Cited by 1,640Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesTryptophan and brain disorders

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Neuroinflammation: the devil is in the details

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DiSabato, Damon J., Quan, Ning, Godbout, Jonathan P.·2016·Journal of Neurochemistry

DOI 10.1111/jnc.13607PMC PMC5025335

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Abstract

There is significant interest in understanding inflammatory responses within the brain and spinal cord. Inflammatory responses that are centralized within the brain and spinal cord are generally referred to as ‘neuroinflammatory’. Aspects of neuroinflammation vary within the context of disease, injury, infection, or stress. The context, course, and duration of these inflammatory responses are all critical aspects in the understanding of these processes and their corresponding physiological, biochemical, and behavioral consequences. Microglia, innate immune cells of the CNS , play key roles in mediating these neuroinflammatory responses. Because the connotation of neuroinflammation is inherently negative and maladaptive, the majority of research focus is on the pathological aspects of neuroinflammation. There are, however, several degrees of neuroinflammatory responses, some of which are positive. In many circumstances including CNS injury, there is a balance of inflammatory and intrinsic repair processes that influences functional recovery. In addition, there are several other examples where communication between the brain and immune system involves neuroinflammatory processes that are beneficial and adaptive. The purpose of this review is to distinguish different variations of neuroinflammation in a context‐specific manner and detail both positive and negative aspects of neuroinflammatory processes. image In this review, we will use brain and spinal cord injury, stress, aging, and other inflammatory events to illustrate the potential harm and benefits inherent to neuroinflammation. Context, course, and duration of the inflammation are highly important to the interpretation of these events, and we aim to provide insight into this by detailing several commonly studied insults. This article is part of the 60th anniversary supplemental issue .

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“Furthermore, persistent changes in microglia and astrocytes after penetrating TBI, such as increased MHC II expression in rats 16 days post-injury, are caused by CCI (Holmin et al. 1995).”
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10.1016/S1071-5576(00)00038-1 · DOI
10.1016/j.bbi.2010.02.001 · DOI · Paper page

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Authors: DiSabato, D. J., Quan, N., & Godbout, J. P.
Affiliations: The Ohio State University (US)
Corresponding author: Godbout, Jonathan P.
ORCID: DiSabato, Damon J.
Quan, Ning
Godbout, Jonathan P.
Venue: Journal of Neurochemistry
Publisher: Wiley
Published: 2016-05-04
Volume: 139
Issue: S2
Pages: 136-153
ISSN: 0022-3042 (ISSN-L)
1471-4159
DOI: 10.1111/jnc.13607
PMC: PMC5025335
OpenAlex: W2302151110
Cited by: 1,640
References: 202
Citations by year: 2026: 159 · 2025: 241 · 2024: 297 · 2023: 265 · 2022: 235 · 2021: 194 · 2020: 129 · 2019: 65 · 2018: 25 · 2017: 22 · 2016: 6
FWCI: 3.45
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neurochemistry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01‐AG‐033028)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: neuroinflammation, microglia, spinal cord injury, brain injury, stress, aging, functional recovery, central nervous system injury
MeSH terms: Aging, Animals, Brain, Humans, Inflammation, Spinal Cord, Microglia, Neurodegenerative Diseases

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Neuroinflammation: the devil is in the details

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