Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 5,818

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Measuring the thickness of the human cerebral cortex from magnetic resonance images

Open access
Fischl, Bruce, Dale, Anders M.·2000·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.200033797
Open this paper in CoChat — free account

Abstract

Accurate and automated methods for measuring the thickness of human cerebral cortex could provide powerful tools for diagnosing and studying a variety of neurodegenerative and psychiatric disorders. Manual methods for estimating cortical thickness from neuroimaging data are labor intensive, requiring several days of effort by a trained anatomist. Furthermore, the highly folded nature of the cortex is problematic for manual techniques, frequently resulting in measurement errors in regions in which the cortical surface is not perpendicular to any of the cardinal axes. As a consequence, it has been impractical to obtain accurate thickness estimates for the entire cortex in individual subjects, or group statistics for patient or control populations. Here, we present an automated method for accurately measuring the thickness of the cerebral cortex across the entire brain and for generating cross-subject statistics in a coordinate system based on cortical anatomy. The intersubject standard deviation of the thickness measures is shown to be less than 0.5 mm, implying the ability to detect focal atrophy in small populations or even individual subjects. The reliability and accuracy of this new method are assessed by within-subject test–retest studies, as well as by comparison of cross-subject regional thickness measures with published values.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1073/pnas.200033797

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 5 references

Research works printed but not linked: 35

  1. 10.1016/B978-0-12-547625-6.50027-1 · DOI
  2. C von Economo The Cytoarchitectonics of the Human Cerebral Cortex (Oxford Univ. Press, London, 1929).
  3. K Brodmann Vergleichende Lokalisationslehre der Großhirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues (Barth, Leipzig, Germany, 1909).
  4. 10.1073/pnas.93.24.13547 · DOI
  5. G B Frisoni, A Beltramello, C Weiss, C Geroldi, A Bianchetti, M Trabucchi Am J Neuroradiol 17, 913–923 (1996).
  6. 10.1007/s004010050816 · DOI
  7. 10.1016/0197-4580(96)00005-X · DOI
  8. 10.1148/radiology.178.1.1984287 · DOI
  9. 10.1097/00005072-199805000-00001 · DOI · Paper page
  10. 10.1006/exnr.1998.6919 · DOI · Paper page
  11. 10.1093/brain/117.4.747 · DOI
  12. 10.1001/archpsyc.1992.01820030027004 · DOI · Paper page
  13. 10.1001/archpsyc.55.6.540 · DOI
  14. A Pfefferbaum, L Marsh Clin Neurosci 3, 105–111 (1995).
  15. 10.1001/archpsyc.56.2.142 · DOI
  16. J R Meyer, S Roychowdhury, E J Russell, C Callahan, D Gitelman, M M Mesulam Am J Neuroradiol 17, 1699–1706 (1996).
  17. 10.1162/jocn.1993.5.2.162 · DOI · Paper page
  18. 10.1006/nimg.1998.0395 · DOI · Paper page
  19. 10.1006/nimg.1998.0396 · DOI · Paper page
  20. Fischl B. Liu A. & Dale A. M. (1999) IEEE Trans. Med. Imaging in press.
  21. 10.1002/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4 · DOI · Paper page
  22. 10.1007/BF01908877 · DOI · Paper page
  23. D MacDonald Ph.D. thesis (McGill University, Montreal, 1998).
  24. 10.1109/42.544496 · DOI
  25. 10.1007/BF00133570 · DOI · Paper page
  26. 10.1162/jocn.1991.3.1.59 · DOI · Paper page
  27. 10.1109/83.536892 · DOI · Paper page
  28. 10.1109/42.511745 · DOI · Paper page
  29. 10.1016/S1361-8415(96)80007-7 · DOI · Paper page
  30. J A Sethian Level Set Methods. Evolving Interfaces in Geometry, Fluid Mechanics, Computer Vision, and Materials Science (Cambridge Univ. Press, Cambridge, U.K., 1996).
  31. 10.4310/jdg/1214444092 · DOI · Paper page
  32. W H Press, S A Teukolsky, W T Vetterling, B P Flannery Numerical Recipes inc (Cambridge Univ. Press, 2nd. Ed., Cambridge, U.K., 1994).
  33. 10.1080/10867651.1997.10487472 · DOI · Paper page
  34. D A Sholl The Organization of the Cerebral Cortex (Wiley, New York, 1956).
  35. J Talairach, P Tournoux Co-Planar Stereotaxic Atlas of the Human Brain (Thieme, New York, 1988).

Cited by

Items 101–200 of 337

Metadata

Authors
Fischl, B., & Dale, A. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2000-09-12
Volume
97
Issue
20
Pages
11050-11055
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.200033797
OpenAlex
W2110208125
Cited by
5,818
References
5
FWCI
18.85
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.