Microbiota-derived metabolites as drivers of gut–brain communication

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · cited 2×

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838

Interaction between microbiota and immunity in health and disease

Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Research · doi:10.1038/s41422-020-0332-7 · Cited by 3,947

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888

Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease

Sampson, T. R., Debelius, J. W., Thron, T., Janssen, S., Shastri, G. G., Ilhan, Z. E., Challis, C., Schretter, C. E., Rocha, S., Gradinaru, V., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.018 · Cited by 3,622

Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis

Yano, J. M., Yu, K., Donaldson, G. P., Shastri, G. G., Ann, P., Ma, L., Nagler, C. R., Ismagilov, R. F., Mazmanian, S. K., & Hsiao, E. Y. (2015) · Cell · doi:10.1016/j.cell.2015.02.047 · Cited by 3,614

Host microbiota constantly control maturation and function of microglia in the CNS

Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569

HMDB 4.0: the human metabolome database for 2018

Wishart, D. S., Feunang, Y. D., Marcu, A., Guo, A. C., Liang, K., Vázquez-Fresno, R., Sajed, T., Johnson, D., Li, C., Karu, N., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1089 · Cited by 3,438

The role of short-chain fatty acids in microbiota–gut–brain communication

Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · cited 1×

Environment dominates over host genetics in shaping human gut microbiota

Rothschild, D., Weissbrod, O., Barkan, E., Kurilshikov, A., Korem, T., Zeevi, D., Costea, P. I., Godneva, A., Kalka, I. N., Bar, N., et al. (2018) · Nature · doi:10.1038/nature25973 · Cited by 2,859

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., & Siuzdak, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812874106 · Cited by 2,677

The gut microbiota influences blood-brain barrier permeability in mice

Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530

Development, maintenance and disruption of the blood-brain barrier

Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

Tolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes · doi:10.2337/db11-1019 · Cited by 2,404

Gut hormone PYY3-36 physiologically inhibits food intake

Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Lavelle, A., & Sokol, H. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0258-z · Cited by 2,015

How neuroinflammation contributes to neurodegeneration

Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967 · cited 1×

The neuroactive potential of the human gut microbiota in quality of life and depression

Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963

Microglia emerge as central players in brain disease

Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C.-C., Patel, B., Yan, R., Blain, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4106 · Cited by 1,559

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

Dodd, D., Spitzer, M. H., Van Treuren, W., Merrill, B. D., Hryckowian, A. J., Higginbottom, S. K., Le, A., Cowan, T. M., Nolan, G. P., Fischbach, M. A., et al. (2017) · Nature · doi:10.1038/nature24661 · Cited by 1,425

Microbiota Transfer Therapy Alters Gut Ecosystem and Improves Gastrointestinal and Autism Symptoms: An Open-Label Study

Kang, D.-W., Adams, J. B., Gregory, A. C., Borody, T., Chittick, L., Fasano, A., Khoruts, A., Geis, E., Maldonado, J., McDonough-Means, S., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0225-7 · Cited by 1,391

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Magistretti, P. J., & Allaman, I. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.035 · Cited by 1,285

The maternal microbiota drives early postnatal innate immune development

Gomez de Agüero, M., Ganal-Vonarburg, S. C., Fuhrer, T., Rupp, S., Uchimura, Y., Li, H., Steinert, A., Heikenwalder, M., Hapfelmeier, S., Sauer, U., et al. (2016) · Science · doi:10.1126/science.aad2571 · Cited by 1,231

Immune system to brain signaling: Neuropsychopharmacological implications

Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195

Minireview: Gut microbiota: The neglected endocrine organ

Clarke, G., Stilling, R. M., Kennedy, P. J., Stanton, C., Cryan, J. F., & Dinan, T. G. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1108 · Cited by 1,192

Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice

Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182

Microglia development follows a stepwise program to regulate brain homeostasis

Matcovitch-Natan, O., Winter, D. R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., et al. (2016) · Science · doi:10.1126/science.aad8670 · Cited by 1,180

GABA-modulating bacteria of the human gut microbiota

Strandwitz, P., Kim, K. H., Terekhova, D., Liu, J. K., Sharma, A., Levering, J., McDonald, D., Dietrich, D., Ramadhar, T. R., Lekbua, A., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0307-3 · Cited by 1,170 · cited 1×

γ-Aminobutyric acid production by culturable bacteria from the human intestine

Barrett, E., Ross, R. P., O'Toole, P. W., Fitzgerald, G. F., & Stanton, C. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05344.x · Cited by 1,156

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

Wang, X., Sun, G., Feng, T., Zhang, J., Huang, X., Wang, T., Xie, Z., Chu, X., Yang, J., Wang, H., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0216-x · Cited by 1,144

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity

Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076

Microglial control of astrocytes in response to microbial metabolites

Rothhammer, V., Borucki, D. M., Tjon, E. C., Takenaka, M. C., Chao, C.-C., Ardura-Fabregat, A., de Lima, K. A., Gutiérrez-Vázquez, C., Hewson, P., Staszewski, O., et al. (2018) · Nature · doi:10.1038/s41586-018-0119-x · Cited by 1,051

Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain

Gao, K., Mu, C.-L., Farzi, A., & Zhu, W.-Y. (2020) · Advances in Nutrition · doi:10.1093/advances/nmz127 · Cited by 1,029

Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling

Levy, M., Thaiss, C. A., Zeevi, D., Dohnalová, L., Zilberman-Schapira, G., Mahdi, J. A., David, E., Savidor, A., Korem, T., Herzig, Y., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.048 · Cited by 960

Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis

Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 940

Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine

Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.09.007 · Cited by 927

Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways

Bellono, N. W., Bayrer, J. R., Leitch, D. B., Castro, J., Zhang, C., O’Donnell, T. A., Brierley, S. M., Ingraham, H. A., & Julius, D. (2017) · Cell · doi:10.1016/j.cell.2017.05.034 · Cited by 910

Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified

De Angelis, M., Piccolo, M., Vannini, L., Siragusa, S., De Giacomo, A., Serrazzanetti, D. I., Cristofori, F., Guerzoni, M. E., Gobbetti, M., & Francavilla, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076993 · Cited by 887

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain–gut axis alterations

van de Wouw, M., Boehme, M., Lyte, J. M., Wiley, N., Strain, C., O'Sullivan, O., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2018) · The Journal of Physiology · doi:10.1113/jp276431 · Cited by 789

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Nemet, I., Saha, P. P., Gupta, N., Zhu, W., Romano, K. A., Skye, S. M., Cajka, T., Mohan, M. L., Li, L., Wu, Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.016 · Cited by 784

Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner

Thion, M. S., Low, D., Silvin, A., Chen, J., Grisel, P., Schulte-Schrepping, J., Blecher, R., Ulas, T., Squarzoni, P., Hoeffel, G., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.042 · Cited by 779

Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour

Desbonnet, L., Clarke, G., Traplin, A., O’Sullivan, O., Crispie, F., Moloney, R. D., Cotter, P. D., Dinan, T. G., & Cryan, J. F. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.04.004 · Cited by 760

Brain metabolism in health, aging, and neurodegeneration

Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal · doi:10.15252/embj.201695810 · Cited by 752

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S., & Fischbach, M. A. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.001 · Cited by 732

Kynurenine pathway metabolism and the microbiota-gut-brain axis

Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., Louie, G., Kueider‐Paisley, A., Moseley, M. A., Thompson, J. W., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.217 · Cited by 706

The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

Zheng, P., Zeng, B., Liu, M., Chen, J., Pan, J., Han, Y., Liu, Y., Cheng, K., Zhou, C., Wang, H., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau8317 · Cited by 704

Gut microbiome pattern reflects healthy ageing and predicts survival in humans

Wilmanski, T., Diener, C., Rappaport, N., Patwardhan, S., Wiedrick, J., Lapidus, J., Earls, J. C., Zimmer, A., Glusman, G., Robinson, M., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00348-0 · Cited by 675

Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice

Asano, Y., Hiramoto, T., Nishino, R., Aiba, Y., Kimura, T., Yoshihara, K., Koga, Y., & Sudo, N. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00341.2012 · Cited by 659

The bowel and beyond: The enteric nervous system in neurological disorders

Rao, M., & Gershon, M. D. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.107 · Cited by 629

The immune system and developmental programming of brain and behavior

Bilbo, S. D., & Schwarz, J. M. (2012) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2012.08.006 · Cited by 606

Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier

Hoyles, L., Snelling, T., Umlai, U.-K., Nicholson, J. K., Carding, S. R., Glen, R. C., & McArthur, S. (2018) · Microbiome · doi:10.1186/s40168-018-0439-y · Cited by 591

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

De Vadder, F., Grasset, E., Mannerås Holm, L., Karsenty, G., Macpherson, A. J., Olofsson, L. E., & Bäckhed, F. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720017115 · Cited by 566

The maternal microbiome modulates fetal neurodevelopment in mice

Vuong, H. E., Pronovost, G. N., Williams, D. W., Coley, E. J. L., Siegler, E. L., Qiu, A., Kazantsev, M., Wilson, C. J., Rendon, T., & Hsiao, E. Y. (2020) · Nature · doi:10.1038/s41586-020-2745-3 · Cited by 564

Aryl hydrocarbon receptor and intestinal immunity

Lamas, B., Natividad, J. M., & Sokol, H. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0019-2 · Cited by 551

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X., Zhang, W., Wang, L., Wang, Q., Wang, D., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14676-4 · Cited by 549

Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells

Chimerel, C., Emery, E., Summers, D. K., Keyser, U., Gribble, F. M., & Reimann, F. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.032 · Cited by 548

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

El Hayek, L., Khalifeh, M., Zibara, V., Abi Assaad, R., Emmanuel, N., Karnib, N., El-Ghandour, R., Nasrallah, P., Bilen, M., Ibrahim, P., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1661-18.2019 · Cited by 539

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

Alexeev, E. E., Lanis, J. M., Kao, D. J., Campbell, E. L., Kelly, C. J., Battista, K. D., Gerich, M. E., Jenkins, B. R., Walk, S. T., Kominsky, D. J., et al. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2018.01.011 · Cited by 532

Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers

Allen, A. P., Hutch, W., Borre, Y. E., Kennedy, P. J., Temko, A., Boylan, G., Murphy, E., Cryan, J. F., Dinan, T. G., & Clarke, G. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.191 · Cited by 513

Role of dietary polyphenols on gut microbiota, their metabolites and health benefits

Aravind, S. M., Wichienchot, S., Tsao, R., Ramakrishnan, S., & Chakkaravarthi, S. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110189 · Cited by 502

Probiotic Lactobacillus plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: a double-blind, randomized, placebo controlled study

Rudzki, L., Ostrowska, L., Pawlak, D., Małus, A., Pawlak, K., Waszkiewicz, N., & Szulc, A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.10.010 · Cited by 499

Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders

MACFABE, D., CAIN, D., RODRIGUEZCAPOTE, K., FRANKLIN, A., HOFFMAN, J., BOON, F., TAYLOR, A., KAVALIERS, M., & OSSENKOPP, K. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.025 · Cited by 497

PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

Batterham, R. L., Ffytche, D. H., Rosenthal, J., Zelaya, F. O., Barker, G. J., Withers, D. J., & Williams, S. (2007) · Nature · doi:10.1038/nature06212 · Cited by 489

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature · doi:10.1038/s41586-022-04396-8 · Cited by 489

Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells

Bohórquez, D. V., Shahid, R. A., Erdmann, A., Kreger, A. M., Wang, Y., Calakos, N., Wang, F., & Liddle, R. A. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78361 · Cited by 484 · cited 2×

The Meningeal Lymphatic System: A New Player in Neurophysiology

Da Mesquita, S., Fu, Z., & Kipnis, J. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.022 · Cited by 479

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

Erny, D., Dokalis, N., Mezö, C., Castoldi, A., Mossad, O., Staszewski, O., Frosch, M., Villa, M., Fuchs, V., Mayer, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.010 · Cited by 478

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Vogt, N. M., Romano, K. A., Darst, B. F., Engelman, C. D., Johnson, S. C., Carlsson, C. M., Asthana, S., Blennow, K., Zetterberg, H., Bendlin, B. B., et al. (2018) · Alzheimer's Research & Therapy · doi:10.1186/s13195-018-0451-2 · Cited by 471

Microglia and early brain development: An intimate journey

Thion, M. S., Ginhoux, F., & Garel, S. (2018) · Science · doi:10.1126/science.aat0474 · Cited by 465

Microbiota modulate sympathetic neurons via a gut–brain circuit

Muller, P. A., Schneeberger, M., Matheis, F., Wang, P., Kerner, Z. J., Ilanges, A., Pellegrino, K., del Mármol, J. I., Castro, T. B. R., Furuichi, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2474-7 · Cited by 465

Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder

Liu, S., Li, E., Sun, Z., Fu, D., Duan, G., Jiang, M., Yu, Y., Mei, L., Yang, P., Tang, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36430-z · Cited by 457

In Vivo Evidence for Lactate as a Neuronal Energy Source

Wyss, M. T., Jolivet, R., Buck, A., Magistretti, P. J., & Weber, B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0415-11.2011 · Cited by 451

A reference map of potential determinants for the human serum metabolome

Bar, N., Korem, T., Weissbrod, O., Zeevi, D., Rothschild, D., Leviatan, S., Kosower, N., Lotan‐Pompan, M., Weinberger, A., Roy, C. I. L., et al. (2020) · Nature · doi:10.1038/s41586-020-2896-2 · Cited by 440

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.004 · Cited by 436

The microbiota regulate neuronal function and fear extinction learning

Chu, C., Murdock, M. H., Jing, D., Won, T. H., Chung, H., Kressel, A. M., Tsaava, T., Addorisio, M. E., Putzel, G. G., Zhou, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1644-y · Cited by 421

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

Christiansen, C. B., Gabe, M. B. N., Svendsen, B., Dragsted, L. O., ROSENKILDE, M. M., & Holst, J. J. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00346.2017 · Cited by 413

Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder

Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid

Chyan, Y., Pöeggeler, B., Omar, R., Chain, D. G., Frangione, B., Ghiso, J. A., & Pappolla, M. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21937 · Cited by 409

Efficacy of omega-3 PUFAs in depression: A meta-analysis

Liao, Y., Xie, B., Zhang, H., He, Q., Guo, L., Subramanieapillai, M., Fan, B., Lu, C., & McIntyre, R. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0515-5 · Cited by 404

Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling

Anitha, M., Vijay–Kumar, M., Sitaraman, S. V., Gewirtz, A. T., & Srinivasan, S. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.034 · Cited by 397

Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders

Kang, D.-W., Ilhan, Z. E., Isern, N. G., Hoyt, D. W., Howsmon, D. P., Shaffer, M., Lozupone, C. A., Hahn, J., Adams, J. B., & Krajmalnik-Brown, R. (2018) · Anaerobe · doi:10.1016/j.anaerobe.2017.12.007 · Cited by 381

Autism-related dietary preferences mediate autism-gut microbiome associations

Yap, C. X., Henders, A. K., Alvares, G. A., Wood, D., Krause, L., Tyson, G. W., Restuadi, R., Wallace, L. M., McLaren, T., Hansell, N. K., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.015 · Cited by 371

Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism

Lauritzen, K. H., Morland, C., Puchades, M. A., Holm‐Hansen, S., Hagelin, E. M. V., Lauritzen, F., Attramadal, H., Storm‐Mathisen, J., GJEDDE, A. H., & Bergersen, L. H. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht136 · Cited by 367

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365

Colonic bacterial metabolites and human health

Russell, W. R., Hoyles, L., Flint, H. J., & Dumas, M. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.07.002 · Cited by 362

Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study

Korpela, K., Helve, O., Kolho, K.-L., Saisto, T., Skogberg, K., Dikareva, E., Stefanović, V., Salonen, A., Andersson, S., & de Vos, W. M. (2020) · Cell · doi:10.1016/j.cell.2020.08.047 · Cited by 358

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife · doi:10.7554/elife.59826 · Cited by 354

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

Marizzoni, M., Cattaneo, A., Mirabelli, P., Festari, C., Lopizzo, N., Nicolosi, V., Mombelli, E., Mazzelli, M., Luongo, D., Naviglio, D., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200306 · Cited by 351

A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

Chen, H., Nwe, P.-K., Yang, Y., Rosen, C. E., Bielecka, A. A., Kuchroo, M. R., Cline, G. W., Kruse, A. C., Ring, A. M., Crawford, J. M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.03.036 · Cited by 349

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers

Nho, K., Kueider‐Paisley, A., MahmoudianDehkordi, S., Arnold, M., Risacher, S. L., Louie, G., Blach, C., Baillie, R., Han, X., Kastenmüller, G., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.08.012 · Cited by 343

Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease

Heinken, A., Ravcheev, D. A., Baldini, F., Heirendt, L., Fleming, R. M. T., & Thiele, I. (2019) · Microbiome · doi:10.1186/s40168-019-0689-3 · Cited by 340

Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

Ye, L., Bae, M., Cassilly, C. D., Jabba, S. V., Thorpe, D. W., Martin, A. M., Lu, H.-Y., Wang, J., Thompson, J., Lickwar, C. R., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.11.011 · Cited by 338

Impact of intestinal microbiota on intestinal luminal metabolome

Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Kurihara, S., Sawaki, E., Koga, Y., & Benno, Y. (2012) · Scientific Reports · doi:10.1038/srep00233 · Cited by 334

High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis

Li, X. O., Li, X. O., Xia, B., Jin, X., Zou, Q., Zeng, Z., Zhao, W., Yan, S., Li, L., Yuan, S., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.02.002 · Cited by 316

Microbiota-driven transcriptional changes in prefrontal cortex override genetic differences in social behavior

Gacias, M., Gaspari, S., Santos, P.-M. G., Tamburini, S., Andrade, M., Zhang, F., Shen, N., Tolstikov, V., Kiebish, M. A., Dupree, J. L., et al. (2016) · eLife · doi:10.7554/elife.13442 · Cited by 308

Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis

McLoughlin, R. F., Berthon, B. S., Jensen, M. E., Baines, K. J., & Wood, L. G. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.156265 · Cited by 308

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

Halliwell, B., Cheah, I. K., & Tang, R. M. Y. (2018) · FEBS Letters · doi:10.1002/1873-3468.13123 · Cited by 305

Bile acid signaling pathways from the enterohepatic circulation to the central nervous system

Mertens, K. L., Kalsbeek, A., Soeters, M. R., & Eggink, H. M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00617 · Cited by 287

Magnetic resonance spectroscopy reveals oral Lactobacillus promotion of increases in brain GABA, N-acetyl aspartate and glutamate

Janik, R., Thomason, L. A. M., Stanisz, A. M., Forsythe, P., Bienenstock, J., & Stanisz, G. J. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.018 · Cited by 283

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

Wang, J., Hodes, G. E., Zhang, H., Zhang, S., Zhao, W., Golden, S. A., Bi, W., Menard, C., Kana, V., Leboeuf, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02794-5 · Cited by 274 · cited 1×

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Collino, S., Montoliu, I., Martin, F.-P. J., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056564 · Cited by 270

Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

Nøhr, M. K., Egerod, K. L., Christiansen, S. H., Gille, A., Offermanns, S., Schwartz, T. W., & Møller, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.040 · Cited by 270

Indole, a signaling molecule produced by the gut microbiota, negatively impacts emotional behaviors in rats

Jaglin, M., Rhimi, M., Philippe, C., Pons, N., Bruneau, A., Goustard, B., Daugé, V., Maguin, E., Naudon, L., & Rabot, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00216 · Cited by 269

Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms

Quinn, M., McMillin, M., Galindo, C., Frampton, G., Pae, H. Y., & DeMorrow, S. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.01.159 · Cited by 259

Plasma and Fecal Metabolite Profiles in Autism Spectrum Disorder

Needham, B. D., Adame, M. D., Serena, G., Rose, D. R., Preston, G. M., Conrad, M. C., Campbell, A. S., Donabedian, D. H., Fasano, A., Ashwood, P., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.09.025 · Cited by 254

An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder

Pu, J., Liu, Y., Zhang, H., Tian, L., Gui, S., Yu, Y., Chen, X., Chen, Y., Yang, L., Ran, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0645-4 · Cited by 252

The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids

Xiao, W., Su, J., Gao, X., Yang, H., Weng, R., Ni, W., & Gu, Y. (2022) · Microbiome · doi:10.1186/s40168-022-01255-6 · Cited by 252

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N6-carboxymethyllysine

Mossad, O., Batut, B., Yilmaz, B., Dokalis, N., Mezö, C., Nent, E., Nabavi, L. S., Mayer, M., Maron, F. J. M., Buescher, J. M., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01027-3 · Cited by 241

Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior

Potter, M., Elmer, G., Bergeron, R., Albuquerque, E. X., Guidetti, P., Wu, H., & Schwarcz, R. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.39 · Cited by 235

Role of intestinal microbiota in the generation of polyphenol‐derived phenolic acid mediated attenuation of Alzheimer's disease β‐amyloid oligomerization

Wang, D., Ho, L., Faith, J. J., Ono, K., Janle, E. M., Lachcik, P. J., Cooper, B. R., Jannasch, A., D’Arcy, B., Williams, B. A., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400544 · Cited by 231

Elevations of Endogenous Kynurenic Acid Produce Spatial Working Memory Deficits

Chess, A. C., Simoni, M. K., Alling, T. E., & Bucci, D. J. (2006) · Schizophrenia Bulletin · doi:10.1093/schbul/sbl033 · Cited by 227

Cerebral low-molecular metabolites influenced by intestinal microbiota: a pilot study

Matsumoto, M., Kibe, R., Ooga, T., Aiba, Y., Sawaki, E., Koga, Y., & Benno, Y. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00009 · Cited by 227

Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism

Rose, S., Bennuri, S. C., Davis, J. E., Wynne, R., Slattery, J. C., Tippett, M., Delhey, L., Melnyk, S., Kahler, S. G., MacFabe, D. F., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0089-z · Cited by 226

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Hoyles, L., Pontifex, M. G., Rodriguez-Ramiro, I., Anis-Alavi, M. A., Jelane, K. S., Snelling, T., Solito, E., Fonseca, S., Carvalho, A. L., Carding, S. R., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01181-z · Cited by 221

Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor

Wei, G. Z., Martin, K. A., Xing, P. Y., Agrawal, R., Whiley, L., Wood, T. K., Hejndorf, S., Ng, Y. Z., Low, J. Z. Y., Rossant, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021091118 · Cited by 220

Lactobacillus plantarum DR7 alleviates stress and anxiety in adults: a randomised, double-blind, placebo-controlled study

Chong, H.-X., Yusoff, N., Hor, Y.-Y., Lew, L.-C., Jaafar, M. H., Choi, S. B., Yusoff, M. S. B., Wahid, N. A., Abdullah, M. F. I. L. B., Zakaria, N., et al. (2019) · Beneficial Microbes · doi:10.3920/bm2018.0135 · Cited by 218

Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism

Shultz, S. R., MacFabe, D. F., Ossenkopp, K.-P., Scratch, S., Whelan, J., Taylor, R., & Cain, D. P. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.01.013 · Cited by 217

The gut microbiota metabolite indole alleviates liver inflammation in mice

Beaumont, M., Neyrinck, A. M., Olivares, M., Rodriguez, J., Nédélec, A., Roumain, M., Bindels, L. B., Cani, P. D., Evenepoel, P., Muccioli, G. G., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800544 · Cited by 214

Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

Baloni, P., Funk, C. C., Yan, J., Yurkovich, J. T., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100138 · Cited by 211

Etiology of autistic features: the persisting neurotoxic effects of propionic acid

El-Ansary, A. K., Bacha, A. B., & Kotb, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-74 · Cited by 209

Microbe-host interactions: influence of the gut microbiota on the enteric nervous system

Hyland, N. P., & Cryan, J. F. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.06.027 · Cited by 207

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

Brunt, V. E., LaRocca, T. J., Bazzoni, A. E., Sapinsley, Z. J., Miyamoto-Ditmon, J., Gioscia-Ryan, R. A., Neilson, A. P., Link, C. D., & Seals, D. R. (2021) · GeroScience · doi:10.1007/s11357-020-00257-2 · Cited by 197

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

Nunes, A. F., Amaral, J. D., Lo, A. C., Fonseca, M. B., Viana, R. J. S., Callaerts-Vegh, Z., D’Hooge, R., & Rodrigues, C. M. P. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8256-y · Cited by 192

Ferulic Acid Is a Nutraceutical β-Secretase Modulator That Improves Behavioral Impairment and Alzheimer-like Pathology in Transgenic Mice

Mori, T., Koyama, N., Guillot‐Sestier, M., Tan, J., & Town, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055774 · Cited by 191

Depression, Serotonin and Tryptophan

Dell’Osso, L., Carmassi, C., Mucci, F., & Marazziti, D. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666151214104826 · Cited by 191

Ferulic acid exerts neuroprotective effects against cerebral ischemia/reperfusion-induced injury via antioxidant and anti-apoptotic mechanisms in vitro and in vivo

Ren, Z., Zhang, R., Li, Y., Yu, L., Yang, Z., & Yang, H. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3127 · Cited by 191

Antiglycative and neuroprotective activity of colon‐derived polyphenol catabolites

Verzelloni, E., Pellacani, C., Tagliazucchi, D., Tagliaferri, S., Calani, L., Costa, L. G., Brighenti, F., Borges, G., Crozier, A., Conte, A., et al. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000525 · Cited by 190

L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE−/− transgenic mice expressing CETP

Collins, H. L., Drazul-Schrader, D., Sulpizio, A. C., Koster, P. D., Williamson, Y., Adelman, S. J., Owen, K., Sanli, T., & Bellamine, A. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.10.108 · Cited by 189

Phytochemicals and cognitive health: Are flavonoids doing the trick?

Bakoyiannis, I., Daskalopoulou, A., Pergialiotis, V., & Perrea, D. N. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.086 · Cited by 189

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

Dragicevic, N., Copes, N., O’Neal-Moffitt, G., Jin, J., Buzzeo, R. W., Mamcarz, M., Tan, J., Cao, C., Olcese, J., Arendash, G. W., et al. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00864.x · Cited by 185

Indoxyl Sulfate Affects Glial Function Increasing Oxidative Stress and Neuroinflammation in Chronic Kidney Disease: Interaction between Astrocytes and Microglia

Adesso, S., Magnus, T., Cuzzocrea, S., Campolo, M., Rissiek, B., Paciello, O., Autore, G., Pinto, A., & Marzocco, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00370 · Cited by 184

Gut microbiota-induced changes in β-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder

Leclercq, S., Le Roy, T., Furgiuele, S., Coste, V., Bindels, L. B., Leyrolle, Q., Neyrinck, A. M., Quoilin, C., Amadieu, C., Petit, G., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108238 · Cited by 178

Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

Xu, R., & Wang, Q. (2016) · BMC Systems Biology · doi:10.1186/s12918-016-0307-y · Cited by 175

Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory

Pocivavsek, A., Wu, H., Potter, M. C., Elmer, G. I., Pellicciari, R., & Schwarcz, R. M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.127 · Cited by 171

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

Li, X. S., Wang, Z., Čajka, T., Buffa, J. A., Nemet, I., Hurd, A. G., Gu, X., Skye, S. M., Roberts, A. B., Wu, Y., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99096 · Cited by 167

The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

Bermudez-Martin, P., Becker, J. A. J., Caramello, N., Fernández, S. P., Campos, R. C., Canaguier, J., Barbosa, S., Martínez-Gili, L., Myridakis, A., Dumas, M., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01103-z · Cited by 166

Urinary p-cresol is elevated in small children with severe autism spectrum disorder

Altieri, L., Neri, C., Sacco, R., Curatolo, P., Benvenuto, A., Muratori, F., Santocchi, E., Bravaccio, C., Lenti, C., Saccani, M., et al. (2011) · Biomarkers · doi:10.3109/1354750x.2010.548010 · Cited by 161

Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer’s disease

Marksteiner, J., Blasko, I., Kemmler, G., Koal, T., & Humpel, C. (2017) · Metabolomics · doi:10.1007/s11306-017-1297-5 · Cited by 161

Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer’s disease

Wong, A. O., Lüth, H., Deuther‐Conrad, W., Dukić-Stefanović, S., Gasic‐Milenkovic, J., Arendt, T., & Münch, G. W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02872-4 · Cited by 160

Obesity impairs short-term and working memory through gut microbial metabolism of aromatic amino acids

Arnoriaga-Rodríguez, M., Mayneris-Perxachs, J., Burokas, A., Contreras-Rodríguez, O., Blasco, G., Coll, C., Biarnés, C., Miranda-Olivos, R., Latorre, J., Moreno-Navarrete, J.-M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.09.002 · Cited by 157

Brain GLP-1 and the regulation of food intake: GLP-1 action in the brain and its implications for GLP-1 receptor agonists in obesity treatment

Trapp, S., & Brierley, D. I. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15638 · Cited by 154

Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice

Li, H., Sun, J., Wang, F., Ding, G., Chen, W., Fang, R., Yao, Y., Pang, M., Lu, Z.-Q., & Liu, J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.031 · Cited by 152

The aryl hydrocarbon receptor and the gut–brain axis

Barroso, A., Mahler, J. V., Fonseca-Castro, P. H., & Quintana, F. J. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00585-5 · Cited by 152

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

Haghikia, A., Jörg, S., Duscha, A., Berg, J., Manzel, A., Waschbisch, A., Hammer, A., Lee, D.-H., May, C., Wilck, N., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.04.006 · Cited by 122

Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders

Thomas, R., Foley, K. A., Mepham, J. R., Tichenoff, L. J., Possmayer, F., & MacFabe, D. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06614.x · Cited by 121

Glycogen is a preferred glutamate precursor during learning in 1‐day‐old chick: Biochemical and behavioral evidence

Gibbs, M. E., Lloyd, H., Santa, T., & Hertz, L. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21307 · Cited by 118

Maternal microbiota-derived metabolic profile in fetal murine intestine, brain and placenta

Pessa‐Morikawa, T., Husso, A., Kärkkäinen, O. K., Koistinen, V., Hanhineva, K., Iivanainen, A., & Niku, M. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02457-6 · Cited by 118

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

Dumas, M.-E., Rothwell, A. R., Hoyles, L., Aranias, T., Chilloux, J., Calderari, S., Noll, E. M., Péan, N., Boulangé, C. L., Blancher, C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.039 · Cited by 114

The Gut Microbiota Links Dietary Polyphenols With Management of Psychiatric Mood Disorders

Westfall, S., & Pasinetti, G. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01196 · Cited by 110

Genetic and metabolic links between the murine microbiome and memory

Mao, J., Kim, Y., Zhou, Y., Hu, D., Zhong, C., Chang, H., Brislawn, C., Fansler, S. J., Langley, S. A., Wang, Y., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00817-w · Cited by 108

Ergothioneine, a metabolite of the gut bacterium Lactobacillus reuteri, protects against stress-induced sleep disturbances

Matsuda, Y., Ozawa, N., Shinozaki, T., Wakabayashi, K.-I., Suzuki, K., Kawano, Y., Ohtsu, I., & Tatebayashi, Y. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0855-1 · Cited by 108

Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson’s disease

Sankowski, B., Księżarczyk, K., Raćkowska, E., Szlufik, S., Koziorowski, D., & Giebułtowicz, J. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.10.038 · Cited by 105

The Function of Lactic Acid Bacteria on Biogenic Amines Production by Food-Borne Pathogens in Arginine Decarboxylase Broth

Özoğul, F., Küley, E., Özoğul, Y., & Özoğul, İ. (2012) · Food Science and Technology Research · doi:10.3136/fstr.18.795 · Cited by 100

Hydrophilic bile acids protect human blood-brain barrier endothelial cells from disruption by unconjugated bilirubin: an in vitro study

Palmela, I., Correia, L., Silva, R. F. M., Sasaki, H., Kim, K. S., Brites, D. M. T. O., & Brito, M. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00080 · Cited by 98

Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats

O’Hagan, C., Li, J. V., Marchesi, J. R., Plummer, S. F., Garaiová, I., & Good, M. A. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.05.015 · Cited by 98

P-cresol Alters Brain Dopamine Metabolism and Exacerbates Autism-Like Behaviors in the BTBR Mouse

Pascucci, T., Colamartino, M., Fiori, E., Sacco, R., Coviello, A., Ventura, R., Puglisi‐Allegra, S., Turriziani, L., & Persico, A. M. (2020) · Brain Sciences · doi:10.3390/brainsci10040233 · Cited by 96

Nϵ-Carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease

Gironès, X., Guimerá, A., Cruz-Sánchez, C.-Z., Aznar, A. O., Sasaki, N., Makita, Z., Lafuente, J. V., Kalaria, R. N., & Cruz-Sánchez, F. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.006 · Cited by 95

The gut microbiota-related metabolite phenylacetylglutamine associates with increased risk of incident coronary artery disease

Ottosson, F. A., Brunkwall, L., Smith, E., Orho‐Melander, M., Nilsson, P. M., Fernandez, C., & Melander, O. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002569 · Cited by 95

Interactions between the microbiota and enteric nervous system during gut-brain disorders

Fried, S. G., Wemelle, E., Cani, P. D., & Knauf, C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108721 · Cited by 95

Contribution of gut microbiota to metabolism of dietary glycine betaine in mice and in vitro colonic fermentation

Koistinen, V., Kärkkäinen, O. K., Borewicz, K., Zarei, I., Jokkala, J., Micard, V., Rosa‐Sibakov, N., Auriola, S. O. K., Aura, A., Smidt, H., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0718-2 · Cited by 94

Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor

Shen, P.-X., Li, X., Deng, S.-Y., Zhao, L., Zhang, Y., Deng, X., Han, B., Yu, J., Li, Y., Wang, Z., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103227 · Cited by 94

Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement

Ota, M., Matsuo, J., Ishida, I., Hattori, K., Teraishi, T., Tonouchi, H., Ashida, K., Takahashi, T., & Kunugi, H. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4414-7 · Cited by 92

Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats

Zhao, Z., Xin, F., Zhou, D., Xue, Y., Liu, X., Yang, R., Pan, Q., & Fan, J. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i20.2450 · Cited by 85

Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice

Zeni, A. L. B., Camargo, A., & Dalmagro, A. P. (2017) · Steroids · doi:10.1016/j.steroids.2017.07.006 · Cited by 83

Neurobehavioral effects of uremic toxin–indoxyl sulfate in the rat model

Karbowska, M., Hermanowicz, J. M., Tankiewicz‐Kwedlo, A., Kałaska, B., Kaminski, T. W., Nosek, K., Rj, W., & Pawlak, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-66421-y · Cited by 82

Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication

Hulme, H., Meikle, L. M., Strittmatter, N., van der Hooft, J. J. J., Swales, J. G., Bragg, R. A., Villar, V. H., Ormsby, M. J., Barnes, S. A., Brown, S. L., et al. (2020) · Science Advances · doi:10.1126/sciadv.aax6328 · Cited by 74

Gut Microbiota-Derived Metabolite Trimethylamine N-Oxide as a Biomarker in Early Parkinson’s Disease

Chung, S. J., Rim, J. H., Ji, D., Lee, S., Yoo, H. S., Jung, J. H., Baik, K., Choi, Y., Ye, B. S., Sohn, Y. H., et al. (2021) · Nutrition · doi:10.1016/j.nut.2020.111090 · Cited by 74

The gut microbiota metabolite indole increases emotional responses and adrenal medulla activity in chronically stressed male mice

Mir, H.-D., Milman, A., Monnoye, M., Douard, V., Philippe, C., Aubert, A., Castanon, N., Vancassel, S., Guérineau, N. C., Naudon, L., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104750 · Cited by 72

Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients

Leyrolle, Q., Cserjési, R., Mulders, M. D. G. H., Zamariola, G., Hiel, S., Gianfrancesco, M. A., Rodriguez, J., Portheault, D., Amadieu, C., Leclercq, S., et al. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.09.025 · Cited by 72

Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats

Shultz, S. R., aziz, N. A., Yang, L., Sun, M., MacFabe, D. F., & O'Brien, T. J. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.050 · Cited by 70

The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats

Meng, F., Li, N., Li, D., Song, B., & Li, L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111902 · Cited by 68

Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study

Zhu, C., Li, G., Lv, Z., Li, J., Wang, X., Kang, J., & Zhan, C. (2019) · Neurological Sciences · doi:10.1007/s10072-019-04040-w · Cited by 65

Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein

da Silva, F. L., Cerqueira, E. C., de Freitas, M. S., Gonçalves, D. L., Costa, L. T., & Follmer, C. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.10.001 · Cited by 61

A host–gut microbial amino acid co-metabolite, p -cresol glucuronide, promotes blood–brain barrier integrity in vivo

Stachulski, A. V., Knausenberger, T. B.-A., Shah, S. N., Hoyles, L., & McArthur, S. (2023) · Tissue Barriers · doi:10.1080/21688370.2022.2073175 · Cited by 61

A Novel Endogenous Indole Protects Rodent Mitochondria and Extends Rotifer Lifespan

Pöeggeler, B., Sambamurti, K., Siedlak, S. L., Perry, G. L., Smith, M. A., & Pappolla, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010206 · Cited by 60

Involvement of classical neurotransmitter systems in memory reconsolidation: Focus on destabilization

Wideman, C. E., Jardine, K. H., & Winters, B. D. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.11.001 · Cited by 57

Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder

Zhou, Y., Zheng, W., Liu, W., Wang, C., Zhan, Y., Li, H., Chen, L., & Ning, Y. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.001 · Cited by 55

The Relationship between Fish Intake and Urinary Trimethylamine‐ N ‐Oxide

Yin, X., Gibbons, H., Rundle, M., Frost, G. S., McNulty, B. A., Nugent, A. P., Walton, J., Flynn, A., & Brennan, L. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900799 · Cited by 54

Whole grain intake associated molecule 5-aminovaleric acid betaine decreases β-oxidation of fatty acids in mouse cardiomyocytes

Kärkkäinen, O. K., Tuomainen, T., Koistinen, V., Tuomainen, M. H., Leppänen, J., Laitinen, T., Lehtonen, M., Rysä, J., Auriola, S. O. K., Poso, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31484-5 · Cited by 49

Causal relationships between gut metabolites and Alzheimer's disease: a bidirectional Mendelian randomization study

Zhuang, Z., Gao, M., Yang, R., Liu, Z., Cao, W., & Huang, T. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.10.022 · Cited by 49

Serotonin's Complex Role in Alcoholism: Implications for Treatment and Future Research

Marcinkiewcz, C. A., Lowery‐Gionta, E. G., & Kash, T. L. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13076 · Cited by 43

Urolithin A Prevents Focal Cerebral Ischemic Injury via Attenuating Apoptosis and Neuroinflammation in Mice

Lin, X.-H., Ye, X., Li, Q.-F., Gong, Z., Cao, X., Li, J., Zhao, S., Sun, X., He, X., & Xuan, A. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.09.027 · Cited by 41

Saccharomyces boulardii CNCM I‐745 modulates the microbiota–gut–brain axis in a humanized mouse model of Irritable Bowel Syndrome

Constante, M., Palma, G. D., Lu, J., Jury, J., Rondeau, L. E., Caminero, A., Collins, S. M., Verdu, E. F., & Berčík, P. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.13985 · Cited by 41

Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes

Jensen, N. J., Nilsson, M., Ingerslev, J. S., Olsen, D. A., Fenger, M., Svart, M. V., Møller, N., Zander, M., Miskowiak, K. W., & Rungby, J. (2019) · European Journal of Endocrinology · doi:10.1530/eje-19-0710 · Cited by 40

Gut microbiota maturation during early human life induces enterocyte proliferation via microbial metabolites

Dougherty, M. W., Kudin, O., Mühlbauer, M., Neu, J., Gharaibeh, R. Z., & Jobin, C. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01892-7 · Cited by 39

Decreased plasma serotonin and other metabolite changes in healthy adults after consumption of wholegrain rye: an untargeted metabolomics study

Keski‐Rahkonen, P., Kolehmainen, M., Lappi, J., Micard, V., Jokkala, J., Rosa‐Sibakov, N., Pihlajamäki, J., Kirjavainen, P. V., Mykkänen, H. M., Poutanen, K. S., et al. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqy394 · Cited by 38

Differential Effects of Whole Red Raspberry Polyphenols and Their Gut Metabolite Urolithin A on Neuroinflammation in BV-2 Microglia

Toney, A. M., Albusharif, M., Works, D., Polenz, L., Schlange, S., Chaidez, V., Ramer‐Tait, A. E., & Chung, S. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18010068 · Cited by 33

Fecal Short-Chain Fatty Acids Levels Were Not Associated With Autism Spectrum Disorders in Chinese Children: A Case–Control Study

Wang, J., Pan, J., Chen, H., Li, Y., Amakye, W. K., Liang, J., Ma, B., Chu, X., Mao, L., & Zhang, Z. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01216 · Cited by 32

Does pipecolic acid interact with the central GABA-ergic system?

Bernasconi, R., Jones, R. S. G., Bittiger, H., et al. (1986) · Journal of Neural Transmission · doi:10.1007/bf01243346 · Cited by 26

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193

Microbiota–neuroepithelial signalling across the gut–brain axis

Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147

Microbiota from healthy mice alleviates cognitive decline via reshaping the gut-brain metabolic axis in diabetic mice

Zhao, Q., Chen, J., Wu, M., Yin, X., Jiang, Q., Gao, H., & Zheng, H. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110638 · Cited by 49

Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy

Wang, X., Wen, X., Yuan, S., & Zhang, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106499 · Cited by 47

The rearing environment persistently modulates mouse phenotypes from the molecular to the behavioural level

Jaric, I., Voelkl, B., Clerc, M., Schmid, M. W., Novak, J., Rosso, M., Rufener, R., von Kortzfleisch, V. T., Richter, S. H., Buettner, M., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001837 · Cited by 32

Gut hormones in microbiota-gut-brain cross-talk

Sun, L.-J., Li, J.-N., & Nie, Y.-Z. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000706 · Cited by 145

The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota

Al-Khafaji, A. H., Jepsen, S. D., Christensen, K. R., & Vigsnæs, L. K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104176 · Cited by 62

The role of gut microbiota in the gut-brain axis: current challenges and perspectives

Chen, X., D’Souza, R., & Hong, S. (2013) · Protein & Cell · doi:10.1007/s13238-013-3017-x · Cited by 160

Role of gut microbiota via the gut-liver-brain axis in digestive diseases

Ding, J., Jin, Z., Yang, X., Lou, J., Shan, W., Hu, Y., Du, Q., Liao, Q., Xie, R., & Xu, J. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i40.6141 · Cited by 183

Gut microbiota-brain axis

Wang, H.-X., & Wang, Y.-P. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.190667 · Cited by 546