Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Autophagy in the Pathogenesis of Disease

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Autophagy fights disease through cellular self-digestion

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Cell Death

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Ageing, Cellular Senescence and Neurodegenerative Disease

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Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR -mediated retinal and macular degeneration

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Egr-1 Regulates Autophagy in Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

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AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

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Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

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Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

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The utilization of extracellular proteins as nutrients is suppressed by mTORC1

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A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy

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Extreme vulnerability of IDH1 mutant cancers to NAD+ depletion

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Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

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Immune mechanisms linked to depression via oxidative stress and neuroprogression

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The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

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MAPK/JNK signalling: a potential autophagy regulation pathway

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Glutamine‐driven oxidative phosphorylation is a major ATP source in transformed mammalian cells in both normoxia and hypoxia

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Autophagic cell death restricts chromosomal instability during replicative crisis

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Huntingtin functions as a scaffold for selective macroautophagy

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Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

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Mitochondria and ageing: Role in heart, skeletal muscle and adipose tissue

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Autophagy in chronically ischemic myocardium

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The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

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Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis

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The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

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Functional interaction between autophagy and ciliogenesis

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Diseases Caused by Defects in the Visual Cycle: Retinoids as Potential Therapeutic Agents

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Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation

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Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease

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Microbiota and metabolic diseases

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Autophagy in osteoblasts is involved in mineralization and bone homeostasis

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Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

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Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases

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AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

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Statins: a repurposed drug to fight cancer

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The cell biology of the retinal pigment epithelium

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Activators and inhibitors of NRF2: a review of their potential for clinical development

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Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism

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Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder

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FLIP-mediated autophagy regulation in cell death control

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The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy

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Autophagy in lysosomal storage disorders

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AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

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Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

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MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages

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Autophagy in acute kidney injury

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Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

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Degradation of AMPK by a Cancer-Specific Ubiquitin Ligase

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Nutrient acquisition strategies of mammalian cells

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Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review

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New frontiers in translational control of the cancer genome

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Targeting the biology of aging with mTOR inhibitors

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mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

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TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

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Parainflammation, Chronic Inflammation and Age-Related Macular Degeneration

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Oxidative phosphorylation: regulation and role in cellular and tissue metabolism

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Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

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An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

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ALS Genetics: Gains, Losses, and Implications for Future Therapies

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BNIP3 Is an RB/E2F Target Gene Required for Hypoxia-Induced Autophagy

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The multifaceted role of Nrf2 in mitochondrial function

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Redox control of senescence and age-related disease.

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Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

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Defective mitophagy in Alzheimer’s disease

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

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The AMPK pathway in fatty liver disease

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Mitophagy in neurodegeneration and aging

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Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

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Chemistry of the Retinoid (Visual) Cycle

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Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142 -TIPARP: implications for cerebral ischemic stroke

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Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

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Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

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Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

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Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice

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Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection

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Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan

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SIRT5 regulation of ammonia-induced autophagy and mitophagy

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Modulation of inflammation by autophagy: Consequences for human disease

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The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

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LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

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Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells.

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Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

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PLIC proteins or ubiquilins regulate autophagy‐dependent cell survival during nutrient starvation

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Autophagy-monitoring and autophagy-deficient mice

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Sestrins inhibit mTORC1 kinase activation through the GATOR complex

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