying several fundamental shortcomings in the model, as well as weaknesses and inconsistencies in the empirical support for it from human neuroscientific research.

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See all 462

Authors: Ziauddeen, H., Farooqi, I. S., & Fletcher, P. C.
Affiliations: University of Cambridge (GB)
Corresponding author: Fletcher, Paul C.
ORCID: Ziauddeen, Hisham
Farooqi, I. Sadaf
Fletcher, Paul C.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2012-03-14
Volume: 13
Issue: 4
Pages: 279-286
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3212
OpenAlex: W2033383318
Cited by: 462
References: 101
Citations by year: 2026: 9 · 2025: 14 · 2024: 7 · 2023: 15 · 2022: 21 · 2021: 16 · 2020: 68 · 2019: 26 · 2018: 32 · 2017: 34 · 2016: 47 · 2015: 49 · 2014: 56 · 2013: 48 · 2012: 20
FWCI: 7.99
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (095692, 093270)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: obesity, food addiction, addiction models, overeating, brain changes, neurobiology of eating, clinical practice, social policy, evidence evaluation
MeSH terms: Brain, Humans, Hyperphagia, Models, Theoretical, Obesity, Behavior, Addictive

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Obesity and the brain: how convincing is the addiction model?

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