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Cited by 1,861

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Recognition of single-stranded RNA viruses by Toll-like receptor 7

Open access
Lund, Jennifer M., Alexopoulou, Lena, Sato, Ayuko, Karow, Margaret, Adams, Niels C., Gale, Nicholas W., Iwasaki, Akiko, Flavell, Richard A.·2004·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0400937101
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Abstract

Viral infection of mammalian host results in the activation of innate immune responses. Toll-like receptors (TLRs) have been shown to mediate the recognition of many types of pathogens, including viruses. The genomes of viruses possess unique characteristics that are not found in mammalian genomes, such as high CpG content and double-stranded RNA. These genomic nucleic acids serve as molecular signatures associated with viral infections. Here we show that TLR7 recognizes the single-stranded RNA viruses, vesicular stomatitis virus and influenza virus. The recognition of these viruses by plasmacytoid dendritic cells and B cells through TLR7 results in their activation of costimulatory molecules and production of cytokines. Moreover, this recognition required intact endocytic pathways. Mice deficient in either the TLR7 or the TLR adaptor protein MyD88 demonstrated reduced responses to in vivo infection with vesicular stomatitis virus. These results demonstrate microbial ligand recognition by TLR7 and provide insights into the pathways used by the innate immune cells in the recognition of viral pathogens.

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Research works printed but not linked: 33

  1. 10.1016/S0065-2776(01)78001-7 · DOI · Paper page
  2. 10.1034/j.1600-065X.2000.917309.x · DOI · Paper page
  3. 10.1016/S0952-7915(02)00349-7 · DOI
  4. 10.1182/blood-2003-08-2674 · DOI · Paper page
  5. 10.1084/jem.20030162 · DOI · Paper page
  6. 10.1016/S1286-4579(02)01583-6 · DOI
  7. Cella, M., Facchetti, F., Lanzavecchia, A. & Colonna, M. (2000) Nat. Immunol. 4, 305–310.
  8. 10.1084/jem.194.8.1171 · DOI · Paper page
  9. 10.1038/ni736 · DOI · Paper page
  10. 10.1038/nature01783 · DOI · Paper page
  11. 10.1006/viro.2000.0736 · DOI
  12. 10.1006/viro.1998.9535 · DOI
  13. 10.1038/nbt822 · DOI · Paper page
  14. Schlaeger, T. M., Qin, Y., Fujiwara, Y., Magram, J. & Sato, T. N. (1995) Development (Cambridge, U.K.) 121, 1089–1098.
  15. 10.1016/S1074-7613(00)80596-8 · DOI · Paper page
  16. 10.4049/jimmunol.171.12.6466 · DOI · Paper page
  17. 10.1126/science.278.5343.1612 · DOI · Paper page
  18. 10.1002/eji.200323797 · DOI · Paper page
  19. 10.1084/jem.20021908 · DOI · Paper page
  20. 10.1016/0022-2836(82)90269-8 · DOI · Paper page
  21. 10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO;2-U · DOI
  22. 10.1002/eji.200324238 · DOI · Paper page
  23. 10.1038/ni758 · DOI · Paper page
  24. 10.1002/1521-4141(200111)31:11<3388::AID-IMMU3388>3.0.CO;2-Q · DOI · Paper page
  25. 10.1073/pnas.0631696100 · DOI · Paper page
  26. 10.1083/jcb.89.3.674 · DOI · Paper page
  27. 10.1128/jvi.47.1.171-177.1983 · DOI · Paper page
  28. 10.1084/jem.20011666 · DOI
  29. 10.1038/nature01889 · DOI · Paper page
  30. 10.1126/science.1087262 · DOI · Paper page
  31. 10.1128/jvi.43.1.361-364.1982 · DOI
  32. Perussia, B., Fanning, V. & Trinchieri, G. (1985) Nat. Immun. Cell Growth Regul. 4, 120–137.2995798
  33. 10.1002/cyto.10118 · DOI

Cited by

Metadata

Authors
Lund, J. M., Alexopoulou, L., Sato, A., Karow, M., Adams, N. C., Gale, N. W., Iwasaki, A., & Flavell, R. A.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2004-03-19
Volume
101
Issue
15
Pages
5598-5603
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0400937101
OpenAlex
W2161208630
Cited by
1,861
References
3
FWCI
47.38
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.