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Signals That Regulate Food Intake and Energy Homeostasis
Abstract
Feeding behavior is critical for survival. In addition to providing all of the body's macronutrients (carbohydrates, lipids, and proteins) and most micronutrients (minerals and vitamins), feeding behavior is a fundamental aspect of energy homeostasis, the process by which body fuel stored in the form of adipose tissue is held constant over long intervals. For this process to occur, the amount of energy consumed must match precisely the amount of energy expended. This review focuses on the molecular signals that modulate food intake while integrating the body's immediate and long-term energy needs.
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Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80949-6 · Cited by 5,501
Abnormal splicing of the leptin receptor in diabetic mice
Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature · doi:10.1038/379632a0 · Cited by 2,327
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014
Self-citationReceptor-mediated regional sympathetic nerve activation by leptin.
Haynes, W. G., Morgan, D. A., Walsh, S. A., Mark, A. L., & Sivitz, W. I. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119532 · Cited by 979
Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus
Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.10.5570 · Cited by 769
Baura, G. D., Foster, D. M., Porte, D., Kahn, S. E., Bergman, R. N., Cobelli, C., & Schwartz, M. W. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116773 · Cited by 489
Self-citationRegulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
Thornton, J. E., Cheung, C. C., Clifton, D. K., & Steiner, R. A. (1997) · Endocrinology · doi:10.1210/endo.138.11.5651 · Cited by 437
Cited by
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Self-citationRole of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586
Motivation concepts in behavioral neuroscience
Berridge, K. C. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.004 · Cited by 1,302
Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area
Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924
Hypothalamic insulin signaling is required for inhibition of glucose production
Obici, S., Zhang, B. B., Karkanias, G., & Rossetti, L. (2002) · Nature Medicine · doi:10.1038/nm1202-798 · Cited by 904
Neuropeptide Transmission in Brain Circuits
van den Pol, A. N. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.014 · Cited by 810
Broberger, C., Johansen, J., Johansson, C., Schalling, M., & Hökfelt, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.15043 · Cited by 798
Leptin Regulation of Neuroendocrine Systems
Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767
Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake
Obici, S., Feng, Z., Morgan, K., Stein, D., Karkanias, G., & Rossetti, L. (2002) · Diabetes · doi:10.2337/diabetes.51.2.271 · Cited by 654
Kumanyika, S. K., Obarzanek, E., Stettler, N., Bell, R., Field, A. E., Fortmann, S. P., Franklin, B. A., Gillman, M. W., Lewis, C. E., Poston, W. C., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189702 · Cited by 636
Key enzyme in leptin-induced anorexia
Niswender, K. D., Morton, G. J., Stearns, W. H., Rhodes, C. J., Myers, M. G., & Schwartz, M. W. (2001) · Nature · doi:10.1038/35101657 · Cited by 585
Self-citationPresynaptic facilitation by neuropeptide signaling mediates odor-driven food search
Root, C. M., Ko, K. I., Jafari, A., & Wang, J. W. (2011) · Cell · doi:10.1016/j.cell.2011.02.008 · Cited by 526
Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin
Clegg, D. J., Brown, L. M., Woods, S. C., & Benoit, S. C. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1339 · Cited by 552
Self-citationHypothalamic sensing of fatty acids
Lam, T. K. T., Schwartz, G. J., & Rossetti, L. (2005) · Nature Neuroscience · doi:10.1038/nn1456 · Cited by 478
Freedman, M. R., King, J., & Kennedy, E. (2001) · Obesity Research · doi:10.1038/oby.2001.113 · Cited by 421
The Catabolic Action of Insulin in the Brain Is Mediated by Melanocortins
Benoit, S. C., Air, E. L., Coolen, L. M., Strauss, R., Jackman, A., Clegg, D. J., Seeley, R. J., & Woods, S. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09048.2002 · Cited by 417
Self-citationDopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice
Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00319-1 · Cited by 354
Neurobiology of Feeding and Energy Expenditure
Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346
Differential Sensitivity to Central Leptin and Insulin in Male and Female Rats
Clegg, D. J., Riedy, C. A., Smith, K. A. B., Benoit, S. C., & Woods, S. C. (2003) · Diabetes · doi:10.2337/diabetes.52.3.682 · Cited by 332
Self-citationMyers, B., McKlveen, J. M., & Herman, J. P. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.12.003 · Cited by 318
Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats
An, H. M., Park, S. Y., Lee, D. K., Kim, J. R., Cha, M. K., Lee, S. W., Lim, H. T., Kim, K. J., & Ha, N. J. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-116 · Cited by 320
Nicotinic receptor‐mediated effects on appetite and food intake
Jo, Y., Talmage, D. A., & Role, L. W. (2002) · Journal of Neurobiology · doi:10.1002/neu.10147 · Cited by 323
Muise, E. S., Azzolina, B., Kuo, D. W., El-Sherbeini, M., Tan, Y., Yuan, X., Mu, J., Thompson, J. R., Berger, J. P., & Wong, K. K. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.044826 · Cited by 294
Cognitive effects of insulin in the central nervous system
Park, C. R. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00016-1 · Cited by 270
Insulin and Leptin as Adiposity Signals
Benoit, S. C. (2004) · Recent Progress in Hormone Research · doi:10.1210/rp.59.1.267 · Cited by 266
“Many reviews of these phenomena have been written (Schwartz et al., 1992; Porte et al., 1998; Woods et al., 1998,2003 ).”
BackgroundInfluentialObesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms
Corbin, K. D., Driscoll, K. A., Pratley, R. E., Smith, S. R., Maahs, D. M., Mayer-Davis, E. J., & Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) (2018) · Endocrine Reviews · doi:10.1210/er.2017-00191 · Cited by 262
Dietary fat is not a major determinant of body fat
Willett, W. C., & Leibel, R. L. (2002) · The American Journal of Medicine · doi:10.1016/s0002-9343(01)00992-5 · Cited by 241
Sexual differences in the control of energy homeostasis
Shi, H., Seeley, R. J., & Clegg, D. J. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.004 · Cited by 242
“Body weight regulation is thought to occur through negative feedback mechanisms which characterize most homeostatic systems [43], [131], [144], [146] and [172] involving adiposity signals.”
BackgroundSelf-citationAnti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice
Kang, J.-H., Yun, S.-I., Park, M.-H., Park, J.-H., Jeong, S.-Y., & Park, H.-O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054617 · Cited by 230
Current and investigational antiobesity agents and obesity therapeutic treatment targets
Bays, H. E. (2004) · Obesity Research · doi:10.1038/oby.2004.151 · Cited by 228
Gerich, J. E. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.4.447 · Cited by 222
A look inside the diabetic brain: Contributors to diabetes-induced brain aging
Wrighten, S. A., Piroli, G. G., Grillo, C. A., & Reagan, L. P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.013 · Cited by 195
Bajzer, M., & Seeley, R. J. (2006) · Nature · doi:10.1038/4441009a · Cited by 196
Self-citationLifetime health and economic benefits of weight loss among obese persons.
Oster, G., Thompson, D., Edelsberg, J., Bird, A. P., & Colditz, G. A. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.10.1536 · Cited by 193
Nogueiras, R., Pérez-Tilve, D., Veyrat-Durebex, C., Morgan, D. A., Varela, L., Haynes, W. G., Patterson, J. T., Disse, E., Pfluger, P. T., López, M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5977-08.2009 · Cited by 182
Self-citationHallschmid, M., Higgs, S., Thienel, M., Ott, V., & Lehnert, H. (2012) · Diabetes · doi:10.2337/db11-1390 · Cited by 181
Cardiovascular and Endocrine Alterations After Masturbation-Induced Orgasm in Women
Exton, M. S., Bindert, A., Kruger, T., Scheller, F., Hartmann, U., & Schedlowski, M. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199905000-00005 · Cited by 174
The physiological control of eating: signals, neurons, and networks
Watts, A. G., Kanoski, S. E., Sanchez-Watts, G., & Langhans, W. (2022) · Physiological Reviews · doi:10.1152/physrev.00028.2020 · Cited by 168
Chen, H., Vlahos, R., Bozinovski, S., Jones, J., Anderson, G. P., & Morris, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300597 · Cited by 165
Hypothalamic inflammation and obesity: a mechanistic review
Seong, J., Kang, J. Y., Sun, J. S., & Kim, K. W. (2019) · Archives of Pharmacal Research · doi:10.1007/s12272-019-01138-9 · Cited by 158
Intraventricular insulin and leptin reduce food intake and body weight in C57BL/6J mice
Brown, L. M., Clegg, D. J., Benoit, S. C., & Woods, S. C. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.08.008 · Cited by 139
Self-citationJousse, C., Parry, L., Lambert‐Langlais, S., Maurin, A., Averous, J., Bruhat, A., Carraro, V., Tost, J., Letteron, P., Chen, P., et al. (2011) · The FASEB Journal · doi:10.1096/fj.11-181792 · Cited by 139
Signals that influence food intake and body weight
WOODS, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.060 · Cited by 131
Self-citationDiet in the management of weight loss
Strychar, I. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.045037 · Cited by 129
The role of hypothalamic estrogen receptors in metabolic regulation
Frank, A., Brown, L. M., & Clegg, D. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.002 · Cited by 128
“The hypothalamus exerts its influence on energy homeostasis through regulation of both anabolic and catabolic pathways [16; 17; 18].”
Dynamic body weight and body composition changes in response to subordination stress
Tamashiro, K. L. K., Hegeman, M. A., Nguyen, M. M. N., Melhorn, S. J., Ma, L. Y., Woods, S. C., & Sakai, R. R. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.004 · Cited by 115
Self-citationThe regulation of total body fat: lessons learned from lipectomy studies
Mauer, M. M., Harris, R. B. S., & Bartness, T. J. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00047-6 · Cited by 112
Watts, A. G., Sanchez-Watts, G., & Kelly, A. B. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-06111.1999 · Cited by 102
Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production
Yang, C. S., Lam, C. K. L., Chari, M., Cheung, G. W. C., Kokorovic, A., Gao, S., Leclerc, I., Rutter, G. A., & Lam, T. K. T. (2010) · Diabetes · doi:10.2337/db10-0221 · Cited by 86
The human intronless melanocortin 4-receptor gene is NMD insensitive
Brocke, K. S. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.3.331 · Cited by 84
Roelofsen, H., Priebe, M., & Vonk, R. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0028 · Cited by 80
Roman, E. A. F. R., Reis, D., Romanatto, T., Maimoni, D., Ferreira, E. A., Santos, G. A., Torsoni, A. S., Velloso, L. A., & Torsoni, M. A. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.007 · Cited by 71
Fibroblast growth factor-21 controls dietary protein intake in male mice
Larson, K. R., Chaffin, A. T.-B., Goodson, M. L., Fang, Y., & Ryan, K. K. (2019) · Endocrinology · doi:10.1210/en.2018-01056 · Cited by 68
Cheng, Y., Zhang, Q., Meng, Q., Xia, T., Huang, Z., Wang, C., Liu, B., Chen, S., Xiao, F., Du, Y., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0028 · Cited by 65
If Body Fatness is Under Physiological Regulation, Then How Come We Have an Obesity Epidemic?
Speakman, J. R. (2014) · Physiology · doi:10.1152/physiol.00053.2013 · Cited by 53
Classically conditioned responses following repeated insulin and glucose administration in humans
Stockhorst, U., Steingrüber, H.-J., & Scherbaum, W. A. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00192-8 · Cited by 44
Mice lacking the thyrotropin-releasing hormone gene: what do they tell us?
Yamada, M., Satoh, T., & Mori, M. (2003) · Thyroid · doi:10.1089/10507250360731505 · Cited by 42
The Brain-Gut-Islet Connection
Woods, S. C., Benoit, S. C., & Clegg, D. J. (2006) · Diabetes · doi:10.2337/db06-s015 · Cited by 30
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West, J. S., Ayton, T., Wallman, K. E., & Guelfi, K. J. (2012) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.22.6.422 · Cited by 25
Chronic food restriction and reduced dietary fat: risk factors for bouts of overeating
OGAWA, R., STRADER, A., CLEGG, D., SAKAI, R., SEELEY, R., & WOODS, S. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.08.028 · Cited by 15
Self-citationCentral Control of Glucose Homeostasis
Puglianiello, A., & Cianfarani, S. (2006) · The Review of Diabetic Studies · doi:10.1900/rds.2006.3.54 · Cited by 14
Metadata
- Authors
- Woods, S. C., Seeley, R. J., Porte, D., & Schwartz, M. W.
- Venue
- Science
- Published
- 1998-05-29
- Volume
- 280
- Issue
- 5368
- Pages
- 1378-1383
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2130935482
- Cited by
- 1,169
- References
- 13
- FWCI
- 29.40
- Type
- journal article
- Language
- en
- Open access
- closed
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