Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Autophagy in the Pathogenesis of Disease

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Autophagy fights disease through cellular self-digestion

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Cell Death

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Rdh12 activity and effects on retinoid processing in the murine retina

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Evaluation of an oral telomerase activator for early age-related macular degeneration - a pilot study

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Programmed cell death 4 as an endogenous suppressor of BDNF translation is involved in stress-induced depression

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ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration

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Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy

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Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target

Karakas, D., & Ozpolat, B. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01917-8 · Cited by 54

Autophagy was involved in the protective effect of metformin on hyperglycemia-induced cardiomyocyte apoptosis and connexin43 downregulation in H9c2 cells

Wang, G.-Y., Bi, Y.-G., Liu, X.-D., Zhao, Y., Han, J.-F., Wei, M., & Zhang, Q.-Y. (2017) · International Journal of Medical Sciences · doi:10.7150/ijms.19800 · Cited by 53

Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis

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The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health

Hevener, A. L., Ribas, V., Moore, T. M., & Zhou, Z. (2020) · Endocrinology · doi:10.1210/endocr/bqz017 · Cited by 54

PLD3 gene and processing of APP

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Application and mechanism of anti-VEGF drugs in age-related macular degeneration

Song, D., Liu, P., Shang, K., & Ma, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.943915 · Cited by 53

ApoE4 attenuates autophagy via FoxO3a repression in the brain

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mTOR Modulates Methamphetamine‐Induced Toxicity through Cell Clearing Systems

Lazzeri, G., Biagioni, F., Fulceri, F., Busceti, C. L., Scavuzzo, M. C., Ippolito, C., Salvetti, A., Lenzi, P., & Fornai, F. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6124745 · Cited by 53

GCA links TRAF6-ULK1-dependent autophagy activation in resistant chronic myeloid leukemia

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ATPase activity of DFCP1 controls selective autophagy

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Phycocyanin Protects Against UVB-induced Apoptosis Through the PKC α/βII-Nrf-2/HO-1 Dependent Pathway in Human Primary Skin Cells

Kim, K. M., Lee, J. Y., Im, A.-R., & Chae, S. (2018) · Molecules · doi:10.3390/molecules23020478 · Cited by 52

Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling

Wang, J., Zhang, J., Lee, Y. M., Ng, S., Shi, Y., Hua, Z.-C., Lin, Q., & Shen, H.-M. (2017) · Nature Protocols · doi:10.1038/nprot.2016.160 · Cited by 52

Chemical Screening Approaches Enabling Drug Discovery of Autophagy Modulators for Biomedical Applications in Human Diseases

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Coenzyme Q10 Inhibits the Activation of Pancreatic Stellate Cells through PI3K/AKT/MTOR Signaling Pathway

Xue, R., Yang, J., Wu, J., Meng, Q., & Hao, J. (2017) · Oncotarget · doi:10.18632/oncotarget.21247 · Cited by 51

Regulation of apoptosis by an intrinsically disordered region of Bcl-xL

Follis, A. V., Llambi, F., Kalkavan, H., Yao, Y., Phillips, A. H., Park, C.-G., Marassi, F. M., Green, D. R., & Kriwacki, R. W. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0011-x · Cited by 47

Structural basis for lipid transfer by the ATG2A–ATG9A complex

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Molecular components affecting ocular carotenoid and retinoid homeostasis

von Lintig, J., Moon, J., & Babino, D. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100864 · Cited by 50

Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors

Campellone, K. G., Lebek, N. M., & King, V. L. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151301 · Cited by 50

Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy

Jin, J., Britschgi, A., Schläfli, A. M., Humbert, M., Shan-Krauer, D., Batliner, J., Federzoni, E. A., Ernst, M., Torbett, B. E., Yousefi, S., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1482795 · Cited by 50

Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges

Viana, S. D., Reis, F., & Alves, R. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/3693625 · Cited by 48

“Get the Balance Right”: Pathological Significance of Autophagy Perturbation in Neuromuscular Disorders

Castets, P., Frank, S., Sinnreich, M., & Rüegg, M. A. (2016) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-160153 · Cited by 49

Mitochondrial Genome Analysis of Primary Open Angle Glaucoma Patients

Banerjee, D., Banerjee, A., Mookherjee, S., Vishal, M., Mukhopadhyay, A., Sen, A., Basu, A., & Ray, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070760 · Cited by 48

Physiologic Functions and Therapeutic Applications of α7 Nicotinic Acetylcholine Receptor in Brain Disorders

Lee, C.-H., & Hung, S.-Y. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010031 · Cited by 50

Synthetic lethality of glutaminolysis inhibition, autophagy inactivation and asparagine depletion in colon cancer

Li, J., Song, P., Zhu, L., Aziz, N., Zhou, Q., Zhang, Y., Xu, W., Feng, L., Chen, D., Wang, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.16844 · Cited by 46

Multi-omics analysis reveals the key factors involved in the severity of the Alzheimer’s disease

Meng, L., Jin, H., Yulug, B., Altay, O., Li, X., Hanoglu, L., Cankaya, S., Coskun, E., Idil, E., Nogaylar, R., et al. (2024) · Alzheimer's Research & Therapy · doi:10.1186/s13195-024-01578-6 · Cited by 49

The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways

Xie, C.-M., Tan, M., Lin, X.-T., Wu, D., Jiang, Y., Tan, Y., Li, H., Ma, Y., Xiong, X., & Sun, Y. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.052 · Cited by 49

The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration–Like Phenotype

Lyzogubov, V. V., Bora, P. S., Wu, X., Horn, L. E., de Roque, R., Rudolf, X. V., Atkinson, J. P., & Bora, N. S. (2016) · The American Journal of Pathology · doi:10.1016/j.ajpath.2016.03.021 · Cited by 45

TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms

Rosengren, T., Larsen, L. J., Pedersen, L. B., Christensen, S. T., & Møller, L. B. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2761-8 · Cited by 45

Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas

Anderson, D. M. G., Ablonczy, Z., Koutalos, Y., Hanneken, A. M., Spraggins, J. M., Calcutt, M. W., Crouch, R. K., Caprioli, R. M., & Schey, K. L. (2017) · Scientific Reports · doi:10.1038/s41598-017-17402-1 · Cited by 48

Autophagy upregulation promotes macrophages to escape mesoporous silica nanoparticle (MSN)-induced NF-κB-dependent inflammation

Xi, C., Zhou, J., Du, S., & Peng, S. (2016) · Inflammation Research · doi:10.1007/s00011-016-0919-0 · Cited by 48

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

Guha, P., Tyagi, R., Chowdhury, S., Reilly, L., Fu, C., Xu, R., Resnick, A. C., & Snyder, S. H. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.013 · Cited by 48

WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells

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HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice

Samardzija, M., Corna, A., Gomez-Sintes, R., Jarboui, M. A., Armento, A., Roger, J. E., Petridou, E., Haq, W., Paquet-Durand, F., Zrenner, E., et al. (2021) · Cell Death & Differentiation · doi:10.1038/s41418-020-00653-3 · Cited by 48

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

Wei, Q., Pinho, S., Dong, S., Pierce, H., Li, H., Nakahara, F., Xu, J., Xu, C., Boulais, P. E., Zhang, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22749-1 · Cited by 47

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells

Matsuda, J., Takahashi, A., Takabatake, Y., Sakai, S., Minami, S., Yamamoto, T., Fujimura, R., Namba-Hamano, T., Yonishi, H., Nakamura, J., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1712107 · Cited by 44

A mutation in the major autophagy gene, WIPI2, associated with global developmental abnormalities

Jelani, M., Dooley, H. C., Gubas, A., Mohamoud, H. S. A., Khan, M. T. M., Ali, Z., Kang, C., Rahim, F., Jan, A., Vadgama, N., et al. (2019) · Brain · doi:10.1093/brain/awz075 · Cited by 48

Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise‐Induced Muscle Damage through Enhancement of Mitochondrial Quality Control

Dun, Y., Liu, S., Zhang, W., Xie, M., & Qiu, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8024857 · Cited by 46

p38β MAPK mediates ULK1-dependent induction of autophagy in skeletal muscle of tumor-bearing mice

Liu, Z., Sin, K. W. T., Ding, H., Doan, H. A., Gao, S., Miao, H., Wei, Y., Wang, Y., Zhang, G., & Li, Y.-P. (2018) · Cell Stress · doi:10.15698/cst2018.11.163 · Cited by 46

Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L

Wang, Q., Wu, S., Zhu, H., Ding, Y., Dai, X., Ouyang, C., Han, Y.-M., Xie, Z., & Zou, M.-H. (2017) · Autophagy · doi:10.1080/15548627.2016.1263776 · Cited by 45

Downregulation of MicroRNA-193b-3p Promotes Autophagy and Cell Survival by Targeting TSC1/mTOR Signaling in NSC-34 Cells

Li, C., Chen, Y., Chen, X., Wei, Q., Cao, B., & Shang, H. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00160 · Cited by 45

From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A

Berge, T., Leikfoss, I., & Harbo, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034476 · Cited by 45

Chaperone-Mediated Autophagy and Its Emerging Role in Hematological Malignancies

Robert, G., Jacquel, A., & Auberger, P. (2019) · Cells · doi:10.3390/cells8101260 · Cited by 45

Fibroblasts from long‐lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress

Wang, M., & Miller, R. A. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00833.x · Cited by 45

Compromised autophagy and mitophagy in brain ageing and Alzheimer’s diseases.

Caponio, D., Veverová, K., Zhang, S.-Q., Shi, L., Wong, G., Vyhnalek, M., & Fang, E. F. (2022) · Aging Brain · doi:10.1016/j.nbas.2022.100056 · Cited by 45

Protective Effects and Molecular Signaling of n-3 Fatty Acids on Oxidative Stress and Inflammation in Retinal Diseases

Suzumura, A., Terao, R., & Kaneko, H. (2020) · Antioxidants · doi:10.3390/antiox9100920 · Cited by 44

Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration

Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44

Early and sustained altered expression of aging-related genes in young 3xTg-AD mice

Gatta, V, D'Aurora, M., Granzotto, A., Stuppia, L., & Sensi, S. L. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.11 · Cited by 44

Neuronal Autophagy: Regulations and Implications in Health and Disease

Liénard, C., Pintart, A., & Bomont, P. (2024) · Cells · doi:10.3390/cells13010103 · Cited by 44

Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A Patients

Lee, S., Bazick, H., Chittoor-Vinod, V., Al Salihi, M. O., Xia, G., & Notterpek, L. (2018) · The American Journal of Pathology · doi:10.1016/j.ajpath.2017.10.021 · Cited by 41

Autophagy and senescence: the molecular mechanisms and implications in liver diseases

Li, Q., Lin, Y., Liang, G., Xiao, N., Zhang, H., Yang, X., Yang, J., & Liu, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316880 · Cited by 43

Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget’s disease

Wong, S.-W., Huang, B.-W., Hu, X., Ho Kim, E., Kolb, J. P., Padilla, R. J., Xue, P., Wang, L., Oguin, T. H., Miguez, P. A., et al. (2020) · Cell Death & Differentiation · doi:10.1038/s41418-019-0341-6 · Cited by 42

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

Bareja, A., Lee, D. E., & White, J. P. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00183 · Cited by 41

Mechanisms of tolvaptan-induced toxicity in HepG2 cells

Wu, Y., Beland, F. A., Chen, S., Liu, F., Guo, L., & Fang, J.-L. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.03.015 · Cited by 41

Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer’s disease

Madadi, S., Schwarzenbach, H., Saidijam, M., Mahjub, R., & Soleimani, M. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0354-3 · Cited by 41

Protein kinase Cα drives fibroblast activation and kidney fibrosis by stimulating autophagic flux

Xue, X., Ren, J., Sun, X., Gui, Y., Feng, Y., Shu, B., Wei, W., Lu, Q., Liang, Y., He, W., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.002191 · Cited by 40

Autophagy supports color vision

Zhou, Z., Vinberg, F., Schottler, F., Doggett, T. A., Kefalov, V. J., & Ferguson, T. A. (2015) · Autophagy · doi:10.1080/15548627.2015.1084456 · Cited by 40

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

Tezil, T., Chamoli, M., Ng, C.-P., Simon, R. P., Butler, V. J., Jung, M., Andersen, J., Kao, A. W., & Verdin, E. (2019) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-019-0037-7 · Cited by 40

AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

Dohmen, M., Krieg, S., Agalaridis, G., Zhu, X., Shehata, S. N., Pfeiffenberger, E., Amelang, J., Bütepage, M., Buerova, E., Pfaff, C. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14812-0 · Cited by 40

Retinal pigment epithelial cells mitigate the effects of complement attack by endocytosis of C5b-9

Georgiannakis, A., Burgoyne, T., Lueck, K., Futter, C., Greenwood, J., & Moss, S. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500937 · Cited by 41

TORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae

Alfatah, M., Wong, J. H., Krishnan, V. G., Lee, Y. C., Sin, Q. F., Goh, C. J. H., Kong, K. W., Lee, W. T., Lewis, J., Hoon, S., et al. (2021) · BMC Biology · doi:10.1186/s12915-021-01030-3 · Cited by 39

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

Geier, E. G., Bourdenx, M., Storm, N. J., Cochran, J. N., Sirkis, D. W., Hwang, J.-H., Bonham, L. W., Ramos, E. M., Diaz, A., Van Berlo, V., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1925-9 · Cited by 39

Cytoplasmic mRNA turnover and ageing

Borbolis, F., & Syntichaki, P. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.09.006 · Cited by 39

RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1

Pei, Y., Lv, S., Shi, Y., Jia, J., Ma, M., Han, H., Zhang, R., Tan, J., & Zhang, X. (2023) · Autophagy · doi:10.1080/15548627.2022.2114271 · Cited by 39

BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells

Sharma, A., Singh, K., Mazumder, S., Hill, B. T., Kalaycio, M., & Almasan, A. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.155 · Cited by 39

Co-delivery of doxorubicin and shRNA of Beclin1 by folate receptor targeted pullulan-based multifunctional nanomicelles for combinational cancer therapy

Chen, L., Qian, M., Zhang, L., Xia, J., Bao, Y., Wang, J., Guo, L., & Li, Y. (2018) · RSC Advances · doi:10.1039/c8ra01679h · Cited by 38

Vorinostat and quinacrine have synergistic effects in T-cell acute lymphoblastic leukemia through reactive oxygen species increase and mitophagy inhibition

Jing, B., Jin, J., Xiang, R., Liu, M., Yang, L., Tong, Y., Xiao, X., Lei, H., Liu, W., Xu, H., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0679-6 · Cited by 38

LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling

IWAI, K. (2021) · Proceedings of the Japan Academy, Series B · doi:10.2183/pjab.97.007 · Cited by 37

Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster

Si, H., Ma, P., Liang, Q., Yin, Y., Wang, P., Zhang, Q., Wang, S., & Deng, H. (2019) · PLOS ONE · doi:10.1371/journal.pone.0225214 · Cited by 37

Defective Beclin-1 and elevated hypoxia-inducible factor (HIF)-1α expression are closely linked to tumorigenesis, differentiation, and progression of hepatocellular carcinoma

Osman, N. A. A., Abd El-Rehim, D. M., & Kamal, I. M. (2015) · Tumor Biology · doi:10.1007/s13277-015-3068-0 · Cited by 37

Astrocytes and Microglia in Stress-Induced Neuroinflammation: The African Perspective

Olude, M. A., Mouihate, A., Mustapha, O. A., Farina, C., Quintana, F. J., & Olopade, J. O. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.795089 · Cited by 37

Inhibition of Protein Ubiquitination by Paraquat and 1-Methyl-4-Phenylpyridinium Impairs Ubiquitin-Dependent Protein Degradation Pathways

Navarro-Yepes, J., Anandhan, A., Bradley, E., Bohovych, I., Yarabe, B., de Jong, A., Ovaa, H., Zhou, Y., Khalimonchuk, O., Quintanilla-Vega, B., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9414-9 · Cited by 37

Effect of β‑ecdysterone on glucocorticoid‑induced apoptosis and autophagy in osteoblasts

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Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease

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