Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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Autophagy in the Pathogenesis of Disease

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

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Autophagy fights disease through cellular self-digestion

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Cell Death

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

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Interplay of pathogenic forms of human tau with different autophagic pathways

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Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase

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Metabolic catastrophe as a means to cancer cell death

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Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration

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Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy

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The cellular and molecular mechanisms of vertebrate lens development

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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

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Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

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KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

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Targeting lysosomes in human disease: from basic research to clinical applications

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ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

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Biomarkers for the Early Detection and Progression of Alzheimer's Disease

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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

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Parkinson’s disease as a result of aging

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Fruit and Vegetable Consumption and Changes in Anthropometric Variables in Adult Populations: A Systematic Review and Meta-Analysis of Prospective Cohort Studies

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Multistep regulation of TFEB by MTORC1

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The Mechanism and Physiological Function of Macroautophagy

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Human TBK1: A Gatekeeper of Neuroinflammation

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miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo

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PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage

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TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation

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Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

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Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases

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mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control

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Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death

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Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease

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Autophagic Stress in Neuronal Injury and Disease

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Mechanisms of Selective Autophagy in Normal Physiology and Cancer

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Role of Platelet Mitochondria: Life in a Nucleus-Free Zone

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Redox control of skeletal muscle atrophy.

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New Autophagy Reporter Mice Reveal Dynamics of Proximal Tubular Autophagy

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Probiotic Bacillus subtilis protects against α-synuclein aggregation in C. elegans

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Autophagy in Alzheimer’s disease

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Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy

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Entosis Is Induced by Glucose Starvation

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PTEN deficiency and AMPK activation promote nutrient scavenging and anabolism in prostate cancer cells

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Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

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Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence

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Endocytosis and Autophagy: Exploitation or Cooperation?

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NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

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Autophagy and ALS: mechanistic insights and therapeutic implications

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RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

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Interferons: Signaling, antiviral and viral evasion

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ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS

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MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-κB-TNFα pathway

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Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling

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PI3K/Akt/mTOR Signaling Pathway as a Target for Colorectal Cancer Treatment

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mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

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A Self-Destructive Nanosweeper That Captures and Clears Amyloid β-Peptides

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Neuroblast senescence in the aged brain augments natural killer cell cytotoxicity leading to impaired neurogenesis and cognition

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Vitamin C: a novel regulator of neutrophil extracellular trap formation.

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The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

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Atg17 Regulates the Magnitude of the Autophagic Response

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Hypoxia and Selective Autophagy in Cancer Development and Therapy

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Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits

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SQSTM1/p62: a potential target for neurodegenerative disease

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A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

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Senescence in the pathogenesis of age-related macular degeneration

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Chemical screening identifies ATM as a target for alleviating senescence

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Crosstalk between ER stress, autophagy and inflammation

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Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy

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Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle

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Boning up on autophagy: The role of autophagy in skeletal biology

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The impact of dietary protein intake on longevity and metabolic health

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Protective role of autophagy against Vibrio cholerae cytolysin, a pore-forming toxin from V. cholerae

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Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort

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Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses

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Inhibition of autophagy as a new means of improving chemotherapy efficiency in high-LC3B triple-negative breast cancers

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Lysosome: The metabolic signaling hub

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Inhibition of MTOR Disrupts Autophagic Flux in Podocytes

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ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

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The Ubiquitin–Proteasome System in Regulation of the Skeletal Muscle Homeostasis and Atrophy: From Basic Science to Disorders

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Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

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The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging‐Related Diseases from Eukaryotic and Prokaryotic Model Organisms

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DNA Damage Response and Autophagy: A Meaningful Partnership

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Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

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Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer’s Disease

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A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

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mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

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ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

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