Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Cell Death

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the presymptomatic stage

Shibuya, Y., Niu, Z., Bryleva, E. Y., Harris, B. T., Murphy, S. R., Kheirollah, A., Bowen, Z. D., Chang, C. C. Y., & Chang, T.-Y. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.002 · Cited by 87

Novel AKT1-GLI3-VMP1 Pathway Mediates KRAS Oncogene-induced Autophagy in Cancer Cells

Lo Ré, A. E., Fernández-Barrena, M. G., Almada, L. L., Mills, L. D., Elsawa, S. F., Lund, G., Ropolo, A., Molejon, M. I., Vaccaro, M. I., & Fernandez-Zapico, M. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.370809 · Cited by 87

Retinal carotenoids can attenuate formation of A2E in the retinal pigment epithelium

Bhosale, P., Serban, B., & Bernstein, P. S. (2009) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.09.012 · Cited by 85

mTOR-Dependent Cell Proliferation in the Brain

Ryskalin, L., Lazzeri, G., Flaibani, M., Biagioni, F., Gambardella, S., Frati, A., & Fornai, F. (2017) · BioMed Research International · doi:10.1155/2017/7082696 · Cited by 86

Mitochondrial Abnormalities in Alzheimer’s Disease

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Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis

Jiang, M., Esteve-Rudd, J., Lopes, V. S., Diemer, T., Lillo, C., Rump, A., & Williams, D. S. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201410112 · Cited by 85

Metabolic regulation of somatic stem cells in vivo

Meacham, C. E., DeVilbiss, A. W., & Morrison, S. J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00462-1 · Cited by 85

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Walters, H. E., & Cox, L. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082325 · Cited by 85

mTORC1 signaling activates NRF1 to increase cellular proteasome levels

Zhang, Y., & Manning, B. D. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1044188 · Cited by 85

Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner

Cardenal-Muñoz, E., Arafah, S., López-Jiménez, A. T., Kicka, S., Falaise, A., Bach, F., Schaad, O., King, J. S., Hagedorn, M., & Soldati, T. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006344 · Cited by 84

Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration

Peng, W., Minakaki, G., Nguyen, M., & Krainc, D. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00742-3 · Cited by 79

p62 provides dual cytoprotection against oxidative stress in the retinal pigment epithelium.

Wang, L., Cano, M., & Handa, J. T. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.03.016 · Cited by 82

NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models

Yang, C., Cai, C.-Z., Song, J.-X., Tan, J.-Q., Durairajan, S. S. K., Iyaswamy, A., Wu, M.-Y., Chen, L.-L., Yue, Z., Li, M., et al. (2017) · Autophagy · doi:10.1080/15548627.2017.1379633 · Cited by 83

Autophagy in traumatic brain injury: a new target for therapeutic intervention

Zhang, L., & Wang, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00190 · Cited by 82

zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function

Herzog, C., Yang, C., Holmes, A., & Kaushal, G. P. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00659.2011 · Cited by 82

Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis

Zhang, W., Zhu, Y.-H., Yang, G.-Y., Liu, X., Xia, B., Hu, X., Su, J.-H., & Wang, J.-F. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02705 · Cited by 80

Aging is associated with a decline in Atg9b-mediated autophagosome formation and appearance of enlarged mitochondria in the heart

Liang, W., Moyzis, A. G., Lampert, M. A., Diao, R. Y., Najor, R. H., & Gustafsson, Å. B. (2020) · Aging Cell · doi:10.1111/acel.13187 · Cited by 80

Chaperone mediated autophagy degrades TDP-43 protein and is affected by TDP-43 aggregation

Ormeño, F., Hormazabal, J., Moreno, J., Riquelme, F., Rios, J., Criollo, A., Albornoz, A., Alfaro, I. E., & Budini, M. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00019 · Cited by 80

Autophagy Promotes Peripheral Nerve Regeneration and Motor Recovery Following Sciatic Nerve Crush Injury in Rats

Huang, H.-C., Chen, L., Zhang, H.-X., Li, S.-F., Liu, P., Zhao, T.-Y., & Li, C.-X. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0672-9 · Cited by 80

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr 682 -phosphorylated APP βCTF

Im, E., Jiang, Y., Stavrides, P. H., Darji, S., Erdjument-Bromage, H., Neubert, T. A., Choi, J. Y., Wegiel, J., Lee, J.-H., & Nixon, R. A. (2023) · Science Advances · doi:10.1126/sciadv.adg1925 · Cited by 80

mTOR and neuronal cell cycle reentry: how impaired brain insulin signaling promotes Alzheimer's disease

Norambuena, A., Wallrabe, H., McMahon, L., Silva, A., Swanson, E., Khan, S. S., Baerthlein, D., Kodis, E., Oddo, S., Mandell, J. W., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.08.015 · Cited by 79

Regulation of mTOR Activity in Snell Dwarf and GH Receptor Gene-Disrupted Mice

Dominick, G., Berryman, D. E., List, E. O., Kopchick, J. J., Li, X., Miller, R. A., & Garcia, G. G. (2015) · Endocrinology · doi:10.1210/en.2014-1690 · Cited by 79

Induction of Covalently Crosslinked p62 Oligomers with Reduced Binding to Polyubiquitinated Proteins by the Autophagy Inhibitor Verteporfin

Donohue, E., Balgi, A. D., Komatsu, M., & Roberge, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114964 · Cited by 79

Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models

Naia, L., Shimozawa, M., Bereczki, E., Li, X., Liu, J., Jiang, R., Giraud, R., Leal, N. S., Pinho, C. M., Berger, E., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02289-4 · Cited by 79

Atg17/FIP200 localizes to perilysosomal Ref(2)P aggregates and promotes autophagy by activation of Atg1 in Drosophila

Nagy, P., Kárpáti, M., Varga, Á., Pircs, K., Venkei, Z., Takáts, S., Varga, K., Érdi, B., Hegedűs, K., & Juhász, G. (2014) · Autophagy · doi:10.4161/auto.27442 · Cited by 79

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure

Hallam, D., Collin, J., Bojic, S., Chichagova, V., Buskin, A., Xu, Y., Lafage, L., Otten, E. G., Anyfantis, G., Mellough, C., et al. (2017) · Stem Cells · doi:10.1002/stem.2708 · Cited by 75

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Gao, A. W., Chatzispyrou, I. A., Kamble, R., Liu, Y. J., Herzog, K., Smith, R. L., van Lenthe, H., Vervaart, M. A. T., van Cruchten, A., Luyf, A. C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02539-w · Cited by 77

A time to reap, a time to sow: Mitophagy and biogenesis in cardiac pathophysiology

Andres, A. M., Stotland, A., Queliconi, B. B., & Gottlieb, R. A. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.10.003 · Cited by 78

Targeting NRF2 for improved skin barrier function and photoprotection: focus on the achiote-derived apocarotenoid bixin

Rojo de la Vega, M., Krajisnik, A., Zhang, D., & Wondrak, G. (2017) · Nutrients · doi:10.3390/nu9121371 · Cited by 77

Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells

Zhao, F., Huang, W., Zhang, Z., Mao, L., Han, Y., Yan, J., & Lei, M. (2016) · Oncotarget · doi:10.18632/oncotarget.6783 · Cited by 77

Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss

Salazar, S. V., Cox, T. O., Lee, S., Brody, A. H., Chyung, A. S., Haas, L. T., & Strittmatter, S. M. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1873-18.2018 · Cited by 77

Activation of Placental Insulin and mTOR Signaling in a Mouse Model of Maternal Obesity Associated with Fetal Overgrowth

Rosario, F. J., Powell, T. L., & Jansson, T. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00356.2015 · Cited by 77

Inhibition of autophagy increased AGE/ROS-mediated apoptosis in mesangial cells

Xu, L., Fan, Q., Wang, X., Zhao, X., & Wang, L. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.322 · Cited by 76

Contribution of muscle satellite cells to sarcopenia

Huo, F., Liu, Q., & Liu, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.892749 · Cited by 74

Autophagy-deficient breast cancer shows early tumor recurrence and escape from dormancy

Aqbi, H. F., Tyutyunyk-Massey, L., Keim, R. C., Butler, S. E., Thekkudan, T., Joshi, S., Smith, T. M., Bandyopadhyay, D., Idowu, M. O., Bear, H. D., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25197 · Cited by 76

Selective inhibition of IFNG-induced autophagy by Mir155 - and Mir31 -responsive WNT5A and SHH signaling

Holla, S., Kurowska-Stolarska, M., Bayry, J., & Balaji, K. N. (2014) · Autophagy · doi:10.4161/auto.27225 · Cited by 76

In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy

Kravic, B., Harbauer, A. B., Romanello, V., Simeone, L., Vögtle, F.-N., Kaiser, T., Straubinger, M., Huraskin, D., Böttcher, M., Cerqua, C., et al. (2018) · Autophagy · doi:10.1080/15548627.2017.1403716 · Cited by 75

Distinct requirements of Autophagy-related genes in programmed cell death

Xu, T., Nicolson, S., Denton, D., & Kumar, S. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.28 · Cited by 75

Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss.

Amartuvshin, O., Lin, C., Hsu, S., Kao, S., Chen, A., Tang, W., Chou, H., Chang, D., Hsu, Y., Hsiao, B., et al. (2020) · Aging Cell · doi:10.1111/acel.13191 · Cited by 75

RUBCN/rubicon and EGFR regulate lysosomal degradative processes in the retinal pigment epithelium (RPE) of the eye

Muniz-Feliciano, L., Doggett, T. A., Zhou, Z., & Ferguson, T. A. (2017) · Autophagy · doi:10.1080/15548627.2017.1380124 · Cited by 73

Ketone body β -hydroxybutyrate is an autophagy-dependent vasodilator

McCarthy, C. G., Chakraborty, S., Singh, G., Yeoh, B. S., Schreckenberger, Z. J., Singh, A., Mell, B., Bearss, N. R., Yang, T., Cheng, X., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.149037 · Cited by 74

Central Role of ULK1 in Type I Interferon Signaling

Saleiro, D., Mehrotra, S., Kroczynska, B., Beauchamp, E. M., Lisowski, P., Majchrzak-Kita, B., Bhagat, T. D., Stein, B. L., McMahon, B., Altman, J. K., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.056 · Cited by 74

Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer

Liu, B., Wang, T., Wang, H., Zhang, L., Xu, F., Fang, R., Li, L., Cai, X., Wu, Y., Zhang, W., et al. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0577-5 · Cited by 73

Activation of autophagy in macrophages by pro-resolving lipid mediators

Prieto, P., Rosales-Mendoza, C. E., TerrÓn, V., Toledano, V., Cuadrado, A., LÓpez-Collazo, E., Bannenberg, G., Martín-Sanz, P., FernÁndez-Velasco, M., & BoscÁ, L. (2015) · Autophagy · doi:10.1080/15548627.2015.1078958 · Cited by 71

Aging conundrum: A perspective for ovarian aging

Wu, J., Liu, Y., Song, Y., Wang, L., Ai, J., & Li, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.952471 · Cited by 73

Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury

Saraswat Ohri, S., Bankston, A. N., Mullins, S. A., Liu, Y., Andres, K. R., Beare, J. E., Howard, R. M., Burke, D. A., Riegler, A. S., Smith, A. E., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0679-17.2018 · Cited by 70

Proteasome dysfunction induces muscle growth defects and protein aggregation

Kitajima, Y., Tashiro, Y., Suzuki, N., Warita, H., Kato, M., Tateyama, M., Ando, R., Izumi, R., Yamazaki, M., Abe, M., et al. (2014) · Journal of Cell Science · doi:10.1242/jcs.150961 · Cited by 79

The impact of ERα action on muscle metabolism and insulin sensitivity – Strong enough for a man, made for a woman

Hevener, A. L., Zhou, Z., Moore, T. M., Drew, B. G., & Ribas, V. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.06.013 · Cited by 72

Reduction of lipid accumulation rescues Bietti's crystalline dystrophy phenotypes

Hata, M., Ikeda, H. O., Iwai, S., Iida, Y., Gotoh, N., Asaka, I., Ikeda, K., Isobe, Y., Hori, A., Nakagawa, S., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717338115 · Cited by 70

Partial inhibition of mitochondrial complex I ameliorates Alzheimer’s disease pathology and cognition in APP/PS1 female mice

Stojakovic, A., Trushin, S., Sheu, A., Khalili, L., Chang, S.-Y., Li, X., Christensen, T., Salisbury, J. L., Geroux, R. E., Gateno, B., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01584-y · Cited by 72

Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?

Deretic, V., & Kroemer, G. (2022) · Autophagy · doi:10.1080/15548627.2021.1933742 · Cited by 71

Myocardial autophagic energy stress responses—macroautophagy, mitophagy, and glycophagy

Delbridge, L. M. D., Mellor, K. M., Taylor, D. J. R., & Gottlieb, R. A. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00002.2015 · Cited by 71

HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease

Brijmohan, A. S., Batchu, S. N., Majumder, S., Alghamdi, T. A., Thieme, K., McGaugh, S., Liu, Y., Advani, S. L., Bowskill, B. B., Kabir, M. G., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00034 · Cited by 71

IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis

Rovetta, A. I., Peña, D., Hernández Del Pino, R. E., Recalde, G. M., Pellegrini, J., Bigi, F., Musella, R. M., Palmero, D. J., Gutierrez, M., Colombo, M. I., et al. (2014) · Autophagy · doi:10.4161/15548627.2014.981791 · Cited by 71

Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner

Tao, S., Rojo de la Vega, M., Quijada, H., Wondrak, G. T., Wang, T., Garcia, J. G. N., & Zhang, D. D. (2016) · Scientific Reports · doi:10.1038/srep18760 · Cited by 68

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

Wang, C., Chen, S., Yeo, S., Karsli-Uzunbas, G., White, E., Mizushima, N., Virgin, H. W., & Guan, J.-L. (2016) · Journal of Cell Biology · doi:10.1083/jcb.201507023 · Cited by 69

Effects of aerobic training on markers of autophagy in the elderly

Mejías-Peña, Y., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Martínez-Flórez, S., Almar, M., de Paz, J. A., Cuevas, M. J., & González-Gallego, J. (2016) · AGE · doi:10.1007/s11357-016-9897-y · Cited by 69

The Neurodevelopmental Pathogenesis of Tuberous Sclerosis Complex (TSC)

Feliciano, D. M. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.00039 · Cited by 69

Targeting the Autophagy/Lysosomal Degradation Pathway in Parkinsons Disease

Rivero-Ríos, P., Madero-Pérez, Fernández, B., & Hilfiker, S. (2016) · Current Neuropharmacology · doi:10.2174/1570159x13666151030103027 · Cited by 69

USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination

Sharma, A., Alswillah, T., Singh, K., Chatterjee, P., Willard, B., Venere, M., Summers, M. K., & Almasan, A. (2018) · Autophagy · doi:10.1080/15548627.2018.1496877 · Cited by 69

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients

Zhang, Y.-K., Qu, Y.-Y., Lin, Y., Wu, X.-H., Chen, H.-Z., Wang, X., Zhou, K.-Q., Wei, Y., Guo, F., Yao, C.-F., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00489-5 · Cited by 68

Markers of autophagy are adapted to hyperglycaemia in skeletal muscle in type 2 diabetes

Kruse, R., Vind, B. F., Petersson, S. J., Kristensen, J. M., & Højlund, K. (2015) · Diabetologia · doi:10.1007/s00125-015-3654-0 · Cited by 67

Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium

Wavre-Shapton, S. T., Tolmachova, T., da Silva, M. L., Futter, C. E., & Seabra, M. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057769 · Cited by 67

mTOR controls ChREBP transcriptional activity and pancreatic β cell survival under diabetic stress

Chau, G. C., Im, D. U., Kang, T. M., Bae, J. M., Kim, W., Pyo, S., Moon, E.-Y., & Um, S. H. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201701085 · Cited by 67

Identification of Withaferin A as a Potential Candidate for Anti-Cancer Therapy in Non-Small Cell Lung Cancer

Hsu, J. H.-M., Chang, P. M.-H., Cheng, T.-S., Kuo, Y.-L., Wu, A. T.-H., Tran, T.-H., Yang, Y.-H., Chen, J.-M., Tsai, Y.-C., Chu, Y.-S., et al. (2019) · Cancers · doi:10.3390/cancers11071003 · Cited by 68

Mitochondrial Quality Control in Aging and Heart Failure: Influence of Ketone Bodies and Mitofusin-Stabilizing Peptides

Thai, P. N., Seidlmayer, L. K., Miller, C., Ferrero, M., Dorn, G. W., Schaefer, S., Bers, D. M., & Dedkova, E. N. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00382 · Cited by 66

Downregulation of VRK1 by p53 in Response to DNA Damage Is Mediated by the Autophagic Pathway

Valbuena, A., Castro-Obregón, S., & Lazo, P. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017320 · Cited by 66

Extracellular Vesicles Derived from Senescent Fibroblasts Attenuate the Dermal Effect on Keratinocyte Differentiation

Choi, E.-J., Kil, I. S., & Cho, E.-G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031022 · Cited by 66

Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration

La Cunza, N., Tan, L. X., Thamban, T., Germer, C. J., Rathnasamy, G., Toops, K. A., & Lakkaraju, A. (2021) · JCI Insight · doi:10.1172/jci.insight.142254 · Cited by 65

Comprehensive autophagy evaluation in cardiac disease models

Kaludercic, N., Maiuri, M. C., Kaushik, S., Fernández, Á. F., de Bruijn, J., Castoldi, F., Chen, Y., Ito, J., Mukai, R., Murakawa, T., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvz233 · Cited by 64

Type I interferon enhances necroptosis of Salmonella Typhimurium–infected macrophages by impairing antioxidative stress responses

Hos, N. J., Ganesan, R., Gutiérrez, S., Hos, D., Klimek, J., Abdullah, Z., Krönke, M., & Robinson, N. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201701107 · Cited by 64

Brain high-throughput multi-omics data reveal molecular heterogeneity in Alzheimer’s disease

Eteleeb, A. M., Novotny, B. C., Tarraga, C. S., Sohn, C., Dhungel, E., Brase, L., Nallapu, A., Buss, J., Farias, F., Bergmann, K., et al. (2024) · PLOS Biology · doi:10.1371/journal.pbio.3002607 · Cited by 64

Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production

Scrivo, A., Codogno, P., & Bomont, P. (2019) · Nature Communications · doi:10.1038/s41467-019-08331-w · Cited by 64

Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure

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Estradiol signaling mediates gender difference in visceral adiposity via autophagy

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