Cited by 34Neuroscience and Neural EngineeringConducting polymers and applicationsAdvanced Materials and Mechanics

From softening polymers to multimaterial based bioelectronic devices

Open access
Ecker, Melanie, Joshi-Imre, Alexandra, Modi, Romil, Frewin, Christopher L., Garcia-Sandoval, Aldo, Maeng, Jimin, Gutierrez-Heredia, Gerardo, Pancrazio, Joseph J +1 more·2019·Multifunctional Materials

Abstract

A recent development in bioelectronic devices involves the utilization of multifunctional polymers as substrate material. Dynamically softening, thin-film polymers reduce the mechanical mismatch between device and tissue after implantation and therefore improves the device–tissue interaction. However, when implementing a new material into the fabrication of fully functional and chronically viable devices, there are specific challenges that need to be addressed. The key for all multimaterial devices is to ensure a good adhesion and connectivity between the different layers. That is especially true if one of the materials is sensitive to stimuli such as temperature and moisture. This review will give an overview on the development of a variety of neural interfaces for recording and stimulation with softening shape memory polymers (SMPs) as substrate material. This review discusses specific requirements for device fabrication, testing, and durability.

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  • Several forms of extraneural electrodes have been proposed to replace intraneural electrodes, which penetrate into the nerve fascicles, to decrease damage to nerves and increase long-term stability.

    “To decrease damage to nerves and increase long-term stability, several forms of extraneural electrodes have been proposed to replace intraneural electrodes, which penetrate into the nerve fascicles (3, 4).”

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Research works printed but not linked: 4

  1. Stiller A et al Chronic intracortical recording and electrochemical stability of thiol-ene/acrylate shape memory polymer electrode arrays Micromachines 2018 9 500 · DOI
  2. S M, Song E, Zhao J, Li J, Rivnay J and Rogers J A 2018 Recent advances in materials, devices, and systems for neural interfaces Adv. Mater. 30 1800534 · DOI · Paper page
  3. Garcia-Sandoval A et al , 2018 Chronic softening spinal cord stimulation arrays J. Neural Eng. 15 045002 · DOI
  4. Zhang J, Li Y, Zhang B, Wang H, Xin Q and Song A 2015 Flexible indium-gallium-zinc-oxide Schottky diode operating beyond 2.45 GHz Nat. Commun. 6 7561 [138] FDA 2016 Updated 510(k) sterility review guidance K90-1; Guidence for industry and FDA US Department of Health and Human Services FaDA, Center for Devices and Radiological Health · DOI

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Authors
Ecker, M., Joshi-Imre, A., Modi, R., Frewin, C. L., Garcia-Sandoval, A., Maeng, J., Gutierrez-Heredia, G., Pancrazio, J. J., & Voit, W. E.
Affiliations
The University of Texas at Dallas (US)
Corresponding author
Ecker, Melanie
Venue
Multifunctional Materials
Published
2018-12-11
Volume
2
Issue
1
Pages
012001
ISSN
2399-7532 (ISSN-L)
OpenAlex
W2899350098
Cited by
34
References
175
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 8 · 2020: 7 · 2019: 7
FWCI
2.51
Type
journal article
Language
en
Open access
Locations
Multifunctional Materials (publishedVersion)
Funders
  • Congressionally Directed Medical Research Programs (W81XWH-15-1-0607)
  • Foundation for the National Institutes of Health (NIH R21EB020318)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
  • Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
Keywords
shape memory polymers, bioelectronic devices, neural interfaces, biomedical implants, polymer thin films, layer adhesion, neural recording, neurostimulation, device durability

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