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Brain Dopamine and Reward
Abstract
While the evidence is strong that dopamine plays some fundamental and special role in the rewarding effects of brain stimulation, psychomotor stimulants, opiates, and food, the exact nature of that role is not clear. One thing is clear: Dopamine is not the only reward transmitter, and dopaminergic neurons are not the final common path for all rewards. Dopamine antagonists and lesions of the dopamine systems appear to spare the rewarding effects of nucleus accumbens and frontal cortex brain stimulation (Simon et al 1979) and certainly spare the rewarding effects of apomorphine (Roberts & Vickers 1988). It is clear that reward circuitry is multisynaptic, and since dopamine cells do not send axons to each other or receive axons from each other, dopamine can at best serve as but a single link in this circuitry. If dopamine is not a final common path for all rewards, could it be an intermediate common path for most rewards? Some workers have argued against such a view, but at present they must do so on incomplete evidence. For example, Phillips (1984) has argued that there must be multiple reward systems, functionally independent and organized in parallel with one another. His primary evidence, however, is the fact that brain stimulation is rewarding at different levels of the nervous system. As we have seen in the case of midline mesencephalic stimulation, the location of the electrode tip in relation to the dopamine cells and fibers tells us little about the role of dopamine in brain stimulation reward. It seems clear that the ventral tegmental dopamine system plays a critical role in midline mesencephalic reward, despite the distance from the electrode tip to the dopamine cells where morphine causes its dopamine-dependent facilitory effects or to the dopamine terminals where low-dose neuroleptics presumably cause theirs. Until pharmacological challenge has been extended to the cases discussed by Phillips, we can only speculate as to the role of dopamine in each of those cases. In the cases where pharmacological challenge has been examined, only nucleus accumbens and frontal cortex have been found to have dopamine-independent reward sites. It is not consistent with the dopamine hypothesis that dopamine-independent reward sites should exist in these areas, since any reward signals carried to nucleus accumbens or frontal cortex by dopamine fibers would-unless we are to believe that reward "happens" at these sites-have to be carried to the next stage of the circuit by nondopaminergic fibers (there are no dopaminergic cell bodies in any of the dopamine terminal areas).(ABSTRACT TRUNCATED AT 400 WORDS)
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“These are key brain regions for reward 22 , and the observed decreased availability of D2/D3 receptors and DAT could explain the decreased motivation in these patients.”
From Motivation Deficit in ADHD is Associated with Dysfunction of the Dopamine Reward Pathway (2011) · cites this paper as [22]
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Melis, M. R., Melis, T., Cocco, C., Succu, S., Sanna, F., Pillolla, G., Boi, A., Ferri, G., & Argiolas, A. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05721.x · Cited by 198
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de la Fuente-Fernández, R., Schulzer, M., & Stoessl, A. J. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00038-8 · Cited by 187
Boileau, I., Payer, D., Chugani, B., Lobo, D., Behzadi, A., Rusjan, P. M., Houle, S., Wilson, A. A., Warsh, J., Kish, S. J., et al. (2013) · Addiction · doi:10.1111/add.12066 · Cited by 190
Wang, Z., Yu, G., Cascio, C., Liu, Y., Gingrich, B., & Insel, T. R. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.3.602 · Cited by 205
Yoshida, M., Yokoo, H., Mizoguchi, K., Kawahara, H., Tsuda, A., Nishikawa, T., & Tanaka, M. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90861-z · Cited by 179
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Stice, E., & Yokum, S. (2016) · Psychological Bulletin · doi:10.1037/bul0000044 · Cited by 179
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Young, K. A., Liu, Y., & Wang, Z. (2008) · Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.02.004 · Cited by 163
Auclair, A., Drouin, C., Cotecchia, S., Glowinski, J., & Tassin, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03805.x · Cited by 163
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Volkow, N. D., Tomasi, D., Wang, G.-J., Logan, J., Alexoff, D. L., Jayne, M., Fowler, J. S., Wong, C., Yin, P., & Du, C. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.58 · Cited by 134
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Blum, K., Noble, E. P., Sheridan, P. J., Montgomery, A., Ritchie, T., Ozkaragoz, T., Fitch, R. J., Wood, R., Finley, O., & Sadlack, F. (1993) · Alcohol · doi:10.1016/0741-8329(93)90054-r · Cited by 123
Nair, S. G., Adams-Deutsch, T., Epstein, D. H., & Shaham, Y. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.05.003 · Cited by 112
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Shi, J., Zhao, L.-Y., Copersino, M. L., Fang, Y.-X., Chen, Y., Tian, J., Deng, Y., Shuai, Y., Jin, J., & Lu, L. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.09.042 · Cited by 108
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Rossetti, Z. L., Melis, F., Carboni, S., Diana, M., & Gessa, G. L. (1992) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb01411.x · Cited by 105
Ishøy, P. L., Knop, F. K., Broberg, B. V., Bak, N., Andersen, U. B., Jørgensen, N. R., Holst, J. J., Glenthøj, B. Y., & Ebdrup, B. H. (2017) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12795 · Cited by 102
Mercuri, N. B., Calabresi, P., & Bernardi, G. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90479-9 · Cited by 86
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Gerrits, M. A. F. M., Lesscher, H. B. M., & van Ree, J. M. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.003 · Cited by 82
Petit, G., Kornreich, C., Verbanck, P., & Campanella, S. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.04.005 · Cited by 81
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Cunningham, S. T., & Kelley, A. E. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90137-m · Cited by 65
Shram, M. J., Funk, D., Li, Z., & Lê, A. D. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.03.034 · Cited by 64
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Wills, L., & Kenny, P. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15356 · Cited by 61
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Schultz, W. (2010) · F1000 Biology Reports · doi:10.3410/b2-2 · Cited by 59
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Liggins, J., Pihl, R. O., Benkelfat, C., & Leyton, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0028370 · Cited by 58
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Jerlhag, E. (2020) · Brain Research · doi:10.1016/j.brainres.2019.146562 · Cited by 53
Yacubian, J., & Büchel, C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.015 · Cited by 53
Rebec, G. V. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03614.x · Cited by 51
Li, Q., Zhang, B., Cao, H., Liu, W., Guo, F., Shen, F., Ye, B., Liu, H., Li, Y., & Liu, Z. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107836 · Cited by 47
Merlo, E., Ratano, P., Ilioi, E. C., Robbins, M. A. L. S., Everitt, B. J., & Milton, A. L. (2015) · eneuro · doi:10.1523/eneuro.0024-14.2015 · Cited by 38
Costanzi, M., Cianfanelli, B., Santirocchi, A., Lasaponara, S., Spataro, P., Rossi-Arnaud, C., & Cestari, V. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11040241 · Cited by 39
Ebdrup, B. H., Broberg, B. V., Ishøy, P. L., Bak, N., Andersen, U. B., Jørgensen, N. R., Holst, J. J., Knop, F. K., & Glenthøj, B. Y. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13204 · Cited by 35
Succu, S., Sanna, F., Argiolas, A., & Melis, M. R. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.026 · Cited by 35
(2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.012 · Cited by 34
Silveira, M. M., Malcolm, E., Shoaib, M., & Winstanley, C. A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.029 · Cited by 31
HORVITZ, J. C., CHOI, W. Y., MORVAN, C., EYNY, Y., & BALSAM, P. D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1390.017 · Cited by 26
Ericson, M., Olausson, P., Engel, J. A., & Söderpalm, B. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00191-6 · Cited by 26
Egan, A. E., Thompson, A. M. K., Buesing, D., Fourman, S. M., Packard, A. E. B., Terefe, T., Li, D., Wang, X., Song, S., Solomon, M. B., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.030 · Cited by 19
Metadata
- Authors
- Wise, R. A., & Rompre, P.-P.
- Affiliations
- Concordia University (CA)
- Center for Studies in Behavioral Neurobiology, Department of Psychology Concordia University, Montreal, Canada, H3G 1M8
- ORCID
- Wise, R. A.
- Venue
- Annual Review of Psychology
- Publisher
- Annual Reviews
- Published
- 1989-01
- Volume
- 40
- Issue
- 1
- Pages
- 191-225
- ISSN
- 0066-4308 (ISSN-L)
- 1545-2085
- OpenAlex
- W2174764226
- Cited by
- 1,968
- References
- 0
- Citations by year
- 2026: 7 · 2025: 27 · 2024: 20 · 2023: 24 · 2022: 27 · 2021: 43 · 2020: 42 · 2019: 60 · 2018: 54 · 2017: 42 · 2016: 51 · 2015: 65 · 2014: 75 · 2013: 59 · 2012: 64
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Psychology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine, reward, brain stimulation reward, nucleus accumbens, frontal cortex, dopamine antagonists, apomorphine, psychostimulants, opiates, food reward, reward systems
- MeSH terms
- Animals, Brain, Electric Stimulation, Humans, Receptors, Dopamine, Reward, Stimulation, Chemical, Illicit Drugs
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