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Cited by 2,179

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Myocardial Fatty Acid Metabolism in Health and Disease

Lopaschuk, Gary D., Ussher, John R., Folmes, Clifford D. L., Jaswal, Jagdip S., Stanley, William C.·2010·Physiological Reviews
DOI 10.1152/physrev.00015.2009
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Abstract

There is a constant high demand for energy to sustain the continuous contractile activity of the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of fatty acid β-oxidation is complex and is aimed at ensuring that the supply and oxidation of the fatty acids is sufficient to meet the energy demands of the heart. The metabolism of fatty acids via β-oxidation is not regulated in isolation; rather, it occurs in response to alterations in contractile work, the presence of competing substrates (i.e., glucose, lactate, ketones, amino acids), changes in hormonal milieu, and limitations in oxygen supply. Alterations in fatty acid metabolism can contribute to cardiac pathology. For instance, the excessive uptake and β-oxidation of fatty acids in obesity and diabetes can compromise cardiac function. Furthermore, alterations in fatty acid β-oxidation both during and after ischemia and in the failing heart can also contribute to cardiac pathology. This paper reviews the regulation of myocardial fatty acid β-oxidation and how alterations in fatty acid β-oxidation can contribute to heart disease. The implications of inhibiting fatty acid β-oxidation as a potential novel therapeutic approach for the treatment of various forms of heart disease are also discussed.

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Metadata

Authors
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2010-01
Volume
90
Issue
1
Pages
207-258
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00015.2009
OpenAlex
W2128606426
Cited by
2,179
References
82
FWCI
12.90
Type
journal article
Language
en
Open access
closed

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