Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Cell Death

Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026

Macropinocytosis, mTORC1 and cellular growth control

Yoshida, S., Pacitto, R., Inoki, K., & Swanson, J. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2710-y · Cited by 114

Membrane proteomics of phagosomes suggests a connection to autophagy

Shui, W., Sheu, L., Liu, J., Smart, B., Petzold, C. J., Hsieh, T.-Y., Pitcher, A., Keasling, J. D., & Bertozzi, C. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809218105 · Cited by 114

Insight into the Role of the PI3K/Akt Pathway in Ischemic Injury and Post-Infarct Left Ventricular Remodeling in Normal and Diabetic Heart

Walkowski, B., Kleibert, M., Majka, M., & Wojciechowska, M. (2022) · Cells · doi:10.3390/cells11091553 · Cited by 117

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

Walters, H. E., Deneka-Hannemann, S., & Cox, L. S. (2016) · Aging · doi:10.18632/aging.100872 · Cited by 113

ACAT1/SOAT1 as a Therapeutic Target for Alzheimer's Disease

Shibuya, Y., Chang, C. C., & Chang, T.-Y. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.161 · Cited by 113

Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: A theoretical review

Salminen, L. E., & Paul, R. H. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0046 · Cited by 113

PGC-1α protects RPE cells of the aging retina against oxidative stress-induced degeneration through the regulation of senescence and mitochondrial quality control. The significance for AMD pathogenesis

Kaarniranta, K., Kajdanek, J., Morawiec, J., Pawlowska, E., & Blasiak, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082317 · Cited by 112

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk

Cai, J., Pires, K. M., Ferhat, M., Chaurasia, B., Buffolo, M. A., Smalling, R., Sargsyan, A., Atkinson, D. L., Summers, S. A., Graham, T. E., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.040 · Cited by 107

Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A

Abdul Rahim, S. A., Dirkse, A., Oudin, A., Schuster, A., Bohler, J., Barthelemy, V., Muller, A., Vallar, L., Janji, B., Golebiewska, A., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.263 · Cited by 111

Chaperone‐mediated autophagy: Molecular mechanisms, biological functions, and diseases

Yao, R., & Shen, J. (2023) · MedComm · doi:10.1002/mco2.347 · Cited by 111

Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens

Fernández, Á. F., Bárcena, C., Martínez-García, G. G., Tamargo-Gómez, I., Suárez, M. F., Pietrocola, F., Castoldi, F., Esteban, L., Sierra-Filardi, E., Boya, P., et al. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.373 · Cited by 109

Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview

Meccariello, R., & D’Angelo, S. (2021) · Antioxidants · doi:10.3390/antiox10040507 · Cited by 110

AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms

Nwadike, C., Williamson, L. E., Gallagher, L. E., Guan, J.-L., & Chan, E. Y. W. (2018) · Molecular and Cellular Biology · doi:10.1128/mcb.00023-18 · Cited by 110

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

Iershov, A., Nemazanyy, I., Alkhoury, C., Girard, M., Barth, E., Cagnard, N., Montagner, A., Chretien, D., Rugarli, E. I., Guillou, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09598-9 · Cited by 109

AMPK negatively regulates tensin-dependent integrin activity

Georgiadou, M., Lilja, J., Jacquemet, G., Guzmán, C., Rafaeva, M., Alibert, C., Yan, Y., Sahgal, P., Lerche, M., Manneville, J.-B., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201609066 · Cited by 109

Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells

Wu, Y. C., Wang, X. J., Yu, L., Chan, F. K. L., Cheng, A. S. L., Yu, J., Sung, J. J. Y., Wu, W. K. K., & Cho, C. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037572 · Cited by 109

Atg9a deficiency causes axon-specific lesions including neuronal circuit dysgenesis

Yamaguchi, J., Suzuki, C., Nanao, T., Kakuta, S., Ozawa, K., Tanida, I., Saitoh, T., Sunabori, T., Komatsu, M., Tanaka, K., et al. (2018) · Autophagy · doi:10.1080/15548627.2017.1314897 · Cited by 109

Spectroscopic and morphological studies of human retinal lipofuscin granules

Haralampus-Grynaviski, N. M., Lamb, L. E., Clancy, C. M. R., Skumatz, C., Burke, J. M., Sarna, T., & Simon, J. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630280100 · Cited by 104

Integrating the DNA damage and protein stress responses during cancer development and treatment

Gorgoulis, V. G., Pefani, D., Pateras, I. S., & Trougakos, I. P. (2018) · The Journal of Pathology · doi:10.1002/path.5097 · Cited by 108

Autophagy promotes mammalian survival by suppressing oxidative stress and p53

Yang, Y., Karsli-Uzunbas, G., Poillet-Perez, L., Sawant, A., Hu, Z. S., Zhao, Y., Moore, D., Hu, W., & White, E. (2020) · Genes & Development · doi:10.1101/gad.335570.119 · Cited by 100

Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD)

Belibi, F., Zafar, I., Ravichandran, K., Segvic, A. B., Jani, A., Ljubanovic, D. G., & Edelstein, C. L. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00348.2010 · Cited by 107

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

Cavadas, C., Aveleira, C. A., Souza, G. F. P., & Velloso, L. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.107 · Cited by 105

AMPK-dependent autophagy upregulation serves as a survival mechanism in response to Tumor Treating Fields (TTFields)

Shteingauz, A., Porat, Y., Voloshin, T., Schneiderman, R. S., Munster, M., Zeevi, E., Kaynan, N., Gotlib, K., Giladi, M., Kirson, E. D., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-1085-9 · Cited by 107

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

Chen, X., Li, Y., Wang, C., Tang, Y., Mok, S.-A., Tsai, R. M., Rojas, J. C., Karydas, A., Miller, B. L., Boxer, A. L., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0354-0 · Cited by 107

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure

Jessop, F., Hamilton, R. F., Rhoderick, J. F., Shaw, P. K., & Holian, A. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.08.029 · Cited by 94

Eaten alive: novel insights into autophagy from multicellular model systems

Zhang, H., & Baehrecke, E. H. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.03.001 · Cited by 102

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Genini, D., Brambilla, L., Laurini, E., Merulla, J., Civenni, G., Pandit, S., D'Antuono, R., Perez, L., Levy, D. E., Pricl, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615730114 · Cited by 106

TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status

Liang, C., Xu, J., Meng, Q., Zhang, B., Liu, J., Hua, J., Zhang, Y., Shi, S., & Yu, X. (2020) · Autophagy · doi:10.1080/15548627.2019.1628540 · Cited by 106

Autophagy is activated to protect against endotoxic acute kidney injury

Mei, S., Livingston, M., Hao, J., li, L., Mei, C., & Dong, Z. (2016) · Scientific Reports · doi:10.1038/srep22171 · Cited by 104

Growth factor signaling to mTORC1 by amino acid–laden macropinosomes

Yoshida, S., Pacitto, R., Yao, Y., Inoki, K., & Swanson, J. A. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201504097 · Cited by 105

DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX

Guan, J.-J., Zhang, X.-D., Sun, W., Qi, L., Wu, J.-C., & Qin, Z.-H. (2015) · Cell Death & Disease · doi:10.1038/cddis.2014.546 · Cited by 105

Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy

Guo, H., Wang, Y., Zhang, X., Zang, Y., Zhang, Y., Wang, L., Wang, H., Wang, Y., Cao, A., & Peng, W. (2017) · Scientific Reports · doi:10.1038/s41598-017-07061-7 · Cited by 104

Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects

Mejías-Peña, Y., Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., Almar, M., de Paz, J. A., González-Gallego, J., & Cuevas, M. J. (2017) · Aging · doi:10.18632/aging.101167 · Cited by 102

Effects of exercise on cellular and tissue aging

Carapeto, P. V., & Aguayo-Mazzucato, C. (2021) · Aging · doi:10.18632/aging.203051 · Cited by 107

Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium

Toops, K. A., Tan, L. X., Jiang, Z., Radu, R. A., & Lakkaraju, A. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-1028 · Cited by 105

The AMPK/p27Kip1 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells

White, J. P., Billin, A. N., Campbell, M. E., Russell, A. J., Huffman, K. M., & Kraus, W. E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.06.014 · Cited by 104

Regular Endurance Exercise Promotes Fission, Mitophagy, and Oxidative Phosphorylation in Human Skeletal Muscle Independently of Age

Balan, E., Schwalm, C., Naslain, D., Nielens, H., Francaux, M., & Deldicque, L. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01088 · Cited by 104

Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery

Hatano, T., Palani, S., Papatziamou, D., Salzer, R., Souza, D. P., Tamarit, D., Makwana, M., Potter, A., Haig, A., Xu, W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30656-2 · Cited by 104

Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction

Vaz‐Silva, J., Gomes, P., Jin, Q., Zhu, M., Zhuravleva, V., Quintremil, S., Meira, T., Silva, J., Dioli, C., Soares‐Cunha, C., et al. (2018) · The EMBO Journal · doi:10.15252/embj.201899084 · Cited by 104

Metabolomic profiling of single enlarged lysosomes

Zhu, H., Li, Q., Liao, T., Yin, X., Chen, Q., Wang, Z., Dai, M., Yi, L., Ge, S., Miao, C., et al. (2021) · Nature Methods · doi:10.1038/s41592-021-01182-8 · Cited by 103

Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion

Tang, Q., Gao, P., Arzberger, T., Höllerhage, M., Herms, J., Höglinger, G., & Koeglsperger, T. (2021) · Cell Death & Disease · doi:10.1038/s41419-021-04138-0 · Cited by 103

Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

Hubbard-Lucey, V. M., Shono, Y., Maurer, K., West, M. L., Singer, N. V., Ziegler, C. G. K., Lezcano, C., Motta, A. C. F., Schmid, K., Levi, S. M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.011 · Cited by 102

661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively

Sayyad, Z., Sirohi, K., Radha, V., & Swarup, G. (2017) · Scientific Reports · doi:10.1038/s41598-017-17241-0 · Cited by 96

Clinical features of TBK1 carriers compared with C9orf72,GRN and non-mutation carriers in a Belgian cohort

Van Mossevelde, S., van der Zee, J., Gijselinck, I., Engelborghs, S., Sieben, A., Van Langenhove, T., De Bleecker, J., Baets, J., Vandenbulcke, M., Van Laere, K., et al. (2016) · Brain · doi:10.1093/brain/awv358 · Cited by 98

Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

Chrisam, M., Pirozzi, M., Castagnaro, S., Blaauw, B., Polishchuck, R., Cecconi, F., Grumati, P., & Bonaldo, P. (2015) · Autophagy · doi:10.1080/15548627.2015.1108508 · Cited by 101

Autophagic vacuoles in cardiomyocytes of dilated cardiomyopathy with initially decompensated heart failure predict improved prognosis

Saito, T., Asai, K., Sato, S., Hayashi, M., Adachi, A., Sasaki, Y., Takano, H., Mizuno, K., & Shimizu, W. (2016) · Autophagy · doi:10.1080/15548627.2016.1145326 · Cited by 101

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

Song, C., Mitter, S. K., Qi, X., Beli, E., Rao, H. V., Ding, J., Ip, C. S., Gu, H., Akin, D., Dunn, W. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171940 · Cited by 100

Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment

Polverino, F., Wu, T. D., Rojas-Quintero, J., Wang, X., Mayo, J., Tomchaney, M., Tram, J., Packard, S., Zhang, D., Cleveland, K. H., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202012-4510oc · Cited by 100

Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility

Yang, X., Brobst, D., Chan, W. S., Tse, M. C. L., Herlea-Pana, O., Ahuja, P., Bi, X., Zaw, A. M., Kwong, Z. S. W., Jia, W.-H., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aau1468 · Cited by 99

Dysregulated autophagy contributes to caspase-dependent neuronal apoptosis

Chung, Y., Lee, J., Jung, S., Lee, Y., Cho, J. W., & Oh, Y. J. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-1229-y · Cited by 99

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1978-z · Cited by 99

Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens

Kumar, S., Jain, A., Choi, S. W., da Silva, G. P. D., Allers, L., Mudd, M. H., Peters, R. S., Anonsen, J. H., Rusten, T.-E., Lazarou, M., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0549-1 · Cited by 95

Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy

Yamamuro, T., Kawabata, T., Fukuhara, A., Saita, S., Nakamura, S., Takeshita, H., Fujiwara, M., Enokidani, Y., Yoshida, G., Tabata, K., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17985-w · Cited by 97

Inhibition of BMI1 induces autophagy-mediated necroptosis

Dey, A., Mustafi, S. B., Saha, S., Kumar Dhar Dwivedi, S., Mukherjee, P., & Bhattacharya, R. (2016) · Autophagy · doi:10.1080/15548627.2016.1147670 · Cited by 97

Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons

Lie, P. P. Y., Yang, D.-S., Stavrides, P., Goulbourne, C. N., Zheng, P., Mohan, P. S., Cataldo, A. M., & Nixon, R. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109034 · Cited by 97

Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF

Jiang, Y., Rigoglioso, A., Peterhoff, C. M., Pawlik, M., Sato, Y., Bleiwas, C., Stavrides, P., Smiley, J. F., Ginsberg, S. D., Mathews, P. M., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.11.013 · Cited by 97

Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy

Zaninello, M., Palikaras, K., Naon, D., Iwata, K., Herkenne, S., Quintana-Cabrera, R., Semenzato, M., Grespi, F., Ross-Cisneros, F. N., Carelli, V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17821-1 · Cited by 92

Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Lachance, V., Wang, Q., Sweet, E., Choi, I., Cai, C.-Z., Zhuang, X.-X., Zhang, Y., Jiang, J. L., Blitzer, R. D., Bozdagi-Gunal, O., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0342-4 · Cited by 96

Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies

Hasan, M., & Yan, N. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.04.008 · Cited by 83

Targeting LKB1 in Cancer – Exposing and Exploiting Vulnerabilities

Momcilovic, M., & Shackelford, D. B. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.261 · Cited by 97

4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1

Yang, H., Wang, J., Liu, M., Chen, X., Huang, M., Tan, D., Dong, M.-Q., Wong, C. C. L., Wang, J., Xu, Y., et al. (2016) · Protein & Cell · doi:10.1007/s13238-016-0346-6 · Cited by 96

Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

Inman, D. M., & Harun-Or-Rashid, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00146 · Cited by 88

mTOR signaling and Alzheimer's disease: What we know and where we are?

Davoody, S., Asgari Taei, A., Khodabakhsh, P., & Dargahi, L. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14463 · Cited by 96

Androgen-mediated regulation of skeletal muscle protein balance

Rossetti, M. L., Steiner, J. L., & Gordon, B. S. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.031 · Cited by 95

Age-Related Oxidative Stress Compromises Endosomal Proteostasis

Cannizzo, E. S., Clement, C. C., Morozova, K., Valdor, R., Kaushik, S., Almeida, L. N., Follo, C., Sahu, R., Cuervo, A. M., Macian, F., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.005 · Cited by 95

Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

Notomi, S., Ishihara, K., Efstathiou, N. E., Lee, J.-J., Hisatomi, T., Tachibana, T., Konstantinou, E. K., Ueta, T., Murakami, Y., Maidana, D. E., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906643116 · Cited by 92

Advanced glycation end‐products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

Zhao, X., Chen, Y., Tan, X., Zhang, L., Zhang, H., Li, Z., Liu, S., Li, R., Lin, T., Liao, R., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5077 · Cited by 93

LKB1 is essential for the proliferation of T‐cell progenitors and mature peripheral T cells

Tamás, P., Macintyre, A., Finlay, D., Clarke, R., Feijoo‐Carnero, C., Ashworth, A., & Cantrell, D. (2010) · European Journal of Immunology · doi:10.1002/eji.200939677 · Cited by 94

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

Zheng, H., Cheng, B., Li, Y., Li, X., Chen, X., & Zhang, Y.-W. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00395 · Cited by 94

Metabolic reprogramming in tumors: Contributions of the tumor microenvironment

Lane, A. N., Higashi, R. M., & Fan, T. W.-M. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2019.10.007 · Cited by 91

Metabolic Basis of Visual Cycle Inhibition by Retinoid and Nonretinoid Compounds in the Vertebrate Retina

Golczak, M., Maeda, A., Bereta, G., Maeda, T., Kiser, P. D., Hunzelmann, S., von Lintig, J., Blaner, W. S., & Palczewski, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708982200 · Cited by 93

Import and Export of Misfolded α-Synuclein

Rodriguez, L., Marano, M. M., & Tandon, A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00344 · Cited by 93

Mitochondrial quality control, promoted by PGC-1 α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice

Greene, N. P., Lee, D. E., Brown, J. L., Rosa, M. E., Brown, L. A., Perry, R. A., Henry, J. N., & Washington, T. A. (2015) · Physiological Reports · doi:10.14814/phy2.12470 · Cited by 89

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

Nam, S. A., Kim, W.-Y., Kim, J. W., Park, S. H., Kim, H. L., Lee, M.-S., Komatsu, M., Ha, H., Lim, J. H., Park, C. W., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1356-0 · Cited by 92

Detyrosinated microtubules spatially constrain lysosomes facilitating lysosome-autophagosome fusion

Mohan, N., Sorokina, E. M., Verdeny, I. V., Alvarez, A. S., & Lakadamyali, M. (2019) · Journal of Cell Biology · doi:10.1083/jcb.201807124 · Cited by 92

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy

Ma, X., Zhang, S., He, L., Rong, Y., Brier, L. W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1269988 · Cited by 92

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