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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Autophagy in the Pathogenesis of Disease

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Autophagy fights disease through cellular self-digestion

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Cell Death

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Targeting Autophagy in Cancer: Recent Advances and Future Directions

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Degradation of misfolded proteins in neurodegenerative diseases: Therapeutic targets and strategies

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Autophagy-Independent Functions of the Autophagy Machinery

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Toll-like Receptor 4 Is a Sensor for Autophagy Associated with Innate Immunity

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Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

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Autophagy during viral infection — a double-edged sword

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Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

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Metabolic control of autophagy

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Autophagy in inflammation, infection, and immunometabolism

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Autophagy and Tumor Metabolism

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Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

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Consensus guidelines for the detection of immunogenic cell death

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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

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Targeting the translation machinery in cancer

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AMPK activators: mechanisms of action and physiological activities

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The mTOR Signalling Pathway in Human Cancer

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Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

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Oxidative stress response and Nrf2 signaling in aging

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NAD+ in Brain Aging and Neurodegenerative Disorders

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The mammalian ULK1 complex and autophagy initiation

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The microbiome in infectious disease and inflammation

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Autophagy in the Cellular Energetic Balance

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

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Autophagy as a promoter of longevity: insights from model organisms

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Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

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Autophagy-dependent cell death

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Benefits of Metformin in Attenuating the Hallmarks of Aging

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Identification of a candidate therapeutic autophagy-inducing peptide

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Nrf2, the Master Regulator of Anti-Oxidative Responses

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Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

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History and progress of hypotheses and clinical trials for Alzheimer’s disease

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p53 status determines the role of autophagy in pancreatic tumour development

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Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

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Genetic variability in the regulation of gene expression in ten regions of the human brain

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Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

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Immune activation in brain aging and neurodegeneration: too much or too little?

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Transcellular degradation of axonal mitochondria

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Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues

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Autophagy mediates degradation of nuclear lamina

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The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

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SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

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Mitochondrial optic neuropathies—Disease mechanisms and therapeutic strategies

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NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

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Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

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Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

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Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

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Intermittent metabolic switching, neuroplasticity and brain health

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TGF-β Family Signaling in the Control of Cell Proliferation and Survival

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The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

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A critical role for the autophagy gene Atg5 in T cell survival and proliferation

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DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

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Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

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Autophagy failure in Alzheimer's disease—locating the primary defect

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Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

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Interplay of LRRK2 with chaperone-mediated autophagy

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Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.

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Cleaning house: selective autophagy of organelles

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Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease

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The GH/IGF-1 axis in ageing and longevity

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Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

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Autophagy Protects against Sindbis Virus Infection of the Central Nervous System

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Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

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mTOR coordinates protein synthesis, mitochondrial activity and proliferation

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Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration

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Dual role of autophagy in hallmarks of cancer

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

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The KEAP1–NRF2 System in Cancer

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Altered metabolism in cancer: insights into energy pathways and therapeutic targets

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Huntingtin Expression Stimulates Endosomal–Lysosomal Activity, Endosome Tubulation, and Autophagy

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Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

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Autophagy and aging: keeping that old broom working

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Molecular mechanisms of tumor resistance to radiotherapy

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Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

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Effects of blue light on the circadian system and eye physiology

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The role of STAT3 in autophagy

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Age-related macular degeneration

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Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

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Reactive Oxygen Species in the Tumor Microenvironment: An Overview

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