The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Recalling Routes around London: Activation of the Right Hippocampus in Taxi Drivers
Open accessAbstract
Functional imaging to date has examined the neural basis of knowledge of spatial layouts of large-scale environments typically in the context of episodic memory with specific spatiotemporal references. Much human behavior, however, takes place in very familiar environments in which knowledge of spatial layouts has entered the domain of general facts often referred to as semantic memory. In this study, positron emission tomography (PET) was used to examine the neural substrates of topographical memory retrieval in licensed London taxi drivers of many years experience while they recalled complex routes around the city. Compared with baseline and other nontopographical memory tasks, this resulted in activation of a network of brain regions, including the right hippocampus. Recall of famous landmarks for which subjects had no knowledge of their location within a spatial framework activated similar regions, except for the right hippocampus. This suggests that the hippocampus is involved in the processing of spatial layouts established over long time courses. The involvement of similar brain areas in routes and landmarks memory indicates that the topographical memory system may be primed to respond to any relevant topographical stimulation; however, the right hippocampus is recruited specifically for navigation in large-scale spatial environments. In contrast, nontopographical semantic memory retrieval involved the left inferior frontal gyrus, with no change in activity in medial temporal regions.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Self-citationThe Development of Spatial Representations of Large-Scale Environments
Siegel, A. W., & White, S. H. (1975) · Advances in Child Development and Behavior · doi:10.1016/s0065-2407(08)60007-5 · Cited by 1,830
The mind's eye – precuneus activation in memory-related imagery
Fletcher, P. C., Frith, C. D., Baker, S. C., Shallice, T., Frackowiak, R. S. J., & Dolan, R. J. (1995) · NeuroImage · doi:10.1006/nimg.1995.1025 · Cited by 680 · cited 1×
“Areas of increased activity when sequencing was required for correct memory recall are compared with memory recall for which no particular sequence of information was necessary. with visual imagery (Fletcher et al., 1995a).”
BackgroundSelf-citation
Cited by
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Navigation-related structural change in the hippocampi of taxi drivers
Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S. J., & Frith, C. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.070039597 · Cited by 3,225
Self-citationSquire, L. R., Stark, C. E. L., & Clark, R. E. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144130 · Cited by 2,680
The human hippocampus and spatial and episodic memory
Burgess, N., Maguire, E. A., & O'Keefe, J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00830-9 · Cited by 2,401
Self-citationSpreng, R. N., Mar, R. A., & Kim, A. S. N. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.21029 · Cited by 2,143
A Structural MRI Study of Human Brain Development from Birth to 2 Years
Knickmeyer, R. C., Gouttard, S., Kang, C., Evans, D., Wilber, K., Smith, J. K., Hamer, R. M., Lin, W., Gerig, G., & Gilmore, J. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3479-08.2008 · Cited by 1,151
Aerobic fitness is associated with hippocampal volume in elderly humans
Erickson, K. I., Prakash, R. S., Voss, M. W., Chaddock, L., Hu, L., Morris, K. S., White, S. M., Wójcicki, T. R., McAuley, E., & Kramer, A. F. (2009) · Hippocampus · doi:10.1002/hipo.20547 · Cited by 1,007
Neural ensembles in CA3 transiently encode paths forward of the animal at a decision point
Johnson, A., & Redish, A. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3761-07.2007 · Cited by 1,003
Moscovitch, M., Rosenbaum, R. S., Gilboa, A., Addis, D. R., Westmacott, R., Grady, C., McAndrews, M. P., Levine, B., Black, S., Winocur, G., et al. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00421.x · Cited by 893
The Well-Worn Route and the Path Less Traveled
Hartley, T., Maguire, E. A., Spiers, H. J., & Burgess, N. (2003) · Neuron · doi:10.1016/s0896-6273(03)00095-3 · Cited by 817
Self-citationTopographical disorientation: a synthesis and taxonomy
Aguirre, G. K. (1999) · Brain · doi:10.1093/brain/122.9.1613 · Cited by 772
What's new with the amnesic patient H.M.?
Corkin, S. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn726 · Cited by 726
Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., VanPatter, M., Pontifex, M. B., Raine, L. B., Konkel, A., Hillman, C. H., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.08.049 · Cited by 687
Hippocampal synaptic plasticity, spatial memory and anxiety
Bannerman, D. M., Sprengel, R., Sanderson, D. J., McHugh, S. B., Rawlins, J. N. P., Monyer, H., & Seeburg, P. H. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3677 · Cited by 688
Human theta oscillations exhibit task dependence during virtual maze navigation
Kahana, M. J., Sekuler, R., Caplan, J. B., Kirschen, M., & Madsen, J. R. (1999) · Nature · doi:10.1038/21645 · Cited by 649
The origin of mind: Evolution of brain, cognition, and general intelligence.
Geary, D. C. (2005) · doi:10.1037/10871-000 · Cited by 551
The role of the hippocampus in flexible cognition and social behavior
Rubin, R. D., Watson, P. D., Duff, M. C., & Cohen, N. J. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00742 · Cited by 489
A temporoparietal and prefrontal network for retrieving the spatial context of lifelike events
Burgess, N., Maguire, E. A., Spiers, H. J., & O'Keefe, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0806 · Cited by 502
Self-citationCytology and functionally correlated circuits of human posterior cingulate areas
Vogt, B. A., Vogt, L., & Laureys, S. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.048 · Cited by 484
Hippocampal Inactivation Disrupts Contextual Retrieval of Fear Memory after Extinction
Corcoran, K. A., & Maren, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-05-01720.2001 · Cited by 455
The role of the hippocampus in navigation is memory
Eichenbaum, H. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00005.2017 · Cited by 430
Dynamic mapping of normal human hippocampal development
Gogtay, N., Nugent, T. F., Herman, D. H., Ordonez, A., Greenstein, D., Hayashi, K. M., Clasen, L., Toga, A. W., Giedd, J. N., Rapoport, J. L., et al. (2006) · Hippocampus · doi:10.1002/hipo.20193 · Cited by 426
Foo, P., Warren, W. H., Duchon, A., & Tarr, M. J. (2005) · Journal of Experimental Psychology: Learning, Memory, and Cognition · doi:10.1037/0278-7393.31.2.195 · Cited by 406
Beckett, C., Maughan, B., Rutter, M., Castle, J., Colvert, E., Groothues, C., Kreppner, J., Stevens, S., O'Connor, T. G., & Sonuga-Barke, E. J. S. (2006) · Child Development · doi:10.1111/j.1467-8624.2006.00898.x · Cited by 377
Event memory: A theory of memory for laboratory, autobiographical, and fictional events.
Rubin, D. C., & Umanath, S. (2015) · Psychological Review · doi:10.1037/a0037907 · Cited by 379
The clinical profile of right temporal lobe atrophy
Chan, D., Anderson, V., Pijnenburg, Y., Whitwell, J., Barnes, J., Scahill, R., Stevens, J. M., Barkhof, F., Scheltens, P., Rossor, M. N., et al. (2009) · Brain · doi:10.1093/brain/awp037 · Cited by 377
Memory for places learned long ago is intact after hippocampal damage
Teng, E., & Squire, L. R. (1999) · Nature · doi:10.1038/23276 · Cited by 372
Remote spatial memory in an amnesic person with extensive bilateral hippocampal lesions
Rosenbaum, R. S., Priselac, S., Köhler, S., Black, S. E., Gao, F., Nadel, L., & Moscovitch, M. (2000) · Nature Neuroscience · doi:10.1038/79867 · Cited by 293
Rosenbaum, R. S., Ziegler, M., Winocur, G., Grady, C. L., & Moscovitch, M. (2004) · Hippocampus · doi:10.1002/hipo.10218 · Cited by 258
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0121 · Cited by 253
Segregation of the human medial prefrontal cortex in social cognition
Bzdok, D., Langner, R., Schilbach, L., Engemann, D. A., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00232 · Cited by 229
Is the avian hippocampus a functional homologue of the mammalian hippocampus?
Colombo, M., & Broadbent, N. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00016-6 · Cited by 237
Hippocampal size predicts rapid learning of a cognitive map in humans
Schinazi, V. R., Nardi, D., Newcombe, N. S., Shipley, T. F., & Epstein, R. A. (2013) · Hippocampus · doi:10.1002/hipo.22111 · Cited by 231
Brain and cognitive evolution: Forms of modularity and functions of mind.
Geary, D. C., & Huffman, K. J. (2002) · Psychological Bulletin · doi:10.1037/0033-2909.128.5.667 · Cited by 234
The Human Hippocampus: Cognitive Maps or Relational Memory?
Kumaran, D., & Maguire, E. A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1103-05.2005 · Cited by 218
Self-citationHippocampal and prefrontal processing of network topology to simulate the future
Javadi, A.-H., Emo, B., Howard, L. R., Zisch, F. E., Yu, Y., Knight, R., Pinelo Silva, J., & Spiers, H. J. (2017) · Nature Communications · doi:10.1038/ncomms14652 · Cited by 207
Weniger, G., Ruhleder, M., Lange, C., Wolf, S., & Irle, E. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2010.12.031 · Cited by 204
Neural correlates of virtual route reCognition in congenital blindness
Kupers, R., Chebat, D. R., Madsen, K. H., Paulson, O. B., & Ptito, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006199107 · Cited by 187
Sugiura, M., Shah, N. J., Zilles, K., & Fink, G. R. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929053124956 · Cited by 167
Chaddock-Heyman, L., Hillman, C. H., Cohen, N. J., & Kramer, A. F. (2014) · Monographs of the Society for Research in Child Development · doi:10.1111/mono.12129 · Cited by 152
Visual Scene Processing in Familiar and Unfamiliar Environments
Epstein, R. A., Higgins, J. S., Jablonski, K., & Feiler, A. M. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00003.2007 · Cited by 153
Neural foundations of emerging route knowledge in complex spatial environments
Wolbers, T., Weiller, C., & Büchel, C. (2004) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2004.06.013 · Cited by 146
Redefining neuroendocrinology: Epigenetics of brain-body communication over the life course
McEwen, B. S. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.11.001 · Cited by 129
Neural evidence supports a novel framework for spatial navigation
Chrastil, E. R. (2013) · Psychonomic Bulletin & Review · doi:10.3758/s13423-012-0351-6 · Cited by 126
Spatial Cognition: Where We Were and Where We Are
Marshall, J. C., & Fink, G. R. (2001) · NeuroImage · doi:10.1006/nimg.2001.0834 · Cited by 118
The neuroscience of remote spatial memory: A tale of two cities
Spiers, H. J., & Maguire, E. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.056 · Cited by 117
Self-citationCardiorespiratory fitness, hippocampal volume, and frequency of forgetting in older adults.
Szabo, A. N., McAuley, E., Erickson, K. I., Voss, M., Prakash, R. S., Mailey, E. L., Wójcicki, T. R., White, S. M., Gothe, N., Olson, E. A., et al. (2011) · Neuropsychology · doi:10.1037/a0022733 · Cited by 110
Ciaramelli, E., Rosenbaum, R. S., Solcz, S., Levine, B., & Moscovitch, M. (2010) · Journal of Experimental Psychology: Learning, Memory, and Cognition · doi:10.1037/a0019181 · Cited by 112
Neural correlates of automatic mood regulation in girls at high risk for depression.
Joormann, J., Cooney, R. E., Henry, M. L., & Gotlib, I. H. (2012) · Journal of Abnormal Psychology · doi:10.1037/a0025294 · Cited by 98
Hirshhorn, M., Grady, C., Rosenbaum, R. S., Winocur, G., & Moscovitch, M. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.08.008 · Cited by 85
Navigation-associated medial parietal neurons in monkeys
Sato, N., Sakata, H., Tanaka, Y. L., & Taira, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604277103 · Cited by 82
Rosenbaum, R. S., Winocur, G., Grady, C. L., Ziegler, M., & Moscovitch, M. (2007) · Hippocampus · doi:10.1002/hipo.20354 · Cited by 58
Gaze patterns in navigation: Encoding information in large-scale environments
Hamid, S. N., Stankiewicz, B., & Hayhoe, M. (2010) · Journal of Vision · doi:10.1167/10.12.28 · Cited by 31
Brünner, Y. F., Rodriguez-Raecke, R., Mutic, S., Benedict, C., & Freiherr, J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.027 · Cited by 17
Ziegler, M. G., Liu, Z.-X., Arsenault, J., Dang, C., Grady, C., Rosenbaum, R. S., & Moscovitch, M. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad272 · Cited by 6
Metadata
- Authors
- Maguire, E. A., Frackowiak, R. S. J., & Frith, C. D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-09-15
- Volume
- 17
- Issue
- 18
- Pages
- 7103-7110
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2145129394
- Cited by
- 653
- References
- 3
- FWCI
- 97.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
