Cited by 221Antifungal resistance and susceptibilityFungal and yeast genetics researchYeasts and Rust Fungi Studies

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Transcriptome Assembly and Profiling of Candida auris Reveals Novel Insights into Biofilm-Mediated Resistance

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Kean, Ryan, Delaney, Christopher, Sherry, Leighann, Borman, Andrew, Johnson, Elizabeth M., Richardson, Malcolm D., Rautemaa-Richardson, Riina, Williams, Craig, Ramage, Gordon·2018·mSphere

DOI 10.1128/msphere.00334-18PMC PMC6041501

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Abstract

Fungal infections represent an important cause of human morbidity and mortality, particularly if the fungi adhere to and grow on both biological and inanimate surfaces as communities of cells (biofilms). Recently, a previously unrecognized yeast, Candida auris , has emerged globally that has led to widespread concern due to the difficulty in treating it with existing antifungal agents. Alarmingly, it is also able to grow as a biofilm that is highly resistant to antifungal agents, yet we are unclear about how it does this. Here, we used a molecular approach to investigate the genes that are important in causing the cells to be resistant within the biofilm. The work provides significant insights into the importance of efflux pumps, which actively pump out toxic antifungal drugs and therefore enhance fungal survival within a variety of harsh environments.

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Authors: Kean, R., Delaney, C., Sherry, L., Borman, A., Johnson, E. M., Richardson, M. D., Rautemaa-Richardson, R., Williams, C., & Ramage, G.
Affiliations: University of Glasgow (GB)
Public Health England (GB)
Manchester Academic Health Science Centre (GB)
Mycology Reference Centre Manchester, University Hospital of South Manchester & University of Manchester, Manchester Academic Health Sciences Centre, Faculty of Biology, Medicine and Health, Division of Infection, Immunity and Respiratory Medicine, Manchester, United Kingdom
European Society of Clinical Microbiology and Infectious Diseases (CH)
Corresponding author: Ramage, Gordon
ORCID: Kean, Ryan
Delaney, Christopher
Sherry, Leighann
Borman, Andrew
Johnson, Elizabeth M.
Richardson, Malcolm D.
Williams, Craig
Ramage, Gordon
Venue: mSphere
Publisher: American Society for Microbiology
Published: 2018-08-29
Volume: 3
Issue: 4
ISSN: 2379-5042 (ISSN-L)
DOI: 10.1128/msphere.00334-18
PMC: PMC6041501
OpenAlex: W2811231377
Cited by: 220
References: 65
Citations by year: 2026: 27 · 2025: 26 · 2024: 28 · 2023: 32 · 2022: 23 · 2021: 28 · 2020: 35 · 2019: 18 · 2018: 3
FWCI: 15.88
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
journals.asm.org/non-commercial-tdm-license (tdm)
Locations: mSphere (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
The UWS Academic Portal (University of the West of Scotland) (submittedVersion, cc-by-nc-nd)
Research Explorer (The University of Manchester) (submittedVersion, cc-by)
The UWS Academic Portal (University of the West of Scotland) (submittedVersion, cc-by)
Funders: ESCMID
RCUK | Biotechnology and Biological Sciences Research Council (BB/P504567/1)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
Keywords: Candida auris, biofilm, antifungal resistance, efflux pumps, transcriptome, gene expression profiling, multidrug resistance, fungal infection
MeSH terms: Biological Transport, Active, Candida, Biofilms, Gene Expression Profiling, Drug Resistance, Fungal, Membrane Transport Proteins

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Transcriptome Assembly and Profiling of Candida auris Reveals Novel Insights into Biofilm-Mediated Resistance

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