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Differences between males and females in rates of serotonin synthesis in human brain

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Nishizawa, S., Benkelfat, C., Young, S. N., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P., Diksic, M.·1997·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.94.10.5308

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Abstract

Rates of serotonin synthesis were measured in the human brain using positron emission tomography. The sensitivity of the method is indicated by the fact that measurements are possible even after a substantial lowering of synthesis induced by acute tryptophan depletion. Unlike serotonin levels in human brain, which vary greatly in different brain areas, rates of synthesis of the indolamine are rather uniform throughout the brain. The mean rate of synthesis in normal males was found to be 52% higher than in normal females; this marked difference may be a factor relevant to the lower incidence of major unipolar depression in males.

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THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
The use of analogue scales in rating subjective feelings
BOND, A., & LADER, M. (1974) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1974.tb02285.x · Cited by 1,972
Depression in Women: Implications for Health Care Research
Weissman, M. M., & Olfson, M. (1995) · Science · doi:10.1126/science.7638596 · Cited by 525

Show all 3 references

Why sex matters for neuroscience
Cahill, L. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1909 · Cited by 1,540
The ABCs of depression: integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression
Hyde, J. S., Mezulis, A. H., & Abramson, L. Y. (2008) · Psychological Review · doi:10.1037/0033-295x.115.2.291 · Cited by 1,146
Evolving Knowledge of Sex Differences in Brain Structure, Function, and Chemistry
Cosgrove, K. P., Mazure, C. M., & Staley, J. K. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.001 · Cited by 996
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis
Jenkins, T., Nguyen, J., Polglaze, K., & Bertrand, P. (2016) · Nutrients · doi:10.3390/nu8010056 · Cited by 904
Serotoninergic regulation of emotional and behavioural control processes
Cools, R., Roberts, A. C., & Robbins, T. W. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2007.10.011 · Cited by 656
Minireview: sex differences in adult and developing brains: compensation, compensation, compensation
De Vries, G. J. (2004) · Endocrinology · doi:10.1210/en.2003-1504 · Cited by 486
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Mallampalli, M. P., & Carter, C. L. (2014) · Journal of Women's Health · doi:10.1089/jwh.2014.4816 · Cited by 504
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Young, S. N., & Leyton, M. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00670-0 · Cited by 396
Self-citation
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Chang, L., & Heitkemper, M. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.36603 · Cited by 351
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Crockett, M. J., Clark, L., & Robbins, T. W. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2513-09.2009 · Cited by 271
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Riedel, W. J., Klaassen, T., Deutz, N. E. P., van Someren, A., & van Praag, H. M. (1999) · Psychopharmacology · doi:10.1007/s002130050845 · Cited by 271
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Deecher, D., Andree, T. H., Sloan, D., & Schechter, L. E. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.006 · Cited by 270
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Silber, B. Y., & Schmitt, J. A. J. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.08.005 · Cited by 260
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Schmitt, J. A. J., Jorissen, B. L., Sobczak, S., van Boxtel, M. P. J., Hogervorst, E., Deutz, N. E. P., & Riedel, W. J. (2000) · Journal of Psychopharmacology · doi:10.1177/026988110001400102 · Cited by 227
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“Furthermore, gender differences in serotonin transporter gene polymorphisms, variations in serotonin synthesis rates, and disparities in serotonin synthesis rates have been noted [74].”
Background
Selective effects of simultaneous monoamine depletion on mood and emotional responsiveness
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The effect of acute tryptophan depletion on performance and the BOLD response during a Stroop task in healthy first-degree relatives of patients with unipolar depression
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Authors: Nishizawa, S., Benkelfat, C., Young, S. N., Leyton, M., Mzengeza, S., de Montigny, C., Blier, P., & Diksic, M.
Venue: Proceedings of the National Academy of Sciences
Publisher: Proceedings of the National Academy of Sciences
Published: 1997-05-13
Volume: 94
Issue: 10
Pages: 5308-5313
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.94.10.5308
OpenAlex: W2051068515
Cited by: 900
References: 3
FWCI: 11.27
Type: journal article
Language: en
Open access: green

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Differences between males and females in rates of serotonin synthesis in human brain

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