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Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report
Abstract
The National Institute of Mental Health (NIMH) convened a meeting in September 2005 to review tobacco use and dependence and smoking cessation among those with mental disorders, especially individuals with anxiety disorders, depression, or schizophrenia. Smoking rates are exceptionally high among these individuals and contribute to the high rates of medical morbidity and mortality in these individuals. Numerous biological, psychological, and social factors may explain these high smoking rates, including the lack of smoking cessation treatment in mental health settings. Historically, "self-medication" and "individual rights" have been concerns used to rationalize allowing ongoing tobacco use and limited smoking cessation efforts in many mental health treatment settings. Although research has shown that tobacco use can reduce or ameliorate certain psychiatric symptoms, overreliance on the self-medication hypothesis to explain the high rates of tobacco use in psychiatric populations may result in inadequate attention to other potential explanations for this addictive behavior among those with mental disorders. A more complete understanding of nicotine and tobacco use in psychiatric patients also can lead to new psychiatric treatments and a better understanding of mental illness. Greater collaboration between mental health researchers and nicotine and tobacco researchers is needed to better understand and develop new treatments for cooccurring nicotine dependence and mental illness. Despite an accumulating literature for some specific psychiatric disorders and tobacco use and cessation, many unstudied research questions remain and are a focus and an emphasis of this review.
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“Research suggests that anxiety and depression are major impediments to smoking cessation,16,17 which is particularly relevant to SLWH given the population’s elevated rates.18”
From Evaluation of an integrated treatment to address smoking cessation and anxiety/depressive symptoms among people living with HIV: Study protocol for a randomized controlled trial (2021) · cites this paper as [16]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Despite these known disparities in tobacco smoking and its health consequences for people with BD, there is limited research on the treatment needs and outcomes of quit attempts for this group of smokers.”
From Smokers with bipolar disorder, other affective disorders, and no mental health conditions: Comparison of baseline characteristics and success at quitting in a large 12-month behavioral intervention randomized trial. (2018) · cites this paper as Ziedonis et al., 2008
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“Specifically, smoking rates have been shown to be significantly higher in the population with anxiety disorders than it is in the nonclinical population, 45.3% and 22.5%, respectively (Lasser et al., 2000; Ziedonis et al., 2008).”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Ziedonis et al., 2008
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“For instance, depressive and anxiety syndromes are more prevalent among smokers than nonsmokers [6,7], and smokers with these conditions are more likely to be nicotine dependent [4,8].”
From Acceptance and Commitment Therapy Wellness Program for Latine Adults Who Smoke and Have Psychological Distress: Protocol for a Feasibility Study (2023) · cites this paper as [6]
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“Limited integration of factors known to interfere with smoking cessation, such as anxiety and depressive symptoms,16,17 within treatments for SLWH may contribute to quit difficulty and mixed findings.”
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“Considerable research has assessed the impact of depression and anxiety on cessation outcomes, with a number of studies reporting that depression and anxiety place smokers at increased risk for cessation failure [9-14], with other studies suggesting that the evidence is inconclusive [6,15-18].”
From Acceptance and Commitment Therapy Wellness Program for Latine Adults Who Smoke and Have Psychological Distress: Protocol for a Feasibility Study (2023) · cites this paper as [6]
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“Anxiety disorders co-occur with smoking at rates that exceed those found in the general population (Ziedonis et al., 2008)”
From A qualitative study of the feasibility and acceptability of a smoking cessation program for people living with HIV and emotional dysregulation. (2019) · cites this paper as Ziedonis et al., 2008
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“For example, there are high rates of comorbidity between substance abuse and other Axis I conditions [747-749], schizophrenia and bipolar disorder [750], and ASD and mood and anxiety disorders [751].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [749]
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Metadata
- Authors
- Ziedonis, D., Hitsman, B., Beckham, J. C., Zvolensky, M., Adler, L. E., Audrain-McGovern, J., Breslau, N., Brown, R. A., George, T. P., Williams, J., Calhoun, P. S., & Riley, W. T.
- Affiliations
- UMass Memorial Health Care (US)
- Northwestern University (US)
- Duke University (US)
- University of Vermont (US)
- University of Colorado Health (US)
- University of Pennsylvania (US)
- Michigan State University (US)
- Brown University (US)
- University of Toronto (CA)
- Rutgers, The State University of New Jersey (US)
- National Institutes of Health (US)
- ORCID
- Venue
- Nicotine & Tobacco Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-12-01
- Volume
- 10
- Issue
- 12
- Pages
- 1691-1715
- ISSN
- 1462-2203 (ISSN-L)
- 1469-994X
- OpenAlex
- W2126866313
- Semantic Scholar
- 1098de69bc87efcdfb0ceacacd784724606d74d2
- Cited by
- 735
- References
- 246
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 18 · 2023: 42 · 2022: 27 · 2021: 30 · 2020: 48 · 2019: 28 · 2018: 50 · 2017: 32 · 2016: 62 · 2015: 65 · 2014: 59 · 2013: 50 · 2012: 62
- FWCI
- 28.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nicotine & Tobacco Research (publishedVersion)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Office of Research and Development
- State of New Jersey Department of Health
- National Alliance for Research on Schizophrenia and Depression
- Missouri Department of Health and Senior Services
- University of Toronto
- National Institutes of Health (5k24da016388-10, 5r01da018734-03)
- National Institute on Alcohol Abuse and Alcoholism (R01AA015950, AA015950)
- National Institute of Mental Health (R01MH076672, MH 076629-01, MH076629, MH050787-11, R01MH050787, MH076672-01A1, R01MH076629)
- National Institute on Drug Abuse (DA020705, R03DA016307, DA015537, DA 16307-01, DA019704, DA016738, R01DA020705, R21DA019704, R01DA016738, DA16611, R01DA017947, DA016388, R01DA013672, DA023190, DA018734--01A1, K08DA017145, DA017145, R01DA015537, R01DA023190, R01DA014039, DA13672, DA14039, DA017947, K02DA016611)
- National Cancer Institute (R01CA096836, CA081595, R01CA081595, CA096836, R01CA109250, CA109250)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- tobacco use, smoking cessation, nicotine dependence, mental illness, anxiety disorders, depression, schizophrenia, self-medication hypothesis
- MeSH terms
- Anxiety Disorders, Mental Disorders, Depression, Humans, National Institute of Mental Health (U.S.), Primary Prevention, Risk Factors, Schizophrenia, Smoking, Social Environment, Tobacco Use Disorder, United States, Comorbidity, Prevalence, Smoking Cessation, Self Efficacy, Mentally Ill Persons, Persons with Psychiatric Disorders
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