Cited by 2,365Muscle metabolism and nutritionClinical Nutrition and GastroenterologyBody Composition Measurement Techniques

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Calculation of substrate oxidation rates in vivo from gaseous exchange.

Frayn, K. N.·1983·Journal of Applied Physiology

DOI 10.1152/jappl.1983.55.2.628

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Abstract

This paper reviews the assumptions involved in calculating rates of carbohydrate and fat oxidation from measurements of O2 consumption, CO2 production, and urinary nitrogen excretion. It is shown that erroneous results are obtained in the presence of metabolic processes such as lipogenesis and gluconeogenesis. The apparent rates calculated under these conditions can, however, be interpreted as net rates of "utilization." Thus the apparent rate of carbohydrate oxidation is the sum of the rates of utilization for oxidation and for lipogenesis minus the rate at which carbohydrate is formed from amino acids. The apparent rate of fat oxidation is the difference between the rates of oxidation and synthesis from carbohydrate, so that the apparently negative rates encountered in patients infused with glucose do quantitatively represent net rates of synthesis. Other processes such as synthesis of ketone bodies or lactate at rates greater than their utilization can also disturb the calculations, but the magnitude of the effect can be estimated from appropriate measurements. Methods of correcting the observed gaseous exchange in these circumstances are given.

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Authors: Frayn, K. N.
Corresponding author: Frayn, K. N.
ORCID: Frayn, K. N.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1983-08-01
Volume: 55
Issue: 2
Pages: 628-634
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1983.55.2.628
OpenAlex: W2131501155
Cited by: 2,365
References: 15
Citations by year: 2026: 66 · 2025: 85 · 2024: 89 · 2023: 96 · 2022: 103 · 2021: 94 · 2020: 130 · 2019: 99 · 2018: 97 · 2017: 96 · 2016: 90 · 2015: 82 · 2014: 72 · 2013: 68 · 2012: 72
FWCI: 1.41
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Keywords: carbohydrate oxidation, fat oxidation, oxygen consumption, CO2 production, urinary nitrogen excretion, lipogenesis, gluconeogenesis, ketone body synthesis, lactic acid production, glucose infusion, in vivo metabolism
MeSH terms: Gluconeogenesis, Glucose, Humans, Lipids, Mathematics, Oxidation-Reduction, Pulmonary Gas Exchange

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Calculation of substrate oxidation rates in vivo from gaseous exchange.

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