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Cited by 865

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

Open access
Lyons, W. Ernest, Mamounas, Laura A., Ricaurte, George A., Coppola, Vincenzo, Reid, Susan W., Bora, Susan H., Wihler, Cornelia, Koliatsos, Vassilis E., Tessarollo, Lino·1999·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.96.26.15239
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Abstract

Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons in the central nervous system. However, the role of endogenous BDNF in the development and function of these neurons has not been established in vivo because of the early postnatal lethality of BDNF null mice. In the present study, we use heterozygous BDNF +/− mice that have a normal life span and show that these animals develop enhanced intermale aggressiveness and hyperphagia accompanied by significant weight gain in early adulthood; these behavioral abnormalities are known to correlate with 5-HT dysfunction. Forebrain 5-HT levels and fiber density in BDNF +/− mice are normal at an early age but undergo premature age-associated decrements. However, young adult BDNF +/− mice show a blunted c-fos induction by the specific serotonin releaser-uptake inhibitor dexfenfluramine and alterations in the expression of several 5-HT receptors in the cortex, hippocampus, and hypothalamus. The heightened aggressiveness can be ameliorated by the selective serotonin reuptake inhibitor fluoxetine. Our results indicate that endogenous BDNF is critical for the normal development and function of central 5-HT neurons and for the elaboration of behaviors that depend on these nerve cells. Therefore, BDNF +/− mice may provide a useful model to study human psychiatric disorders attributed to dysfunction of serotonergic neurons.

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Metadata

Authors
Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1999-12-21
Volume
96
Issue
26
Pages
15239-15244
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.96.26.15239
OpenAlex
W2159692236
Cited by
865
References
2
FWCI
4.58
Type
journal article
Language
en
Open access
green

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