Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Autophagy in the Pathogenesis of Disease

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Autophagy fights disease through cellular self-digestion

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Cell Death

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis

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Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia

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Cellular Metabolism in Lung Health and Disease

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Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

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The Actin Cytoskeleton Is Required for Selective Types of Autophagy, but Not Nonspecific Autophagy, in the Yeast Saccharomyces cerevisiae

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Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

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PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development

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The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis

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Coordinate Autophagy and mTOR Pathway Inhibition Enhances Cell Death in Melanoma

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Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs

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Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration

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Impaired GAPDH‐induced mitophagy contributes to the pathology of Huntington's disease

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Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons

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Metformin Targets Multiple Signaling Pathways in Cancer

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Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

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Lipid sorting and multivesicular endosome biogenesis

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The role of mitophagy in the regulation of mitochondrial energetic status in neurons

Han, S., Zhang, M., Jeong, Y. Y., Margolis, D. J., & Cai, Q. (2021) · Autophagy · doi:10.1080/15548627.2021.1907167 · Cited by 151

Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation

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Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8–Mediated Cleavage of Beclin 1

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The role of raptor in the mechanical load‐induced regulation of mTOR signaling, protein synthesis, and skeletal muscle hypertrophy

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Cell “Self‐Eating” (Autophagy) Mechanism in Alzheimer's Disease

Funderburk, S. F., Marcellino, B. K., & Yue, Z. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20161 · Cited by 139

Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity

Lo Verso, F., Carnio, S., Vainshtein, A., & Sandri, M. (2014) · Autophagy · doi:10.4161/auto.32154 · Cited by 146

ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer

Hashimoto, S., Furukawa, S., Hashimoto, A., Tsutaho, A., Fukao, A., Sakamura, Y., Parajuli, G., Onodera, Y., Otsuka, Y., Handa, H., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901765116 · Cited by 149

Defective autophagy in atherosclerosis: to die or to senesce?

Grootaert, M. O. J., Roth, L., Schrijvers, D. M., De Meyer, G. R. Y., & Martinet, W. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7687083 · Cited by 147

Glutaminolysis and autophagy in cancer

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A systems study reveals concurrent activation of AMPK and mTOR by amino acids

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Isolation and characterization of a retinal pigment epithelial cell fluorophore: An all-trans -retinal dimer conjugate

Fishkin, N. E., Sparrow, J. R., Allikmets, R., & Nakanishi, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501266102 · Cited by 146

Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin

Maurer, K., Reyes-Robles, T., Alonzo, F., Durbin, J., Torres, V. J., & Cadwell, K. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.001 · Cited by 146

Autophagy and misfolded proteins in neurodegeneration

Metcalf, D. J., García-Arencibia, M., Hochfeld, W. E., & Rubinsztein, D. C. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.003 · Cited by 138

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

Schäffner, I., Minakaki, G., Khan, M. A., Balta, E.-A., Schlötzer-Schrehardt, U., Schwarz, T. J., Beckervordersandforth, R., Winner, B., Webb, A. E., DePinho, R. A., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.017 · Cited by 145

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-dependent Foxk1 Phosphorylation

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Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease

Bhatti, G. K., Reddy, A. P., Reddy, P. H., & Bhatti, J. S. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00369 · Cited by 145

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

Yamamoto, S., Kuramoto, K., Wang, N., Situ, X., Priyadarshini, M., Zhang, W., Cordoba-Chacon, J., Layden, B. T., & He, C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.032 · Cited by 144

DAMPs, ageing, and cancer: The ‘DAMP Hypothesis’

Huang, J., Xie, Y., Sun, X., Zeh, H. J., Kang, R., Lotze, M. T., & Tang, D. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.004 · Cited by 144

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders

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Neuroglialpharmacology: Myelination as a shared mechanism of action of psychotropic treatments

Bartzokis, G. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.015 · Cited by 142

Cocaine-mediated microglial activation involves the ER stress-autophagy axis.

Guo, M.-L., Liao, K., Periyasamy, P., Yang, L., Cai, Y., Callen, S. E., & Buch, S. (2015) · Autophagy · doi:10.1080/15548627.2015.1052205 · Cited by 144

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

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MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling

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Autophagy in animal development

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Mechanisms of protein toxicity in neurodegenerative diseases

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Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass

Sakuma, K., & Yamaguchi, A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-011-0052-4 · Cited by 137

Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways

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ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

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HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

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KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

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Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila

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Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms

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Strategies Used by Bacteria to Grow in Macrophages

Mitchell*, G., Chen*, C., & Portnoy, D. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0012-2015 · Cited by 137

Oligemic Hypoperfusion Differentially Affects Tau and Amyloid-β

Koike, M. A., Green, K. N., Blurton-Jones, M., & LaFerla, F. M. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090750 · Cited by 130

Time-dependent dysregulation of autophagy: Implications in aging and mitochondrial homeostasis in the kidney proximal tubule

Yamamoto, T., Takabatake, Y., Kimura, T., Takahashi, A., Namba, T., Matsuda, J., Minami, S., Kaimori, J.-Y., Matsui, I., Kitamura, H., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1159376 · Cited by 135

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

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Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

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Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases

Sardiello, M. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13131 · Cited by 135

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy–Lysosome System in a γ-Secretase-Independent Manner

Neely, K. M., Green, K. N., & LaFerla, F. M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5156-10.2010 · Cited by 134

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

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Intermittent hypoxia induces a metastatic phenotype in breast cancer

Chen, A., Sceneay, J., Gödde, N., Kinwel, T., Ham, S., Thompson, E. W., Humbert, P. O., & Möller, A. (2018) · Oncogene · doi:10.1038/s41388-018-0259-3 · Cited by 133

The endocytic pathway in microglia during health, aging and Alzheimer’s disease

Solé-Domènech, S., Cruz, D. L., Capetillo-Zarate, E., & Maxfield, F. R. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.07.002 · Cited by 133

Glucose Transporter 1–Dependent Glycolysis Is Increased during Aging-Related Lung Fibrosis, and Phloretin Inhibits Lung Fibrosis

Cho, S. J., Moon, J.-S., Lee, C.-M., Choi, A. M. K., & Stout-Delgado, H. W. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0225oc · Cited by 133

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., Kosberg, K., Adame, A., Spencer, B., Rockenstein, E., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.3207-14.2015 · Cited by 133

Alternative fuels for cancer cells

Keenan, M. M., & Chi, J.-T. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000104 · Cited by 131

Pathophysiological role of different tubular epithelial cell death modes in acute kidney injury

Sancho-Martínez, S. M., López-Novoa, J. M., & López-Hernández, F. J. (2015) · Clinical Kidney Journal · doi:10.1093/ckj/sfv069 · Cited by 130

A gene toolbox for monitoring autophagy transcription

Bordi, M., De Cegli, R., Testa, B., Nixon, R. A., Ballabio, A., & Cecconi, F. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04121-9 · Cited by 131

TOR‐mediated regulation of metabolism in aging

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Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium

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Role of Sphingolipid Metabolism in Neurodegeneration

Alaamery, M., Albesher, N., Aljawini, N., Alsuwailm, M., Massadeh, S., Wheeler, M. A., Chao, C., & Quintana, F. J. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15044 · Cited by 129

Protein misfolding disorders and macroautophagy

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Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

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Placental transport in response to altered maternal nutrition

Gaccioli, F., Lager, S., Powell, T. L., & Jansson, T. (2013) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000529 · Cited by 129

Hypoxia-inducible factor-1α promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis

Liu, H., Zhang, Z., Xiong, W., Zhang, L., Xiong, Y., Li, N., He, H., Du, Y., & Liu, Y. (2017) · Reproduction · doi:10.1530/rep-16-0643 · Cited by 127

Cystatin C in aging and in Alzheimer’s disease

Mathews, P. M., & Levy, E. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.003 · Cited by 133

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux

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Rare pathogenic variants predispose to hepatocellular carcinoma in nonalcoholic fatty liver disease

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Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

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Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

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An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

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Prognostic value of the autophagy markers LC3 and p62/SQSTM1 in early-stage non-small cell lung cancer

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Role of Parkin and endurance training on mitochondrial turnover in skeletal muscle

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Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice

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