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Cited by 521

The DOI matches its Crossref record; 151 of the 151 references it cites were found in a registry or an index.

Hallmarks of glycosylation in cancer

Open access
Munkley, Jennifer, Elliott, David J.·2016·Oncotarget
DOI 10.18632/oncotarget.8155
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Abstract

// Jennifer Munkley 1 and David J. Elliott 1 1 Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, NE1 3BZ, UK Correspondence to: Jennifer Munkley, email: // Keywords : cancer, glycosylation, hallmarks, glycans, aberrant Received : January 28, 2016 Accepted : March 02, 2016 Published : March 17, 2016 Abstract Aberrant glycosylation plays a fundamental role in key pathological steps of tumour development and progression. Glycans have roles in cancer cell signalling, tumour cell dissociation and invasion, cell-matrix interactions, angiogenesis, metastasis and immune modulation. Aberrant glycosylation is often cited as a ‘hallmark of cancer’ but is notably absent from both the original hallmarks of cancer and from the next generation of emerging hallmarks. This review discusses how glycosylation is clearly an enabling characteristic that is causally associated with the acquisition of all the hallmark capabilities. Rather than aberrant glycosylation being itself a hallmark of cancer, another perspective is that glycans play a role in every recognised cancer hallmark.

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Metadata

Authors
Munkley, J., & Elliott, D. J.
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2016-03-17
Volume
7
Issue
23
Pages
35478-35489
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.8155
OpenAlex
W2311800161
Cited by
521
References
151
FWCI
17.00
Type
journal article
Language
en
Open access
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