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Rho GTPases and the Actin Cytoskeleton

Hall, Alan·1998·Science

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Abstract

The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.

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Untitled work
(2000) · PubMed

Authors: Hall, A.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-01-23
Volume: 279
Issue: 5350
Pages: 509-514
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.279.5350.509
OpenAlex: W2096791952
Cited by: 6,140
References: 1
FWCI: 147.22
Type: journal article
Language: en
Open access: closed

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Rho GTPases and the Actin Cytoskeleton

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