Cited by 348Neuroscience and Neuropharmacology ResearchRNA and protein synthesis mechanismsGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

Open access

Buffington, Shelly A., Huang, Wei, Costa-Mattioli, Mauro·2014·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-071013-014100PMC PMC4721605

Open this paper in CoChat — free account Open PDF

Abstract

Activity-dependent changes in the strength of synaptic connections are fundamental to the formation and maintenance of memory. The mechanisms underlying persistent changes in synaptic strength in the hippocampus, specifically long-term potentiation and depression, depend on new protein synthesis. Such changes are thought to be orchestrated by engaging the signaling pathways that regulate mRNA translation in neurons. In this review, we discuss the key regulatory pathways that govern translational control in response to synaptic activity and the mRNA populations that are specifically targeted by these pathways. The critical contribution of regulatory control over new protein synthesis to proper cognitive function is underscored by human disorders associated with either silencing or mutation of genes encoding proteins that directly regulate translation. In light of these clinical implications, we also consider the therapeutic potential of targeting dysregulated translational control to treat cognitive disorders of synaptic dysfunction.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1146/annurev-neuro-071013-014100

Cites

166 of 166 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
Genome-wide atlas of gene expression in the adult mouse brain
Lein, E. S., Hawrylycz, M. J., Ao, N., Ayres, M., Bensinger, A., Bernard, A., Boe, A. F., Boguski, M. S., Brockway, K. S., Byrnes, E. J., et al. (2007) · Nature · doi:10.1038/nature05453 · Cited by 5,572
Memory - A century of consolidation
McGaugh, J. L. (2000) · Science · doi:10.1126/science.287.5451.248 · Cited by 4,250
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181
LTP and LTD
Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304
The mechanism of eukaryotic translation initiation and principles of its regulation
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2838 · Cited by 2,759
Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval
Nader, K., Schafe, G. E., & Le Doux, J. E. (2000) · Nature · doi:10.1038/35021052 · Cited by 2,706
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558
FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736 · cited 1×
“Proteins synthesized locally in dendrites could be captured by synapses that have been “tagged” by previous activity, in what is defined as the synaptic tagging hypothesis (Frey & Morris 1997, Martin et al. 1997, Redondo & Morris 2011).”
Background
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
Vattem, K. M., & Wek, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400541101 · Cited by 1,696
A unifying model for mTORC1-mediated regulation of mRNA translation
Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., & Sabatini, D. M. (2012) · Nature · doi:10.1038/nature11083 · Cited by 1,477
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,366
The translational landscape of mTOR signalling steers cancer initiation and metastasis
Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., et al. (2012) · Nature · doi:10.1038/nature10912 · Cited by 1,313
TRANSLATIONAL REGULATION OFGCN4AND THE GENERAL AMINO ACID CONTROL OF YEAST
Hinnebusch, A. G. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.031805.133833 · Cited by 1,297
Synaptic plasticity, memory and the hippocampus: a neural network approach to causality
Neves, G., Cooke, S. F., & Bliss, T. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2303 · Cited by 1,287
Multiplex Targeted Sequencing Identifies Recurrently Mutated Genes in Autism Spectrum Disorders
O’Roak, B. J., Vives, L., Fu, W., Egertson, J. D., Stanaway, I. B., Phelps, I. G., Carvill, G., Kumar, A., Lee, C., Ankenman, K., et al. (2012) · Science · doi:10.1126/science.1227764 · Cited by 1,240
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051
mRNA localization: Gene expression in the spatial dimension
Martin, K. C., & Ephrussi, A. (2009) · Cell · doi:10.1016/j.cell.2009.01.044 · Cited by 1,048
Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression.
Huber, K., Kayser, M., & Bear, M. (2000) · Science · doi:10.1126/science.288.5469.1254 · Cited by 1,015
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
Lu, P. D., Harding, H. P., & Ron, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408003 · Cited by 1,006
A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity
Kang, H., & Schuman, E. M. (1996) · Science · doi:10.1126/science.273.5280.1402 · Cited by 996
The epidemiology of autism: a review
FOMBONNE, E. (1999) · Psychological Medicine · doi:10.1017/s0033291799008508 · Cited by 981
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970
Translational control of long-lasting synaptic plasticity and memory
Costa-Mattioli, M., Sossin, W. S., Klann, E., & Sonenberg, N. (2009) · Neuron · doi:10.1016/j.neuron.2008.10.055 · Cited by 944
Self-citation
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 938
Application of a translational profiling approach for the comparative analysis of CNS cell types
Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.029 · Cited by 912
Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Ehninger, D., Han, S., Shilyansky, C., Zhou, Y., Li, W., Kwiatkowski, D. J., Ramesh, V., & Silva, A. J. (2008) · Nature Medicine · doi:10.1038/nm1788 · Cited by 882
Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities
Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797
Making memories last: the synaptic tagging and capture hypothesis
Redondo, R. L., & Morris, R. G. M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2963 · Cited by 792
Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage
Martin, K. C., Casadio, A., Zhu, H., Yaping, E., Rose, J. C., Chen, M., Bailey, C. H., & Kandel, E. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80484-5 · Cited by 740
A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus
Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734
Protein synthesis at synaptic sites on dendrites.
Steward, O., & Schuman, E. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.299 · Cited by 731
Pharmacological brake-release of mRNA translation enhances cognitive memory
Sidrauski, C., Acosta‐Alvear, D., Khoutorsky, A., Vedantham, P., Hearn, B. R., Li, H., Gamache, K., Gallagher, C. M., Ang, K. K. H., Wilson, C. G. M., et al. (2013) · eLife · doi:10.7554/elife.00498 · Cited by 716
The local transcriptome in the synaptic neuropil revealed by deep sequencing and high-resolution imaging
Cajigas, I. J., Tushev, G., Will, T. J., tom Dieck, S., Fuerst, N., & Schuman, E. M. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.036 · Cited by 709
Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus
Steward, O., & Levy, W. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-03-00284.1982 · Cited by 676
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasisPreprint
Ruvinsky, I., Sharon, N., Lerer, T., Cohen, H., Stolovich-Rain, M., Nir, T., Dor, Y., Zisman, P., & Meyuhas, O. (2005) · Genes & Development · doi:10.1101/gad.351605 · Cited by 668
Translational control in biology and medicine
Mathews, M. B., Sonenberg, N., & Hershey, J. W. B. (2007) · Cited by 661
The Restless Engram: Consolidations Never End
Dudai, Y. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150500 · Cited by 644
The dsRNA protein kinase PKR: Virus and cell control
García, M. A., Meurs, E. F., & Esteban, M. (2007) · Biochimie · doi:10.1016/j.biochi.2007.03.001 · Cited by 644
Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.025 · Cited by 633
Miniature Neurotransmission Stabilizes Synaptic Function via Tonic Suppression of Local Dendritic Protein Synthesis
Sutton, M. A., Ito, H. T., Cressy, P., Kempf, C., Woo, J. C., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.03.040 · Cited by 633
Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease
Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627
The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
Napoli, I., Mercaldo, V., Boyl, P. P., Eleuteri, B., Zalfa, F., De Rubeis, S., Di Marino, D., Mohr, E., Massimi, M., Falconi, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.031 · Cited by 609
Self-citation
Mutations causing syndromic autism define an axis of synaptic pathophysiology
Auerbach, B. D., Osterweil, E. K., & Bear, M. F. (2011) · Nature · doi:10.1038/nature10658 · Cited by 592
Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
Ma, T., Trinh, M. A., Wexler, A. J., Bourbon, C., Gatti, E., Pierre, P., Cavener, D. R., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3486 · Cited by 575
Evidence that fragile X mental retardation protein is a negative regulator of translation
Laggerbauer, B. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.4.329 · Cited by 571
A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties
Si, K., Lindquist, S. L., & Kandel, E. R. (2003) · Cell · doi:10.1016/s0092-8674(03)01020-1 · Cited by 565
The Elongation, Termination, and Recycling Phases of Translation in EukaryotesPreprint
Dever, T. E., & Green, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a013706 · Cited by 561
Dysregulation of mTOR signaling in fragile X syndrome
Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557
Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression
Hou, L., & Klann, E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0995-04.2004 · Cited by 527
Autism-related deficits via dysregulated eIF4E-dependent translational control
Gkogkas, C. G., Khoutorsky, A., Ran, I., Rampakakis, E., Nevarko, T., Weatherill, D. B., Vasuta, C., Yee, S., Truitt, M., Dallaire, P., et al. (2013) · Nature · doi:10.1038/nature11628 · Cited by 522
Elongation Factor 2 and Fragile X Mental Retardation Protein Control the Dynamic Translation of Arc/Arg3.1 Essential for mGluR-LTD
Park, S., Park, J. M., Kim, S., Kim, J.-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.023 · Cited by 516
eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory
Costa‐Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, A. C., Sossin, W. S., Kaufman, R. J., Pelletier, J., Rosenblum, K., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.050 · Cited by 515
Self-citation
A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis
Casadio, A., Martin, K. C., Giustetto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C. H., & Kandel, E. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81653-0 · Cited by 503
The translation of translational control by FMRP: therapeutic targets for FXS
Darnell, J. C., & Klann, E. (2013) · Nature Neuroscience · doi:10.1038/nn.3379 · Cited by 491
CPEB-Mediated Cytoplasmic Polyadenylation and the Regulation of Experience-Dependent Translation of α-CaMKII mRNA at Synapses
Wu, L., Wells, D., Tay, J., Mendis, D., Abbott, M.-A., Barnitt, A., Quinlan, E., Heynen, A., Fallon, J. R., & Richter, J. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80630-3 · Cited by 488 · cited 1×
“PABP promotes the recruitment of the eIF4F complex to the 5′ end of the mRNA and promotes translation of CamKIIα and NR2A mRNAs (Huang et al. 2002, Udagawa et al. 2012, Wu et al. 1998).”
Background
Temporally graded requirement for protein synthesis following memory reactivation
Milekic, M. H., & Alberini, C. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00976-5 · Cited by 455
The fragile X mental retardation protein inhibits translation via interacting with mRNA
Li, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.11.2276 · Cited by 448
A Neuronal Isoform of CPEB Regulates Local Protein Synthesis and Stabilizes Synapse-Specific Long-Term Facilitation in Aplysia
Si, K., Giustetto, M., Etkin, A., Hsu, R., Janisiewicz, A. M., Miniaci, M. C., Kim, J., Zhu, H., & Kandel, E. R. (2003) · Cell · doi:10.1016/s0092-8674(03)01021-3 · Cited by 442
TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys
Lourenco, M. V., Clarke, J. R., Frozza, R. L., Bomfim, T. R., Forny‐Germano, L., Batista, A. F., Sathler, L. B., Brito‐Moreira, J., Amaral, O. B., Silva, C. A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.002 · Cited by 430
Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis
O’Connor, T., Sadleir, K. R., Maus, E., Velliquette, R. A., Zhao, J., Cole, S. L., Eimer, W. A., Hitt, B. D., Bembinster, L. A., Lammich, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.047 · Cited by 429
Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome
Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0937-07.2007 · Cited by 421
Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2
Costa‐Mattioli, M., Gobert, D., Harding, H. P., Herdy, B., Azzi, M., Bruno, M. A., Bidinosti, M., Mamou, C. B., Marcinkiewicz, E., Yoshida, M., et al. (2005) · Nature · doi:10.1038/nature03897 · Cited by 412
Self-citation
Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1
Tsukiyama–Kohara, K., Poulin, F., Kohara, M., DeMaria, C. T., Cheng, A., Wu, Z., Gingras, A., Katsume, A., Elchebly, M., Spiegelman, B. M., et al. (2001) · Nature Medicine · doi:10.1038/nm1001-1128 · Cited by 392
Aplysia CPEB Can Form Prion-like Multimers in Sensory Neurons that Contribute to Long-Term Facilitation
Si, K., Choi, Y., White‐Grindley, E., Majumdar, A., & Kandel, E. R. (2010) · Cell · doi:10.1016/j.cell.2010.01.008 · Cited by 385
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Santini, E., Huynh, T. N., MacAskill, A. F., Carter, A. G., Pierre, P., Ruggero, D., Kaphzan, H., & Klann, E. (2012) · Nature · doi:10.1038/nature11782 · Cited by 383
The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)
Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370
mTOR complexes in neurodevelopmental and neuropsychiatric disorders
Costa-Mattioli, M., & Monteggia, L. M. (2013) · Nature Neuroscience · doi:10.1038/nn.3546 · Cited by 367
Self-citation
Making synaptic plasticity and memory last: mechanisms of translational regulationPreprint
Richter, J. D., & Klann, E. (2009) · Genes & Development · doi:10.1101/gad.1735809 · Cited by 350
The Dendritic Branch Is the Preferred Integrative Unit for Protein Synthesis-Dependent LTP
Govindarajan, A., Israely, I., Huang, S.-Y., & Tonegawa, S. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.008 · Cited by 349
Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis
Bateup, H. S., Johnson, C. A., Denefrio, C. L., Saulnier, J. L., Kornacker, K., & Sabatini, B. L. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.017 · Cited by 343
Genomics, Intellectual Disability, and Autism
Mefford, H. C., Batshaw, M. L., & Hoffman, E. P. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1114194 · Cited by 329
Fragile X syndrome: causes, diagnosis, mechanisms, and therapeutics
Bagni, C., Tassone, F., Neri, G., & Hagerman, R. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63141 · Cited by 321
Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice
Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.022 · Cited by 316
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1
Cammalleri, M., Lütjens, R., Berton, F., King, A. R., Simpson, C., Francesconi, W., & Sanna, P. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2336098100 · Cited by 314
mTORC2 controls actin polymerization required for consolidation of long-term memory
Huang, W., Zhu, P. J., Zhang, S., Zhou, H., Stoica, L., Galiano, M., Krnjević, K., Roman, G., & Costa-Mattioli, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3351 · Cited by 307
Self-citation
CYFIP1 Coordinates mRNA Translation and Cytoskeleton Remodeling to Ensure Proper Dendritic Spine Formation
De Rubeis, S., Pasciuto, E., Li, K. W., Fernández, E., Di Marino, D., Buzzi, A., Ostroff, L. E., Klann, E., Zwartkruis, F. J. T., Komiyama, N. H., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.039 · Cited by 296
The Translation Repressor 4E-BP2 Is Critical for eIF4F Complex Formation, Synaptic Plasticity, and Memory in the Hippocampus
Banko, J. L., Poulin, F., Hou, L., DeMaria, C. T., Sonenberg, N., & Klann, E. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2423-05.2005 · Cited by 290
Phosphorylation of eukaryotic initiation factor-2α (eIF2α) is associated with neuronal degeneration in Alzheimerʼs disease
Chang, R. C. C., Wong, A. K. Y., Ng, H.-K., & Hugon, J. (2002) · NeuroReport · doi:10.1097/00001756-200212200-00011 · Cited by 289
Altered Cortical Synaptic Morphology and Impaired Memory Consolidation in Forebrain- Specific Dominant-Negative PAK Transgenic Mice
Hayashi, M. L., Choi, S.-Y., Rao, B. S. S., Jung, H.-Y., Lee, H.-K., Zhang, D., Chattarji, S., Kirkwood, A., & Tonegawa, S. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.003 · Cited by 280
Inducible Enhancement of Memory Storage and Synaptic Plasticity in Transgenic Mice Expressing an Inhibitor of ATF4 (CREB-2) and C/EBP Proteins
Chen, A. Y.-C., Muzzio, I. A., Malleret, G., Bartsch, D., Verbitsky, M., Pavlidis, P., Yonan, A. L., Vronskaya, S., Grody, M. B., Cepeda, I. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00501-4 · Cited by 279
Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory
Majumdar, A., Cesario, W. C., White‐Grindley, E., Jiang, H., Ren, F., Khan, M. R., Li, L., Choi, E. M.-L., Kannan, K. S., Guo, F., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.004 · Cited by 275
Postsynaptic Decoding of Neural Activity: eEF2 as a Biochemical Sensor Coupling Miniature Synaptic Transmission to Local Protein Synthesis
Sutton, M. A., Taylor, A. M., Ito, H. T., Pham, A., & Schuman, E. M. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.030 · Cited by 274
Fragile X mental retardation protein is associated with translating polyribosomes in neuronal cells
Stefani, G., Fraser, C. E., Darnell, J. C., & Darnell, R. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2306-04.2004 · Cited by 274
Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events
Sutton, M. A., Wall, N. R., Aakalu, G., & Schuman, E. M. (2004) · Science · doi:10.1126/science.1096202 · Cited by 270
N‐methyl‐D‐aspartate receptor signaling results in Aurora kinase‐catalyzed CPEB phosphorylation and αCaMKII mRNA polyadenylation at synapses
Huang, Y., Jung, M., Sarkissian, M., & Richter, J. D. (2002) · The EMBO Journal · doi:10.1093/emboj/21.9.2139 · Cited by 270
Termination and post-termination events in eukaryotic translation
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-386497-0.00002-5 · Cited by 267
Postadolescent Changes in Regional Cerebral Protein Synthesis: An In Vivo Study in the Fmr1 Null Mouse
Qin, M., Kang, J., Burlin, T. V., Jiang, C., & Smith, C. B. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0093-05.2005 · Cited by 263
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486
Dolan, B. M., Duron, S. G., Campbell, D. A., Vollrath, B., Rao, B. S. S., Ko, H.-Y., Lin, G. G., Govindarajan, A., Choi, S.-Y., & Tonegawa, S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219383110 · Cited by 260
eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchangePreprint
Pavitt, G. D., Ramaiah, K. V. A., Kimball, S. R., & Hinnebusch, A. G. (1998) · Genes & Development · doi:10.1101/gad.12.4.514 · Cited by 256
mTOR Signaling to Translation
Gingras, A., Raught, B., & Sonenberg, N. (2004) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-18930-2_11 · Cited by 252
mRNA Localization in Neurons: A Multipurpose Mechanism?
Steward, O. (1997) · Neuron · doi:10.1016/s0896-6273(01)80041-6 · Cited by 252
Local Protein Synthesis Mediates a Rapid Increase in Dendritic Elongation Factor 1A after Induction of Late Long-Term Potentiation
Tsokas, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0599-05.2005 · Cited by 251
The fragile X mental retardation protein is associated with ribosomes
Khandjian, E. W., Corbin, F., Woerly, S., & Rousseau, F. (1996) · Nature Genetics · doi:10.1038/ng0196-91 · Cited by 251
Targeting the endocannabinoid system in the treatment of fragile X syndrome
Busquets-Garcia, A., Gomis-González, M., Guegan, T., Agustín-Pavón, C., Pastor, A., Mato, S., Pérez-Samartín, A., Matute, C., de la Torre, R., Dierssen, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3127 · Cited by 241
Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage
Stoica, L., Zhu, P. J., Huang, W., Zhou, H., Kozma, S. C., & Costa-Mattioli, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014715108 · Cited by 232
Self-citation
Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures
Goorden, S. M. I., van Woerden, G. M., van der Weerd, L., Cheadle, J. P., & Elgersma, Y. (2007) · Annals of Neurology · doi:10.1002/ana.21317 · Cited by 230
PTEN signaling in brain: neuropathology and tumorigenesis
Endersby, R., & Baker, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.239 · Cited by 229
CPEB3 and CPEB4 in neurons: analysis of RNA‐binding specificity and translational control of AMPA receptor GluR2 mRNA
Huang, Y., Kan, M.-C., Lin, C., & Richter, J. D. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601322 · Cited by 229
Identification of Process-Localized mRNAs from Cultured Rodent Hippocampal Neurons
Poon, M. M., Choi, S.-H., Jamieson, C. A. M., Geschwind, D. H., & Martin, K. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3432-06.2006 · Cited by 225
Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
Ehninger, D., & Silva, A. J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.10.002 · Cited by 223
Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition
Zhu, P. J., Huang, W., Kalikulov, D., Yoo, J. W., Placzek, A. N., Stoica, L., Zhou, H., Bell, J. C., Friedlander, M. J., Krnjević, K., et al. (2011) · Cell · doi:10.1016/j.cell.2011.11.029 · Cited by 223
Self-citation
Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory
Bolduc, F. V., Bell, K., Cox, H., Broadie, K. S., & Tully, T. (2008) · Nature Neuroscience · doi:10.1038/nn.2175 · Cited by 211
The Unstable Repeats—Three Evolving Faces of Neurological Disease
Nelson, D. L., Orr, H. T., & Warren, S. T. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.022 · Cited by 207
Loss of Tsc1 In Vivo Impairs Hippocampal mGluR-LTD and Increases Excitatory Synaptic Function
Bateup, H. S., Takasaki, K. T., Saulnier, J. L., Denefrio, C. L., & Sabatini, B. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1617-11.2011 · Cited by 204
Brain-derived Neurotrophic Factor Enhances Neuronal Translation by Activating Multiple Initiation Processes
Takei, N., Kawamura, M., Hara, K., Yonezawa, K., & Nawa, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103237200 · Cited by 202
Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α
Prisco, G. V. D., Huang, W., Buffington, S. A., Hsu, C.-C., Bonnen, P. E., Placzek, A. N., Sidrauski, C., Krnjević, K., Kaufman, R. J., Walter, P., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3754 · Cited by 201
Self-citation
Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E., & Tassone, F. (2012) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2012.00768.x · Cited by 198
Spatially restricting gene expression by local translation at synapses
Wang, D. O., Martin, K. C., & Zukin, R. S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.005 · Cited by 196
Antiviral effect of the mammalian translation initiation factor 2α kinase GCN2 against RNA viruses
Berlanga, J. J., Ventoso, I., Harding, H. P., Deng, J., Ron, D., Sonenberg, N., Carrasco, L., & de Haro, C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601073 · Cited by 196
Involvement of double‐stranded RNA‐dependent protein kinase and phosphorylation of eukaryotic initiation factor‐2α in neuronal degeneration
Chang, R. C., Suen, K., Ma, C., Elyaman, W., Ng, H., & Hugon, J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01237.x · Cited by 180
Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse
Barak, S., Liu, F., Hamida, S. B., Yowell, Q. V., Neasta, J., Kharazia, V., Janak, P. H., & Ron, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3439 · Cited by 172
Local Presynaptic Activity Gates Homeostatic Changes in Presynaptic Function Driven by Dendritic BDNF Synthesis
Jakawich, S. K., Nasser, H. B., Strong, M. J., McCartney, A. J., Perez, A. S., Rakesh, N., Carruthers, C. J. L., & Sutton, M. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.034 · Cited by 171
An RNA‐dependent protein kinase is involved in tunicamycin‐induced apoptosis and Alzheimer's disease
Onuki, R., Bando, Y., Suyama, E., Katayama, T., Kawasaki, H., Baba, T., Tohyama, M., & Taira, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600049 · Cited by 163
Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation
Blundell, J., Kouser, M., & Powell, C. M. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.12.004 · Cited by 162 · cited 2×
“…2011). mTORC1 is also crucial for the reconsolidation of memories associated with electric footshocks or addictive substances (Barak et al. 2013, Blundell et al. 2008, Stoica et al. 2011, Wang et al. 2010b), a process that depends on new protein synthesis (Barak et al. 2013, Milekic & Alberini…”
Background
Selective Modulation of Some Forms of Schaffer Collateral-CA1 Synaptic Plasticity in Mice With a Disruption of the CPEB-1 GenePreprint
Alarcón, J. M., Hodgman, R., Theis, M., Huang, Y.-S., Kandel, E. R., & Richter, J. D. (2004) · Learning & Memory · doi:10.1101/lm.72704 · Cited by 161
Dual Interactions of the Translational Repressor Paip2 with Poly(A) Binding Protein
Khaleghpour, K., Kahvejian, A., Crescenzo, G. D., Roy, G., Svitkin, Y. V., Imataka, H., O'Connor‐McCourt, M. D., & Sonenberg, N. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5200-5213.2001 · Cited by 159
Mitogen-Activated Protein Kinase Upregulates the Dendritic Translation Machinery in Long-Term Potentiation by Controlling the Mammalian Target of Rapamycin Pathway
Tsokas, P., Ma, T., Iyengar, R., Landau, E. M., & Blitzer, R. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4548-06.2007 · Cited by 151
Sustained CPEB-Dependent Local Protein Synthesis Is Required to Stabilize Synaptic Growth for Persistence of Long-Term Facilitation in Aplysia
Miniaci, M. C., Kim, J., Puthanveettil, S. V., Si, K., Zhu, H., Kandel, E. R., & Bailey, C. H. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.036 · Cited by 149
Bidirectional Control of mRNA Translation and Synaptic Plasticity by the Cytoplasmic Polyadenylation Complex
Udagawa, T., Swanger, S. A., Takeuchi, K., Jong Heon, K. I. M., Nalavadi, V., Shin, J., Lorenz, L. J., Zukin, R. S., Bassell, G. J., & Richter, J. D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.016 · Cited by 148
Translational Control of Entrainment and Synchrony of the Suprachiasmatic Circadian Clock by mTOR/4E-BP1 Signaling
Cao, R., Robinson, B., Xu, H., Gkogkas, C. G., Khoutorsky, A., Alain, T., Yanagiya, A., Nevarko, T., Liu, A. C., Amir, S., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.026 · Cited by 148
Brain-Specific Disruption of the eIF2α Kinase PERK Decreases ATF4 Expression and Impairs Behavioral Flexibility
Trinh, M. A., Kaphzan, H., Wek, R. C., Pierre, P., Cavener, D. R., & Klann, E. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.04.010 · Cited by 146
Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path
Bliss, T. V. P., & Lømo, T. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010273 · Cited by 135
Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology
Udagawa, T., Farny, N. G., Jakovcevski, M., Kaphzan, H., Alarcón, J. M., Anilkumar, S., Ivshina, M. P., Hurt, J. A., Nagaoka, K., Nalavadi, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3353 · Cited by 134
eIF2α Phosphorylation-Dependent Translation in CA1 Pyramidal Cells Impairs Hippocampal Memory Consolidation without Affecting General Translation
Jiang, Z., Belforte, J. E., Lü, Y., Yabe, Y., Pickel, J. M., Smith, C. B., Je, H. S., Lu, B., & Nakazawa, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3971-09.2010 · Cited by 127
Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism
Takeuchi, K., Gertner, M. J., Zhou, J., Parada, L. F., Bennett, M. V. L., & Zukin, R. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222803110 · Cited by 124
Analysis of Subcellularly Localized mRNAs Using in Situ Hybridization, mRNA Amplification, and Expression Profiling
Eberwine, J. H., Belt, B. A., Kacharmina, J. E., & Miyashiro, K. (2002) · Neurochemical Research · doi:10.1023/a:1020956805307 · Cited by 122
Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer’s disease
Page, G., Rioux Bilan, A., Ingrand, S., Lafay-Chebassier, C., Pain, S., Perault Pochat, M. C., Bouras, C., Bayer, T., & Hugon, J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.047 · Cited by 116
Alzheimer's disease-associated reduction of polysomal mRNA translation
Langstrom, N. S., Anderson, J. P., Lindroos, H., Winbland, B., & Wallace, W. (1989) · Molecular Brain Research · doi:10.1016/0169-328x(89)90060-0 · Cited by 114
Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation
Hoeffer, C. A., Cowansage, K. K., Arnold, E. C., Banko, J. L., Moerke, N. J., Rodriguez, R., Schmidt, E. K., Klosi, E., Chorev, M., Lloyd, R. E., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013063108 · Cited by 114
mGluR-Dependent Long-Term Depression Is Associated with Increased Phosphorylation of S6 and Synthesis of Elongation Factor 1A but Remains Expressed in S6K-Deficient Mice
Antion, M., Hou, L., Wong, H., Hoeffer, C. A., & Klann, E. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00201-08 · Cited by 113
The mRNA for Elongation Factor 1α Is Localized in Dendrites and Translated in Response to Treatments That Induce Long-Term Depression
Huang, F.-S., Chotiner, J. K., & Steward, O. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1779-05.2005 · Cited by 112
Characterization of the Role of Microtubule-Associated Protein 1B in Metabotropic Glutamate Receptor-Mediated Endocytosis of AMPA Receptors in Hippocampus
Davidkova, G., & Carroll, R. C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3334-07.2007 · Cited by 112
Reduced extinction of hippocampal-dependent memories in CPEB knockout micePreprint
Berger-Sweeney, J. E., Zearfoss, N. R., & Richter, J. D. (2006) · Learning & Memory · doi:10.1101/lm.73706 · Cited by 112
The role of eEF2 pathway in learning and synaptic plasticity
Taha, E., Gildish, I., Gal-Ben-Ari, S., & Rosenblum, K. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.04.015 · Cited by 111
Behavioral alterations in mice lacking the translation repressor 4E-BP2
Banko, J. L., Merhav, M., Stern, E., Sonenberg, N., Rosenblum, K., & Klann, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.08.012 · Cited by 110
Drosophila CPEB Orb2A Mediates Memory Independent of Its RNA-Binding Domain
Krüttner, S., Stepien, B., Noordermeer, J. N., Mommaas, M. A., Mechtler, K., Dickson, B. J., & Keleman, K. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.028 · Cited by 104
A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding
Karim, M. M., Svitkin, Y. V., Kahvejian, A., Crescenzo, G. D., Costa‐Mattioli, M., & Sonenberg, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603701103 · Cited by 102
Self-citation
Postnatal Deamidation of 4E-BP2 in Brain Enhances Its Association with Raptor and Alters Kinetics of Excitatory Synaptic Transmission
Bidinosti, M., Ran, I., Sánchez‐Carbente, M. D. R., Martineau, Y., Gingras, A., Gkogkas, C. G., Raught, B., Bramham, C. R., Sossin, W. S., Costa‐Mattioli, M., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.02.022 · Cited by 100
Self-citation
13 eIF2α Phosphorylation in Cellular Stress Responses and DiseasePreprint
Ron, D., & Harding, H. (2007) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969767.48.345 · Cited by 92
TOR Is Required for the Retrograde Regulation of Synaptic Homeostasis at the Drosophila Neuromuscular Junction
Penney, J., Tsurudome, K., Liao, E. H., Elazzouzi, F., Livingstone, M., González, M., Sonenberg, N., & Haghighi, A. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.030 · Cited by 90
Nucleus Accumbens Core Mammalian Target of Rapamycin Signaling Pathway Is Critical for Cue-Induced Reinstatement of Cocaine Seeking in Rats
Wang, X., Luo, Y.-X., He, Y.-Y., Li, F.-Q., Shi, H.-S., Xue, L.-F., Xue, Y.-X., & Lu, L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1264-10.2010 · Cited by 88
A molecular switch for translational control in taste memory consolidation
Belelovsky, K., Elkobi, A., Kaphzan, H., Nairn, A. C., & Rosenblum, K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04428.x · Cited by 85
Blocking the eIF2α Kinase (PKR) Enhances Positive and Negative Forms of Cortex-Dependent Taste Memory
Stern, E., Adaikkan, C., David, O., Sonenberg, N., & Rosenblum, K. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2322-12.2013 · Cited by 81
Making and breaking synapses through local mRNA regulation
Swanger, S. A., & Bassell, G. J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.04.002 · Cited by 74
Control of Synaptic Plasticity and Memory via Suppression of Poly(A)-Binding Protein
Khoutorsky, A., Yanagiya, A., Gkogkas, C. G., Fabian, M. R., Prager‐Khoutorsky, M., Cao, R., Gamache, K., Bouthiette, F., Parsyan, A. E., Sorge, R. E., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.025 · Cited by 72
Synaptic tagging and capture in the living rat
Shires, K. L., Silva, B. M. D., Hawthorne, J. P., Morris, R., & Martin, S. J. (2012) · Nature Communications · doi:10.1038/ncomms2250 · Cited by 72
Retrograde Changes in Presynaptic Function Driven by Dendritic mTORC1
Henry, F. E., McCartney, A. J., Neely, R., Perez, A. S., Carruthers, C. J. L., Stuenkel, E. L., Inoki, K., & Sutton, M. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2149-12.2012 · Cited by 69
Targeted treatment trials for tuberous sclerosis and autism: no longer a dream
Şahin, M. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.04.008 · Cited by 66
Deletion of the eIF2α Kinase GCN2 Fails to Rescue the Memory Decline Associated with Alzheimer’s Disease
Devi, L., & Ohno, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077335 · Cited by 66
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures
Couturier, J., Paccalin, M., Morel, M., Terro, F., Milin, S., Pontcharraud, R., Fauconneau, B., & Page, G. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-72 · Cited by 65
An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation
Dyer, J. R., Michel, S. H., Lee, W., Castellucci, V. F., Wayne, N. L., & Sossin, W. S. (2003) · Nature Neuroscience · doi:10.1038/nn1018 · Cited by 63
Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K micePreprint
Gildish, I., Manor, D., David, O., Sharma, V. K., Williams, D., Agarwala, U., Wang, X., Kenney, J. W., Proud, C. G., & Rosenblum, K. (2012) · Learning & Memory · doi:10.1101/lm.023937.111 · Cited by 63
Selective Regulation of GluA Subunit Synthesis and AMPA Receptor-Mediated Synaptic Function and Plasticity by the Translation Repressor 4E-BP2 in Hippocampal Pyramidal Cells
Ran, I., Gkogkas, C. G., Vasuta, C., Tartas, M., Khoutorsky, A., Laplante, I., Parsyan, A. E., Nevarko, T., Sonenberg, N., & Lacaille, J. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3264-12.2013 · Cited by 50
PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease
Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · cited 1×
“A uthor M anuscript A uthor M anuscript A uthor M anuscript A uthor M anuscript PKR-eIF2α signaling is also implicated in AD (Morel et al. 2009).”
Background
Interaction of Double-stranded RNA-dependent Protein Kinase (PKR) with the Death Receptor Signaling Pathway in Amyloid β (Aβ)-treated Cells and in APPSLPS1 Knock-in Mice
Couturier, J., Morel, M., Pontcharraud, R., Gontier, V., Fauconneau, B., Paccalin, M., & Page, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041954 · Cited by 44
Multiple components of eIF4F are required for protein synthesis-dependent hippocampal long-term potentiation
Hoeffer, C. A., Santini, E., Ma, T., Arnold, E. C., Whelan, A., Wong, H., Pierre, P., Pelletier, J., & Klann, E. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00342.2012 · Cited by 37
Compartment-specific, differential regulation of eukaryotic elongation factor 2 and its kinase within Aplysia sensory neurons
Weatherill, D. B., McCamphill, P. K., Pethoukov, E., Dunn, T. W., Fan, X., & Sossin, W. S. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07251.x · Cited by 30
Ribosomal Protein S6 Kinase Is a Critical Downstream Effector of the Target of Rapamycin Complex 1 for Long-term Facilitation in Aplysia
Weatherill, D. B., Dyer, J., & Sossin, W. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.071142 · Cited by 30

Research works printed but not linked: 2

Bliss TV, 1973, J. Physiol., 232, 381
Gingras AC, 2004, Curr. Top. Microbiol. Immunol., 279, 169

Sorted by citations

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043
The integrated stress response: From mechanism to disease
Costa-Mattioli, M., & Walter, P. (2020) · Science · doi:10.1126/science.aat5314 · Cited by 1,617
Self-citation
ER stress and the unfolded protein response in neurodegeneration
Hetz, C. A., & Saxena, S. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.99 · Cited by 1,006
Advancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686

See all 348

Authors: Buffington, S. A., Huang, W., & Costa-Mattioli, M.
Affiliations: Baylor College of Medicine (US)
Department of Neuroscience, Memory and Brain Research Center, Baylor College of Medicine, Houston, Texas 77030;, ,
ORCID: Buffington, Shelly A.
Huang, Wei
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2014-07-08
Volume: 37
Issue: 1
Pages: 17-38
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-071013-014100
PMC: PMC4721605
OpenAlex: W2120053143
Cited by: 348
References: 166
Citations by year: 2026: 17 · 2025: 23 · 2024: 21 · 2023: 20 · 2022: 24 · 2021: 36 · 2020: 36 · 2019: 30 · 2018: 43 · 2017: 33 · 2016: 33 · 2015: 21 · 2014: 11
FWCI: 3.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: U.S. Department of Defense
Searle Scholars Program
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke (R01NS076708)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: translational regulation, synaptic plasticity, long-term potentiation, long-term depression, hippocampus, mRNA translation, memory formation, cognitive impairment, synaptic dysfunction
MeSH terms: Animals, Cognition Disorders, Hippocampus, Humans, Models, Biological, Nerve Tissue Proteins, Neuronal Plasticity, Protein Biosynthesis, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Translational Control in Synaptic Plasticity and Cognitive Dysfunction

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks